检索结果-南通市图书馆

PCDH17 restricts dendritic spine morphogenesis by regulating ROCK2-dependent control of the actin cytoskeleton,modulating emotional behavior

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Zoological research 2024年第3期45卷 535-550页

作者： Laidong Yu Fangfang Zeng Mengshu Fan Kexuan Zhang Jingjing Duan Yalu Tan Panlin Liao Jin Wen Chenyu Wang Meilin Wang Jialong Yuan Xinxin Pang Yan Huang Yangzhou Zhang Jia-Da Li Zhuohua Zhang Zhonghua Hu Hunan Key Laboratory of Molecular Precision Medicine Department of Critical Care MedicineXiangya HospitalCentral South UniversityChangshaHunan 410008China Center for medical Genetics and Hunan Key Laboratory of medical Genetics School of Life SciencesCentral South UniversityChangshaHunan 410008China National Clinical research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Provincial Clinical research Center for Critical Care Medicine Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Key Laboratory of Animal Models for Human Diseases School of Life SciencesCentral South UniversityChangshaHunan 410008China MOE Key Lab of Rare Pediatric Diseases School of Life SciencesCentral South UniversityChangshaHunan 410008China Department of Neurosciences University of South China Medical SchoolHengyangHunan 421001China

Proper regulation of synapse formation and elimination is critical for establishing mature neuronal circuits and maintaining brain *** abnormalities,such as defects in the density and morphology of postsynaptic dendritic spines,underlie the pathology of various neuropsychiatric *** 17(PCDH17)is associated with major mood disorders,including bipolar disorder and ***,the molecular mechanisms by which PCDH17 regulates spine number,morphology,and behavior remain *** this study,we found that PCDH17 functions at postsynaptic sites,restricting the number and size of dendritic spines in excitatory *** overexpression of PCDH17 in the ventral hippocampal CA1 results in spine loss and anxiety-and depression-like behaviors in ***,PCDH17 interacts with actin-relevant proteins and regulates actin filament(F-actin)***,PCDH17 binds to ROCK2,increasing its expression and subsequently enhancing the activity of downstream targets such as LIMK1 and the phosphorylation of cofilin serine-3(Ser3).Inhibition of ROCK2 activity with belumosudil(KD025)ameliorates the defective F-actin organization and spine structure induced by PCDH17 overexpression,suggesting that ROCK2 mediates the effects of PCDH17 on F-actin content and spine ***,these findings reveal a novel mechanism by which PCDH17 regulates synapse development and behavior,providing pathological insights into the neurobiological basis of mood disorders.

关键词： Synapse development Dendritic spine Mood disorder Actin cytoskeleton Animal behavior

Hemorrhagic transformation in patients with large-artery atherosclerotic stroke is associated with the gut microbiota and lipopolysaccharide

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration research 2024年第7期19卷 1532-1540页

作者： Qin Huang Minping Wei Xianjing Feng Yunfang Luo Yunhai Liu Jian Xia Department of Neurology Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Neurology Peking University People’s HospitalBeijingChina Clinical research Center for Cerebrovascular Disease of Hunan Province Central South UniversityChangshaHunan ProvinceChina National Clinical research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Hemorrhagic transformation is a major complication of large-artery atheroscle rotic stroke(a major ischemic stro ke subtype)that wo rsens outcomes and increases *** of the gut microbiota is an important feature of stroke,and some specific bacteria and bacterial metabolites may contribute to hemorrhagic transformation *** aimed to investigate the relationship between the gut microbiota and hemorrhagic transformation in largearte ry atheroscle rotic stro *** observational retrospective study was *** May 2020 to September 2021,blood and fecal samples were obtained upon admission from 32 patients with first-ever acute ischemic stroke and not undergoing intravenous thrombolysis or endovascular thrombectomy,as well as 16 healthy *** with stro ke who developed hemorrhagic transfo rmation(n=15)were compared to those who did not develop hemorrhagic transformation(n=17)and with healthy *** gut microbiota was assessed through 16S ribosomal ribonucleic acid *** also examined key components of the lipopolysaccharide pathway:lipopolysaccharide,lipopolysaccharide-binding protein,and soluble *** observed that bacterial diversity was decreased in both the hemorrhagic transformation and non-hemorrhagic transfo rmation group compared with the healthy *** patients with ischemic stro ke who developed hemorrhagic transfo rmation exhibited altered gut micro biota composition,in particular an increase in the relative abundance and dive rsity of members belonging to the Enterobacteriaceae *** lipopolysaccharide and lipopolysaccharide-binding protein levels were higher in the hemorrhagic transformation group compared with the non-hemorrhagic transfo rmation ***,lipopolysaccharide-binding protein,and soluble CD14 concentrations were associated with increased abundance of Enterobacte ***,the role of the gut microbiota in hemorrhagic transformation was evaluated using

