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Left bundle branch pacing vs biventricular pacing in heart failure patients with left bundle branch block:A systematic review and meta-analysis

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World Journal of Cardiology 2024年第1期16卷 40-48页

作者： Farah Yasmin Abdul Moeed Rohan Kumar Ochani Hamna Raheel Malik Ali Ehtsham Awan Ayesha Liaquat Arisha Saleem Muhammad Aamir Nael Hawwa Salim Surani Department of Internal Medicine Yale University School of MedicineNew HavenCT 06511United States Department of Medicine Dow University of Health ScienceKarachi 74200SindhPakistan Department of Medicine SUNNY Upstate Medical UniversitySyracuseNY 13210United States Department of Cardiovascular Medicine Lehigh Valley Heart and Vascular InstituteAllentownPA 18105United States Department of Medicine Cleveland ClinicClevelandOH 44195United States Department of Medicine&Pharmacology Texas A&M UniversityCollege StationTX 77843United States

BACKGROUND Left bundle branch pacing(LBBP)is a novel pacing modality of cardiac resynchronization therapy(CRT)that achieves more physiologic native ventricular activation than biventricular pacing(BiVP).AIM To explore the validity of electromechanical resynchronization,clinical and echocardiographic response of *** Systematic review and Meta-analysis were conducted in accordance with the standard guidelines as mentioned in detail in the methodology *** In our analysis,the success rate of LBBP-CRT was determined to be 91.1%.LBBP CRT significantly shortened QRS duration,with significant improvement in echocardiographic parameters,including left ventricular ejection fraction,left ventricular end-diastolic diameter and left ventricular end-systolic diameter in comparison with *** A significant reduction in New York Heart Association class and B-type natriuretic peptide levels was also observed in the LBBP-CRT group vs BiVP-CRT ***,the LBBP-CRT cohort had a reduced pacing threshold at follow-up as compared to BiVP-CRT.

关键词： Left bundle branch pacing Biventricular pacing QRS duration Left ventricular ejection fraction Heart failure

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Hepatitis D: Scenario in the Asia-Pacifi c region

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World Journal of Gastroenterology 2010年第5期16卷 554-562页

作者： Zaigham Abbas Wasim Jafri Sajjad Raza Department of Hepatogastroenterology Sindh Institute of Urology and Transplantation Karachi 74200 Sindh Pakistan Department of Medicine The Aga Khan University Hospital Karachi 74800 Pakistan Dow medical college Karachi 74200 Pakistan

Hepatitis D virus (HDV) infection is present worldwide and affects all age groups. Around 18 million people are estimated to be infected with HDV. An important trend in HDV infection is global decline. HDV prevalence has decreased significantly in Europe since the 1970s and 1980s when it was f irst reported. The Asia-Pacif ic region now seems to be where HDV is a major health concern. There is a lack of available data from most of the countries from this region; hence, the true status of HDV cannot be determined. In South Asia, most of the countries have conditions that are favorable for the spread of hepatitis B and other related infections. Countries like Pakistan and Iran have shown an increase in HDV prevalence over a period of time. Other countries and region like China, Turkey, Australia, Japan, India and Taiwan, some of which had very high HDV prevalence in the past, have shown a decline in the incidence, but high prevalence persists in some. Intravenous drug abusers, homosexual men and women, prostitutes, and people on hemodialysis are the groups with very high HDV prevalence.

