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A novel vanadium complex VO(p-dmada)inhibits neuroinflammation induced by lipopolysaccharide

Chinese Chemical Letters 2023年第10期34卷 209-214页

作者： Zhijun He Xiaoqian Li Huajie Zhang Xin Liu Shuangxue Han Anwar Abdurahman Liming Shen Xiubo Du Nan Li Xiaoda Yang Qiong Liu shenzhen key laboratory of marine Biotechnology and Ecology College of Life Sciences and OceanographyShenzhen UniversityShenzhen 518055China National R&D Center for Se-rich Agricultural Products Processing Hubei Engineering Research Center for Deep Processing of Green Se-rich Agricultural ProductsSchool of Modern Industry for Selenium Science and EngineeringWuhan Polytechnic UniversityWuhan 430023China shenzhen Bay laboratory Shenzhen 518055China State key Laboratories of Natural and Biomimetic Drugs Department of Chemical BiologySchool of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China Department of Pharmacy Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020China shenzhen-Hong Kong Institute of Brain Science-shenzhen Fundamental Research Institutions Shenzhen 518055China

Uncontrolled microglial activation is decisively involved in the neuroinflammatory pathogenesis of brain diseases. Consequently, suppression of microglial overactivation appears to be a strategy for the prevention of nerve injury. In this paper, a novel vanadium complex, vanadyl N-(p-N,Ndimethylaminophenylcarbamoylmethyl)iminodiacetate(VO(p-dmada)), was synthesized from vanadyl sulfate and N,N-dimethyl-p-phenylenediamine, which was structurally characterized by Fourier transform infrared spectrum and ESI-MS analysis. The effect of VO(p-dmada) on neuroinflammation was investigated by using the models of lipopolysaccharide(LPS)-induced BV2 microglial cells and BALB/c mice.Our data demonstrated that VO(p-dmada) significantly suppressed microglial activation by downregulating inflammatory mediators and associated proteins, and inactivating nuclear factor-κ B(NF-κ B) signaling pathway. VO(p-dmada) also upregulated peroxisome proliferator activated receptor gamma(PPARγ) by reducing transglutaminase 2 and heat shock protein 60 expression. Co-treatment with PPARγ antagonist GW9662 significantly impeded the inhibitory effect of VO(p-dmada) on LPS-induced neuroinflammation.These cumulative findings demonstrated that VO(p-dmada) is a potential new drug for the treatment of neuroinflammation-related neurodegenerative diseases.

关键词： Vanadium Vanadyl N-(p-N,Ndimethylaminophenylcarbamoylmethyl)iminodiacetate (VO(p-dmada)) Neuroinflammation Microglia Proteomics Peroxisome proliferator activated receptor gamma(PPARγ)

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Biomimetic extracellular vesicles for the tumor targeted treatment

Engineered Regeneration

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Engineered Regeneration 2023年第4期4卷 427-437页

作者： Ruolin Shi An Zhan Xinze Li Bin Kong Gaofeng Liang Medical College and Henan key laboratory of microbiome and Esophageal Cancer Prevention and Treatment The First Affiliated HospitalSchool of Basic MedicineHenan University of Science and TechnologyLuoyang471023China School of Biomedical engineering Shenzhen University Medical SchoolShenzhen UniversityShenzhenGuangdong518055China Department of Neurosurgery Health Science CenterThe First Affiliated Hospital of Shenzhen UniversityShenzhen Second People’s HospitalShenzhenGuangdong518035China Institute of Biomedical Sciences Henan Academy of SciencesZhengzhou 450046China

Extracellular vesicles(EVs)are nanoscale substances produced by most cells,which were not fully understood in the early years.However,with the development of advanced techniques,researchers have discovered that EVs play an essential role in information exchange and signal transduction between cells.Nowadays,EVs are being used,modified,and developed as a natural drug carrier in various medical fields because of their high biocompatibility and natural affinity with the source body.Many studies have shown that multiple sources of EVs have been modified and utilized in cancer therapy to improve patients’treatment windows and effectively prolong patient survival.In this paper,we review the advances in the treatment of cancer based on EVs.We summarize the types of EVs loading therapy,the modes of drug loading and the latest therapeutic applications of multiple modes combined with EVs in cancer treatment.We conclude with a discussion of the current status,challenges,and prospects of EVs as a tool for tumor therapy.

