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Clinical and microstructural changes with different iontophoresis-assisted corneal cross-linking methods for keratoconus

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International Journal of ophthalmology(English edition) 2019年第2期12卷 219-225页

作者： Kai Liao Min Hu Fen Chen Pei Li Peng Song Qing-Yan Zeng aier School of ophthalmology Central South University Hankou aier Eye hospital

AIM: To compare the clinical and microstructural changes induced by different transepithelial iontophoresis-assisted corneal cross-linking(I-CXL) methods for keratoconus. METHODS: A total of 42 eyes of 42 patients with progressive keratoconus were divided into two groups. Group A received I-CXL for 5 min, while group B received I-CXL for 10 min. Visual acuity, optical coherence tomography(OCT), specular microscopy and confocal microscopy were evaluated preoperatively and at 1, 3, 6, and 12 mo postoperatively. RESULTS: Twelve months after the operation, uncorrected visual acuity(UCVA) and corrected distance visual acuity(CDVA) were improved in both groups, with a better outcome in the I-CXL 10 min group(P=0.025, 0.021, respectively). Kmax values decreased by 0.94±3.00 D in the I-CXL 10 min group(P=0.033) but increased by 1.87±3.29 D in the I-CXL 5 min group(P=0.012). OCT scans showed that the demarcation line was most visible and substantially deeper in the I-CXL 10 min group. Confocal microscopy showed greater anterior stromal keratocyte decreases in the I-CXL 10 min group than in the I-CXL 5 min group at 3 and 6 mo postoperatively(P<0.001); however, anterior stromal keratocytes and subbasal nerve density were not significantly different between the two groups at 12 mo postoperatively. CONCLUSION: I-CXL for 10 min more effectively halts the progression of keratoconus than I-CXL for 5 min after 12 mo of follow-up. However, long-term studies are needed to evaluate the efficacy and safety of I-CXL.

关键词： keratoconus transepithelial corneal crosslinking iontophoresis anterior stromal keratocyte subbasal nerve density

Clinical outcomes of small incision lenticule extraction versus femtosecond laser-assisted LASIK for myopia: a Meta-analysis

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International Journal of ophthalmology(English edition) 2017年第9期10卷 1436-1445页

作者： Huan Yan Li-Yan Gong Wei Huang Yan-Li Peng Department of ophthalmology the Second Affiliated Hospital of Chongqing Medical University Chongqing Medical University Department of ophthalmology Chongqing Aier-Mega Eye Hospital Aier Eye Hospital Group aier School of ophthalmology Central South University

AIM：To evaluate the possible differences in visual quality between small incision lenticule extraction（SMILE）and femtosecond laser in situ keratomileusis（FS-LASIK）for ***：A Meta-analysis was *** were from previously reported comparative studies treated with SMILE versus *** Pub Med,EMBASE,Cochrane,Web of Science and Chinese databases（*** and CNKI）were searched in *** 2016 using Rev Man 5.1 version *** differences in visual acuity,aberration and biomechanical effects within six months postoperatively were ***-seven studies including 4223 eyes were ***：No significant differences were observed between SMILE and FS-LASIK in terms of the proportion of eyes that lost one or more lines of corrected distance visual acuity after surgery（P=0.14）,the proportion of eyes achieving an uncorrected distance visual acuity of 20/20or better（P=0.43）,the final refractive spherical equivalent（P=0.89）,the refractive spherical equivalent within±1.00diopter of the target values（P=0.80）,vertical coma（P=0.45）and horizontal coma（P=0.06）.Compared with the FSLASIK group,total higher-order aberration（P〈0.001）and spherical aberration（P〈0.001）were higher and the decrease in corneal hysteresis（P=0.0005）and corneal resistance factor（P=0.02）were lower in the SMILE ***：SMILE and FS-LASIK are comparable in efficacy,safety and predictability for correcting ***,the aberration in the SMILE group is superior to that in the FS-LASIK group,and the loss of biomechanical effects may occur less frequently after SMILE than after FS-LASIK.

