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A Biosurfactant-containing TSd Strategy to Modify Bovine Pericardial Bioprosthetic Valves for Anticalcification

Chinese Journal of Polymer Science 2023年第1期41卷 51-66页

作者： Cai-Yun Gao Gang Wang Lin Wang Qun-Song Wang Han-Cheng Wang Lin Yu Jian-Xiong Liu Jian-dong ding State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200438China r&d center Lifetech Scientific(Shenzhen)Co.Ltd.Shenzhen518057China r&d center Lifevalve Medical Scientific Co.Ltd.Shenzhen518057China

Bioprosthetic heart valves(BHVs)are important for transcatheter valve replacement.Current commercial BHVs on the market are basically porcine or bovine pericardium(BP)crosslinked with glutaraldehyde(GA).Simply applying GA to BHVs can enhance mechanical stability,but cannot alleviate in vivo calcification.In this work,we developed a two-step decellularization(TSd)strategy to modify this biomacromolecular network,in which BP was post-treated,as the second step of decellularization,with a mild biosurfactant n-dodecyl-β-d-maltoside in a mixture of isopropanol and phosphate-buffered saline after the first step of traditional decellularization and GA cross-linking.The TSd-treated BP exhibited not only low cytotoxicity and excellent mechanical properties in vitro,but also low immune responses and significant anticalcification in vivo.After 60 days of subcutaneous implantation in the back of Wistar rats,the calcium content was,as quantified with an inductively coupled plasma optical emission spectrometer,only 1.1µg/mg compared to 138.6µg/mg in the control group without the post-treatment.In addition,collagen fibrils were observed with field emitting scanning electron microscopy(SEM),and the morphology and composition of the calcified sites resulting from in vivo biomineralization were studied with SEM with energy dispersive spectroscopy and also X-ray diffraction.This study proposes a facile yet effective anticalcification strategy for the modification of the bovine pericardial bioprosthetic heart valve,a natural biomacromolecular network.

关键词： Heart valve Anticalcification Collagen In vivo biomineralization Transcatheter aortic valve implantation(TAVI) Extracellular matrix Biomacromolecular network Biosurfactant Bovine pericardium

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Biological mechanisms and clinical efficacy of sulforaphane for mental disorders

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General Psychiatry 2022年第2期35卷 79-84页

作者： Wensi Zheng Xiaolong Li Tianhong Zhang Jijun Wang Shanghai Key Laboratory of Psychotic disorders Shanghai Jiao Tong University School of Mental Health CenterShanghai MedicineShanghaiChina Shenzhen R&D Center Shenzhen Fushan BiotechShenzhenChina

Current clinical management of major mental disorders,such as autism spectrum disorder,depression and schizophrenia,is less than optimal.recent scientific advances have indicated that deficits in oxidative and inflammation systems are lessthanoptimal.recentscientific advances have indicated extensively involved in the pathogenesis of these disorders. These findings have led to expanded considerations for treatment.Sulforaphane(SFN)is a dietary phytochemical extracted from cruciferous vegetables.It is an effective activator of the transcription factor nuclear erythroid-2 like factor-2,which can upregulate multiple antioxidants and protect neurons against various oxidative damages.On the other hand,it can also significantly reduce inflammatory response to pathological states and decrease the damage caused by the immune response via the nuclear factor-kB pathway and other pathways.In this review,we introduce the biological mechanisms of SFN and the pilot evidence from its clinical trials of major mental disorders,hoping to promote an increase in psychiatric clinical studies of SFN.

关键词： SFN mechanisms expanded

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discovery of N-benzyl hydroxypyridone carboxamides as a novel and potent antiviral chemotype against human cytomegalovirus (HCMV)

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Acta Pharmaceutica Sinica B 2022年第4期12卷 1671-1684页

作者： Sameera Senaweera Tiffany C.Edwards Jayakanth Kankanala Yan Wang rajkumar Lalji Sahani Jiashu Xie robert J.Geraghty Zhengqiang Wang center for drug design College of PharmacyUniversity of MinnesotaMinneapolisMN 55455USA Translational Medicine r&d center Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Current drugs for treating human cytomegalovirus(HCMV)infections are limited by resistance and treatment-associated toxicities.In developing mechanistically novel HCMV antivirals,we discovered an N-benzyl hydroxypyridone carboxamide antiviral hit(8a)inhibiting HCMV in submicromolar range.We describe herein the structure–activity relationship(SAr)for 8a,and the characterization of potent analogs for cytotoxicity/cytostatic property,the preliminary mechanism of action,and the absorption,distribution,metabolism and excretion(AdME)properties.The SAr revealed a few pharmacophore features conferring optimal antiviral profile,including the 5-OH,the N-1 benzyl,at least one–CH_(2)−in the linker,and a di-halogen substituted phenyl ring in the amide moiety.In the end,we identified numerous analogs with sub-micromolar antiviral potency and good selectivity index.The preliminary mechanism of action characterization used a pUL89-C biochemical endonuclease assay,a virus entry assay,a time-of-addition assay,and a compound withdrawal assay.AdME profiling measuring aqueous solubility,plasma and liver microsomal stability,and parallel artificial membrane permeability assay(PAMPA)permeability demonstrated largely favorable drug-like properties.Together,these studies validate the N-benzyl hydroxypyridone carboxamide as a viable chemotype for potent and mechanistically distinct antivirals against HCMV.