关键词： Hepatitis D Asia-Pacif ic region Prevalence Epidemiology

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Dosage and utilization of dexamethasone in the management of COVID-19: A critical review

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World Journal of Virology 2024年第3期13卷 107-114页

作者： Imran Sethi Asim Shaikh Musa Sethi Hira Khalid Chohan Sheraz Younus Syed A Khan Salim Surani Department of Critical Care Medicine Marion General HospitalMarionIN 46952United States Department of Medicine Aga Khan UniversityKarachi 74200SindhPakistan Department of Medicine Eman SchoolFishersIN 46038United States Department of Internal Medicine Dow University of Health ScienceKarachi 74200SindhPakistan Department of Hospital Medicine Franciscan HealthIndianapolisIN 46237United States Department of Critical Care Medicine Mayo Clinic Health SystemMankatoMN 56001United States Department of Medicine and Pharmacology Texas A and M UniversityCollege StationTX 77843United States

BACKGROUND The severe respiratory manifestations observed in severe coronavirus disease 2019(COVID-19)cases are often associated with an excessive inflammatory ***,a synthetic glucocorticoid,exerts its anti-inflammatory effects by inhibiting the transcription of pro-inflammatory genes and suppressing the activity of various immune *** mechanism has implications for mitigating the cytokine storm observed in severe COVID-19 *** on in the pandemic,the Recovery Collaborative working group showed a mortality benefit of using dexamethasone in decreasing mortality in patients with COVID-19 requiring respiratory ***,the optimal dosage of corticosteroids remains *** studies that compare different doses of dexamethasone in COVID-19 exist,but the results are *** To review the latest evidence regarding dosage,safety,and efficacy of dexamethasone in severe *** We followed preferred reporting items for systematic reviews and meta-analysis guidelines.A detailed literature search was conducted across PubMed,Google Scholar,and Medline to include publications up to March *** keywords included“COVID-19”“SARS-CoV-2”“dexamethasone”“corticosteroid”“steroid”and“glucocorticoid”-along with their *** employed the Cochrane Risk of Bias Tool and the Newcastle-Ottawa scale to evaluate the integrity and potential of bias in the included studies.A meta-analysis was conducted using a random-effects model,assessing pooled odds ratios and mean differences,with heterogeneity gauged by the I2 statistic and theχ^(2) *** No statistical differences were found in 28-day all-cause mortality[pooled odds ratio(OR)=1.109,95%CI:0.918-1.340],60-day all-cause mortality(OR=0.873,95%CI:0.744-1.024;I2=47.29%),mean length of hospital stay(mean difference=-0.08 days,95%CI:-0.001 to 0.161)and adverse events(OR=0.877,95%CI:0.707-1.087).CONCLUSION Differing doses of corticosteroids have no clinical implication

关键词： COVID-19 Steroids Corticosteroids Steroid dosage Critical care Corona virus

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Epidermal growth factor receptor rs17337023 polymorphism in hypertensive gestational diabetic women: A pilot study

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World Journal of Diabetes 2019年第7期10卷 396-402页

作者： Russell S Martins Taimur Ahmed Sabah Farhat Sana Shahid Syeda Sadia Fatima medical college Aga Khan UniversityKarachiSindh 74800Pakistan Department of Biological and Biomedical Sciences Aga Khan UniversityKarachiSindh 74800Pakistan Department of Physiology Sir Syed Medical College for GirlsKarachiPakistan

BACKGROUND Women with gestational diabetes mellitus have an increased risk of developing gestational hypertension,which can increase fetal and neonatal morbidity and *** the past decade,single nucleotide polymorphisms in several genes have been identified as risk factors for development of gestational *** epidermal growth factor receptor activates tyrosine kinase mediated blood vessels contractility;and inflammatory *** in these mechanism are known to contribute towards *** is thus plausible that polymorphisms in the epidermal growth factor receptor gene would be associated with the development of hypertension in women with gestational *** To determine whether the epidermal growth factor receptor rs17337023 SNP is associated with the occurrence of hypertension in gestational diabetic *** This pilot case-control study was conducted at two tertiary care hospitals in Karachi,from January 2017-August *** hundred and two women at 28 week of gestation with gestational diabetes were recruited and classified into normotensive(n=80)and hypertensive(n=122)*** blood samples were genotyped for epidermal growth factor receptor polymorphism rs17337023 using tetra-ARMS polymerase chain *** analysis was applied on baseline *** data was analyzed for genotype and allele frequency determination using chi-squared *** all cases,a P value of0.05).Body fat percentage was significantly higher in hypertensive females as compared to normotensive subjects(35.138±4.29 Case vs 25.01±8.28 Control;P<0.05).Similarly,systolic and diastolic blood pressures among groups were significantly higher in hypertensive group than the normotensive group(P<0.05).Overall epidermal growth factor receptor rs17337023 polymorphism genotype frequen

