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Vitamin E isoform γ-tocotrienol alleviates cigarette smoke-induced chronic obstructive pulmonary disease

中国药理学与毒理学杂志 2015年第S1期29卷 51-51页

作者： HongYongPEH WanShunDanielTAN TzeKheeCHAN ChenWeiPOW ChoonNamONG Wai-ShiuFredWONG Department of Pharmacology Yong Loo Lin School of Medicine National University Health System Singapore Immunology Program Life Science Institute National University of singapore singapore-MIT alliance for research and Technology Singapore Saw Swee Hock School of Public Health National University Health System Singapore

OBJECTIVE Cigarette smoke-induced chronic obstructive pulmonary disease(COPD)is a leading cause of death,where inflammation and oxidative stress are involved in the *** E isoformγ-tocotrienol possesses both anti-oxidative and anti-inflammatory *** hypothesized thatγ-tocotrienol may have protective effects against *** BALB/c mice were exposedto cigarette smoke daily for 2 weeks with oralγ-tocotrienol treatment in the second *** lavage(BAL)fluid was assessed for total and differential cell counts,oxidative damage biomarkers,and cytokine *** tissues were examined for the expression of antioxidants and pro-inflammatory *** order to measure changes in lung functions in COPD,another set of mice was exposed to cigarette smoke for 2 months with oralγ-tocotrienol treatment in the last 2 ***γ-Tocotrienol dose-dependently abated cigarette smoke-induced elevation of BAL fluid total and neutrophil cell counts,cytokine and chemokine(IL-1β,IL-6,IL-17,LIX,G-CSF,KC,RANTES and VEGF)levels,as well as oxidative/nitrosative damage biomarker(advanced oxidation of protein products,8-isoprostane,8-hydroxy-2-deoxyguanosine and 3-nitrotyrosine)levels.γ-Tocotrienol promoted total lung antioxidant capacity and endogenous antioxidant activities of superoxide dismutase,catalase and glutathione *** importantly,γ-tocotrienol markedly restored work of breathing and lung functions(total lung capacity,static compliance and FEV100/FVC)in chronic experimental ***,γ-tocotrienol demonstrated better anti-oxidative,anti-inflammatory,and restoration of lung functions in COPD than *** We have shown for the first time the efficacy of vitamin E isomerγ-tocotrienol in protection against cigarette smoke-induced COPD by direct neutralization of free radicals,abating oxidative damage,and restoring antioxidants activities,coupled with anti-inflammatory actions in the inflamed airways.

关键词： cigarette smoke inflammation oxidative damage lung

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Spectral control of nonclassical light pulses using an integrated thin-film lithium niobate modulator

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Light(Science & Applications) 2022年第12期11卷 2922-2930页

作者： Di Zhu Changchen Chen Mengjie Yu Linbo Shao Yaowen Hu CJXin Matthew Yeh Soumya Ghosh Lingyan He Christian Reimer Neil Sinclair Franco N.C.Wong Mian Zhang Marko Loncar John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA Institute of Materials research and Engineering Agency for ScienceTechnology and Research(A*STAR)Singapore 138634Singapore research Laboratory of Electronics Massachusetts Institute of TechnologyCambridgeMA 02139USA HyperLight Corporation 1 Bow StreetSuite 420CambridgeMA 02139USA Division of Physics Mathematics and Astronomyand Alliance for Quantum Technologies(AQT)California Institute of TechnologyPasadenaCA 91125USA

Manipulating the frequency and bandwidth of nonclassical light is essential for implementing frequency-encoded/multiplexed quantum computation,communication,and networking protocols,and for bridging spectral mismatch among various quantum ***,quantum spectral control requires a strong nonlinearity mediated by light,microwave,or acoustics,which is challenging to realize with high efficiency,low noise,and on an integrated ***,we demonstrate both frequency shifting and bandwidth compression of heralded single-photon pulses using an integrated thin-film lithium niobate(TFLN)phase *** achieve record-high electro-optic frequency shearing of telecom single photons over terahertz range(±641 GHz or±5.2 nm),enabling high visibility quantum interference between frequency-nondegenerate photon *** further operate the modulator as a time lens and demonstrate over eighteen-fold(6.55 nm to 0.35 nm)bandwidth compression of single *** results showcase the viability and promise of on-chip quantum spectral control for scalable photonic quantum information processing.

