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China Medical Abstracts(Internal Medicine) 2024年第1期41卷 2-3页

作者：钟文新 Dept Radiol Huazhong Univ Sci&Technol Union Shenzhen HospShenzhen 518052

Objective To establish and verify a nomogram model based on MRI liver imaging reporting and data system (LI-RADS) features for predicting microvascular invasion (MVI) in hepatocellular carcinoma (HCC)following the Milan criteria.Methods A retrospective analysis was conducted on data from 118 HCC patients(121 lesions) confirmed by pathology from June 2016 to June 2022 at the Third Affiliated hospital of Soochow University.

关键词： invasion hepatocellular microvascular

Diagnosis of bacterial hepatic abscess by CT

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Hepatobiliary & Pancreatic Diseases International 2007年第3期6卷 271-275页

作者： Wang, Cheng-Lin Guo, Xue-Jun Qiu, Shui-Bo Lei, Yi Yuan, Zhi-Dong Dong, Han-Bin Liu, Hui-An Peking Univ Shenzhen Hosp Dept Imaging Shenzhen 518036 Peoples R China Peoples hosp shenzhen 4 Dept Imaging Shenzhen 518036 Peoples R China Buji Peoples hosp shenzhen Dept Imaging Shenzhen 518036 Peoples R China

BACKGROUND: Bacterial hepatic abscess usually is acute and progressive, often resulting in sepsis, impairment of liver function and disseminated intravascular coagulation. The mortality rate was as high as 80% in the past. For the purpose of early diagnosis and differential diagnosis of this disease, we probed the imaging manifestations and their characteristics in bacterial hepatic abscesses by CT scan. METHODS: Twenty-four lesions from 21 patients with bacterial hepatic abscesses that were confirmed by clinical features, puncture and culture were reviewed for CT manifestations. Fourteen patients were male and 7 were female, with an average age of 56.2 years. All lesions underwent CT plain scan and three-phase enhanced scan and 15 patients underwent delayed-phase imaging. Three senior radiologists read the films in accordance with a standard. RESULTS: Among 24 lesions, 18 (75%) were situated in the right liver with diameters of 1.4-9.3 cm (average 4.5 cm). Nineteen (79.2%) lesions were round or sub-round in shape, and 22 (91.7%) had smooth, uninterrupted and sharp edges. All lesions showed low attenuation of less than 20 Hu. Twenty-two enhanced lesions (91.7%) had rim-shaped enhancement in the abscess wall, and 13 (54.2%) showed single or double-ring signs. Eighteen (75%) displayed honeycomb-like, grid-like or strip-like enhancement. Eighteen (75%) were regionally enhanced in the surroundings or upper or lower layers. Only 2 (8.3%) displayed a gas-liquid surface sign. CONCLUSIONS: The CT findings of bacterial hepatic abscess are usually typical, and the diagnosis of the abscess is not difficult. To precisely diagnose atypical cases, it is necessary to combine CT with clinical observations and follow-up.

关键词： hepatic abscess bacterial CT imaging characteristics

A novel arg616Cys mutation in the DNA-binding domain of complete androgen insensitivity syndrome in a Chinese family

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Chinese Medical Journal 2013年第21期126卷 4192-4193页

作者： Zhou Lu Wang Chen-hong Southern Med Univ Affiliated Hosp Shenzhen Maternal & Child Hlth Hosp Dept Lab Ctr Shenzhen 518028 Guangdong Peoples R China Southern Med Univ Affiliated Hosp Shenzhen Maternal & Child Hlth Hosp Dept Obstet & Gynecol Shenzhen 518028 Guangdong Peoples R China

Awide spectrum of Androgen insensitivity syndrome （AIS） occur due to mutations in the androgen receptor（AR）. The clinical presentation of AIS ranges from a typically male phenotype with decreased body hair and/ or... 详细信息

关键词： androgen insensitivity syndrome androgen receptor DNA-binding domain single aminoacid substitution

A comparative study of sleep and power spectral density in schizophrenic patients with and without suicidal behavior

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China Medical Abstracts (Internal Medicine) 2022年第4期 236-237页

作者：周云飞 shenzhen Mental Health Center/shenzhen Kangning hosp

Objective To compare the sleep and EEG power spectral density of schizophrenic patients with and without suicidal behavior.Methods Twenty schizophrenia patients with suicidal behavior and twenty schizophrenia patients without suicidal behavior were selected.Subjective sleep was assessed by Insomnia Severity Index Scale(ISI),

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Differentiation of human bone marrow precursor cells into neuronal-like cells after transplantation into canine spinal cord organotypic slice cultures

