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research of cycloaliphatic epoxy resin and silicone rubber composite insulator interface based on four-electrode system and temperature rise model

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High Voltage 2023年第3期8卷 560-569页

作者： Yunsong Wang Yuhao Liu Hongwei Mei Min Xie Liming Wang shenzhen international Graduate School(SIGS) Tsinghua UniversityShenzhenChina research institute of Tsinghua Pearl River DeltaGuangzhouChina

Interface degradation between mandrel and sheath can cause a decrease in insulation performance and mechanical strength of composite insulators.In this study,the interface ageing properties of cycloaliphatic epoxy resin and silicone rubber composite insulator were compared.A water diffusion test was adopted to simulate the composite insulator ageing in a hot and humid environment.A four-electrode system was built to detect leakage current at different locations(mandrel,sheath and interface),which is an important basis for evaluating insulator performance.The ageing degree of insulator could be quantitatively characterised by leakage current change.It was found that the infiltrated moisture had a great effect on insulation performance.Based on the water absorption test result,the interface performance of two insulators was mainly influenced by their sheath sealing quality.As an auxiliary evaluation method,temperature rise during the test was recorded using an infrared camera.The experiment results showed that interface degradation was the main factor for the insulation performance decrease of silicone rubber composite insulators.However,insulation level reduction of the cycloaliphatic epoxy resin was caused by the wet sheath.In addition,a model for temperature rise of cycloaliphatic epoxy resin insulators was proposed based on good correspondence between sheath material and insulation.The model incorporated multiple processes such as ageing and heating of insulators,and it can predict the early temperature rise well.

关键词： insulator composite interface

Progress on metal-support interactions in Pd-based catalysts for automobile emission control

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Journal of Environmental Sciences 2023年第3期125卷 401-426页

作者： Yidan Cao Rui Ran Xiaodong Wu Zhichun Si Feiyu Kang Duan Weng institute of Materials research Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Tsinghua-Berkeley shenzhen institute Tsinghua UniversityShenzhen 518055China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

The interactions between metals and oxide supports,so-called metal-support interactions(MSI),are of great importance in heterogeneous catalysis.Pd-based automotive exhaust control catalysts,especially Pd-based three-way catalysts (TWCs),have received considerable research attention owing to its prominent oxidation activity of HCs/CO,as well as excellent thermal stability.For Pd-based TWCs,the dispersion,chemical state and thermal stability of Pd species,which are crucial to the catalytic performance,are closely associated with interactions between metal nanoparticles and their supporting matrix.Progress on the research about MSI and utilization of MSI in advanced Pd-based three-way catalysts are reviewed here.Along with the development of advanced synthesis approaches and engine control technology,the study on MSI would play a notable role in further development of catalysts for automobile exhaust control.

关键词： Palladium Three-way catalysts(TWCs) Metal-support interaction Oxide supports

Isolation and characterization of novel peptides from fermented products of Lactobacillus for ulcerative colitis prevention and treatment

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Food Science and Human Wellness 2022年第6期11卷 1464-1474页

作者： Dong He Wen Zeng Yi Wang Yifan Xing Kang Xiong Nan Su Chong Zhang Yuan Lu Xinhui Xing School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China Key Laboratory for Industrial Biocatalysis Ministry of EducationInstitute of Biochemical EngineeringDepartment of Chemical EngineeringChina Center for Synthetic and Systems BiologyTsinghua UniversityBeijing 100084China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China institute of biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 440300China

Ulcerative colitis(UC)is an incurable and highly complex digestive disease affecting millions of people worldwide.Compared to the current therapeutic drugs,bioactive peptides are more promising and safe substances as functional foods or drugs for the prevention and treatment of UC.The alcohol-soluble components from fermentation broth by fresh wheat germ and apple(AC-WGAF)were found to be effective in UC prevention in dextran sulfate sodium-induced mice in vivo.Herein,4 novel peptides are identifi ed from AC-WGAF by membrane ultrafi ltration,recycling preparative high-performance liquid chromatography,and matrix-assisted laser desorption–ionization time-of-fl ight/time-of-fl ight mass spectrometry,possessing anticolitis activity via using an in vitro model.One of those peptides named T24(PVLGPVRGPFPLL)exhibited the most remarkable anti-colitis activity by preventing tight junction protein loss,maintaining epithelial barrier integrity,and promoting cell proliferation during in vitro and in vivo studies by regulating mitogen-activated protein kinase signaling pathways.Thus,T24 is a promising peptide as a functional food or novel drug for UC prevention and treatment.