关键词： quantum lithium film

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Non-typeable haemophilus influenzae-induced exacerbation on a cigarette smoke lung injury model:Protective effect of andrographolide

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中国药理学与毒理学杂志 2015年第S1期29卷 54-54页

作者： Wan-shunDanielTAN Hong-yonPEH Chu-huiPANG Wu-pengLIAO Tze-kheeCHAN Suk-hiangLAU VincentT.K.CHOW Wai-shiuFredWONG Immunology Program Life Science Institute National University of singapore Department of Pharmacology Yong Loo Lin School of Medicine National University Health System Interdisciplinary research Group in Infectious Diseases singapore-MIT alliance for research and Technology Department of Microbiology Yong Loo Lin School of Medicine National University of singapore

OBJECTIVE To develop a 2-week cigarette smoke(CS)acute lung injury model exacerbated by haemophilus influenzae(NTHi)and study the protective effect of andrographolide in this COPD *** Female BALB/c mice,6-8-week-old,were exposed to 4% 3R4 FCS delivered using aperistaltic pump daily for 2 weeks to induce an acute lung injury *** 2 weeks of smoking,mice were inoculated intratracheally with NTHi to induce exacerbation on the *** were sacrificed 48 h after last bacteria challenge and lung samples were collected for various *** After developing a 2-week CS acute lung injury model exacerbated by NTHi,the CS+NTHi group was shown to have a higher inflammatory response,higher bacterial clearance,an upregulation of MMP12 mRNA levels and decrease in TIMP1 mRNA levels in the *** of Andrographolide suppressed BALF lung cellular infiltrates,TNF-α,CXCL1/KC,IL-1βand 8-OHdG protein levels,together with increased HO-1 and GR mRNA levels and decreased MMP-8 and MMP-9 mRNA *** was able to ameliorate lung histopathology as observed with H&E staining and inflammation *** was also shown to reduce Keap-1 level in lungs without affecting DJ-1 *** This study demonstrates the protective effect of andrographolide in a novel 2-week CS acute lung injury model exacerbated by NTHi and presents it as a potential therapeutic for COPD.

关键词： COPD haemophilus influenzae smoke andrographolide

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微波辐射合成钌/碳纳米复合材料及其在电化学超级电容器的应用

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化学学报 2003年第12期61卷 2033-2035页

作者：陈卫祥韩贵 LEE Jim-Yang 刘昭林徐铸德浙江大学化学系杭州310027 Institute of Materials research and Engineering singapore MITalliance

以RuCl3 的乙二醇溶液作为前驱体 ,利用微波辐射技术合成了Ru/C (19 1wt % )纳米复合材料 .TEM观察表明这些纳米粒子具有均匀的尺寸 ,其平均粒径为 3 2nm ,并均匀地分散在纳米碳的表面 .Ru/C纳米复合材料在电化学氧化后可以作为电化学... 详细信息

以RuCl3 的乙二醇溶液作为前驱体 ,利用微波辐射技术合成了Ru/C (19 1wt % )纳米复合材料 .TEM观察表明这些纳米粒子具有均匀的尺寸 ,其平均粒径为 3 2nm ,并均匀地分散在纳米碳的表面 .Ru/C纳米复合材料在电化学氧化后可以作为电化学超级电容器的电极材料 ,循环伏安实验表明其比电容为 14 4F/g ,而未负载纳米钌的XC 72碳的比电容为 3 1F/g .

关键词：微波辐射合成钌/碳纳米复合材料电化学超级电容器

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AN IMPROVED MODAL ANALYSIS FOR THREE-DIMENSIONAL PROBLEMS USING FACE-BASED SMOOTHED FINITE ELEMENT METHOD

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Acta Mechanica Solida Sinica 2013年第2期26卷 140-150页

作者： Zhicheng He Guangyao Li Zhihua Zhong Aiguo Cheng Guiyong Zhang Eric Li State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body Hunan University Intelligent Systems for Medicine Laboratory School of Mechanical and Chemical EngineeringThe University of Western Australia35 Stirling HighwayCrawley WA 6009Australia Department of Mechanical Engineering National University of Singapore9 Engineering Drive 1117576Singapore

In this work, we further extended the face-based smoothed finite element method （FS-FEM） for modal analysis of three-dimensional solids using four-node tetrahedron elements. The FS-FEM is formulated based on the smoothed Calerkin weak form which employs smoothed strains obtained using the gradient smoothing operation on face-based smoothing domains. This strain smoothing operation can provide softening effect to the system stiffness and make the FSFEM provide more accurate eigenfrequency prediction than the FEM does. Numerical studies have verified this attractive property of FS-FEM as well as its ability and effectiveness on providing reliable eigenfrequency and eigenmode prediction in practical engineering application.

