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Grazing incidence polarized light imaging of footwear prints

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Frontiers of Information Technology & Electronic Engineering 2019年第11期20卷 1543-1550页

作者： Xin-yi BI Rui-fang HAN Ran LIAO Wu-sheng FENG Da LI Xue-jie ZHANG Hui MA shenzhen key laboratory for Minimal invasive medical technologies Graduate School at ShenzhenTsinghua UniversityShenzhen 518055China Department of Biomedical Engineering Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Division of Ocean Science and Technology Graduate School at ShenzhenTsinghua UniversityShenzhen 518055China Criminal Police Team Municipal Public Security BureauZhuhai 519000China Tsinghua-Berkeley shenzhen Institute Shenzhen 518071China

Footwear prints are important evidence in criminal investigation. They represent changes in the surface morphology due to disturbance to fine particle distributions. Existing non-contact optical detection methods usually measure the light intensity contrasts between the footwear prints and the ground, which can be enhanced by grazing incident illumination. We take polari-zation images of footwear prints on different types of floors using a commercial single lens reflex color camera. Results show that adding linear polarizers in front of the camera lens and light source improves the contrast of footwear print images. The best contrasts are achieved in degree of linear polarization. In addition, the three-color channels of the camera can be used to examine the spectral features of the polarization images. According to the experimental results, the best contrast is obtained at the blue channel. The current work shows that grazing incidence polarized light imaging can effectively enhance the contrast of the footwear prints against the floors, which would help obtain footwear evidence in criminal investigation.

关键词： Polarization Image enhancement Scattering Particle

Influence of absorption in linear polarization imaging of melanoma tissues

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Journal of Innovative Optical Health Sciences 2014年第3期7卷 59-66页

作者： Dongzhi Li Honghui He Nan Zeng Weidong Xie Ran Liao Jian Wu Yonghong He Hui Ma shenzhen key laboratory for Minimal invasive medical technologies graduate school at shenzhen Tsinghua UniversityShenzhen 518055P.R.China Department of Physics Tsinghua University Beijing 100084P.R.Chinat

The contrast mechanism of different polarization imaging techniques for melanoma in mouse skin is st udied using both experiments and Monte Carlo *** intensity,linear polariz-ation diference imaging(DPI),degree of polarization imaging(DOPI)and'rotating linearpolarization imaging(RLPl)are applied and the relative contrasts of these polarization imagingmethods between the normal and cancerous tissues are compared.A two-layer absorption-scat-tering model is proposed to explain the contrast mechanism of the polarization imaging *** taking into account of both scattering of symmetrical and asymmetrical scat terersand absorption of inter-scatterer medium,the two-layer model reproduces the relative con trastsfor polarization images observed in *** simulation results also show that,theparameters of polarization imaging change more dramatically with the variation of absorption inthe bottom layer than the top layer.

关键词： Polarization imaging melanoma two-layer model Monte Carlo simulation.

Surface functionalization of SPR chip for specific molecular interaction analysis under flow condition

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Journal of Innovative Optical Health Sciences 2017年第2期10卷 30-39页

作者： Tao Ma Xiaoxia Chen Qing Peng Pengfei Zhang Yonghong He Department of Ophthalmology Shanxi Eye Hospital Taiyuan 030002P.R.China Department of Ophthalmology Xin Hua hospital affiliated to Shanghai Jiao Tong University school of Medicine Shanghai 200092 P.R.China Department of Ophthalmology MinHang Hospital Affiliated to Fudan University Shanghai 201199P.R.China shenzhen key laboratory for Minimal invasive medical technologies Institute of optical imaging and sensing graduate school at shenzhen Tsinghua University Shenzhen 518055P.R.China Department of Physics Tsinghua University Beijing 100084P.R.China

Surface functionalization of sensor chip for probe immobilization is crucial for the biosensing applications of surface plasmon resonance(SPR)*** this paper,we report a method circulating the dopamine aqueous solution to coat polydopamine film on sensing surface for surface functionalization of SPR *** polydopamine film with available thickness can be easily prepared by controlling the circulation time and the biorecognition elements can be immobilized on the polydopamine film for specific molecular interaction *** opera-tions are all performed under flow condition in the fuidic system,and have the advantages of easy implementation,less time consuming,and low cost,because the reagents and devices used in the operations are routinely applied in most *** this study,the specific absorption between the protein A probe immobilized on the sensing surface and human immunoglobulin G in the buffer is monitored based on this surface functionalization strategy to demonstrated its feasibility for SPR biosensing applications.