关键词： Ulcerative colitis Peptide Fermentation product Intestinal epithelial barrier Cell proliferation Mitogen-activated protein kinase signaling pathways

Engineering organoid microfluidic system for biomedical and health engineering:A review

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Chinese Journal of Chemical Engineering 2021年第2期34卷 244-254页

作者： Yifan Xing Junyu Liu Xiaojie Guo Haipeng Liu Wen Zeng Yi Wang Chong Zhang Yuan Lu Dong He Shaohua Ma Yonghong He Xin-Hui Xing Key Laboratory for Industrial Biocatalysis Ministry of Education of ChinaDepartment of Chemical EngineeringTsinghua UniversityBeijing 100084China Centre for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China institute of biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 518055China

In recent years,organoid technology,i.e.,in vitro three-dimensional(3D)tissue culture,has attracted increasing attention in biomedical engineering.Organoids are cell complexes induced by differentiation of stem cells or organ-progenitor cells in vitro using 3D culture technology.They can replicate the key structural and functional characteristics of the target organs in vivo.With the opening up of this new field of health engineering,there is a need for engineering-system approaches to the production,control,and quantitative analysis of organoids and their microenvironment.Traditional organoid technology has limitations,including lack of physical and chemical microenvironment control,high heterogeneity,complex manual operation,imperfect nutritional supply system,and lack of feasible online analytical technology for the organoids.The introduction of microfluidic chip technology into organoids has overcome many of these limitations and greatly expanded the scope of applications.Engineering organoid microfluidic system has become an interdisciplinary field in biomedical and health engineering.In this review,we summarize the development and culture system of organoids,discuss how microfluidic technology has been used to solve the main technical challenges in organoid research and development,and point out new opportunities and prospects for applications of organoid microfluidic system in drug development and screening,food safety,precision medicine,and other biomedical and health engineering fields.

关键词： Organoids Stem cell Culture system Microfluidics biomedical engineering Human health

Mental Stress Affects the Occurrence and Development of Psoriasis Through Neuroendocrine-Immune Regulation:A Narrative Review

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international Journal of Dermatology and Venereology 2023年第2期6卷 87-95页

作者： Fei Li Yin-Lian Zhang Xi Chen Jing-Yu Zhang Li Fu Bao Chai Hong-Xiang Chen Guangdong Key Laboratory for biomedical Measurements and Ultrasound Imaging National-Regional Key Technology Engineering Laboratory for Medical UltrasoundSchool of Biomedical EngineeringShenzhen University Medical SchoolShenzhen 518060China Department of Dermatology Huazhong University of Science and Technology Union Shenzhen HospitalShenzhen 518052China Department of Dermatology The 6th Affiliated Hospital of Shenzhen University Medical SchoolShenzhen 518052China shenzhen Qianhai Shekou Free Trade Zone Hospital Shenzhen 518067China shenzhen institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China shenzhen University Medical School Shenzhen 518060China Guangdong Provincial Key Laboratory of Regional Immunity and Diseases Department of Pharmacology and International Cancer CenterShenzhen University Medical SchoolShenzhen 518060China Department of Dermatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China

Psoriasis is a systemic immune-mediated inflammatory disease that presents at any age and is characterized by excessive proliferation and abnormal differentiation of keratinocytes as well as infiltration of multiple inflammatory cells.It has been gradually attracting more attention because of not only the increased risk of cardiovascular,metabolic,and autoimmune-related diseases but also the accompanying depression,anxiety,self-affirmation impairments,dementia,sleep disorders,and other mental disorders that place a substantial psychosocial burden on society and individuals.Mental and psychological disorders are involved in the occurrence,development,outcome,recurrence,and treatment of psoriasis through the neuroendocrine-immune signaling network.This review summarizes the pathogenesis of psychological and psychological disorders in patients with psoriasis with the aim of deepening clinicians’awareness of the mental and psychiatric comorbidities in patients with psoriasis.