关键词： numerical method meshfree method modal analysis face-based smoothed finiteelement method (FS-FEM)

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Artistic Urbanism: Multi-Scalar Spatial Governance of Songzhuang Art District by the Local Government

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China City Planning Review 2021年第3期30卷 19-29页

作者： Zhu Zhao Department of Urban Planning Tongji UniversityShanghaiP.R.China Department of Real Estate National University of SingaporeSingapore

Taking Beijing’s Songzhuang Art District as an example, this paper conducts an integrated evolutionary and multi-scalar governance analytical framework through participant’s observations, in-depth qualitative interviews, and extensive evaluations of policy documents. It aims to explore the transformation modes of art districts under the intervention of multi-scalar spatial governance and the roles of local governments in the course of development. The research places the spatial development into a wider theoretical context of local developmental state, local state corporatism, and entrepreneurial state, as well as to combine the socio-political objectives together with economic goals of the local government. The study argues that Songzhuang has witnessed a unique form of artistic urbanism, a process of rapid urbanization of villages in the art-led development. Local governments have competed for taking control of spatial governance through actions characterized by decentralization, alliance, and entrepreneurship, following the logic of performing an overall control over the socio-political, economic, and cultural aspects of art districts, and profiting from land market.

关键词： artistic urbanism spatial governance art district local government Songzhuang

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半定优化与半光滑牛顿算法(英文)

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运筹学学报 2004年第1期8卷 41-52页

作者：孙捷 School of Business National University of SingaporeRepublic of Singapore.

本文讨论半光滑牛顿算法的基本概念与其在求解半定优化问题中的应用.特别地,该算法可用于求解线性或非线性半定互补问题.本文同时综述最近在矩阵方程,增广拉格朗日公式和半定优化稳定性方面的、源于半光滑牛顿算法的理论成果.

关键词：半定优化半光滑牛顿算法变分不等式矩阵方程拉格朗日公式

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Enhanced YOLOv5 network-based object detection(BALFilter Reader)promotes PERFECT filter-enabled liquid biopsy of lung cancer from bronchoalveolar lavage fluid(BALF)

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Microsystems & Nanoengineering 2023年第5期9卷 177-189页

作者： Zheng Liu Jixin Zhang Ningyu Wang Yun’ai Feng Fei Tang Tingyu Li Liping Lv Haichao Li Wei Wang Yaoping Liu School of Software and Microelectronics Peking UniversityBeijing 100871China Department of Pathology Peking University First HospitalBeijing 100034China School of Integrated Circuits Peking UniversityBeijing 100871China Department of Respirology and Critical Care Medicine Peking University First HospitalBeijing 100034China Department of Interventional Lung Disease and Center of Endoscopic Diagnosis and Treatment Anhui Chest HospitalHefeiAnhui 230022China National Key Laboratory of Advanced Micro and Nano Manufacture Technology Beijing 100871China Frontiers Science Center for Nano-optoelectronics Peking UniversityBeijing 100871China AntiMicrobial Resistance(AMR)and Critical Analytics for Manufacturing Personalized-Medicine(CAMP)IRGs Singapore-MIT Alliance for Research and Technology(SMART)CenterSingapore 138602Singapore

Liquid biopsy of cancers,detecting tumor-related information from liquid samples,has attracted wide attentions as an emerging *** previously reported large-area PERFECT(Precise-Efficient-Robust-Flexible-Easy-ControllableThin)filter has demonstrated competitive sensitivity in recovering rare tumor cells from clinical ***,it is time-consuming and easily biased to manually inspect rare target cells among numerous background cells distributed in a large area(Φ≥13 mm).This puts forward an urgent demand for rapid and bias-free ***,this paper implemented deep learning-based object detection for the inspection of rare tumor cells from large-field images of PERFECT filters with hematoxylin-eosin(HE)-stained cells recovered from bronchoalveolar lavage fluid(BALF).CenterNet,EfficientDet,and YOLOv5 were trained and validated with 240 and 60 image blocks containing tumor and/or background cells,***5 was selected as the basic network given the highest mAP@0.5 of 92.1%,compared to those of CenterNet and EfficientDet at 85.2%and 91.6%,***,tricks including CIoU loss,image flip,mosaic,HSV augmentation and TTA were applied to enhance the performance of the YOLOv5 network,improving mAP@0.5 to 96.2%.This enhanced YOLOv5 network-based object detection,named as BALFilter Reader,was tested and cross-validated on 24 clinical *** overall diagnosis performance(~2 min)with sensitivity@66.7%±16.7%,specificity@100.0%±0.0%and accuracy@75.0%±12.5%was superior to that from two experienced pathologists(10–30 min)with sensitivity@61.1%,specificity@16.7%and accuracy@50.0%,with the histopathological result as the gold *** AUC of the BALFilter Reader is 0.84±***,a customized Web was developed for a user-friendly interface and the promotion of wide *** current results revealed that the developed BALFilter Reader is a rapid,bias-free and easily accessible AI-enabled tool to promote the transplantation