关键词： Human cytomegalovirus N-Benzyl hydroxypyridone carboxamides Structureeactivity relationship Mechanism of action

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A method to evaluate the spatial extensibility of a switching unit and network

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Science China(Information Sciences) 2014年第2期57卷 140-156页

作者： ZHANG Bo WU JunTing WANG BinQiang LI Hui National digital Switching System Engineering Technological r&d center shenzhen Key Lab of Cloud Computing Technology and Application

Switching units and networks have been analyzed as extensible fabrics,mostly in terms of their scheduling algorithms.The traditional literature on switching extensibility has provided complexity theory only relating to the total numbers of inputs(or outputs)and exchange lines.This paper analyzes switching extensibility in terms of not only the scheduling algorithm and also the fabric itself.It is found that determining extensibility from soft complexity related to the number of inputs(or outputs)of the scheduling algorithm and the fabric extensibility in previous studies without quantization is a flawed conception.A method is thus proposed to express the spatial extensibility of a switching unit or network in terms of the connections of a switching resource and capacity.The method calculates parameter ES(the efciency of switching)of an m×n switching unit and obtains two functions of the switching unit to describe spatial extensibility along with the number of unilateral inputs or outputs.It is found that the range of ES is(0,1]and three types of switching unit and two types of crosspoint networks have ES=1.ES is calculated for banyan,Clos,parallel packet,fully interconnected and recirculation switching networks.The ES value for the banyan switching network is larger than that for other networks,and switching networks are classified into three types that have absolute/linear/denied spatial extensibility according to the limES value.It is demonstrated that a switching network has the largest ES value when it contains only the five types of switching unit for which ES=1.Finally,a group-switching-first self-routing banyan switching network with lower blocking probability and time delay is deduced,and the ES method is contrasted with two other methods of evaluating spatial extensibility in terms of their mathematical expressions and intuitive graphics,for the five types of switching network listed above.

关键词： spatial extensibility connection state efciency of switching banyan fully interconnected recirculation switching network

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research on Normal Pythagorean Neutrosophic Set Choquet Integral Operator and Its Application

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Computer Modeling in Engineering & Sciences 2022年第4期131卷 477-491页

作者： Changxing Fan Jihong Chen Keli Hu En Fan Xiuqing Wang department of Computer Science Shaoxing UniversityShaoxingChina College of Management shenzhen University ShenzhenChina Information Technology r&d Innovation center of Peking University ShaoxingChina

We first propose the normal Pythagorean neutrosophic set(NPNS)in this paper,which synthesizes the distribution of the incompleteness,indeterminacy,and inconsistency of the Pythagorean neutrosophic set(PNS)and normal fuzzy number.We also define some properties of NPNS.For solving the decision-making problem of the nonstrictly independent and interacting attributes,two kinds of NPNS Choquet integral operators are proposed.First,the NPNS Choquet integral average(NPNSCIA)operator and the NPNS Choquet integral geometric(NPNSCIG)operator are proposed.Then,their calculating formulas are derived,their properties are discussed,and an approach for solving the interacting multi-attribute decision making based on the NPNS is studied.Finally,the two kinds of operators are applied to validate the stability of the new method.

关键词： Normal pythagorean neutrosophic set(NPNS) NPNS choquet integral average(NPNSCIA)operator NPNS choquet integral geometric(NPNSCIG)operator multi-attribute decision making(MAdM)

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Novel and durable composite phase change thermal energy storage materials with controllable melting temperature

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Journal of Materials Science & Technology 2021年第27期86卷 11-19页

作者： Haiting Wei Shuiyuan Yang Cuiping Wang Changrui Qiu Kairui Lin Jiajia Han Yong Lu Xingjun Liu College of Materials and Fujian Provincial Key Laboratory of Materials Genome Xiamen UniversityXiamen 361005China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyShenzhen 518055China Institute of Materials Genome and Big data Harbin Institute of TechnologyShenzhen 518055China Shenzhen R&D Center for Al-based Hydrogen Hydrolysis Materials Shenzhen 518055China