关键词： Surface plasmon resonance surface functionalization dopamine molecular interac-tion analysis

Development of a CLDN18.2-targeting immuno-PET probe for non-invasive imaging in gastrointestinal tumors

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Journal of Pharmaceutical Analysis 2023年第4期13卷 367-375页

作者： Yan Chen Xingguo Hou Dapeng Li Jin Ding Jiayue Liu Zilei Wang Fei Teng Hongjun Li Fan Zhang Yi Gu Steven Yu Xueming Qian Zhi Yang Hua Zhu Guizhou University Medicine College Guiyang550025China The Ministry of Education key laboratory of Carcinogenesis and Translational Research NMPA Key Laboratory for Research and Evaluation of RadiopharmaceuticalsDepartment of Nuclear MedicinePeking University Cancer Hospital&InstituteBeijing100142China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouSichuan646000China Suzhou Transcenta Therapeutics Co. LtdSuzhouJiangsu215127China Institute of Biomedical Engineering Peking University Shenzhen Graduate SchoolShenzhenGuangdong518055China

Claudin18.2(CLDN18.2)is a tight junction protein that is overexpressed in a variety of solid tumors such as gastrointestinal cancer and oesophageal *** has been identified as a promising target and a potential biomarker to diagnose tumor,evaluate efficacy,and determine patient ***001 is a recombinant humanized CLDN18.2 antibody that selectively binds to the extracellular loop of human *** this study,we constructed a solid target radionuclide zirconium-^(89)(^(89)Zr)labled-TST001 to detect the expression of in the human stomach cancer BGC823CLDN18.2 cell ***[^(89)Zr]Zr-desferrioxamine(DFO)-TST001 showed high radiochemical purity(RCP,>99%)and specific activity(24.15±1.34 GBq/mmol),and was stable in 5%human serum albumin,and phosphate buffer saline(>85%RCP at 96 h).The EC_(50) values of TST001 and DFO-TST001 were as high as 0.413±0.055 and 0.361±0.058 nM(P>0.05),*** radiotracer had a significantly higher average standard uptake values in CLDN18.2-positive tumors than in CLDN18.2-negative tumors(1.11±0.02 vs.0.49±0.03,P=0.0016)2 days post injection(p.i.).BGC823CLDN18.2 mice models showed high tumor/muscle ratios 96 h ***[^(89)Zr]Zr-DFO-TST001 was much higher than those of the other imaging *** results showed that BGC823CLDN18.2 tumors were highly positive(+++)for CLDN18.2,while those in the BGC823 group did not express CLDN18.2().The results of ex vivo biodistribution studies showed that there was a higher distribution in the BGC823CLDN18.2 tumor bearing mice(2.05±0.16%ID/g)than BGC823 mice(0.69±0.02%ID/g)and blocking group(0.72±0.02%ID/g).A dosimetry estimation study showed that the effective dose of[^(89)Zr]Zr-DFO-TST001 was 0.0705 mSv/MBq,which is within the range of acceptable doses for nuclear medicine *** together,these results suggest that Good Manufacturing Practices produced by this immuno-positron emission tomography probe can detect CLDN18.2-overexpressing tumors.