关键词： Meta-analysis small incision lenticuleextraction femtosecond laser in situ keratomileusis myopia

Interleukin-6 in epilepsy and its neuropsychiatric comorbidities: How to bridge the gap

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World Journal of Psychiatry 2025年第1期15卷 1-6页

作者： Xiao-Man Chen Shuo Zhang Shi-Qi Gao Michael Xu Department of Neurology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Rehabilitation Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110004Liaoning ProvinceChina International Education School China Medical UniversityShenyang 110004Liaoning ProvinceChina

There is growing evidence that interleukin(IL)-6 plays an important role in neurological and psychiatric *** editorial comments on the study published in the recent issue of the World Journal of Psychiatry,which employed Mendelian randomization to identify a causal relationship between IL-6 receptor blockade and decreased epilepsy *** purpose of this editorial is to highlight the dual effects of IL-6 in epilepsy and its related neuropsychiatric ***-6 plays a critical role in the facilitation of epileptogenesis and maintenance of epileptic seizures and is implicated in neuroinflammatory proce-sses associated with ***,IL-6 significantly influences mood regulation and cognitive dysfunction in patients with epilepsy,highlighting its involvement in neuropsychiatric *** summary,IL-6 is not only a pivotal factor in the pathogenesis of epilepsy but also significantly contributes to the emergence of epilepsy-related neuropsychiatric *** resear-ch should prioritize elucidating the specific mechanisms by which IL-6 operates across different subtypes,stages and neuropsychiatric comorbidities of epilepsy,with the aim of developing more precise and effective ***,the potential of IL-6 as a biomarker for the early diagnosis and prognosis of epile-psy warrants further investigation.

关键词： Epilepsy Interleukin-6 Neuropsychiatric comorbidities Depression Tocilizu-mab Neuroinflammation Interleukin-6 receptor blockade

Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-Yu Zhao Juan-Han Yu Yi-Hua Wang Yi-Xin Liu Lu Xu Lin Fu Ning Yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

Clinical study on the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes

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World Journal of Diabetes 2025年第1期16卷 58-64页

作者： Ji-Kui Wang Di Zhang Jin-Feng Wang Wan-Lin Lu Jing-Yuan Wang Shi-Feng Liang Ran Liu Jing-Xin Jiang Hong-Tao Li Xuan Yang Department of General Thoracic Surgery Liaoning Electric Power Center HospitalShenyang 110000Liaoning ProvinceChina Department of Health Management Center Liaoning Electric Power Center HospitalShenyang 110000Liaoning ProvinceChina

BACKGROUND At present,the existing internal medicine drug treatment can alleviate the high glucose toxicity of patients to a certain extent,to explore the efficacy of laparoscopic jejunoileal side to side anastomosis in the treatment of type 2 diabetes,the report is as *** To investigate the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes mellitus(T2DM).METHODS We retrospectively analyzed the clinical data of 78 patients with T2DM who were treated via jejunoileal lateral *** indicators were collected preoperatively,as well as at 3 and 6 months *** metabolic indicators analyzed included body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),fasting blood glucose(FBG),2-hour blood glucose(PBG),glycated hemoglobin(HbA1c),fasting C-peptide,2-hour C-peptide(PCP),fasting insulin(Fins),2-hour insulin(Pins),insulin resistance index(HOMA-IR),βCellular function index(HOMA-β),alanine aminotransferase,aspartate aminotransferase,serum total cholesterol(TC),low-density lipoprotein cholesterol(L DL-C),triglycerides(TG),high-density lipoprotein,and uric acid(UA)*** SBP,DBP,PBG,HbA1c,LDL-C,and TG were all significantly lower 3 months postoperative vs preoperative values;body weight,BMI,SBP,DBP,FBG,PBG,HbA1c,TC,TG,UA,and HOMA-IR values were all significantly lower 6 months postoperative vs at 3 months;and PCP,Fins,Pins,and HOMA-βwere all significantly higher 6 months postoperative vs at 3 months(all P<0.05).CONCLUSION Side-to-side anastomosis of the jejunum and ileum can effectively treat T2DM and improve the metabolic index levels associated with it.