关键词： Gestational diabetes mellitus Gestational hypertension Epidermal growth factor receptor rs17337023 Single nucleotide polymorphism Polymorphism Casecontrol

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Prevalence of Iron Deficiency Anaemia in School and college Going Students of District Shaheed Benazirabad sindh Province, Pakistan

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Open Journal of Blood Diseases 2016年第4期6卷 67-78页

作者： Niaz Hussain Jamali Hidayatullah Mahesar Muhammad Aqeel Bhutto Department of Community Medicine Peoples University of Medical and Health Sciences for Women Nawabshah Pakistan Department of Physiology University of Sindh Jamshoro Jamshoro Pakistan Institute of Biotechnology and Genetic Engineering University of Sindh Jamshoro Pakistan

The present study aimed to estimate the occurrence of Iron Deficiency anemia (IDA) in school and college going students (aged 11 - 18 years). Anemia is the most public health problem in school age children. It has a wide range of adverse results involving, poor cognitive performance, poor development of infants, preschool and school-aged children. Anemia also causes the impairment of physical capacity, work performance of adolescents and adults, reduction in immune competence and increased morbidity from infections in all age groups. Our study based on 1686 volunteers was randomly selected from different Government High schools and colleges. A Questionnaire was utilized for data collection. BMI was also calculated by dividing weight in kg by the square of height in meters. Hemoglobin (Hb), Hematocrite (Hct), Mean Corpuscular volume (MCV), Mean Corpuscular hemoglobin concentration (MCHC), white blood cell (WBC) and red blood cell was examined using Sysmex kx-21N hemoglobin auto analyzer (Hedwin, 2008). The total percentage of anaemic students (43.1%) and non-anaemic (56.9%) were observed in district Shaheed Benazirabad. The mean Hb level of anaemic students (11.1 ± 4.94) was observed. In males (12.7%) and females (30.4%) anemic was observed. The prevalence of anemia high (16.2%) was observed in the age of 14 - 16 years. The majority of anemic patients (30.2%) belonged to low income group. Area wise prevalence, in rural areas 27.8% and urban areas 15.3% volunteers anaemic was observed. Taluka wise occurrence of anaemia in taluka Sakrand was (14.6%), in taluka Kazi Ahmed (15.0%), in taluka Daur (8.0%) and in taluka Nawabshah was (5.5%). Clinically signs and symptoms showed, pale skin 57.7% and weakness 42.3% were observed in school children.

关键词： Iron Deficiency Anaemia (IDA) Haemglobin (Hb) Red Blood Cell (RBC) White Blood Cell (WBC) Hematocrit (Hct) Body Mass Index (BMI) School Children Pale Skin

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Burnout amongst radiologists:A bibliometric study from 1993 to 2020

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World Journal of Psychiatry 2022年第2期12卷 368-378页

作者： Muhammad Fazal Hussain Qureshi Danish Mohammad Syed Mustafa Ali Shah Mahira Lakhani Muzna Shah Muhammad Hassan Ayub Sara Sadiq medical college Ziauddin UniversityKarachi 75000SindhPakistan Department of Physiology CMH Institute of Medical SciencesBahawalpur 75000Pakistan