关键词： gut microbiota hemorrhagic transformation inflammation lipopolysaccharide stroke

Stable ultraviolet ultrafast laser based on all-polarizationmaintaining fiber femtosecond laser

在线全文

学校读者我要写书评

暂无评论

Chinese Optics Letters 2024年第3期22卷 76-82页

作者：田昊朱喆林巍李子豪温俊鹏修昊范怡衡韦池一韦小明杨中民 School of Physics and Optoelectronics/State Key Laboratory of Luminescent Materials and Devices Guangdong Engineering Technology Research and Development Center of Special Optical Fiber Materials and DevicesGuangdong Provincial Key Laboratory of Fiber Laser Materials and Applied TechniquesSouth China University of TechnologyGuangzhou 510640China research Institute of Future Technology South China Normal UniversityGuangzhou 510006China

We report a high-stability ultrafast ultraviolet(UV)laser source at 352 nm by exploring an all-fiber,all-polarizationmaintaining(all-PM),Yb-doped femtosecond fiber laser at 1060 *** output power,pulse width,and optical spectrum width of the fiber laser are 6 W,244 fs,and 17.5 nm,*** UV ultrashort pulses at a repetition rate of 28.9 MHz are generated by leveraging single-pass second-harmonic generation in a 1.3-mm-long BiB_(3)O_(6)(BIBO)and sum frequency generation in a 5.1-mm-long *** maximum UV output power is 596 *** root mean square error of the output power of UV pulses is 0.54%.This laser,with promising stability,is expected to be a nice source for frontier applications in the UV wavelength window.

关键词： all-polarization-maintaining fiber ultrafast fiber laser UV laser

CRABP2 regulates infiltration of cancer-associated fibroblasts and immune response in melanoma

在线全文

学校读者我要写书评

暂无评论

Oncology research 2024年第2期32卷 261-272页

作者： SHUANGSHUANG ZENG XI CHEN QIAOLI YI ABHIMANYU THAKUR HUI YANG YUANLIANG YAN SHAO LIU Department of Pharmacy Xiangya HospitalCentral South UniversityChangsha410008China National Clinical research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha410008China Pritzker School of Molecular Engineering Ben May Department for Cancer ResearchUniversity of ChicagoChicagoILUSA Department of Pathology The Second Affiliated Hospital of Shandong First Medical UniversityTaian271000China

Finding biomarkers for immunotherapy is an urgent issue in cancer *** retinoic acid-binding protein 2(CRABP2)is a controversial factor in the occurrence and development of human ***,there is limited research on the relationship between CRABP2 and immunotherapy *** study found that negative correlations of CRABP2 and immune checkpoint markers(PD-1,PD-L1,and CTLA-4)were observed in breast invasive carcinoma(BRCA),skin cutaneous melanoma(SKCM),stomach adenocarcinoma(STAD)and testicular germ cell tumors(TGCT).In particular,in SKCM patients who were treated with PD-1 inhibitors,high levels of CRABP2 predicted poor ***,CRABP2 expression was elevated in cancer-associated fibroblasts(CAFs)at the single-cell *** expression of CRABP2 was positively correlated with markers of CAFs,such as MFAP5,PDPN,ITGA11,PDGFRα/βand THY1 in *** validate the tumor-promoting effect of CRABP2 in vivo,SKCM xenograft mice models with CRABP2 overexpression have been *** models showed an increase in tumor weight and *** analysis indicated that CRABP2 may be involved in immunerelated pathways of SKCM,such as extracellular matrix(ECM)receptor interaction and epithelial-mesenchymal transition(EMT).The study suggests that CRABP2 may regulate immunotherapy in SKCM patients by influencing infiltration of *** conclusion,this study provides new insights into the role of CRABP2 in immunotherapy *** findings suggest that CRABP2 may be a promising biomarker for PD-1 inhibitors in SKCM *** research is needed to confirm these findings and to explore the clinical implications of CRABP2 in immunotherapy.

