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Atmospheric fate of typical liquid crystal monomers in the tropospheric gas,liquid,and granular phases

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Journal of Environmental Sciences 2024年第2期136卷 348-360页

作者： Yanru Huo Zexiu An Mingxue Li Jinchan Jiang Yuxin Zhou Ju Xie Jianguo Zhang Maoxia He Environment research institute Shandong UniversityQingdao 266237China College of Plant Protection Hebei Agricultural UniversityBaoding 071000China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China jinan Environmental research Academy Jinan 250000China

Mineral aerosol particles significantly impact environmental risk prediction of liquid crystal monomers(LCMs).In this work,we investigated the reaction mechanisms and kinetics of three typical LCMs(4-cyano-3,5-difluorophenyl 4-ethylbenzoate(CEB-2F),4-cyano-3-fluorophenyl 4-ethylbenzoate(CEB-F),and 4-cyanophenyl 4-ethylbenzoate(CEB))with ozone(O_(3))in the atmospheric gas,liquid,and particle phases employing density functional theory(DFT).Here,O_(3)is prone to add to the benzene ring without F atom(s)in the selected LCMs.The ozonolysis products are aldehydes,carboxylic acids,epoxides,and unsaturated hydrocarbons containing aromatic rings.Those products undergo secondary ozonolysis to generate small molecular compounds such as glyoxal,which is beneficial for generating secondary organic aerosol(SOA).Titanium dioxide(TiO_(2)),an essential component of mineral aerosol particles,has good adsorption properties for LCMs;however,it slightly reduces the reactivity with O_(3).At 298 K,the reaction rate constant of the selected LCMs reacting with O_(3)in the gas and atmospheric liquid phases is(2.74–5.53)×10^(-24)cm^(3)/(mol·sec)and 5.58×10^(-3)–39.1 L/(mol·sec),while CEB-2F reacting with O_(3)on(TiO_(2))_(6)cluster is 1.84×10^(-24)cm^(3)/(mol·sec).The existence of TiO_(2)clusters increases the persistence and long-distance transportability of LCMs,which enlarges the contaminated area of LCMs.

关键词： Liquid crystal monomers(LCMs) Ozonolysis TiO_(2)clusters Adsorption Toxicity assessment

Proactive Resilience Enhancement of Power Systems with Link Transmission Model-based Dynamic Traffic Assignment Among Electric Vehicles

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1320-1330页

作者： Haoyuan Yan Tianyang Zhao Zhanglei Guan Energy Electricity research Center Jinan UniversityGuangzhou 510632China Energy research institute Nanyang Technological UniversitySingapore IEEE

The rapid development of electric vehicles(EVs)is strengthening the bi-directional interactions between electric power networks(EPNs)and transportation networks(TNs)while providing opportunities to enhance the resilience of power systems towards extreme events.To quantify the temporal and spatial flexibility of EVs for charging and discharging,a novel dynamic traffic assignment(DTA)problem is proposed.The DTA problem is based on a link transmission model(LTM)with extended charging links,depicting the interaction between EVs and power systems.It models the charging rates as continuous variables by an energy boundary model.To consider the evacuation requirements of TNs and the uncertainties of traffic conditions,the DTA problem is extended to a two-stage distributionally robust version.It is further incorporated into a two-stage distributionally robust unit commitment problem to balance the enhancement of EPNs and the performance of TNs.The problem is reformulated into a mixed-integer linear programming problem and solved by off-the-shelf commercial solvers.Case studies are performed on two test networks.The effectiveness is verified by the numerical results,e.g.,reducing the load shedding amount without increasing the unmet traffic demand.

