检索结果-南通市图书馆

Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

引用

Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei Zhao Wenjie Ren Institute of disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for disaster Medicine technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Beyond Performance of Learning Control Subject to Uncertainties and Noise: A Frequency-Domain Approach Applied to Wafer Stages

引用

IEEE/CAA Journal of Automatica Sinica 2025年第1期12卷 198-214页

作者： Fazhi Song Ning Cui Shuaiqi Chen Kai Zhang Yang Liu Xinkai Chen Jiubin Tan IEEE the center of Ultra-precision Optoelectronic Instrument Engineering Harbin Institute of Technology the Key Laboratory of Ultra-Precision Intelligent Instrumentation Ministry of Industry and Information Technology the State Key Laboratory of Precision Electronic Manufacturing technology and Equipment Guangdong University of Technology the center of Ultraprecision Optoelectronic Instrument Engineering Harbin Institute of Technology the Key Laboratory of UltraPrecision Intelligent Instrumentation Ministry of Industry and Information Technology the Department of Electronic and Information Systems Shibaura Institute of Technology

The increasingly stringent performance requirement in integrated circuit manufacturing, characterized by smaller feature sizes and higher productivity, necessitates the wafer stage executing a extreme motion with the accuracy in terms of nanometers. This demanding requirement witnesses a widespread application of iterative learning control(ILC), given the repetitive nature of wafer scanning. ILC enables substantial performance improvement by using past measurement data in combination with the system model knowledge. However, challenges arise in cases where the data is contaminated by the stochastic noise, or when the system model exhibits significant uncertainties, constraining the achievable performance. In response to this issue, an extended state observer(ESO) based adaptive ILC approach is proposed in the frequency *** being model-based, it utilizes only a rough system model and then compensates for the resulting model uncertainties using an ESO, thereby achieving high robustness against uncertainties with minimal modeling effort. Additionally, an adaptive learning law is developed to mitigate the limited performance in the presence of stochastic noise, yielding high convergence accuracy yet without compromising convergence speed. Simulation and experimental comparisons with existing model-based and data-driven inversion-based ILC validate the effectiveness as well as the superiority of the proposed method.

关键词： Extended state observer learning control model uncertainties motion control stochastic noise

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Evaluating complementaries among urban water,energy,infrastructure,and social Sustainable Development Goals in China

引用

Journal of Environmental Sciences 2025年第3期149卷 585-597页

作者： Ke Yu Yifan Song Jin Lin Shen Qu School of Management and Economics Beijing Institute of TechnologyBeijing 100081China center for Energy&Environmental Policy Research Beijing Institute of TechnologyBeijing 100081China

Urban areas’performance in water,energy,infrastructure,and socio-economic sectors is intertwined and measurable through Sustainable Development Goals(SDGs)6–*** synergy among these is critical for *** study constructs an indicator framework that reflects progress towards these urban SDGs in *** indicate underperformance in SDGs 8–11,suggesting the need for transformative *** network analysis,the research reveals complementarities among these ***,the SDG space divides into socio-economic and ecological clusters,with SDG 6(Clean Water and Sanitation)central to ***,SDG 8(Decent Work and Economic Growth)and SDG 9(Industry,Innovation,and Infrastructure)act as bridges,while greater synergies exist between SDG 12(Responsible Consumption and Production)and SDG 13(Climate Action).An in-depth view at the indicator-level shows a core-periphery structure,emphasizing indicators like SDG 6.2(Wastewater Treatment Rate)and SDG 6.6(Recycled Water Production Capacity per capita)as *** study confirms the urban SDG space’s stability and predictiveness,underscoring its value in steering well-aligned policy decisions for sustainable growth.

关键词： Sustainable development goals Synergy Urban development Policy decisions

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Isothermal reduction kinetics and reduction prediction for iron ore pellets

引用

Journal of Iron and Steel Research International 2025年第1期32卷 64-72页

作者： Fei Meng Hao Liu Yue-lin Qin Huang-jie Hua Yin Deng Ze-zheng Sun Long-hai Liu School of Metallurgy and Materials Engineering Chongqing University of Science and TechnologyChongqing401331China CISDI Group Co. Ltd.Chongqing401122China College of Materials Science and Engineering Chongqing UniversityChongqing400044China sichuan Desheng Group Vanadium&Titanium Co. Ltd.Leshan614000SichuanChina