关键词： CRABP2 Melanoma PD-1 Cancer-associated fibroblasts Immune infiltration

Experimental investigation of vibration pretreatment-microwave curing process for carbon fiber reinforced resin matrix composites

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Central south University 2024年第6期31卷 1838-1855页

作者： ZHANG De-chao ZHAN Li-hua MA Bo-lin YAO Shun-ming GUO Jin-zhan GUAN Cheng-long LIU Shu Light Alloys research Institute Central South UniversityChangsha 410083China College of Mechanical and Electrical Engineering Central South UniversityChangsha 410083China School of Mechanical Engineering and Automation Fuzhou UniversityFuzhou 350108China

The vibration pretreatment-microwave curing process is an efficient,low energy consumption,and high-quality out-of-autoclave curing process for carbon fiber resin matrix *** study aims to investigate the impact of vibration pretreatment temperature on the fiber weight content,microscopic morphology and mechanical properties of the composite laminates by using optical digital microscopy,universal tensile testing machine and thermo-gravimetric ***,the combined mode of Bragg fiber grating sensor and temperature measurement fiber was employed to explore the effect of vibration pretreatment on the strain process during microwave *** study results revealed that the change in vibration pretreatment temperature had a slight impact on the fiber weight content when the vibration acceleration remained *** metallographic and interlaminar strength of the specimen formed at a vibration pretreatment temperature of 80℃ demonstrated a porosity of 0.414% and a 10.69% decrease in interlaminar shear strength compared to autoclave ***,the introduction of the vibration energy field during the microwave curing process led to a significant reduction in residual strain in both the 0°and 90°fiber directions,when the laminate was cooled to 60℃.

关键词： vibration microwave curing porosity interlaminar shear strength thermo-gravimetric analysis curing strain

What is the Role of Gravity,Turbulence and Magnetic Fields in High-mass Star Formation Clouds?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

research in Astronomy and Astrophysics 2024年第6期24卷 21-27页

作者： An-Xu Luo Hong-Li Liu Guang-Xing Li Sirong Pan Dong-Ting Yang School of Physics and Astronomy Yunnan UniversityKunming 650091China south-Western Institute for Astronomy research Yunnan UniversityKunming 650500China

To explore the potential role of gravity,turbulence and magnetic fields in high-mass star formation in molecular clouds,this study revisits the velocity dispersion–size(σ–L)and density–size(ρ–L)scalings and the associated turbulent energy spectrum using an extensive data *** sample includes various hierarchical density structures in high-mass star formation clouds,across scales of 0.01–100 *** observeσ∝L^(0.26)andρ∝L^(-1.54)scalings,converging toward a virial equilibrium state.A nearly flat virial parameter–mass(α_(vir)-M)distribution is seen across all density scales,withα_(vir)values centered around unity,suggesting a global equilibrium maintained by the interplay between gravity and turbulence across multiple *** turbulent energy spectrum(E(k))analysis,based on theσ–L andρ–L scalings,yields a characteristic E(k)∝k^(-1.52).These findings indicate the potential significance of gravity,turbulence,and possibly magnetic fields in regulating dynamics of molecular clouds and high-mass star formation therein.

关键词： ISM:clouds stars:formation stars:kinematics and dynamics

An Imperative Role of Fetal Autopsy in Previable Fetuses-Amniotic Deformity Adhesions,Mutilations Complex

在线全文

学校读者我要写书评

暂无评论

Maternal-Fetal Medicine 2024年第3期6卷 134-140页

作者： Harini Devi JKA Nidhya Ganesan Umamaheswari Gurusamy Department of Pathology PSG Institute of Medical Sciences and ResearchPeelameduCoimbatore 641004India

Objective:To identify the occurrence of the amniotic deformity adhesions,mutilation(ADAM)complex and imperative role of fetal autopsy in diagnosing this ***:A retrospective descriptive study spanning nine years,from January 2014 to January 2022,was conducted at the Department of Pathology within a tertiary care hospital in south *** study focused on analyzing the clinical presentation,prenatal ultrasonogram,and morphological features of fetuses with the ADAM complex,limb body wall complex,or amniotic ***:Among the 438 fetuses assessed during the study period,five fetuses showed features of the ADAM complex(0.01%).The most frequent gestational age observed was 12–18 weeks andmost fetuseswere *** common anomaly encountered was limb defects,followed by abdominal and cranial ***:The diagnosis of the ADAM complex relies primarily on fetal autopsy to differentiate it from similar conditions like anencephaly or body-stalk *** pathologist plays a crucial role in understanding the complexities of the ADAM *** antenatal imaging and therapies offer potential for prevention through improved counseling.

