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World’s first implementation of close-fit pipe jacking of twin tunnels for construction of subway station--Innovation in equipment and construction technology

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Frontiers of Engineering Management 2024年第2期11卷 369-376页

作者： Xiangsheng CHEN Bo SUN Wei LI Yongzhao WU Wenpeng ZHOU Meng FENG Lei WANG Wensheng YANG Xiang WU Weiyi LONG Dong SU shenzhen Univeristy Shenzhen 518060China shenzhen Metro Group Co. Ltd.Shenzhen 518031China shenzhen Municipal Design&Research Co. Ltd.Shenzhen 518000China Sinohydro bureau 11 Co. Ltd.Zhengzhou 450001China China Railway Engineering Equipment Group Co. LTD.Zhengzhou 450000China shenzhen University Shenzhen 518060China

1 Project overview The Shasan station of Phase II of shenzhen’s urban rail transit Line 12 is situated in Bao’an District,*** comprises a two-level underground island platform station,measuring 212 m in length,and 22.6 m in width,with an overburden thickness of about 7.0 ***.1 illustrates the presence of a large underground reinforced concrete stormwater culvert,measuring 11.5 m by 3.6 m,traversing the station’s center.

关键词： Subway station close-fit pipe jacking of twin tunnels modular rectangular pipe jacking machine Structural Transformation equipment construction

In-situ interfacial passivation and self-adaptability synergistically stabilizing all-solid-state lithium metal batteries

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Journal of Energy Chemistry 2024年第1期88卷 282-292,I0007页

作者： Huanhui Chen Xing Cao Moujie Huang Xiangzhong Ren Yubin Zhao Liang Yu Ya Liu Liubiao Zhong Yejun Qiu shenzhen Engineering Lab of Flexible Transparent Conductive Films School of Materials Science and EngineeringHarbin Institute of TechnologyShenzhen 518055GuangdongChina Guangdong Provincial Key Laboratory of Semiconductor Optoelectronic Materials and Intelligent Photonic Systems School of Materials Science and EngineeringHarbin Institute of TechnologyShenzhen 518055GuangdongChina College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060GuangdongChina School of Resource and Environmental Sciences Wuhan UniversityWuhan 430072HubeiChina

The function of solid electrolytes and the composition of solid electrolyte interphase(SEI)are highly significant for inhibiting the growth of Li ***,we report an in-situ interfacial passivation combined with self-adaptability strategy to reinforce Li_(0.33)La_(0.557)TiO_(3)(LLTO)-based solid-state ***,a functional SEI enriched with LiF/Li_(3)PO_(4) is formed by in-situ electrochemical conversion,which is greatly beneficial to improving interface compatibility and enhancing ion *** the polarized dielectric BaTiO_(3)-polyamic acid(BTO-PAA,BP)film greatly improves the Li-ion transport kinetics and homogenizes the Li *** expected,the resulting electrolyte offers considerable ionic conductivity at room temperature(4.3 x 10~(-4)S cm^(-1))and appreciable electrochemical decomposition voltage(5.23 V)after electrochemical *** Li-LiFePO_(4) batteries,it shows a high specific capacity of 153 mA h g^(-1)at 0.2C after 100 cycles and a long-term durability of 115 mA h g^(-1)at 1.0 C after 800 ***,a stable Li plating/stripping can be achieved for more than 900 h at 0.5 mA cm^(-2).The stabilization mechanisms are elucidated by ex-situ XRD,ex-situ XPS,and ex-situ FTIR techniques,and the corresponding results reveal that the interfacial passivation combined with polarization effect is an effective strategy for improving the electrochemical *** present study provides a deeper insight into the dynamic adjustment of electrode-electrolyte interfacial for solid-state lithium batteries.

关键词： Solid-state lithium batteries Composite solid electrolyte In-situ polymerization Interfacial passivation layer Self-adaptability

Flashover Probability of Wind Turbine Blade and Impact of Strong Electromagnetic Pulse from Lightning Strikes on Wind Turbine Safety

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meteorological and Environmental Research 2024年第1期15卷 62-66页

作者： Lixin YAO Bin XIAO Jianwen ZHANG Weixiang FENG Renhong GUO Zengru YANG Chunliang ZHANG Hui YANG Hunan Branch of Guangdong Wind Power Generation Co. Ltd.Changsha 410000China CGN New Energy South China Branch Shenzhen 518000China Maoming meteorological bureau Maoming 525000China Guangdong Yuedian Yangjiang Offshore Wind Power Co. Ltd.Yangjiang 510630China Guangdong Foshan Shunde Lunjiao Jindun Lightning Protection Technology Development Co. Ltd.Foshan 528308China Guangzhou meteorological bureau Guangzhou 510530China

This paper systematically studies the flashover probability of wind turbine blade lightning arrester and the impact of strong electromagnetic pulses on the local and surrounding wind turbines during lightning *** research results indicate that the flashover probability of direct lightning strikes by the wind turbine blade lightning arrester is almost negligible,and the strong electromagnetic pulse of wind turbine blade during lightning strikes has a serious impact on the electronic equipment of the machine,while the impact on the surrounding wind turbine is relatively *** the same time,the calculation formula for the reflection of lightning current on the carbon brush between the wind turbine hub and the engine compartment during the flashing of the wind turbine blades is provided,and the calculation method for calculating the spatial gradient distribution of electromagnetic field intensity using Biot-Savart Law theorem is *** limitations of using wind turbine blades for lightning protection are pointed out,and a technical route for achieving wind turbine lightning safety is proposed,which can be used as a reference for wind turbine lightning protection technicians.