关键词： Extracellular vesicles Exosomes Nanomedicine Drug delivery systems Cancer treatment

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Gut lumen-targeted oral delivery system for bioactive agents to regulate gut microbiome

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Journal of Future Foods 2022年第4期2卷 307-325页

作者： Junyu Liu Xiaobin Li Xiaopeng Zhang Runming Wang Sanyang Han Peiwu Qin Xin-Hui Xing Canyang Zhang Institute of Biopharmaceutical and Health engineering Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China Institute of Biochemical engineering Department of Chemical EngineeringKey Laboratory for Industrial BiocatalysisMinistry of EducationCenter for Synthetic and Systems BiologyTsinghua UniversityBeijing 100084China Institute of Biomedical Health Technology and engineering Shenzhen Bay LaboratoryShenzhen 518055China

Gut microbiome(GM)is closely related to the overall health status for the human being.The dysfunction of microbiome can lead to many diseases such as inflammation,cancer and neurodegenerative disease.Therefore,it's of great importance to develop effective strategy to regulate GM.Gut lumen-targeted oral delivery system(GLT-ODS)has been extensively investigated and widely used in food science and engineering in these years,due to the targeted delivery property,controlled release profile,high biocompatibility and enhanced bioavailability of cargos.Herein,we comprehensively summarized the current advances in GLT-ODS for bioactive agent.Specifically,we systematically summarize the GLT-ODS for pre-agents(prebiotics and probiotics)and anti-agents(antibiotics and bacteriophages)according to the type of cargos.Through in-depth discussion of representative researches,we refined the limitations of existing research in carrier material and target selection,and drew a blueprint for the future technological research and development.We believe that GLT-ODS will become a safe,efficient,simple and precise GM management strategy for improvement of health and shine in the development of precision food and pharmaceutical engineering in future.

关键词： Gut lumen-targeted Oral delivery systems Bioactive agents Gut microenvironment Food engineering

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Cultivation of uncultured marine microorganisms

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marine Life Science & Technology 2021年第2期3卷 117-120页

作者： Fengping Wang Meng Li Li Huang Xiao-Hua Zhang State key laboratory of Microbial Metabolism School of OceanographySchool of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai200240China shenzhen key laboratory of marine microbiome engineering Institute for Advanced StudyShenzhen UniversityShenzhen518060China key laboratory of Microbial Resources Institute of Microbiology Chinese Academy of SciencesBeijing100101China College of marine Life Sciences and Institute of Evolution and marine Biodiversity Ocean University of ChinaQingdao266003China

Microorganisms(both pro-and eukaryotes)occur in all marine environments with an estimated abundance of 10^(3)–10^(10)cells/cm^(3)in sediments and 10^(4)–10^(7)cells/ml in seawater;in these habitats they play key roles in marine biogeochemical cycles(Overmann and Lepleux 2016).Surveys employing molecular marker-based high-throughput sequencing and sophisticated metagenomic approaches have revealed the vast diversity of microorganisms in marine environments and have substantially expanded the tree of life(Castelle and Banfield 2018;Hug et al.2016;Nayfach et al.2020).However,many of the novel lineages have no cultured representatives.In fact,most(>99%)of the marine microorganisms have not been cultured under laboratory conditions(Hofer 2018;Jiao et al.2020)and are seen as“microbial dark matter”(Lok 2015).Although culture-independent approaches have enabled elucidation of the marine microbial assemblies and their metabolic potentials,pure cultures remain needed for microbiological studies.For example,pure cultures are critical for an understanding of the morphology,ecophysiology,and biochemistry of these organisms,which are key to recognizing their functions in complex environmental processes.Likewise,cultures are needed for discovering new bioactive substances,such as anti-tumor bioactive substances,new antibiotics and other secondary metabolites(Ding et al.2020).