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Chinese Medical Journal 2012年第22期125卷 4049-4054页

作者： FEI Zhi-qiang, XIONG Jian-yi CHEN Lei SHEN Hui-yong Ngo Stephanie Wang Jeffrey WANG Da-ping shenzhen Second Peoples hosp Dept Orthopaed Shenzhen Key Lab Tissue Engn Res Ctr Shenzhen 518035 Guangdong Peoples R China Sun Yat Sen Univ Mem Hosp Dept Orthopaed Guangzhou 510120 Guangdong Peoples R China Univ Calif Los Angeles UCLA Spine Ctr Santa Monica CA 90404 USA

Background Treatments to regenerate different tissue involving the transplantation of bone marrow derived mesenchymal precursor cells are anticipated. Using an alternative methods, in vitro organotypic slice culture method, would be useful to transplant cells and assessing the effects. This study was to determine the possibility of differentiating human bone marrow precursor cells into cells of the neuronal lineage by transplanting into canine spinal cord organotypic slice cultures. Methods Bone marrow aspirates were obtained from posterior superior iliac spine （PSIS） of patients that had undergone spinal fusion due to a degenerative spinal disorder. For cell imaging, mesenchymal precursor cells （MPCs） were pre-stained with PKH-26 just before transplantation to canine spinal cord slices. Canine spinal cord tissues were obtained from three adult beagle dogs. Spinal cords were cut into transverse slices of 1 mm using tissue chopper. Two slices were transferred into 6-well plate containing 3 ml DMEM with antibiotics. Prepared MPCs （lx104） were transplanted into spinal cord slices. On days 0, 3, 7, 14, MPCs were observed for morphological changes and expression of neuronal markers through immunofluorescence and reverse transcription-polymerase chain reaction （RT-PCR）. Results The morphological study showed： spherical cells in the control and experiment groups on day 0; and on day 3, cells in the control group had one or two thick, short processes and ones in the experiment group had three or four thin, long processes. On day 7, these variously-sized processes contacted each other in the experiment group, but showed typical spindle-shaped cells in the control group. Immunofluorescence showed that PKH-26（＋） MPCs stained positive for NeuN （＋） and GFAP（＋） in experimental group only. Also RT-PCR showed weak expression of β-tubulin III and GFAP. Conclusions Human bone marrow mesenchymal precursor cells （hMPCs） have the potential to differentiate into the neuronal like cells in this canine spinal cord organotypic slice cult

关键词： differentiation mesenchymal precursor cell organotypic slice culture spinal cord

Correlation between hemoglobin and progression of renal function in patients with proliferative lupus nephritis

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China Medical Abstracts(Internal Medicine) 2022年第1期39卷 53-54页

作者：刘洋 Dept Nephrol 1st Affil HospShenzhen UnivShenzhen 518035

Objective To explore the correlation between hemoglobin(Hb)and progression of renal function in patients with proliferative lupus nephritis(PLN).Methods Data of biopsy-proven PLN patients from January 2010 to February 2019 in Department of Nephrology,the First Affiliated hospital of shenzhen University were retrospectively analyzed.The patients were divided into stable renal function group and renal function progression group according to changes of renal function including serum creatinine doubling/end-stage renal disease(ESRD)and the demographic,clinical,and pathological characteristics were compared between the two groups.

关键词： patients nephritis lupus

Study on the susceptibility genes that mediate the resistance of Helicobacter pylori to clarithromycin and levofloxacin based on comprehensive antibiotic research database comparison

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China Medical Abstracts(Internal Medicine) 2022年第2期39卷 109-110页

作者：吕涛 Dept Gastroenterol&Hepatol Univ Hong Kong-Shenzhen HospShenzhen 518053

Objective To explore the new genes related to the resistance of H. pylori to clarithromycin (CLA) and levofloxacin (LVX) based on whole-genome sequencing.Methods From September 1st, 2016 to August 31st,2019, 1 749 patients with upper gastrointestinal symptoms and positive13C urea breath test who visited the Department of Gastroenterology and Hepatology, the University of Hong Kong-shenzhen hospital were enrolled.