关键词： specificity network consuming

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Recent progress in the synthesis of novel two-dimensional van der Waals materials

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National Science Review 2022年第5期9卷 57-76页

作者： Renji Bian Changcun Li Qing Liu Guiming Cao Qundong Fu Peng Meng Jiadong Zhou Fucai Liu Zheng Liu School of Optoelectronic Science and Engineering University of Electronic Science and Technology of China School of Electrical and Electronic Engineering Nanyang Technological University CNRS-International-NTU-Thales research alliance (CINTRA) Yangtze Delta Region Institute (Huzhou) University of Electronic Science and Technology of China Key Lab of Advanced Optoelectronic Quantum Architecture and Measurement(Ministry of Education) Beijing Key Lab of Nanophotonics and Ultrafine Optoelectronic Systems and School of Physics Beijing Institute of Technology School of Materials Science and Engineering Nanyang Technological University

The last decade has witnessed the significant progress of physical fundamental research and great success of practical application in two-dimensional(2D) van der Waals(vdW) materials since the discovery of graphene in *** date,vdW materials is still a vibrant and fast-expanding field,where tremendous reports have been published covering topics from cutting-edge quantum technology to urgent green energy,and so ***,we briefly review the emerging hot physical topics and intriguing materials,such as 2D topological materials,piezoelectric materials,ferroelectric materials,magnetic materials and twistronic ***,various vdW material synthetic strategies are discussed in detail,concerning the growth mechanisms,preparation conditions and typical ***,prospects and further opportunities in the booming field of 2D materials are addressed.

关键词： two-dimensional materials synthesis exfoliation chemical vapor deposition

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Identifying Key Descriptors for the Single-Atom Catalyzed CO Oxidation

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CCS Chemistry 2022年第10期4卷 3296-3308页

作者： Max J.Hülsey Sambath Baskaran Shipeng Ding Sikai Wang Hiroyuki Asakura Shinya Furukawa Shibo Xi Qi Yu Cong-Qiao Xu Jun Li Ning Yan Department ofChemicalandBiomolecularEngineering NationalUniversityofSingaporeSingapore 117585 Department of Chemistry Southern University of Science and TechnologyShenzhen 518055 Joint School of National University of singapore Tianjin UniversityInternational Campus of Tianjin UniversityBinhai New CityFuzhou 350207 Department of Molecular Engineering Graduate School of EngineeringKyoto UniversityKyoto 615-8510615-8245 Elements Strategy Initiative for Catalysts and Batteries(ESICB) Kyoto UniversityKyoto 615-8245 Institute for Catalysis Hokkaido UniversitySapporo 001-0021 Institute for Chemical and Engineering Sciences Agency for ScienceTechnologyand Research in SingaporeSingapore 138634 Shaanxi Key Laboratory of Catalysis Shaanxi University of TechnologyHangzhou 723001 Department of Chemistry Key Laboratory of Organic Optoelectronics and Molecular Engineering of Ministry of EducationTsinghua UniversityBeijing 100084

Fundamental knowledge of structure-activity correlations for heterogeneous single-atom catalysts(SACs)is essential in guiding catalytic *** linear scaling relations are powerful for predicting the performance of traditionalmetal catalysts,they appear to fail with the involvement of *** the catalytic CO oxidation activity of different atomically dispersed metals(3d,4d,and 5d)in conjunction with computational modeling enabled us to establish multiple scaling relations between the activity and simply calculated descriptors.

关键词： scaling relations transition metals carbon monoxide single-site catalysts polyoxometalate

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