关键词： marine environments expanded

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Differentiating structure of in situ and ex situ formation of laser-induced graphene hybrids

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Rare Metals 2022年第9期41卷 3035-3044页

作者： Li-Bei Huang Wei-Hua Guo Le Cheng Jian-Jun Su Yun Song Fei-Jun Hu Ying Lo Law Zheng Yan Jian Lin Ru-Quan Ye State key laboratory of marine Pollution Department of ChemistryCity University of Hong KongHong Kong999077China Department of Mechanical and Aerospace engineering University of MissouriColumbiaMO65211USA Department of Biomedical Biological&Chemical EngineeringUniversity of MissouriColumbiaMO65211USA Department of Electrical engineering and Computer Science University of MissouriColumbiaMO65211USA City University of Hong Kong shenzhen Research Institute Shenzhen518057China

Laser-induced graphene(LIG)has been exploited in various fields,such as batteries,water treatment,and flexible actuators and sensors,with the advantages of ease in patternable fabrication and graphene/metal hybrid preparation.The in situ method which includes a single lase step and the ex situ method which uses two lase steps are both widely implemented to synthesize graphene/metal hybrids.However,the differences in the structures and properties of the resulting hybrids are not fully understood.Here,we investigate the advantages of ex situ and in situ methods for preparing LIG hybrids using NiFe/LIG as an example.The morphology,elemental composition,resistance to strong acid,and application in electrocatalysis and dye adsorption of ex situ and in situ NiFe/LIG hybrids were systematically studied and compared.Energy-dispersive X-ray spectrometry(EDS)and vibrating sample magnetometry(VSM)results confirmed the structural differences between the NiFe/LIG hybrids.Metal nanoparticles are mostly wrapped by carbon layers in the in situ NiFe/LIG hybrid,while the ex situ NiFe/LIG hybrid largely exposes the metal nanoparticles.These structural differences are significant for tailoring performance in applications,such as wastewater treatment and electrocatalysis.This work provides insights into the synthesis and properties of LIGs and has important implications for future applications.

关键词： Ex situ In situ Laser-induced graphene Metal-containing hybrids Oxygen evolution reaction Dye adsorption

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key factors governing alkaline pretreatment of waste activated sludge

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Chinese Journal of Chemical engineering 2015年第5期23卷 842-846页

作者： Xianli Shi Li Deng Fangfang Sun Jieyu Liang Xu Deng College of Life Sciences Shenzhen Key Laboratory of Marine Bioresources and Ecology Shenzhen University

Alkaline pretreatment is an effective technology to disintegrate sewage sludge, where alkali dosage and sludge concentration are two important factors. p H value or alkali concentration is usually adjusted in order to determine a proper dosage of alkali. Our work has found that this is not a good strategy. A new parameter, the ratio of alkali to sludge(Ra/s), is more sensitive in controlling the alkali dosage. The sludge concentration Csand retention time t are two other important factors to consider. The validity of these arguments is confirmed with modeling and experiments. The individual effect of Ra/s, Csand t was studied separately. Then the combined effect of these three factors was evaluated. The sludge disintegration degree of 44.7% was achieved with the optimized factors. Furthermore, an alkaline-microwave combined pretreatment process was carried out under these optimized conditions. A high disintegration degree of 62.3% was achieved while the energy consumption of microwave was much lower than previously reported.

关键词：废活性污泥碱预处理碱性预处理污泥浓度预处理工艺污水污泥保留时间碱用量

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Discharge of treated Fukushima nuclear accident contaminated water:macroscopic and microscopic simulations

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National Science Review 2022年第1期 14-16页

作者：刘毅郭雪卿李孙伟张建民胡振中 Institute for Ocean engineering Shenzhen International Graduate School Tsinghua University Institute for Ocean engineering Tsinghua University Department of Hydraulic engineering Tsinghua University shenzhen key laboratory of marine Intelli Sense and Computation Shenzhen International Graduate School Tsinghua University

On 26 August 2021, the Japanese Cabinet passed a bill to discharge treated Fukushima nuclear accident contaminated water into the Pacific Ocean to alleviate the problem of nuclear wastewater storage.

