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An AIEgens and exonuclease Ⅲ aided quadratic amplification assay for detecting and cellular imaging of telomerase activity

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science Bulletin 2017年第14期62卷 997-1003页

作者： Xuehong Min Lei Xia Yuan Zhuang Xudong Wang Jie Du Xiaojin Zhang Xiaoding Lou Fan Xia Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica School of Chemistry and Chemical Engineering Huazhong University of Science and Technology College of Materials and Chemistry Engineering Hainan University Faculty of Material science and Chemistry China University of Geosciences shenzhen institute of huazhong university of science & technology

Monitoring telomerase activity with high sensitive and reliable is of great importance to cancer analysis. In this paper, we report a sensitive and facile method to detect telomerase activity using AIEgens mod- ified probe （TPE-Py-DNA） as a fluorescence reporter and exonuclease llI （Exo lIl） as a signal amplifier. With the aid of telomerase, repeat units （TrAGGG）n are extended from the end of template substrate oligonucleotides （TS primer） that form duplex DNAs with TPE-Py-DNA. Then, Exo llI catalyzes the diges- tion of duplex DNAs, liberating elongation product and releasing hydrophobic TPE-Py. The released hydrophobic TPE-Py aggregate together and produce a telomerase-activity-related fluorescence signal. The liberated product hybridizes with another TPE-Py-DNA probe, starting the second cycle. Finally, we obtain the target-to-signal amplification ratio of 1 ：N2. This strategy exhibits good performance for detecting clinical urine samples （distinguishing 15 cancer patients＇ samples from 8 healthy ones） and checking intracellular telomerase activity （differentiating cell lines including HeLa, MDA-MB-231, MCF-7, A375, HLF and MRC-5 from the cells pretreated with telomerase-related drug）, which shows its potential in clinical diagnosis as well as therapeutic monitoring of cancer.

关键词： Quadratic amplification AIEgens Telomerase Urine samples Exonuclease Ill Cell imaging

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Ultra-reliable and low-latency communications:applications, opportunities and challenges

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science China(Information sciences) 2021年第2期64卷 60-71页

作者： Daquan FENG Lifeng LAI Jingjing LUO Yi ZHONG Canjian ZHENG Kai YING College of Electronic and Information Engineering Shenzhen University School of Electronic and Information Engineering Harbin Institute of Technology School of Electronic Information and Communications Huazhong University of Science and Technology

In the upcoming 5G and beyond systems, ultra-reliable and low latency communication (URLLC) has been considered as the key enabler to support diverse mission-critical services, such as industrial automation, remote healthcare, and intelligent transportation. However, the two stringent requirements of URLLC:extremely low latency and ultra-strict reliability have posed great challenges in system designing. In this article, the basic concepts and the potential applications of URLLC are first introduced. Then, the state-ofthe-art research of URLLC in the physical layer, link layer and the network layer are overviewed. In addition,some potential research topics and challenges are also identified.

关键词： ultra-reliable and low-latency advanced transmission technologies physical layer network design real-time guarantee

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Efficient Pose: Efficient human pose estimation with neural architecture search

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Computational Visual Media 2021年第3期7卷 335-347页

作者： Wenqiang Zhang Jiemin Fang Xinggang Wang Wenyu Liu School of EIC Huazhong University of Science and TechnologyWuhan 430074China institute of Artificial Intelligence Huazhong University of Science and TechnologyWuhan 430074China

Human pose estimation from image and video is a key task in many multimedia *** methods achieve great performance but rarely take efficiency into consideration,which makes it difficult to implement the networks on lightweight ***,real-time multimedia applications call for more efficient models for better ***,most deep neural networks for pose estimation directly reuse networks designed for image classification as the backbone,which are not optimized for the pose estimation *** this paper,we propose an efficient framework for human pose estimation with two parts,an efficient backbone and an efficient *** implementing a differentiable neural architecture search method,we customize the backbone network design for pose estimation,and reduce computational cost with negligible accuracy *** the efficient head,we slim the transposed convolutions and propose a spatial information correction module to promote the performance of the final *** experiments,we evaluate our networks on the MPII and COCO *** smallest model requires only0.65 GFLOPs with 88.1%PCKh@0.5 on MPII and our large model needs only 2 GFLOPs while its accuracy is competitive with the state-of-the-art large model,HRNet,which takes 9.5 GFLOPs.