关键词： Claudin18.2 Gastrointestinal cancers Zirconium-89 Positron emission tomography Good Manufacturing Practices

Correlation of image textures of a polarization feature parameter and the microstructures of liver fibrosis tissues

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Journal of Innovative Optical Health Sciences 2023年第5期16卷 59-68页

作者： Yue Yao Jiachen Wan Fengdi Zhang Yang Dong Lihong Chen Hui Ma Tsinghua shenzhen International graduate school shenzhen key laboratory for Minimal invasive medical technologies Institute of Optical Imaging and Sensing Shenzhen 518055P.R.China Tsinghua University Department of Physics Beijing 100084P.R.China Fujian medical University Department of Pathology and Institute of OncologySchool of Basic Medical Sciences Fuzhou 350014P.R.China Fujian medical University Diagnostic Pathology Center Fuzhou 350014P.R.China Fujian medical University Mengchao Hepatobiliary Hospital Fuzhou 350014P.R.China

Mueller matrix imaging is emerging for the quantitative characterization of pathological microstructures and is especially sensitive to fibrous *** fibrosis is a characteristic of many types of chronic liver *** clinical diagnosis of liver fibrosis requires time-consuming multiple staining processes that specifically target on fibrous *** staining proficiency of technicians and the subjective visualization of pathologists may bring inconsistency to clinical *** matrix imaging can reduce the multiple staining processes and provide quantitative diagnostic indicators to characterize liver fibrosis *** this study,a fibersensitive polarization feature parameter(PFP)was derived through the forward sequential feature selection(SFS)and linear discriminant analysis(LDA)to target on the identification of fibrous ***,the Pearson correlation coeffcients and the statistical T-tests between the fiber-sensitive PFP image textures and the liver fibrosis tissues were *** results show the gray level run length matrix(GLRLM)-based run entropy that measures the heterogeneity of the PFP image was most correlated to the changes of liver fibrosis tissues at four stages with a Pearson correlation of *** results also indicate the highest Pearson correlation of 0.9996 was achieved through the linear regression predictions of the combination of the PFP image *** study demonstrates the potential of deriving a fiber-sensitive PFP to reduce the multiple staining process and provide textures-based quantitative diagnostic indicators for the staging of liver fibrosis.

关键词： Polarization feature parameter polarization image textures liver fibrosis.

Identification of serous ovarian tumors based on polarization imaging and correlation analysis with clinicopathological features

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Journal of Innovative Optical Health Sciences 2023年第5期16卷 33-46页

作者： Yulu Huang Anli Hou Jing Wang Yue Yao Wenbin Miao Xuewu Tian Jiawen Yu Cheng Li Hui Ma Yujuan Fan Department of Gynaecology Wuzhou Red Cross HospitalWuzhou Guangxi 543002P.R.China shenzhen key laboratory for Minimal invasive medical technologies Guangdong Engineering Center of Polarization Imaging and Sensing Technology Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhenGuangdong 518055P.R.China Department of Gynaecology University of Chinese Academy of Sciences Shenzhen HospitalShenzhen Guangdong 518106P.R.China Tsinghua-Berkeley shenzhen Institute Tsinghua University ShenzhenGuangdong 518071P.R.China |Department of Physics Tsinghua University Beijing 100084P.R.China Department of Pathology University of Chinese Academy of Sciences Shenzhen HospitalShenzhen Guangdong 518106P.R.China Department of Pathology Wuzhou Red Cross Hospital Wuzhou Guangxi 543002P.R.China

Ovarian cancer is one of the most aggressive and heterogeneous female tumors in the world,and serous ovarian cancer(SOC)is of particular concern for being the leading cause of ovarian cancer *** to its clinical and biological complexities,ovarian cancer is still considered one of the most di±cult tumors to diagnose and *** this study,three datasets were assembled,including 30 cases of serous cystadenoma(SCA),30 cases of serous borderline tumor(SBT),and 45 cases of serous adenocarcinoma(SAC).Mueller matrix microscopy is used to obtain the polarimetry basis parameters(PBPs)of each case,combined with a machine learning(ML)model to derive the polarimetry feature parameters(PFPs)for distinguishing serous ovarian tumor(SOT).The correlation between the mean values of PBPs and the clinicopathological features of serous ovarian cancer was *** accuracies of PFPs obtained from three types of SOT for identifying dichotomous groups(SCA versus SAC,SCA versus SBT,and SBT versus SAC)were 0.91,0.92,and 0.8,*** accuracy of PFP for identifying triadic groups(SCA versus SBT versus SAC)was *** analysis between PBPs and the clinicopathological features of SOC was *** were correlations between some PBPs(δ,β,q_(L),E_(2),rqcross,P_(2),P_(3),P_(4),and P_(5))and clinicopathological features,including the International Federation of Gynecology and Obstetrics(FIGO)stage,pathological grading,preoperative ascites,malignant ascites,and peritoneal *** research showed that PFPs extracted from polarization images have potential applications in quantitatively differentiating the *** polarimetry basis parameters related to the clinicopathological features of SOC can be used as prognostic factors.