关键词： Metabolic diseases Type 2 diabetes Jejunoileal side-to-side anastomosis Glycolipid metabolism Islet function

Bibliometric analysis and mapping knowledge domain of pterygium:2000-2019

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International Journal of ophthalmology(English edition) 2021年第6期14卷 903-914页

作者： Yu-Chi Wang Fang-Kun Zhao Qian Liu Zi-Yan Yu Jing Wang Jin-Song Zhang Department of ophthalmology the Fourth Affiliated Hospital of China Medical UniversityEye Hospital of China Medical Universitythe Key Laboratory of Lens in Liaoning ProvinceShenyang 110000Liaoning ProvinceChina Cataract Centre Shenyang Aier Excellent Eye HospitalShenyang 110000Liaoning ProvinceChina aier School of ophthalmology Central South UniversityChangsha 410000Hunan ProvinceChina

AIM:To track the knowledge structure,topics in focus,and trends in emerging research in pterygium in the past 20 ***:Base on the Web of Science Core Collection(Wo SCC),studies related to pterygium in the past 20 y from 2000-2019 have been *** the help of VOSviewer software,a knowledge map was constructed and the distribution of countries,institutions,journals,and authors in the field of pterygium ***,using cocitation analysis of references and co-occurrence analysis of keywords,we identified basis and hotspots,thereby obtaining an overview of this ***:The search retrieved 1516 publications from Wo SCC on pterygium published between 2000 and *** the past two decades,the annual number of publications is on the rise and fluctuated a *** productive institutions are from Singapore but the most prolific and active country is the United *** Cornea published the most articles and Coroneo MT contributed the most publications on *** cooccurrence analysis,the keywords formed 3 clusters:1)surgical therapeutic techniques and adjuvant of pterygium,2)occurrence process and pathogenesis of pterygium,and 3)epidemiology,and etiology of pterygium *** three clusters were consistent with the clustering in co-citation analysis,in which Cluster 1 contained the most references(74 publications,47.74%),Cluster 2 contained 53 publications,accounting for 34.19%,and Cluster 3 focused on epidemiology with 18.06%of total 155 cocitation ***:This study demonstrates that the research of pterygium is gradually attracting the attention of scholars and *** interaction between authors,institutions,and countries is lack *** though,the research hotspot,distribution,and research status in pterygium in this study could provide valuable information for scholars and researchers.

关键词： pterygium bibliometric analysis mapping knowledge domain VOSviewer

MicroRNA-34a promoting apoptosis of human lens epithelial cells through down-regulation of B-cell lymphoma-2 and silent information regulator

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International Journal of ophthalmology(English edition) 2016年第11期9卷 1555-1560页

作者： Qing-Lan Li Hong-Yang Zhang Yong-Jie Qin Qian-Li Meng Xiao-Lei Yao Hai-Ke Guo Department of ophthalmology Ruikang Hospital affiliated to Guangxi University of Chinese Medicine Department of ophthalmology Guangdong General Hospital and Guangdong Academy of Medical Sciences Zhengzhou aier Eye hospital Aier School of OphthalmologyCentral South University

AIM： To investigate the role of micro RNA-34a（mi R-34a） in the induction of apoptosis of human lens epithelial（HLE-B3） cells. METHODS： The apoptosis of HLE-B3 cells was detected by Annexin V-PE apoptosis detection kit after the treatment with 200 μmol/L H2O2 for 24h and lentiviral mi R-34 a vector transfection. The expression of mi R-34 a in the cells was quantified by quantitative real time polymerase chain reaction（q RT-PCR） in response to H2O2 exposure and the vector transfection. The effects of overexpression of mi R-34 a on the expression of B-cell lymphoma-2（Bcl-2） and silent information regulator 1（SIRT1） was determined by q RT-PCR and Western blot. RESULTS： The expression of mi R-34 a was up-regulated by the treatment of H2O2 in HLE-B3 cells. The increased expression of mi R-34 a is accompanied with the cell apoptosis. Consistence with the H2O2 exposure,ectopic overexpression of mi R-34 a in HLE-B3 cells promoted cells apoptosis. Importantly the anti-apoptosis factors Bcl-2 and SIRT1 were reduced significantly by up-regulation of mi R-34 a in HLE-B3 ***： Mi R-34 a promotes the apoptosis of HLE-B3 cells by down-regulating Bcl-2 and SIRT1,suggesting that mi R-34 a may involve in the pathogenesis of cataract formation and targeting mi R-34 a may be a potentially therapeutic approach for treatment of cataract.