Iron ore pellets,as one of the main charges of blast furnaces,have a greater impact on the CO_(2)emission reduction and stable operation of blast *** isothermal reduction behavior of the pellets obtained from a Chinese steel plant was studied in the gas mixtures of CO and N_(2).The results showed the reduction process is divided into two *** reduction in the initial stage(time t≤40 min)is cooperatively controlled by internal diffusion and interface chemical reactions with the activation energy of 30.19 and 16.67 kJ/mol,*** controlling step of the reduction in the final stage(t>40 min)is internal diffusion with the activation energy of 34.60 kJ/*** reduction process can be described by two equations obtained from kinetic *** reduction degree can be predicted under different temperatures and time,and the predicted results showed an excellent correlation with the experimental *** reduction mechanisms were confirmed by the analysis of the scanning electron microscope equipped with an energy dispersive spectrometer and optical microscope.

关键词： Pellet Reduction behavior Kinetics Mechanism Reduction prediction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Raindrop Size Distribution Measurements at High Altitudes in the Northeastern Tibetan Plateau during Summer

引用

Advances in Atmospheric Sciences 2023年第7期40卷 1244-1256页

作者： Huibang HAN Yuxin ZHANG Jianbing TIAN Xiaoyan KANG meteorological disaster prevention technology center in Qinghai Province Xining 810000China Key Laboratory for disaster prevention and Mitigation in Qinghai Province Xining 810000China

Characteristics of raindrop size distribution during summer are studied by using the data from six Parsivel disdrometers located in the northeastern Tibetan *** analysis focuses on convective and stratiform precipitation at high altitudes from 2434 m to 4202 *** results show that the contribution of stratiform and convective precipitation with rain rate between 1≤R<5 mm h^(-1) to the total precipitation increases with altitude,and the raindrop scale and number concentration of convective precipitation is larger than that for stratiform *** droplet size spectra of both stratiform and convective precipitation shows a single peak with a peak particle size between 0.31–0.50 mm,and they have essentially the same peak particle size and number concentration at the same *** maximum spectral widths of stratiform clouds are between 4 mm and 5 mm,while those of convective clouds range from 4 mm to 8 *** Gamma distribution is more suitable than the Marshall-Palmer distribution in terms of the actual raindrop spectrum *** stratiform precipitation particles are smaller with higher number concentration,while the opposite is true for the convective precipitation *** convective precipitation particles drop faster than stratiform precipitation particles when the particle size exceeds 2 mm,and the falling velocity of raindrops after standard curve fitting is underestimated during the observation ***,conventional radar estimation methods would underestimate the precipitation in the Northeastern Tibetan Plateau.

关键词： raindrop size distribution precipitation microphysics Northeastern Tibetan Plateau fall velocity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of initial microstructure on microstructure evolution and mechanical properties of 0.12C martensitic steels during quenching and tempering

引用

Journal of Iron and Steel Research International 2025年第1期32卷 260-269页

作者： Ya-ru Wang Zi-yong Hou He Yang Jun Zhao Zhi-yuan Chang Fan-mao Meng Ling Zhang Gui-lin Wu Xiao-xu Huang State Key Laboratory of Vanadium and Titanium Resource Comprehensive Utilization Panzhihua 617000SichuanChina State Key Laboratory of Advanced Special Steel Shanghai Key Laboratory of Advanced FerrometallurgySchool of Materials Science and EngineeringShanghai UniversityShanghai 200444China International Joint Laboratory for Light Alloys(Ministry of Education) College of Materials Science and EngineeringChongqing UniversityChongqing 400044China Institute of Steel technology for Automobile and Household Appliance Pangang Group Co.Ltd.Panzhihua 617000SichuanChina ATB Motor(Shanghai)Co. Ltd.Keen International CenterShanghai 200041China Beijing Advanced Innovation center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China

The microstructure evolution and mechanical properties of a Fe-0.12C-0.2Si-1.6Mn-0.3Cr-0.0025B(wt.%)steel with different initial microstructures,i.e.,hot rolled(HR)and cold rolled-annealed(CRA),were studied through optical microscopy,scanning electron microscopy,electron channeling contrast imaging,microhardness and room temperature uniaxial tensile *** water quenching from 930℃ to room temperature,a fully martensitic microstructure was obtained in both as-quenched HR and CRA specimens,which shows a microhardness of 480±5 HV,and no significant difference in microstructure and microhardness was *** test results show that the product of tensile strength and total elongation(UTS×TE)of the as-quenched HR specimen,i.e.,24.1 GPa%,is higher than that of the as-quenched CRA specimen,i.e.,18.9 GPa%.While,after being tempered at 300℃,the martensitic microstructures and mechanical properties of the two as-quenched specimens change significantly due to the synergy role of the matrix phase softening and the precipitation *** the maximum UTS×TE,it is 18.9 GPa%obtained in the as-quenched CRA one,while that is 24.4 GPa%obtained in the HR specimen after tempered at 300℃ for 5 min.