关键词： Amniotic band syndrome ADAM complex Previable fetus Fetal autopsy

在线全文

学校读者我要写书评

暂无评论

肌骨系统疾病临床研究方法专家共识

中华医学杂志 2024年第23期104卷 2123-2141页

作者：中华医学会骨科学分会中国医师协会骨科医师分会国家老年疾病临床医学研究中心(湘雅医院) Department of Orthopedics Xiangya Hospital Central South University National Clinical Research Center for Geriatric Disorders Xiangya Hospital Changsha 410008 China Department of Orthopedics Third Hospital of Hebei Medical University Shijiazhuang 050051 China

肌骨系统疾病的临床研究对明确该类疾病的危险因素、规范和创新诊疗方法十分重要, 为进一步促进肌骨系统疾病临床研究规范化, 满足当前临床研究实践需要, 中华医学会骨科学分会、中国医师协会骨科医师分会及国家老年疾病临床医学研究中... 详细信息

肌骨系统疾病的临床研究对明确该类疾病的危险因素、规范和创新诊疗方法十分重要, 为进一步促进肌骨系统疾病临床研究规范化, 满足当前临床研究实践需要, 中华医学会骨科学分会、中国医师协会骨科医师分会及国家老年疾病临床医学研究中心(湘雅医院)组织专家基于国际权威肌骨系统疾病临床研究方法学标准和指南, 结合我国医疗卫生实践, 制订出符合我国国情的肌骨系统疾病临床研究方法专家共识, 旨在促进肌骨系统疾病临床研究规范化、科学化。

关键词：肌骨系统疾病临床研究专家共识

Isolation and Characterization of SARS-CoV-2 in Kenya

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

American Journal of Molecular Biology 2024年第2期14卷 66-83页

作者： Albina Makio Robinson Mugasiali Irekwa Matthew Mutinda Munyao Caroline Wangui Njoroge Peter Kipkemboi Rotich Tonny Teya Nyandwaro Joanne Jepkemei Yego Anne Wanjiru Mwangi James Hungo Kimotho Ronald Tanui Vincent Rutto Samson Muuo Nzou Center for Traditional Medicine and Drug research Kenya Medical Research Institute Nairobi Kenya Center for Microbiology research Kenya Medical Research Institute Nairobi Kenya Production Department Kenya Medical Research Institute Nairobi Kenya Department of Biochemistry and Microbiology Rhodes University Grahamstown South Africa Center for Virus research Kenya Medical Research Institute Nairobi Kenya

The discovery of Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) in Wuhan, Hubei province, China, in December 2019 raised global health warnings. Quickly, in 2020, the virus crossed borders and infected individuals across the world, evolving into the COVID-19 pandemic. Notably, early signs of the virus’s existence were observed in various countries before the initial outbreak in Wuhan. As of 12th of April, the respiratory disease had infected over 762 million people worldwide, with over 6.8 million deaths recorded. This has led scientists to focus their efforts on understanding the virus to develop effective means to diagnose, treat, prevent, and control this pandemic. One of the areas of focus is the isolation of this virus, which plays a crucial role in understanding the viral dynamics in the laboratory. In this study, we report the isolation and detection of locally circulating SARS-CoV-2 in Kenya. The isolates were cultured on Vero Cercopithecus cell line (CCL-81) cells, RNA extraction was conducted from the supernatants, and reverse transcriptase-polymerase chain reaction (RT-PCR). Genome sequencing was done to profile the strains phylogenetically and identify novel and previously reported mutations. Vero CCL-81 cells were able to support the growth of SARS-CoV-2 in vitro, and mutations were detected from the two isolates sequenced (001 and 002). Genome sequencing revealed the circulation of two isolates that share a close relationship with the Benin isolate with the D614G common mutation identified along the S protein. These virus isolates will be expanded and made available to the Kenya Ministry of Health and other research institutions to advance SARS-CoV-2 research in Kenya and the region.

关键词： SARS-CoV-2 COVID-19 Whole Genome Sequencing Phylogenetic Analysis Nucleotide Substitutions Amino Acid Changes