BACKGROUND Burnout amongst radiologists is common in many different institutions and is increasing day by *** battle burnout,we have to address the root causes already recognized in published ***,it is crucial to examine and discern important *** To provide evidence-based data and trends related to burnout in radiologists so that researchers can work on it further and develop preventive strategies to overcome this *** Bibliometric analysis conducted by two independent reviewers separately used Scopus Library for data extraction by using medical subject heading and International Classification of Diseases ***-nine articles were selected for analysis after an extensive *** Package for the Social Sciences version 20 was used for *** correlation coefficient,Kruskal Wallis test,and Mann-Whitney U test were *** The most productive period with regards to the number of publications was between 2017 and 2019.A total of 160 authors contributed to the topic burnout among radiologists,with an average of 3.26 authors per *** 41.68%of the authors were female,whilst 35%of them were first *** co-citation analysis by author involved 188 cited authors,13 of whom were cited at least 70 *** six out of forty-nine studies were funded by various government institutions and non-governmental *** Current analysis casts a spotlight on important trends being witnessed in regard to the mental health of radiologists,including lack of funding for mental health research,narrowing of female vs male citation gap,as well as authorship and citation trends.

关键词： Bibliometric Analysis Burnout Radiologist Stress Scientometrics

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Immobilization of Lead and Cadmium in Contaminated Soil Using Amendments: A Review

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Pedosphere 2015年第4期25卷 555-568页

作者： Amanullah MAHAR WANG Ping LI Ronghua ZHANG Zengqiang college of Natural Resources and Environment Northwest A&F University Centre for Environmental Sciences University of Sindh

Since the inception of industrial revolution, metal refining plants using pyrometallurgical processes have generated the prodigious emissions of lead(Pb) and cadmium(Cd). As the core target of such pollutants, a large number of soils are nowadays contaminated over widespread areas, posing a great threat to public health worldwide. Unlike organic pollutants, Pb and Cd do not undergo chemical or microbial breakdown and stay likely in site for longer duration after their release. Immobilization is an in-situ remediation technique that uses cost-effective soil amendments to reduce Pb and Cd availability in the contaminated soils. The Pb and Cd contamination in the soil environment is reviewed with focus on source enrichment, speciation and associated health risks, and immobilization options using various soil amendments. Commonly applied and emerging cost-effective soil amendments for Pb and Cd immobilization include phosphate compounds, liming, animal manure, biosolids, metal oxides, and biochar. These immobilizing agents could reduce the transfer of metal pollutants or residues to food web(plant uptake and leaching to subsurface water) and their long-term sustainability in heavy metal fixation needs further assessment.

关键词： bioavailability biochar biosolids heavy metal public health remediation soil extraction

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Capacity building for the identification,mitigation,and communication of DURC in Pakistan:A cross-sectional study

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Journal of Biosafety and Biosecurity 2021年第2期3卷 141-146页

作者： Shamsul Arfin Qasmi Samreen Sarwar Muhammad Azheruddin Department of Pathology Fazaia Ruth Pfau Medical CollegeKarachiSindhPakistan Technical Advisor Health Security PartnersLahorePakistan and Department of MicrobiologyUniversity of Health Sciences LahorePakistan Department of Community Medicine Fazaia Ruth Pfau Medical CollegeKarachiSindhPakistan

The increasing threat posed by state and nonstate actors seeking to misuse scientific and technological developments means it is more important than ever to ensure the responsible conduct of life sciences research,biosecurity research,and dual-use research of concern(DURC).Pakistan has a rapidly growing research environment and,being a signatory to the Biological Toxins and Weapons Convention,is committed to raising DURC awareness among its *** this end,a series of five workshops were conducted in Pakistan between July 2018 and January 2020 with the support of the United States organization Health Security *** workshops targeted universities offering postgraduate programs in life and medical *** purpose of the workshops was to enable participants to understand the concept of DURC,review their own research,determine if any of their experiments may be DURC,identify potential risks while conducting the research,and develop protocols to mitigate DURC threats.A pre-and post-workshop questionnaire evaluated the knowledge of the *** of both the course and facilitators were obtained at each workshop.