关键词： Wind turbine Flashover probability of blade lightning arrester Spatial gradient of electromagnetic field intensity Technical route

Unconfined compressive strength and failure behaviour of completely weathered granite from a fault zone

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Journal of Mountain Science 2024年第6期21卷 2140-2158页

作者： DU Shaohua MA Jinyin MA Liyao ZHAO Yaqian School of Civil Engineering and Architecture Henan University of Science and TechnologyLuoyang 471023China School of Resources and Safety Engineering Central South UniversityChangsha 410083China China Railway 18th bureau Group Co. LtdTianjin 300222 China China General Nuclear Power Corporation Shenzhen 518031China

Understanding the strength characteristics and deformation behaviour of the tunnel surrounding rock in a fault zone is significant for tunnel stability *** this study,a series of unconfined compression tests were conducted to investigate the mechanical characteristics and failure behaviour of completely weathered granite(CWG)from a fault zone,considering with height-diameter(h/d)ratio,dry densities(ρd)and moisture contents(ω).Based on the experimental results,a regression mathematical model of unconfined compressive strength(UCS)for CWG was developed using the Multiple Nonlinear Regression method(MNLR).The research results indicated that the UCS of the specimen with a h/d ratio of 0.6 decreased with the increase ofω.When the h/d ratio increased to 1.0,the UCS increasedωwith up to 10.5%and then ***ρd is conducive to the improvement of the UCS at anyω.The deformation and rupture process as well as final failure modes of the specimen are controlled by h/d ratio,ρd andω,and the h/d ratio is the dominant factor affecting the final failure mode,followed byωandρ*** specimens with different h/d ratio exhibited completely different fracture mode,i.e.,typical splitting failure(h/d=0.6)and shear failure(h/d=1.0).By comparing the experimental results,this regression model for predicting UCS is accurate and reliable,and the h/d ratio is the dominant factor affecting the UCS of CWG,followed byρd and thenω.These findings provide important references for maintenance of the tunnel crossing other fault fractured zones,especially at low confining pressure or unconfined condition.

关键词： Fault fracture zone Completely weathered granite(CWG) Unconfined compression strength(UCS) Multiple nonlinear regression model

Platelet-based bioactive systems guided precision targeting and immune regulation for cancer therapy

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Nano Research 2024年第9期17卷 8269-8284页

作者： Xinyi Cai Long Qiu Zhenying Diao Lintao Cai Ting Yin Hong Pan Guangdong Key Laboratory of Nanomedicine CAS-HK Joint Lab of BiomaterialsCAS Key Laboratory of Biomedical Imaging Science and SystemInstitute of Biomedicine and BiotechnologyShenzhen Institute of Advanced Technology(SIAT)Chinese Academy of SciencesShenzhen 518055China School of pharmacy Guangdong Medical UniversityDongguan 523808China Sino-Euro Center of Biomedicine and Health Shenzhen 518024China

The antitumor effects of conventional drug carriers are often attenuated and limited in application by biological barriers associated with tumor heterogeneity and resistance brought about by low tumor *** the rapid development of nanotechnology,naturally derived bioactive materials,and live cell carriers,a promising strategy emerges for targeting the tumor microenvironment(TME)for precision cancer *** unique injury-targeting properties of platelets can significantly extend functional activity,which cannot be achieved with conventional *** this review,three strategies based on platelet-engineered materials are systematically described,namely nanoparticles for platelet membrane camouflage,engineered activated platelets,and targeted-platelets ***-based nanomaterials can effectively coordinate local and distant tumor-host crosstalk with controlled active tumor site recognition and killing effects due to the presence of specific membrane proteins on the surface and the self-secretion of a large number of *** advances in platelets for effectively overcoming biological barriers and reducing immune resistance in cancer immunotherapy applications will be discussed in future clinical *** review provides an overview of recent research advances in platelet-based bioactive material-directed immunotherapy and chemotherapy to inform future antitumor combination therapies.

