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The Pattern of Neurological Disorders;Revisited Prevalence Data of a Dedicated Neurology Clinic in Sudan

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Case Reports in Clinical Medicine 2021年第11期10卷 339-358页

作者： Muaz Elsayed Omer Aladil Abdalla Hamid Rayan Tonga Sara Misbah Elsadig Mohamed Hasan Ahmed Musaab Ahmed Mohamed Khalafallah Saeed Omdurman Islamic University Faculty of Medicine and Health Sciences Khartoum Sudan International University of Africa Faculty of Medicine and Health Sciences Khartoum Sudan MBBS Resident in Internal Medicine Sudan Medical Specialization Board SMSB Khartoum Sudan MRCP Senior Consultant Neurologist soba University hospital Department of Medicine Faculty of Medicine University of Khartoum Khartoum Sudan Department of Medicine and HIV Metabolic Clinic Milton Keynes University Hospital NHS Foundation Trust Eaglestone Milton Keynes Buckinghamshire UK College of Medicine Physiology Department Ajman University Ajman UAE The University of Science and Technology Faculty of Medicine Omdurman Teaching Hospital Khartoum Sudan

Background: The diverse modes in geographical locations, environmental factors, genetic and racial characteristics play a complex role in determining the pattern of neurological disorders worldwide. Determining the pattern of neurological disorders enables health policymakers to plan evidently for service, training, and research priorities. Few prevalence studies in neurology were conducted in Sudan. Methods: This is a retrospective hospital-based study that reviewed the medical records of patients who attended a Dedicated Neurology Clinic (DNC) in Omdurman, the national Capital of Sudan, for 24 months, from January 2016 to January 2018. This study aimed to determine the DNC pattern of neurological disorders as a representative subset prevalence in Sudan. Neurologists conducted the medical workup for diagnosis after at least two visits. All patients have ethically consented. Results: The total number of patients was 1050. Only 749 patients (71.3%) fulfilled the inclusion criteria. The mean age was 46.5 ± 1.9, and males were 45.3%. 72% were from the Capital. The presenting symptoms were headache (16.6%), seizures (11.5%), limbs weakness (11.2%), and lower percentages for other neurological symptoms. The commonest diagnoses were Stroke 12.4%, Epilepsy 9.3%, Primary Headache 8.8%, Movement Disorders 7.3%, Peripheral Neuropathy 6%, Dementia 4% Neuroinfections 1.4%, Demyelinating Disorders 2.6%, Spinal Spondylotic Radiculopathy 2.6% and 1.7% for Cerebral Venous Thrombosis. Conclusion: The data from Sudan-DNC showed that the most common neurological disorders descendingly were Stroke, Epilepsy, Headache, Movement Disorders, Peripheral Neuropathy, Dementia, Infections, Demyelinating Disorders, Spinal Spondylotic Radiculopathy, and Cerebral Venous Thrombosis. The demyelinating disorders and peripheral neuropathy showed a higher percentage than our previous preliminary prevalence study in 2012 compared to th

关键词： Sudan Prevalence Neurological Disorder Stroke Dedicated Clinic

Detection and Quantification of Anti-Inflammatory Cytokine in Sera and Urine of Sudanese Patients Infected with Schistosoma haematobium

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Open Journal of Medical Microbiology 2016年第1期6卷 32-41页

作者： A. Hammad Manahil Nouri Abdelbagi Alfadil H. A. Musa M. A. Osman A. Bashir Nawal Eltayeb Omer Yasir Hassan A. Alfarazdeg A. Mustafa Department of Parasitology National Ribat University Khartoum Sudan Department of Community Medicine Al Neelain University Khartoum Sudan Department of Immunology National Ribat University Khartoum Sudan Department of Microbiology National Ribat University Khartoum Sudan Department of Microbiology University of Bacht Elruda Eldeum Sudan Department of Microbiology Khartoum University Khartoum Sudan Department of Pathology Khartoum College of Medical Sciences Khartoum Sudan Sudan Medical Specialization Board Khartoum Sudan Department of Biochemistry Khartoum University Khartoum Sudan soba hospital Khartoum University Khartoum Sudan

Cytokines have been in focus of scientific in for more than decade now. Analyzing their expression has enabled a better understanding of pathogenesis of various diseases. Moreover, they are now for beyond their stage when they were of interest for pathophysiological research. In the present study, we used an assay to anti-inflammatory cytokines. One hundred and thirty sera and urine from egg positive individuals and 42 samples of healthy individuals in Eldeum locality—an endemic area of S. haematobum and 28 healthy individuals from non-endemic area were tested. Concentration of IL5 and IL10 is reverse. IL5 is low in serum but high in urine before treatment and high in serum and low in urine after treatment. IL10 is high in serum, low in urine before treatment and low in serum, high in urine after treatment.