关键词： pose estimation neural architecture search efficient deep learning

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PARALLEL LATTICE BGK SIMULATION OF NATURAL CONVECTION IN A CAVITY

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Journal of Hydrodynamics 2005年第5期17卷 564-570页

作者： SHI Bao-chang LIU Hong-juan Parallel Computing institute Huazhong University of Science and Technology Wuhan 430074 China Department of Mathematics Huazhong University of Science and Technology Wuhan 430074 China

A Coupled Lattice Bhatnagar Gross Krook （CLBGK） model was proposed with a robust boundary scheme to model the Bossinesq incompressible flows. The LBGK method is a powerful approach, but is also computationally demanding. Therefore, parallel computing was implemented, and the codes were run on the parallel computer “Lenovo DeepComp 1800” with 24 nodes written in C＋＋ using the Message Passing Interface （MPI） library. Numerical results for natural convection in a cavity with the Rayleigh number （ Ra ） ranging from 10^6 to 4× 10^10 were presented, and found to agree well with the previous work. And with the increase of the resolution rate, the accuracy has been greatly improved. In addition, new models were set up by applying different equilibriums to the CLBGK model to simulate the same problem, which all yield sound results.

关键词： Lattice Bhatnagar Gross-Krook ( LB( K )model, Lattice Boltzmann Method (LBM), natural convection, parallel computing, high resolution

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An inorganic liquid crystalline dispersion with 2D ferroelectric moieties

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National science Review 2024年第5期11卷 254-263页

作者： Ziyang Huang Zehao Zhang Rongjie Zhang Baofu Ding Liu Yang Keyou Wu Youan Xu Gaokuo Zhong Chuanlai Ren Jiarong Liu Yugan Hao Menghao Wu Teng Ma Bilu Liu shenzhen Graphene Centre Shenzhen Key Laboratory of Advanced Layered Materials for Value-added ApplicationsTsinghua-Berkeley Shenzhen Institute and Institute of Materials ResearchTsinghua Shenzhen International Graduate School Tsinghua University institute of technology for Carbon Neutrality Faculty of Materials Science and Engineering Shenzhen Institute of Advanced Technology Chinese Academy of Sciences School of Physics and institute for Quantum science and Engineering School of Chemistry and Institute of Theoretical ChemistryHuazhong University of Science and Technology Xi'an Research institute of High technology shenzhen institute of Advanced technology Chinese Academy of Sciences Department of Applied Physics Hong Kong Polytechnic University

Electro-optical effect-based liquid crystal devices have been extensively used in optical modulation techniques, in which the Kerr coefficient reflects the sensitivity of the liquid crystals and determines the strength of the device's operational electric field. The Peterlin–Stuart theory and the O'Konski model jointly indicate that a giant Kerr coefficient could be obtained in a material with both a large geometrical anisotropy and an intrinsic polarization, but such a material is not yet reported. Here we reveal a ferroelectric effect in a monolayer two-dimensional mineral vermiculite. A large geometrical anisotropy factor and a large inherent electric dipole together raise the record value of Kerr coefficient by an order of magnitude, till 3.0 × 10-4mV-2. This finding enables an ultra-low operational electric field of10～2–10～4V m-1and the fabrication of electro-optical devices with an inch-level electrode separation, which has not previously been practical. Because of its high ultraviolet stability（decay <1% under ultraviolet exposure for 1000 hours）, large-scale production, and energy efficiency, prototypical displayable billboards have been fabricated for outdoor interactive scenes. This work provides new insights for both liquid crystal optics and two-dimensional ferroelectrics.