关键词： pylori ofloxacin Helicobacter

Pathogenetic factors affecting gastroesophageal refluxin patients with esophagitis and concomitant duodenal ulcer:a multivariate analysis

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World Journal of Gastroenterology 1998年第2期4卷 61-65页

作者： Zhu, HM Huang, X Deng, CZ Porro, GP Pace, F Sangaletti, O Jinan Univ Coll Med Affiliated Hosp 2 Dept Gastroenterol Shenzhen 518001 Guangdong Peoples R China Milan Univ hosp Div Gastroenterol Milan Italy

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Ｐａｔｈｏｇｅｎｅｔｉｃｆａｃｔｏｒｓａｆｅｃｔｉｎｇｇａｓｔｒｏｅｓｏｐｈａｇｅａｌｒｅｆｌｕｘｉｎｐａｔｉｅｎｔｓｗｉｔｈｅｓｏｐｈａｇｉｔｉｓａｎｄｃｏｎｃｏｍｉｔａｎｔｄｕｏｄｅｎａｌｕｌｃｅｒ：ａｍｕｌｔｉｖａｒｉａｔｅａｎａｌｙｓｉｓＺＨ...

关键词： esophagitis/etiology gastric acid/secretion duodenal ulcer/etiology gastroesophageal reflux/etiology hydrogen ion concentration multivariate analysis

Effects of long-term sustained naltrexone release on the optic center in opioid-dependent patients Case-control study in four provinces of China

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Neural Regeneration Research 2011年第3期6卷 236-240页

作者： He, Shengxi Yu, Longchuan Jia, Shaowei Chen, Qing Wang, Dongmei Hu, Shu Hong Kong Univ Sci & Technol Shenzhen Peking Univ Med Ctr Shenzhen 518036 Guangdong Peoples R China Peking Univ Shenzhen Hosp Shenzhen 518036 Guangdong Peoples R China Peking Univ Coll Life Sci Beijing 100112 Peoples R China Chinese Acad Sci Inst Psychol Beijing 100101 Peoples R China

Very little is known about visual functional recovery following long-term naltrexone administration in opioid-dependent patients. In the present study, a portable event-related potential （ERP） working system was utilized to collect and record ERP in opioid-dependent patients and normal controls in visual half-field testing. In addition, the influence of long-term sustained naltrexone release on the visual nervous system was observed in opioid-dependent patients. Results revealed a significant main group effect in reaction time to visual signal stimulations. The reaction time of normal controls was shortest, but longest in opioid-dependent patients. The reaction time of long-term sustained naltrexone release group and compulsory detoxification group was similar to normal controls. A significant main group effect was also observed in P100 latency, and P100 latency in normal controls and the compulsory detoxification group was significantly decreased compared with the opioid-dependent patients. P100 amplitude at the Oz-electrode resulted in a significant main group effect. In particular, normal controls exhibited significant differences compared with long-term sustained release naltrexone and compulsory detoxification groups. These findings demonstrated that long-term sustained naltrexone release effectively ameliorated optic center function and improved visual sensitivity and reactions in opioid-dependent patients.

关键词： long-term sustained naltrexone release opioid dependence projection of unilateralvisual field event-related potential PIO0

Gastroesophageal reflux: the features in elderlypatients

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World Journal of Gastroenterology 1999年第5期5卷 421-423页

作者： Huang X Zhu HM Deng CZ Porro GB Sangaletti O Pace F shenzhen Peoples hosp Dept Gastroenterol Shenzhen 518001 Guangdong Prov Peoples R China Univ Milan Gastrointestinal Unit Milan Italy

AIM To compare the features ofgastroesophageal reflux disease between elderlyand younger patients.METHODS Twenty-four hour pH-monitoring andendoscopy were P6rformed for the 66 elderlypatients with typical gastroesophageaI refluxsymptoms, and the results were compared with112 symptomatic younger patients.RESULTS The results of 24-h pH-monitoringand endoscopy showed that the elderly patientshad pathological reflux and reflux esophagitismore frequently than the younger patients.P6rcentage time with pH< 4 in elderly patientswith reflux esophagitis was 32.5% in 24 hours,as compared with 12.9% in the younger patientswith reflux esophagitis (P < 0 .05 ). The elderlypatients with reflux esophagitis have longerP6riOds of acid reflux in both upright and Supinepositions than the younger patients. Endoscopyshowed that 20 .8% of elderIy patients had grade Ⅲ / Ⅳ esophagitis, whereas only 3.4% ofyounger patients had grade Ⅲ/ Ⅳ esophagitis(P < 0.002 ). Percentages of grades Ⅰ /Ⅱesophagitis in the two groups were 12.5% and26. 5%, respectiveIy (P< 0. 002 ).CONCLUSION Elderly patients, as comparedwith younger patients, have more severegastroesophageal reflux and esophageal lesions.The incompetence of lower esophageal sphincter and the presence of hiataI hernia may beimportant factors leading to the difference in incidence and severity of reflux esophagitisbetween elderly and younger patients.

关键词： gastroesophageal reflux esophagitis hiatal hernia