The development of high temperature phase change materials(PCMs)with great comprehensive performance is significant in the future thermal energy storage system.In this study,novel and durable Al-Si/Al_(2)O_(3)-Al N composite PCMs with controllable melting temperature were successfully synthesized by using pristine Al powder as raw material and tetraethyl orthosilicate as SiO_(2)source.The Al_(2)O_(3)shell and Al-Si alloy were in-situ produced via the substitution reaction between molten Al and SiO_(2).Importantly,the crack caused by the incomplete encapsulation of the Al_(2)O_(3)shell could repair itself by the nitridation reaction of internal molten Al and thereby forming a highly dense Al_(2)O_(3)-Al N composite shell.The produced dense Al_(2)O_(3)-Al N composite shell could significantly improve the thermal cycling stability of composite PCMs,and thus,the thermal storage density decrease of the Al-Si/Al_(2)O_(3)-Al N(59.8 J/g to77.7 J/g)was far less than that of the Al-Si/Al_(2)O_(3)(118.5 J/g)after 3000 thermal cycles.Moreover,the synthesized Al-Si/Al_(2)O_(3)-Al N still exhibited a controllable melting temperature(571.5-637.9℃),relatively high thermal storage density(105.6-150.7 J/g),great dimensional stability and structural stability after3000 thermal cycles.Hence,the synthesized Al-Si/Al_(2)O_(3)-Al N composite PCMs,as promising preferential thermal energy storage materials,can be stably used in the energy utilization efficiency improvement of various systems for more than 6 years.

关键词： Al-Si Al_(2)O_(3)-AlN durable Controllable melting temperature Phase change thermal storage material

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A high-throughput study on endothelial cell adhesion and growth mediated by adsorbed serum protein via signaling pathway PCr array

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regenerative Biomaterials 2018年第1期5卷 25-34页

作者： Xiaoying Lü Yayun Qu Ying Hong Yan Huang Yiwen Zhang dayun Yang Fudan Zhang Tingfei Xi deyuan Zhang State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096P.R.China Nanjing drum Tower Hospital Nanjing 210008P.R.China SQ Medical device Co. Ltd.Nanjing 210008P.R.China shenzhen research Institute Peking UniversityShenzhen 518055P.R.China r&d center of Lifetech Scientific(shenzhen)Co. LtdShenzhen 518057P.R.China

The purpose of this paper is to utilize the signaling pathway polymerase chain reaction(PCr)arrays to investigate the activation of two important biological signaling pathways in endothelial cell adhesion and growth mediated by adsorbed serum protein on the surface of bare and titanium nitride(TiN)-coated nickel titanium(NiTi)alloys.First,the endothelial cells were cultured on the bare and TiN-coated NiTi alloys and chitosan films as control for 4 h and 24 h,respectively.Then,the total rNA of the cells was collected and the PCr arrays were performed.After that,the differentially expressed genes in the transforming growth factor beta(TGF-b)signaling pathway and the regulation of actin cytoskeleton pathway were screened out;and the further bioinformatics analyses were performed.The results showed that both TGF-b signaling pathway and regulation of actin cytoskeleton pathway were activated in the cells after 4 h and 24 h culturing on the surface of bare and TiN-coated NiTi alloys compared to the chitosan group.The activated TGF-b signaling pathway promoted cell adhesion;the activated regulation of actin cytoskeleton pathway promoted cell adhesion,spreading,growth and motility.In addition,the activation of both pathways was much stronger in the cells cultured for 24 h versus 4 h,which indicated that cell adhesion and growth became more favorable with longer time on the surface of two NiTi alloy materials.

关键词： biomaterials protein adsorption and cell adhesion signaling pathway PCr array biological signaling pathway

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X-ray phase-sensitive microscope imaging with a grating interferometer:Theory and simulation

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Chinese Physics B 2022年第9期31卷 652-657页

作者：杨杰成朱佩平梁栋郑海荣葛永帅 research center for Medical Artificial Intelligence Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Platform of Advanced Photon Source Technology r&d Laboratory of X-ray Optics and TechnologyBeijing Synchrotron Radiation FacilityInstitute of High Energy PhysicsChinese Academy of SciencesBeijing100049China Beijing Advanced Innovation center for Imaging Theory and Technology Capital Normal UniversityBeijing 100048China Paul C Lauterbur research center for Biomedical Imaging Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China4.Paul C Lauterbur Research Center for Biomedical ImagingShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

A general theoretical framework is presented to explain the formation of the phase signal in an x-ray microscope integrated with a grating interferometer,which simultaneously enables the high spatial resolution imaging and the improved image contrast.By using this theory,several key parameters of phase contrast imaging can be predicted,for instance,the fringe visibility and period,and the conversion condition from the differential phase imaging(dPI)to the phase difference imaging(PdI).Additionally,numerical simulations are performed with certain x-ray optical components and imaging geometry.Comparison with the available experimental measurement[Appl.Phys.Lett.113063105(2018)]demonstrates the accuracy of this developed quantitative analysis method of x-ray phase-sensitive microscope imaging.