关键词： 2D materials layered minerals vermiculite ferroelectric inorganic liquid crystal Kerr coefficient

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Recent advances in two-dimensional photovoltaic devices

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Journal of Semiconductors 2024年第5期45卷 26-40页

作者： Haoyun Wang Xingyu Song Zexin Li Dongyan Li Xiang Xu Yunxin Chen Pengbin Liu Xing Zhou Tianyou Zhai State Key Laboratory of Materials Processing and Die&Mould technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China Research institute of huazhong university of science and technology in shenzhen Shenzhen 518057China Optics Valley Laboratory Wuhan 430074China

Two-dimensional(2D)materials have attracted tremendous interest in view of the outstanding optoelectronic properties,showing new possibilities for future photovoltaic devices toward high performance,high specific power and *** recent years,substantial works have focused on 2D photovoltaic devices,and great progress has been ***,we present the review of recent advances in 2D photovoltaic devices,focusing on 2D-material-based Schottky junctions,homojunctions,2D−2D heterojunctions,2D−3D heterojunctions,and bulk photovoltaic effect ***,advanced strategies for improving the photovoltaic performances are demonstrated in ***,conclusions and outlooks are delivered,providing a guideline for the further development of 2D photovoltaic devices.

关键词： two-dimensional materials photovoltaic devices photodetectors solar cells heterostructures

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EmotionIC: emotional inertia and contagion-driven dependency modeling for emotion recognition in conversation

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science China(Information sciences) 2024年第8期67卷 130-146页

作者： Yingjian LIU Jiang LI Xiaoping WANG Zhigang ZENG School of Artificial Intelligence and Automation Huazhong University of Science and Technology Hubei Key Laboratory of Brain-inspired Intelligent Systems Huazhong University of Science and Technology Key Laboratory of Image Processing and Intelligent Control (huazhong university of science and technology) Ministry of Education institute of Artificial Intelligence Huazhong University of Science and Technology

Emotion recognition in conversation(ERC) has attracted growing attention in recent years as a result of the advancement and implementation of human-computer interface technologies. In this paper,we propose an emotional inertia and contagion-driven dependency modeling approach(EmotionIC) for ERC tasks. Our EmotionIC consists of three main components, i.e., identity masked multi-head attention(IMMHA), dialogue-based gated recurrent unit(DiaGRU), and skip-chain conditional random field(SkipCRF).Compared to previous ERC models, EmotionIC can model a conversation more thoroughly at both the feature-extraction and classification levels. The proposed model attempts to integrate the advantages of attention-and recurrence-based methods at the feature-extraction level. Specifically, IMMHA is applied to capture identity-based global contextual dependencies, while Dia GRU is utilized to extract speaker-and temporal-aware local contextual information. At the classification level, SkipCRF can explicitly mine complex emotional flows from higher-order neighboring utterances in the conversation. Experimental results show that our method can significantly outperform the state-of-the-art models on four benchmark *** ablation studies confirm that our modules can effectively model emotional inertia and contagion.

关键词： emotion recognition in conversation emotional inertia and contagion multi-head attention gated recurrent unit conditional random field

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Lattice Boltzmann method with the cell-population equilibrium

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Chinese Physics B 2008年第1期17卷 238-248页

作者：周晓阳程冰施保昌 Department of Mathematics Huazhong University of Science and Technology Department of science institute Qingdao Agricultural University

The central problem of the lattice Boltzmann method （LBM） is to construct a discrete equilibrium. In this paper, a multi-speed 1D cell-model of Boltzmann equation is proposed, in which the cell-population equilibrium, a direct non- negative approximation to the continuous Maxwellian distribution, plays an important part. By applying the explicit one-order Chapman-Enskog distribution, the model reduces the transportation and collision, two basic evolution steps in LBM, to the transportation of the non-equilibrium distribution. Furthermore, 1D dam-break problem is performed and the numerical results agree well with the analytic solutions.