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Mantle sources of Cenozoic volcanoes around the South China Sea revealed by geochemical and isotopic data using the principal component analysis

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Journal of Oceanology and Limnology 2023年第2期41卷 562-574页

作者： Shuangshuang CHEN Zewei WANG Rui GAO Yongzhang ZHOU School of Earth Sciences and engineering Sun Yat-sen UniversityGuangzhou 510275China Southern marine Science and engineering Guangdong laboratory(Zhuhai) Zhuhai 519080China Guangdong Provincial key Lab of Geological Processes and Mineral Resources Guangzhou 510275China State key laboratory of marine Environmental Science Xiamen UniversityXiamen 361102China Department of Earth and Space Sciences Southern University of Science and TechnologyShenzhen 518055China State key laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China

Principal component analysis(PCA)was employed to determine the implications of geochemical and isotopic data from Cenozoic volcanic activities in the Southeast Asian region,including China(South China Sea(SCS),Hainan Island,Fujian-Zhejiang coast,Taiwan Island),and parts of Vietnam and Thailand.We analyzed 15 trace element indicators and 5 isotopic indicators for 623 volcanic rock samples collected from the study region.Two principal components(PCs)were extracted by PCA based on the trace elements and Sr-Nd-Pb isotopic ratios,which probably indicate an enriched oceanic island basalt-type mantle plume and a depleted mid-ocean ridge basalt-type spreading ridge.The results show that the influence of the Hainan mantle plume on younger volcanic activities(13 Ma)at the same location in the Southeast Asian region.PCA was employed to verify the mantle-plume-ridge interaction model of volcanic activities beneath the expansion center of SCS and refute the hypothesis that the tension of SCS is triggered by the Hainan plume.This study reveals the efficiency and applicability of PCA in discussing mantle sources of volcanic activities;thus,PCA is a suitable research method for analyzing geochemical data.

关键词： volcanic rocks geochemical indicators mantle source principal component analysis South China Sea

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Occurrence and light response of residual plastid genes in a Euglena gracilis bleached mutant strain OflB2

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Journal of Oceanology and Limnology 2020年第6期38卷 1858-1866页

作者： QIN Huan GUO Qingqing LIU Chenchen LI Fenglan ZHANG Hua CHU Zihan WANG Jiangxin LEI Anping shenzhen key laboratory of marine Bioresource and Eco-environmental Science Shenzhen Engineering Laboratory for Marine Algal BiotechnologyGuangdong Provincial Key Laboratory for Plant EpigeneticsCollege of Life Sciences and OceanographyShenzhen UniversityShenzhen 518000China Basis International School SZ Shenzhen 518000China

Euglena gracilis is a unicellular green eukaryotic microalga that features characteristics of both plants and animals.The photosynthetic function of its chloroplast is easily lost under stress resulting in bleached mutants,while the physiological role of their residual plastid DNAs remains unclear.In this study,we obtained five bleached mutants by ofloxacin(Ofl)treatment,identified 12 residual plastid genes in five bleached mutants,and determined the mRNA levels in the wild type E.gracilis(WT)and one bleached mutant(OflB2)under dark and light stimulation conditions by quantitative reverse transcribed PCR(qRTPCR).Results show that the expression of all selected plastid genes in both WT and OflB2 mutant did not change significantly in darkness,while their responses to light stimulation were different.Under the light stimulation conditions,half of the genes did not change significantly,while most of the other genes were down-regulated in OflB2 mutant and up-regulated in WT.Therefore,the bleached mutant retains part of the plastid genome and the plastid relic is responsive to light.Our research will help to understand the functions of residual plastid DNA and evolution of chloroplasts.

关键词： Euglena gracilis bleached mutant residual plastid genes light response

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基于摩擦伏特效应的卤化物钙钛矿用于自供能传感器

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Science Bulletin 2023年第17期68卷 1849-1852页

作者：吴颖辉黄龙彪潘曹峰 key laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China Beijing key laboratory of Micro-nano Energy and Sensor Beijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 100083China Guangdong Provincial key laboratory of Durability for Ocean Civil engineering College of Civil and Transportation EngineeringShenzhen UniversityShenzhen 518060China shenzhen key laboratory for Low-carbon Construction Material and Technology College of Civil and Transportation EngineeringShenzhen UniversityShenzhen 518060China

With the rapid development of aerospace,the Internet of Things,wearable devices,and portable instruments,the application scenarios for sensors are expanding and requiring higher performance in terms of conversion efficiency,flexibility,and stability.However,most sensors are powered by an external power source,which hinders the construction of flexible sensors due to their rigid nature.

关键词： stability hinder portable

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