关键词： platelets bionic targeting immune modulation precision therapy deep penetration

Synergy of Prediction Rule and Total Synthesis in Solving the Stereochemical Puzzle of Valactamides

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Precision Chemistry 2024年第3期2卷 120-126页

作者： Tao Zhang Jiaxuan Feng Hideaki Oikawa Yian Guo Tao Ye State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate SchoolShenzhen 518055China Innovation Center of Marine Biotechnology and Pharmaceuticals School of Biotechnology and Health SciencesWuyi UniversityJiangmen 529020China QianYan(shenzhen)Pharmatech.Ltd. Shenzhen 518172China

Natural products with diverse functional groups and stereo-genic centers have inspired therapeutics and underpin the modern drug discovery *** three-dimensional molecular structures need to be unambiguously determined in order to be realized as clinical candidates or to achieve further activity-guided structural *** recent advances in spectroscopic methods have made it possible for researchers to determine the structures of microgram samples of complex natural products,there is no universally accepted method for determining the relative and absolute configuration of a naturally occurring *** report the determination of the full stereostructure of valactamide A,an eight-stereogenic-center-containing fungal metabolite by the synergy of prediction rule-guided analysis and chemical *** expedient total synthesis resulted in unambiguous verification of the predicted stereochemistry for valactamide A.

关键词： stereochemistry configuration prediction total synthesis valactamide A

Comparison and correction of IDW based wind speed interpolation methods in urbanized shenzhen

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Frontiers of Earth Science 2022年第3期16卷 798-808页

作者： Wei ZHAO Yuping ZHONG Qinglan LI Minghua LI Jia LIU Li TANG shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518055China shenzhen meteorological bureau Shenzhen 518040China

Based on the 2-min average wind speed observations at 100 automatic weather stations in shenzhen from January 2008 to December 2018,this study tries to explore the ways to improve wind interpolation quality over the shenzhen *** IDW based methods,i.e.,traditional inverse distance weight(IDW),modified inverse distance weight(MIDW),and gradient inverse distance weight(GIDW)are used to interpolate the near surface wind field in *** addition,the gradient boosted regression trees(GBRT)model is used to correct the wind interpolation results based on the three IDW based *** results show that among the three methods,GIDW has better interpolation effects than the other two in the case of stratified *** MSE and R2 for the GIDW’s in different months are in the range of 1.096-1.605 m/s and 0.340-0.419,***,in the case of leave-one-group-out crossvalidation,GIDW has no advantage over the other two *** the stratified sampling,GBRT effectively corrects the interpolated results by the three IDW based *** decreases to the range of 0.778-0.923 m/s,and R2 increases to the range of *** the nonstation area,the correction effect of GBRT is still robust,even though the elevation frequency distribution of the non-station area is different from that of the stations’*** correction performance of GBRT mainly comes from its consideration of the nonlinear relationship between wind speed and the elevation,and the combination of historical and current observation data.

关键词： wind interpolation shenzhen inverse distance weight gradient boosted regression trees

Integrating sequence and graph information for enhanced drug-target affinity prediction

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Science China(Information Sciences) 2024年第2期67卷 325-326页

作者： Haohuai HE Guanxing CHEN Calvin Yu-Chian CHEN Artificial Intelligence Medical Research Center School of Intelligent Systems EngineeringShenzhen Campus of Sun Yat-sen University

Drug discovery is a pivotal discipline involving the identification and development of innovative pharmaceuticals designed to combat a wide array of illnesses. It plays a crucial role in advancing global health outcomes and improving the standard of living for individuals worldwide. However,drug discovery often relies on laborious in vitro experiments,

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An approximate analytical model for unconventional reservoir considering variable matrix blocks and simultaneous matrix depletion

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Petroleum Science 2024年第1期21卷 352-365页

作者： Kai-Xuan Qiu Jia Li Dong Feng Shi-Ming Wei Gang Lei Jiangmen Laboratory of Carbon Science and Technology Jiangmen529100GuangdongChina The Hong Kong University of Science and Technology(Guangzhou) Guangzhou511400GuangdongChina China University of Geosciences(Beijing) Beijing100083China China University of Petroleum(Beijing) Beijing102249China China University of Geosciences(Wuhan) Wuhan430074HubeiChina shenzhen Research Institute China University of GeosciencesShenzhen518063GuangdongChina

In regard to unconventional oil reservoirs,the transient dual-porosity and triple-porosity models have been adopted to describe the fluid flow in the complex fracture *** has been proven to cause inaccurate production evaluations because of the absence of matrix-macrofracture *** addition,most of the existing models are solved analytically based on Laplace transform and numerical ***,an approximate analytical solution is derived directly in real-time space considering variable matrix blocks and simultaneous matrix *** simplify the derivation,the simultaneous matrix depletion is divided into two parts:one part feeding the macrofractures and the other part feeding the ***,a series of partial differential equations(PDEs)describing the transient flow and boundary conditions are constructed and solved analytically by ***,a relationship between oil rate and production time in real-time space is *** new model is verified against classical analytical *** the microfracture system and matrix-macrofracture communication is neglected,the result of the new model agrees with those obtained with the dual-porosity and triple-porosity model,***,the new model also has an excellent agreement with the numerical *** model is then applied to two actual tight oil wells completed in western Canada sedimentary *** identifying the flow regime,the solution suitably matches the field production data,and the model parameters are *** these output parameters,we can accurately forecast the production and even estimate the petrophysical properties.

关键词： Analytical solution Unconventional reservoir Variable matrix Simultaneous flow