关键词： psoriasis stress hypothalamic-pituitary-adrenal axis pressure neuroimmune regulation

Theranostic gold cluster nanoassembly for simultaneous enhanced cancer imaging and photodynamic therapy

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Chinese Chemical Letters 2017年第7期28卷 1391-1398页

作者： Hao-Dong Cui De-Hong Hu Jing-Nan Zhang Guan-Hui Gao Cui-Fang Zheng Ping Gong Xing-Hua Xi Zong-Hai Sheng Lin-Tao Cai Guangdong Key Laboratory of Nanomedicine Institute of Biomedicine and BiotechnologyShenzhen Institute of Advanced TechnologyChinese of Academy of SciencesShenzhen 518055Chino Departrnent of Nano Science and Technology institute University of Science and Technology of ChinoSuzhou 215123China Paul C Lauterbur research Center for biomedical Imaging Institute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese of Academy of SciencesShenzhen 518055China Poul-Drude-lnstitut fur Festkorperelektronik Berlin 10117Germany Department of Ophthalmology Shenzhen People's Hospital2nd Clinical Medical College of Jinon UniviersityShenzhen 518020China

As one of near-infrared（NIR） fluorescent（FL） nanoprobes, gold nanoclusters（Au NCs） are delicated to passive-targeting tumors for NIR FL imaging, but which easily cleared by the kidneys for the small size（〈1.5 nm）. Herein, the well-defined gold clusters nanoassembly（Au CNA） was synthesized by the selfassembly of Au NCs based on protein cross-linking approach. The as-prepared Au CNA demonstrated highly effective cellular uptake and precise tumor targeting compared to that of Au NCs. Moreover, with the irradiation of 660 nm laser, Au CNA generated largely reactive oxygen species（ROS） for photodynamic therapy（PDT）. In vitro and [39TD$IF]in vivo PDT revealed that Au CNA exhibited largely cell death and significantly tumor removal at a low power density of 0.2 W/cm^2. It could be speculated that the laser-excited Au CNA produced photon energy, which further obtained electron from oxygen to generate radical species.Therefore, Au CNA as a photosensitizer could realize NIR FL imaging and NIR laser induced PDT.

关键词： Gold nanoclusters Self-assembly Near-infrared fluorescent nanoprobe In vivo imaging Photodynamic therapy

MOF-Transformed In_(2)O_(3-x)@C Nanocorn Electrocatalyst for Efficient CO_(2)Reduction to HCOOH

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Nano-Micro Letters 2022年第10期14卷 219-234页

作者： Chen Qiu Kun Qian Jun Yu Mingzi Sun Shoufu Cao Jinqiang Gao Rongxing Yu Lingzhe Fang Youwei Yao Xiaoqing Lu Tao Li Bolong Huang Shihe Yang Guangdong Key Lab of Nano-Micro Material research School of Chemical Biology and BiotechnologyPeking University Shenzhen Graduate SchoolShenzhen 518055People’s Republic of China Department of Chemistry and Biochemistry Northern Illinois UniversityDeKalbIL 60115USA Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China School of Materials Science and Engineering China University of PetroleumQingdaoShandong 266580People’s Republic of China shenzhen international Graduate School Tsinghua UniversityShenzhenPeople’s Republic of China X-Ray Science Division and Joint Center for Energy Storage research Argonne National LaboratoryLemontIL 60439USA institute of biomedical Engineering Shenzhen Bay LaboratoryShenzhen 518107People’s Republic of China

For electrochemical CO_(2) reduction to HCOOH,an ongoing challenge is to design energy efficient electrocatalysts that can deliver a high HCOOH current density(JHCOOH)at a low overpotential.Indium oxide is good HCOOH production catalyst but with low con-ductivity.In this work,we report a unique corn design of In_(2)O_(3-x)@C nanocatalyst,wherein In_(2)O_(3-x)nanocube as the fine grains dispersed uniformly on the carbon nanorod cob,resulting in the enhanced conductivity.Excellent performance is achieved with 84%Faradaic efficiency(FE)and 11 mA cm^(−2)JHCOOH at a low potential of−0.4 V versus RHE.At the current density of 100 mA cm^(−2),the applied potential remained stable for more than 120 h with the FE above 90%.Density functional theory calculations reveal that the abundant oxygen vacancy in In_(2)O_(3-x) has exposed more In^(3+) sites with activated electroactivity,which facilitates the formation of HCOO*intermediate.Operando X-ray absorp-tion spectroscopy also confirms In^(3+) as the active site and the key intermediate of HCOO*during the process of CO_(2) reduction to HCOOH.