关键词： Schistosoma haematobum Interleukin ELISA

The organization and function of the Golgi apparatus in dendrite development and neurological disorders

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Genes & Diseases 2023年第6期10卷 2425-2442页

作者： Meilan Chen Lu Xu Yi Wu Peter soba Chun Hu Key Laboratory of Brain Cognition and Education SciencesMinistry of Education Institute for BrainScience and RehabilitationSouth China Normal UniversityGuangzhouGuangdong 510631China Department of Ophthalmology Guangdong Second Provincial General HospitalGuangzhouGuangdong 510320China LIMES Institute Department of Molecular Brain Physiology and BehaviorUniversity of BonnBonn 53115Germany Institute of Physiology and Pathophysiology Friedrich-Alexander-Universität Erlangen-NürnbergErlangen 91054Germany

Dendrites are specialized neuronal compartments that sense, integrate and transfer information in the neural network. Their development is tightly controlled and abnormal dendrite morphogenesis is strongly linked to neurological disorders. While dendritic morphology ranges from relatively simple to extremely complex for a specified neuron, either requires a functional secretory pathway to continually replenish proteins and lipids to meet dendritic growth demands. The Golgi apparatus occupies the center of the secretory pathway and is regulating posttranslational modifications, sorting, transport, and signal transduction, as well as acting as a non-centrosomal microtubule organization center. The neuronal Golgi apparatus shares common features with Golgi in other eukaryotic cell types but also forms distinct structures known as Golgi outposts that specifically localize in dendrites. However, the organization and function of Golgi in dendrite development and its impact on neurological disorders is just emerging and so far lacks a systematic summary. We describe the organization of the Golgi apparatus in neurons, review the current understanding of Golgi function in dendritic morphogenesis, and discuss the current challenges and future directions.

关键词： Dendrite Golgi Golgi outposts Microtubule Neurodevelopmental disorders Secretory pathway

Burden of Congenital Defects Diagnosed through Ultrasonography in soba Fetomaternal Unit, Khartoum, Sudan

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Open Journal of Radiology 2023年第1期13卷 67-76页

作者： Mona Awadallah Mohammed Ali Osman Isam Ahmed Ali Elhassan Fareeda Nikhat Khan Abdulmutallab Alimam Mounkaila Noma Atif Fazari Faculty of Medicine University of Medical Sciences and Technology Khartoum Sudan Department of Obstetrics & Gynecology Latifa Hospital DHA Dubai UAE Department of Obstetrics and Gynecology Faculty of Medicine University of Khartoum Khartoum Sudan

Background: Congenital anomalies are among the leading causes of fetal loss, despite it can be identified prior to birth through advanced technology in expert hands. Our research aimed at estimating the prevalence of congenital anomalies in Sudan. Methods: A facility-based retrospective cross-sectional study combined with a community-based survey through a telephone interview was implemented on a purposive convenient sample of 138 participants. The data were computerized in Epi Info 7. Google Earth Pro enabled to collect the geographical coordinates for the residence of the participants. Descriptive statistics were performed through SPSS 23 and ArcGIS 10.3 was used to generate the geographical distribution map of congenital defects to visualize the catchment areas of soba Ultrasonography Unit. Results: Of the 138 participants, the estimated prevalence of congenital defects was 2.2/10,000 live births. The ultrasonography screening revealed that neural tube defects were the most prevalent anomalies with 13.0% (18/138), which represented 47.4% (18/38) of all defects. Concerning children, a mortality rate of 23.2% (32/138) was reported. Conclusions: The child mortality rate post ultrasound screening of 23.2%, and the neural tube defects being the most common anomalies appealed to Sudan health authorities for focusing on more preventive antenatal practices to strengthen and promote maternal and child health.

关键词： Prevalence Congenital Defects Ultrasound Spatial Distribution

Presentation and Management of Wilm’s Tumour in Sudan (Three Centre Experience from 2014-2016)

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Open Journal of Urology 2021年第10期11卷 358-366页

作者： Ahmed Mohammed Atiaallah Mutaz Ogeal Osman Aamir Abdallah Hamza Mawadda Farah Omer Alamin Faculty of Medicine Red Sea University Port Sudan Sudan Faculty of Medicine University of Bahri Khartoum Bahri Sudan Sudan Medical Specializations Board Khartoum Sudan National Elribat University hospital Khartoum Sudan

Background: Wilm’s tumour is a cancer of the kidneys that typically occurs in children younger than fifteen years of age and rarely in adults. With an early diagnosis and proper management of Wilm’s tumour by Multi-modal approach, excellent outcome can be obtained. This study was designed to reflect the clinical presentations and focus on different management modalities with an outcome of Wilm’s tumour in Sudan. Patients and methods: This descriptive, retro-prospective analytic study included all patients of Wilm’s tumour at soba University hospital, Gezira national paediatric surgery centre and Khartoum teaching hospital from January 2014 to January 2016. Results: Thirty patients (pts) were included. Females were predominant in a ratio of 3: 1 to males. The mean age was 3.0 - 5.9 years. Those who came from central and western of Sudan were more affected. Most patients presented with abdominal mass 28 pts (93.3%), followed by abdominal distension in 16 pts (53.3%), while the less frequent presentation was haematuria seen only in 2 pts (6.7%). The multimodal approach: surgery and chemotherapy used in 21 pts (70%) and single modality was used in nine patients: surgery alone in 6 pts (20%), or chemotherapy alone in 3 pts (10%). The patients discharged uneventfully 23 pts (76%). Morbidity was seen in two patients. Deaths were occurred in five patients in the study (16.7%). Conclusion: The finding of this study reflected that Wilm’s tumour has an excellent outcome when patient was managed by multimodal approach.

关键词： Wilm’s Tumour Multi-Modal Approach Nephrectomy Chemotherapy Outcome