关键词： Serous ovarian tumor(SOT) polarimetry basis parameter(PBP) polarimetry feature parameter(PFP) polarization imaging machine learning(ML).

Recent Progress in Wearable Brain-Computer Interface(BCI)Devices Based on Electroencephalogram(EEG)for medical Applications:A Review

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Health Data Science 2023年第1期3卷 102-116页

作者： Jiayan Zhang Junshi Li Zhe Huang Dong Huang Huaiqiang Yu Zhihong Li Beijing Advanced Innovation Center for Integrated Circuits BeijingChina. National key laboratory of Advanced Micro and Nano Manufacture Technology School of Integrated CircuitsPeking UniversityBeijingChina. shenzhen graduate school Peking UniversityShenzhenChina. school of Electronics Peking UniversityBeijingChina. Sichuan Institute of Piezoelectric and Acousto-optic Technology ChongqingChina.

Importance:Brain-computer interface(BCI)decodes and converts brain signals into machine instructions to interoperate with the external ***,limited by the implantation risks of invasive BCIs and the operational complexity of conventional noninvasive BCIs,applications of BCIs are mainly used in laboratory or clinical environments,which are not conducive to the daily use of BCI *** the increasing demand for intelligent medical care,the development of wearable BCI systems is ***:Based on the scalp-electroencephalogram(EEG),forehead-EEG,and ear-EEG,the state-of-the-art wearable BCI devices for disease management and patient assistance are *** paper focuses on the EEG acquisition equipment of the novel wearable BCI devices and summarizes the development direction of wearable EEG-based BCI ***:BCI devices play an essential role in the medical *** review briefly summarizes novel wearable EEG-based BCIs applied in the medical field and the latest progress in related technologies,emphasizing its potential to help doctors,patients,and caregivers better understand and utilize BCI devices.

关键词： field. utilize implantation

Comparative analysis of single-and multiple-frequency thermal wave radar imaging inspection of glass fiber reinforced polymer(GFRP)

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International Journal of Extreme Manufacturing 2022年第2期4卷 161-172页

作者： Lishuai Liu Andreas Mandelis Alexander Melnikov Liming Wang key laboratory of Pressure Systems and Safety of MOE School of Mechanical and Power EngineeringEast China University of Science and TechnologyShanghai 200237People’s Republic of China Center for Advanced Diffusion-Wave and Photoacoustic technologies(CADIPT) Department of Mechanical and Industrial EngineeringUniversity of TorontoTorontoON M5S 3G8Canada Institute for Advanced Non-Destructive and Non-invasive Diagnostic technologies(IANDIT) TorontoONM5S 3G8Canada shenzhen International graduate school Tsinghua UniversityShenzhen 518055People’s Republic of China

Active infrared thermography has gained increasing popularity for nondestructive testing and evaluation in various industrial fields,especially for composite *** this regard,thermal wave radar(TWR)imaging is recognized as the next-generation active thermography technology to obtain great resolution and depth range over the inspected objects.A critical aspect concerns the optimal test parameter selection to guarantee reliable quality assurance required for industrial *** this work,single-and multiple-frequency TWR was investigated in a quantitative manner with the goal of optimizing the detection parameters in terms of probing range and lateral and depth *** effects of test parameters,including sampling frequency,modulation frequency,chirp duration,chirp bandwidth,etc,were investigated in detail through experiments on a glass fiber reinforced polymer specimen with multi-scale diameter-to-depth ratio *** paper aims to help yield a better understanding of the physical mechanism behind TWR and propose a workable scheme for testing parameter selection in practical applications.

关键词： GFRP thermal wave radar testing parameters nondestructive testing