关键词： lattice Boltzmann method non-negative equilibrium cell approximation scheme dambreak

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Review on flexible perovskite photodetector:processing and

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Frontiers of Mechanical Engineering 2023年第2期18卷 1-31页

作者： Xuning ZHANG Xingyue LIU Yifan HUANG Bo SUN Zhiyong LIU Guanglan LIAO Tielin SHI State Key Laboratory of Digital Manufacturing Equipment and technology Huazhong University of Science and TechnologyWuhan 430074China School of Mechanical Engineering and Electronic Information China University of Geoscience(Wuhan)Wuhan 430074China School of Aerospace Engineering Huazhong University of Science and TechnologyWuhan 430074China shenzhen huazhong university of science and technology Research institute Shenzhen 518100China

Next-generation optoelectronics should possess lightweight and flexible characteristics,thus conforming to various types of surfaces or human skins for portable and wearable *** photodetectors as fundamental devices have been receiving increasing attention owing to their potential applications in artificial intelligence,aerospace industry,and wise information technology of 120,among which perovskite is a promising candidate as the light-harvesting material for its outstanding optical and electrical properties,remarkable mechanical flexibility,low-cost and low-temperature processing *** date,most of the reports have demonstrated the fabrication methods of the perovskite materials,materials engineering,applications in solar cells,light-emitting diodes,lasers,and photodetectors,strategies for device performance enhancement,few can be seen with a focus on the processing strategies of perovskite-based flexible photodetectors,which we will give a comprehensive summary,*** begin with,a brief introduction to the fabrication methods of perovskite(solution and vapor-based methods),device configurations(photovoltaic,photoconductor,and phototransistor),and performance parameters of the perovskite-based photodetectors are first ***,processing strategies for photodetectors are presented following,including flexible substrates(i.e.,polymer,carbon cloth,fiber,paper,etc.),soft electrodes(i.e.,metal-based conductive networks,carbon-based conductive materials,and two-dimensional(2D)conductive materials,etc.),conformal encapsulation(single-layer and multilayer stacked encapsulation),low-dimensional perovskites(0D,1D,and 2D nanostructures),and elaborate device *** applications of perovskite-based flexible photodetectors such as optical communication,image sensing,and health monitoring are further exhibited to learn the flexible photodetectors on a deeper *** and future research directions of perovskite-based fl

关键词： photodetector perovskite flexible processing application

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Cu/chiral phosphoric acid-catalyzed radical-initiated asymmetric aminosilylation of alkene with hydrosilane

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science China Chemistry 2019年第11期62卷 1529-1536页

作者： Yang Zeng Xiao-Dong Liu Xian-Qi Guo Qiang-Shuai Gu Zhong-Liang Li Xiao-Yong Chang Xin-Yuan Liu shenzhen Grubbs institute Southern University of Science and TechnologyShenzhen 518055China Academy for Advanced Interdisciplinary Studies Southern University of Science and TechnologyShenzhen 518055China Department of Chemistry Southern University of Science and TechnologyShenzhen 518055Chin

The catalytic radical-initiated asymmetric 1,2-aminosilylation of alkene with a hydrosilane under Cu(I)/CPA cooperative catalysis has been *** method features the use of hydrosilane as the reductive radical precursor,enabling efficient access to skeletally diverse silicon-containing azaheterocycles including pyrrolidine,indoline and isoindoline bearing anα-tertiary stereocenter with high *** key to the success includes the use of Cu(I)/CPA cooperative catalyst system and theβ-silicon effect of the silyl group to stabilize the in situ generated carbocation intermediate.

关键词： asymmetric radical chemistry aminosilylation alkenes Cu/chiral phosphoric acid silyl radical

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