关键词： human lens epithelial cells microRNA-34a apoptosis

Different approaches for treating myopic choroidal neovascularization:a network Meta-analysis

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International Journal of ophthalmology(English edition) 2023年第12期16卷 2105-2116页

作者： Ya-Jun Wu Yu-Liang Feng Jia-Song Yang Hua Fan Wen-Sheng Li aier School of ophthalmology Central South UniversityChangsha 410000Hunan ProvinceChina Department of ophthalmology Shanghai Aier Eye HospitalShanghai 200235China Shanghai aier Eye Institute Shanghai 200235China

AIM:To evaluate the efficacy of intravitreal injection of anti-vascular endothelial growth factor(anti-VEGF),photodynamic therapy(PDT),and laser treatment(LT)for anatomical and functional improvement in myopic choroidal neovascularization(mCNV)***:Two researchers independently searched PubMed,Cochrane Library,Web of Science,and other databases to screen studies comparing best-corrected vision acuity(BCVA)and foveal center thickness(FCT)changes after mCNV ***-treatment chorioretinal atrophy(CRA)is a secondary outcome *** retrieval time limit is from the database construction to January 30,***:A total of 1072 eyes in 16 articles were *** the RCTs,intravitreal bevacizumab(IVB)and intravitreal ranibizumab(IVR)were superior to PDT(MD=0.18,95%CI:0.02,0.40,MD=0.18,95%CI:0.01,0.42)in improving BCVA of mCNV patients(P<0.05).The relative effectiveness in improving BCVA,from high to low,appeared to be IVR,intravitreal aflibercept(IVA),IVB,LT,PDT,and sham first followed by IVA(Sham/IVA).While improving the FCT from high to low was IVA,IVR,IVB,*** retrospective studies,the results of BCVA after long-term treatment showed that all the therapeutic effects from high to low was IVA,intravitreal conbercept(IVC),IVR,IVB,IVB/IVR,PDT with IVB/IVR,*** effect of improving FCT was IVA,IVR,IVC,PDT,and IVB from high to *** in the effects of improving CRA,the IVB appeared to be higher than IVR,while the PDT was the smallest,but none of the differences in the results were statistically ***:Anti-VEGF has the best effect on longterm vision improvement in mCNV patients,using IVB or IVR alone to treat mCNV may be better than IVB or IVR combined with *** is no significant difference in the improvement of visual acuity,macular edema,and CRA in mCNV patients treated with any different anti-VEGF drugs.

关键词： myopic choroidal neovascularization aflibercept bevacizumab conbercept laser treatment ranibizumab photodynamic therapy

Visual quality after implantation of trifocal intraocular lenses in highly myopic eyes with different axial lengths

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International Journal of ophthalmology(English edition) 2021年第3期14卷 371-377页

作者： Hui Liu Fang-Fang Li Hai-Jun Xia Jin Zhou Department of ophthalmology Chengdu Aier Eye HospitalChengdu 610041Sichuan ProvinceChina Depapartment of ophthalmology Chongqing Aier Eye HospitalChongqing 400020China Department of ophthalmology Aier School of OphthalmologyCentral South UniversityChangsha 410012Hunan ProvinceChina

AIM:To analyze postoperative clinical results after implantation of trifocal intraocular lenses(IOLs)in highly myopic eyes with different axial lengths(ALs).METHODS:This retrospective study describes 61 eyes of 44 patients that were implanted with trifocal diffractive IOLs(AT LISA tri 839 MP).Twenty-one eyes(15 patients)were included in the AL0.05).Better near and intermediate visual acuity(from-1.5 D to-3.0 D)were noted on the defocus curve of the AL<26 mm group(P<0.01 vs AL≥28 mm group).Significantly higher objective scatter index(OSI)values and lower modulation transfer function(MTF)cut-off values,Strehl ratio(SR),and OQAS values(OVs)were observed in the AL≥28 mm group(P<0.01 vs AL<26 mm group).All OQAS parameters had statistically significant correlations with DCNVA and visual acuity at the vergence of-2.5 D(P<0.05 to P<0.01).CONCLUSION:Implantation of trifocal IOLs provides good short-term visual and refractive outcomes in highly myopic eyes with different ***,the near vision decreases in the extremely myopic eyes at lower luminance,which is associated with the lower objective optical quality in these eyes.

关键词： cataract trifocal IOL OQAS high myopia