关键词： x-ray phase contrast imaging x-ray microscope grating interferometer

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Enhanced bifunctional catalytic activities of N-doped graphene by Ni in a 3d trimodal nanoporous nanotubular network and its ultralong cycling performance in Zn-air batteries

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Journal of Energy Chemistry 2022年第3期31卷 466-473,I0013页

作者： Yanyi Zhang Xiang-Peng Kong Xiaorong Lin Kailong Hu Weiwei Zhao Guoqiang Xie Xi Lin Xingjun Liu Yoshikazu Ito Hua-Jun Qiu School of Materials Science and Engineering Harbin Institute of TechnologyShenzhen 518055GuangdongChina Shenzhen R&D Center for Al-based Hydrogen Hydrolysis Materials Shenzhen 518055GuangdongChina State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001HeilongjiangChina Blockchain development and research Institute Harbin Institute of TechnologyShenzhen 518055GuangdongChina Institute of Applied Physics Graduate School of Pure and Applied SciencesUniversity of TsukubaTsukuba 305-8573Japan

Free-standing and fexible air electrodes with long-lasting bifunctional activities for both the oxygen reduction reaction(Orr)and the oxygen evolution reaction(OEr)are crucial to the development of wearable Zn-air rechargeable batteries.In this work,we synthesize a fexible air electrode consisting of 3d nanoporous N-doped graphene with trimodal shells and Ni particles through repeated chemical vapor deposition(CVd)and acidic etching processes.Our results indicate that such trimodal graphene morphology significantly enhances the active N-dopant sites and graphene-coated Ni surface,which consequentially boosts both the Orr and OEr activities,as well as catalytic durability.First-principles density functional theory(dFT)calculations reveal the synergetic effects between the Ni and the N-doped graphene;namely,the Ni nanoparticles boost the bifunctional activities of the coated N-doped graphene,and in turn the graphene-covering layers enhance the stability of Ni.Thanks to the better protection from the triple graphene shells,our trimodal N-doped graphene/Ni-based Zn-air battery can be stably discharged/recharged beyond 2500 h with low overpotentials.It is reasonable to expect that such freestanding trimodal graphene/Ni would be promising in many fexible energy conversion/storage devices.

关键词： Triple shells Bifunctional Hierarchical Cycling durability Orr/OEr

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High-entropy alloy catalysts:From bulk to nano toward highly efficient carbon and nitrogen catalysis

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Carbon Energy 2022年第5期4卷 731-761页

作者： Lanlan Yu Kaizhu Zeng Chenghang Li Xiaorong Lin Hanwen Liu Wenhui Shi Hua-Jun Qiu Yifei Yuan Yonggang Yao State Key Laboratory of Materials Processing and die and Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhanHubeiChina College of Chemistry and Materials Engineering Wenzhou UniversityWenzhouZhejiangChina Shenzhen R&D Center for Al-based Hydrogen Hydrolysis Materials School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)ShenzhenGuangdongChina

High-entropy alloys(HEAs)have attracted widespread attention as both structural and functional materials owing to their huge multielement composition space and unique high-entropy mixing structure.recently,emerging HEAs,either in nano or highly porous bulk forms,are developed and utilized for various catalytic and clean energy applications with superior activity and remarkable durability.Being catalysts,HEAs possess some unique advantages,including(1)a multielement composition space for the discovery of new catalysts and fine-tuning of surface adsorption(i.e.,activity and selectivity),(2)diverse active sites derived from the random multielement mixing that are especially suitable for multistep catalysis,and(3)a high-entropy stabilized structure that improves the structural durability in harsh catalytic environments.Benefited from these inherent advantages,HEA catalysts have demonstrated superior catalytic performances and are promising for complex carbon(C)and nitrogen(N)cycle reactions featuring multistep reaction pathways and many different intermediates.However,the design,synthesis,characterization,and understanding of HEA catalysts for C-and N-involved reactions are extremely challenging because of both complex high-entropy materials and complex reactions.In this review,we present the recent development of HEA catalysts,particularly on their innovative and extensive syntheses,advanced(in situ)characterizations,and applications in complex C and N looping reactions,aiming to provide a focused view on how to utilize intrinsically complex catalysts for these important and complex reactions.In the end,remaining challenges and future directions are proposed to guide the development and application of HEA catalysts for highly efficient energy storage and chemical conversion toward carbon neutrality.

关键词： carbon conversion electrocatalysis high-entropy alloy catalysts multifunctionality nitrogen conversion

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