关键词： CO_(2)reduction Indium oxide Formate Corn design Active sites

Microplastics’Aging Processes in the Aquatic Environment:Aging Mechanisms,Altered Environmental Behaviors and Ecotoxicity

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Chemical research in Chinese Universities 2023年第3期39卷 378-388页

作者： HU Yongrong YING Siying HUANG Yuxiong Tsinghua-Berkeley shenzhen institute(TBSI) Shenzhen International Graduate SchoolTsinghua

Microplastics(MPs)have been one of the most concerned environmental issues since the 21st century.MPs are plastic particles with diameters less than 5 mm,which are widely sourced in the aquatic environment.After being released into the aquatic environment,MPs would experience complicated physical,chemical and biological aging processes driven by mechanical forces,photooxidation,and biological degradation,which would result in changes in MPs’physicochemical properties,such as the particle size,specific surface area,hydrophobicity,crystallinity,etc.In this review,we have illustrated the current study status on MPs’environmental aging processes and pointed out the knowledge gaps.MPs’aging processes would consequentially influence MPs’interaction with the co-existing organic and inorganic pollutants in the aquatic environment as well as lead to the leaching of chemical additives involved in plastic production,including plasticizers and flame retardants,which can trigger high ecotoxicity to the aquatic environment.Furthermore,aged MPs would cause ecotoxicity to aquatic organisms via bioaccumulation,biomagnification,and indirect carrier pathways.The review would provide an in-depth overview of MPs’environmental aging processes and consequential ecotoxicity implications,as well as propose future research needs.

关键词： Microplastics Aging process Environmental behavior Toxicity

Functional polymer passivatingFA_(0.85)PEA_(0.15)SnI_(3) for efficient and stable lead-free perovskite solar cells

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Nano research 2023年第1期16卷 481-488页

作者： Wenzhan Xu Yu Gao Miao He Shuyan Chen Hongyan Fu Guodan Wei Tsinghua-Berkeley shenzhen institute(TBSI) Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518000China Tsinghua shenzhen international Graduate School Tsinghua UniversityShenzhen 518000China

Due to their excellent advantages such as low toxicity,superior optoelectronic properties,low-temperature fabrication,and costeffectiveness,Sn-based perovskites have become the most promising alternatives for high performance lead-free perovskite solar cells.However,the character of Sn ^(2+)is easily oxidized toSn ^(4+),causing unnecessary p-type self-doping and high leakage current.More seriously,trap-induced non-radiative recombination from rapid crystallization causes into large energy loss with a low open circuit voltage.Therefore,the Sn-based solar cells have efficiency far behind the Pb-based solar cells.Herein,the polymer poly(ethylene glycol)diacrylate(PEGDA)is used to control crystal growth and passivate the defects in FA_(0.85)PEA_(0.15)SnI_(3) thin film.This Sn-perovskite layer shows compact crystal with large grain size and reduced defects.Optimized perovskite thin film is further processed to fabricate the inverted solar cell with device structure of ITO(indium tin oxide)/PEDOT:PSS(Poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonate))/FA_(0.85)PEA_(0.15)SnI_(3)/ICBA(indene-C60 bisadduct)/BCP(bathocuproine)/Ag,which shows the power conversion efficiency(PCE)of 11.45%with voltage of 0.82 V.Moreover,corresponding perovskite solar cells exhibit an enhanced stability due to PEGDA induced compressive strain in perovskite.This work could shed light on one of successful attempts to improve Sn-based solar cell efficiency for sustainable energy conversion.

关键词： FA_(0.85)PEA_(0.15)SnI_(3) perovskites solar cells crystal growth modulation stability