关键词： Dual-use research Knowledge Pakistan Training

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Angiotensin converting enzyme inhibitor associated spontaneous herniation of liver mimicking a pleural mass:A case report

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World Journal of Hepatology 2022年第4期14卷 854-859页

作者： Sameer Saleem Tebha Zain Ali Zaidi Sehrish Sethar Muhammad Asif Abbas Virk Muhammad Nadeem Yousaf Department of Neurosurgery and Neurology Jinnah Medical and Dental CollegeKarachi 75600SindhPakistan Department of Medicine Jinnah Medical and Dental CollegeKarachi 75600SindhPakistan Department of Radiology Jinnah Medical and Dental CollegeKarachi 75600SindhPakistan Department of Medicine Division of GastroenterologyWell Span York HospitalYorkPA 17403United States Department of Medicine Division of Gastroenterology and HepatologyUniversity of MissouriColumbiaMO 65212United States

BACKGROUND Spontaneous diaphragmatic herniation of the liver is a rare *** may mimic pulmonary mass especially in the absence of *** is a common side effect of angiotensin converting enzyme(ACE)inhibitors that may cause diaphragmatic rupture due to a sudden increase in trans-diaphragmatic *** present a case of ACE-inhibitor associated spontaneous herniation of the liver mimicking pleural *** SUMMARY An 80-year-old woman presented with dry cough for 1 mo and sudden onset of cramping abdominal pain for 1 *** denied history of trauma,prior surgeries,smoking,alcohol or illicit drug *** has a history of diabetes and was started on an ACE inhibitor 6 mo ago for the management of *** was remarkable for right upper quadrant *** work-up was *** X-ray showed a right lower lung opacity suspecting right pleural *** computed tomography scan ruled out pleural mass,however,revealed herniated right lobe of the liver(3.9 cm×3.6 cm×3.4 cm)into the thoracic cavity through the posterolateral diaphragmatic *** repair of the diaphragmatic defect was performed and the ACE inhibitor was ***’symptoms had completely resolved on *** ACE inhibitor-associated cough may cause diaphragmatic liver herniation mimicking pleural *** diagnosis,surgical repair and addressing the triggering factors improve patients’outcomes.

关键词： Diaphragmatic hernia Liver herniation ACE-inhibitors Cough Non-traumatic diaphragmatic hernia Case report

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Microwave-assisted synthesis of L-cysteine-capped nickel nanoparticles for catalytic reduction of 4-nitrophenol

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Rare Metals 2015年第10期34卷 683-691页

作者： Nazar Hussain Kalwar Ayman Nafady Razium Ali Soomro Sirajuddin Syed Tufail Hussain Sherazi Abdul Rauf Khaskheli Keith Richard Hallam National Centre of Excellence in Analytical Chemistry University of Sindh Department of Chemistry College of ScienceKing Saud University Interface Analysis Centre School of PhysicsUniversity of Bristol Department of Pharmacy Shaheed Mohtarma Benazir Bhutto Medical University

A simple and efficient microwave-assisted procedure for synthesis of L-cysteine-capped nickel nanoparticles(cyst-Ni NPs) in ethylene glycol solvent was demonstrated. The as-synthesised NPs were characterised by ultraviolet–visible(UV–Vis) spectrophotometer, Fourier transform infrared(FTIR) spectroscopy, transmission electron microscopy(TEM) and X-ray diffractometry(XRD). The cyst-Ni NPs are proved to be excellent heterogeneous catalysts for the 100% reduction of 4-nitrophenol(4-NPh) in the presence of reductant(Na BH4)within reaction time of 40 s. In contrast, Raney nickel in similar sample environments shows only 25.5% *** kinetic and energetic behaviours of cyst-Ni NPs were also studied, and the reduction reaction is determined to follow pseudo-first-order kinetics with a rate constant value of 0.115 s-1 and activation energy of 36.1 kJ·mol-1. In addition to its high catalytic competence, cyst-Ni NPs catalyst exhibits excellent recyclability with negligible catalytic poisoning.

关键词： L-cysteine Nickel nanoparticles Catalyst Reduction

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