关键词： Initial microstructure Lath martensite Quenching Tempering Mechanical property

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dynamic properties of low-density expandable polystyrene concrete materials

引用

Defence technology(防务技术) 2025年第1期43卷 94-108页

作者： Jue Han Hualin Fan Army Engineering University of PLA Nanjing 210007China Research center of Lightweight Structures and Intelligent Manufacturing State Key Laboratory of Mechanics and Control of Aerospace StructuresNanjing University of Aeronautics and AstronauticsNanjing 210016China Henan International Joint Laboratory of Dynamics of Impact and disaster of Engineering Structures Department of Civil EngineeringNanyang Institute of TechnologyNanyang 473004China

Expanded polystyrene(EPS)concrete,known for its environmental friendliness,energy absorption capacity,and low impedance,has significant potential application in the fields of wave absorption and vibration *** study designed and prepared EPS concrete materials with four levels of ***-static uniaxial compression and Split Hopkinson Pressure Bar(SHPB)impact tests were conducted to obtain stress-strain curves,elastic moduli,failure modes,energy absorptions,and strain rate effects of the EPS concrete under quasi-static and dynamic loading *** influences of density on various performance indicators were *** combining the Zhu-Wang-Tang(ZWT)constitutive model with a modified elastic-brittle model,a modified dynamic constitutive model was *** accuracy of the model was validated by the experimental *** results indicate that the addition of EPS particles enhances the ductility of the EPS *** EPS concrete has significant strain rate effect,which gets stronger as density *** modifiedconstitutive model accurately characterizes the dynamic stress-strain curves of the EPS concrete.

关键词： EPS concrete Impact behavior Constitutive model SHPB test

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Development of an automated photolysis rates prediction system based on machine learning

引用

Journal of Environmental Sciences 2025年第5期151卷 211-224页

作者： Weijun Pan Sunling Gong Huabing Ke Xin Li Duohong Chen Cheng Huang Danlin Song State Key Laboratory of Severe Weather&Key Laboratory of Atmospheric Chemistry of CMA Chinese Academy of Meteorological SciencesBeijing 100081China College of Environmental Sciences and Engineering Peking UniversityBeijing 100871China State Environmental Key Laboratory of Reginal Air Quality Monitoring Guangdong Ecological Environmental Monitoring CenterGuangzhou 510308China State Environmental Protection Key Laboratory of Formation and prevention of the Urban Air Complex Shanghai Academy of Environmental SciencesShanghai 200233China Chengdu Academy of Environmental Sciences Chengdu 610072China National Observation and Research Station of Coastal Ecological Environments in Macao Macao Environmental Research InstituteMacao University of Science and TechnologyMacao 999078China

Based on observed meteorological elements,photolysis rates(J-values)and pollutant concentrations,an automated J-values predicting system by machine learning(J-ML)has been developed to reproduce and predict the J-values of O^(1)D,NO_(2),HONO,H_(2)O_(2),HCHO,and NO_(3),which are the crucial values for the prediction of the atmospheric oxidation capacity(AOC)and secondary pollutant concentrations such as ozone(O_(3)),secondary organic aerosols(SOA).The J-ML can self-select the optimal“Model+Hyperparameters”without human *** evaluated results showed that the J-ML had a good performance to reproduce the J-values wheremost of the correlation(R)coefficients exceed 0.93 and the accuracy(P)values are in the range of 0.68-0.83,comparing with the J-values from observations and from the tropospheric ultraviolet and visible(TUV)radiation model in Beijing,Chengdu,Guangzhou and Shanghai,*** hourly prediction was also well performed with R from 0.78 to 0.81 for next 3-days and from 0.69 to 0.71 for next 7-days,*** with O_(3)concentrations by using J-values from the TUV model,an emission-driven observation-based model(e-OBM)by using the J-values from the J-ML showed a 4%-12%increase in R and 4%-30%decrease in ME,indicating that the J-ML could be used as an excellent supplement to traditional numerical *** feature importance analysis concluded that the key influential parameter was the surface solar downwards radiation for all J-values,and the other dominant factors for all J-values were 2-m mean temperature,O_(3),total cloud cover,boundary layer height,relative humidity and surface pressure.

关键词： J-values Automated prediction system Machine learning Short-term prediction O_(3) simulated improvement

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Taming of trinitromethyl-oxadiazole to access high density and high oxygen balance via a dual modulation strategy

引用

Defence technology(防务技术) 2025年第1期43卷 142-149页

作者： Jinya Zhang Teng Fei Jingwei Meng Jinxiong Cai Lei Zhang Siping Pang Chunlin He School of Materials Science&Engineering Beijing Institute of TechnologyBeijing 100081China Experimental center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 100081China hongqing Innovation center Beijing Institute of TechnologyChongqing 401120China

Energetic compounds bearing the trinitromethyl group are garnering broad attraction as potential candidates for a new generation of high energy dense *** this work,an effective dual modulation strategy involving both molecular isomerization and crystal morphology control was employed to design and optimize trinitromethyl-oxadiazole with improved comprehensive *** this dual strategy,3,5-bis(trinitromethyl)-1,2,4-oxadiazole(3)was synthesized,resulting in the formation of two distinct crystal morphologies(needle and sheet)corresponding to two crystal forms(3-a and3-b).Encouragingly,while maintaining ultra-high oxygen balance(21.73%),3 achieves impressive densities(1.97-1.98 g/cm^(3)).To our knowledge,the density of 1.98 g/cm^(3)for 3-a sets a new record among that of nitrogen-rich monocyclic ***,practical crystal morphology prediction was creatively introduced to guide the experimental crystallization conditions of 3,increasing the impact sensitivity and friction sensitivity from 1 J to 80 N(3-a)to 10 J and 240 N(3-b),***,the crystal structural analyses and theoretical calculations were conducted to elucidate the reasons of differences between 3-a and 3-b in density and *** work provides an efficient strategy to enhance performance of trinitromethyl derivatives,broadening the path and expanding the toolbox for energetic materials.

关键词： Energetic materials High oxygen balance High density Dual modulation Trinitromethyl group

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A highly sensitive electrochemical sensor based on poly(3-aminobenzoic acid)/graphene oxide-gold nanoparticles modified screen printed carbon electrode for paraquat detection

引用

Journal of Environmental Sciences 2025年第2期148卷 139-150页

作者： Dechnarong Pimalai Thitirat Putnin Suwussa Bamrungsap National Nanotechnology center(NANOTEC) National Science and Technology Development Agency(NSTDA)Pathum Thani 12120Thailand

Herein,a modified screen printed carbon electrode(SPCE)based on a composite material,graphene oxide-gold nanoparticles(GO-AuNPs),and poly(3-aminobenzoic acid)(P3ABA)for the detection of paraquat(PQ)is *** modified electrode was fabricated by drop casting of the GO-AuNPs,followed by electropolymerization of 3-aminobenzoic acid to achieve SPCE/GO-AuNPs/*** morphology and microstructural characteristics of the modified electrodes were revealed by scanning electron microscopy(SEM)for each step of *** composite GO-AuNPs can provide high surface area and enhance electroconductivity of the *** addition,the presence of negatively charged P3ABA notably improved PQ adsorption and electron transfer rate,which stimulate redox reaction on the modified electrode,thus improving the sensitivity of PQ *** SPCE/GOAuNPs/P3ABA offered a wide linear range of PQ determination(10^(−9)-10^(−4) mol/L)and low limit of detection(LOD)of 0.45×10^(−9) mol/L or 0.116μg/L,which is far below international safety *** modified electrode showed minimum interference effect with percent recovery ranging from 96.5%to 116.1%after addition of other herbicides,pesticides,metal ions,and *** stability of the SPCE/GO-AuNPs/P3ABA was evaluated,and the results indicated negligible changes in the detection signal over 9 ***,this modified electrode was successfully implemented for PQ analysis in both natural and tapped water with high accuracy.

关键词： Paraquat Electrochemical sensor Graphene oxide(GO) Gold nanoparticle(AuNP) Poly(3-aminobenzoic acid)(P3ABA)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：