关键词： Coupled transportation and power network link transmission model resilience enhancement

Effect of Y_(2)O_(3) on microstructure and properties of CoCrFeNiTiNb high entropy alloy coating on Ti-6Al-4V surface by laser cladding

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Journal of Rare Earths 2024年第3期42卷 586-599,I0006页

作者： Zhen Li Wei Zhao Kedong Yu Ning Guo Guangchun Xiao Zhiming Wang Hui Zhang College of Mechanical Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan250353China Shandong institute of Mechanical Design and research Jinan250031China

The effects of Y_(2)O_(3) on the microstructure, microhardness, wear resistance, high-temperature oxidation resistance, hot corrosion resistance, and electrochemical corrosion behaviour of CoCrFeNiTiNb high entropy alloy coatings formed on Ti-6Al-4V alloy surfaces were studied. The results show that the addition of Y_(2)O_(3) changes the proportion of the phase but does not change its type. The average grain size is only 1/4.7 of that of the high entropy alloy(HEA) coating, and the fine-grained strengthening leads to increases in the microhardness and wear resistance of 21.8% and 26.9%, respectively. The addition of Y_(2)O_(3) enhances the denseness and bonding properties of the oxide and corrosion product layers, reducing the oxidation and hot corrosion rates by 60.3% and 40.3%, respectively. The addition of Y_(2)O_(3) doubles the corrosion resistance which is attributed to the refinement of the grains, the increased proportion of HCP and TiN, and the weakening of galvanic coupling corrosion.

关键词： Laser cladding High entropy alloy coatings Rare earths Wear properties High temperature properties Electrochemical corrosion

In situ plasmonic & electrochemical fiber-optic sensor for multi-metal-ions detection

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Science China(Information Sciences) 2024年第1期67卷 292-302页

作者： Xiaoling PENG Zhiyong YANG Bo PENG Zhi LI Zhicong REN Xicheng WANG Jiahai LI Zhencheng LI Liang CHEN Daotong YOU Kaiwei LI Jianqing LI Tuan GUO institute of Photonics Technology Jinan University School of Computer Science and Engineering Macau University of Science and Technology institute for Environmental and Climate research Jinan University Key Laboratory of Bionic Engineering of Ministry of Education Jilin University

High precision and high throughput detection of heavy metal ions is essential for water quality monitoring and assessment.Herein,we propose a plasmonic & electrochemical dual-mode fiber sensing probe for label-free and real-time detection of multiple ions(Pb2+and Cu2+as examples).This sensor comprises a multimode fiber-single mode fiber reflection probe,the outer surface of which is coated with a gold nanofilm to excite the surface plasmon resonance(SPR) optically and simultaneously serves as an electrochemical working electrode.In traditional electrochemical detection,the enrichment of ions cannot be detected in real-time.However,by utilizing the plasmonic & electrochemical dual-mode detection method,various kinds of metal ions can be deposited onto the gold nanofilm and selectively oxidized during forward potential scanning,and the entire electrochemical process can be monitored by SPR measurement.We experimentally demonstrate that the sensor can simultaneously detect Pb2+and Cu2+in a mixed solution in real-time,providing a linear response over the ion concentration range from 10-12to 10-7M and offering an excellent detection limit(1.69×10-14–5.49×10-13M).The proposed dual-mode fiber sensor has the benefits of remote sensing,compact footprint,and cost-effectiveness and shows excellent potential for water quality risk management in difficult-to-reach environments.

关键词： optical fiber sensor surface plasmon resonance electrochemical measurement ions detection water pollution

Large animal models for Huntington's disease research

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Zoological research 2024年第2期45卷 275-283页

作者： Bofeng Han Weien Liang Xiao-Jiang Li Shihua Li Sen Yan Zhuchi Tu Guangdong-Hongkong-Macao CNS Regeneration institute of jinan university Key Laboratory of CNS Regeneration(Jinan University)-Ministry of EducationGuangdong Key Laboratory of Non-Human Primate ResearchGuangzhouGuangdong 510632China Department of Pathophysiology School of MedicineJinan UniversityGuangzhouGuangdong 510632China

Huntington'sdisease(HD)isahereditary neurodegenerative disorder for which there is currently no effectivetreatmentavailable.Consequently,the development of appropriate disease models is critical to thoroughly investigate disease progression.The genetic basis of HD involves the abnormal expansion of CAG repeats in the huntingtin(HTT)gene,leading to the expansion of a polyglutamine repeat in the HTT protein.Mutant HTT carrying the expanded polyglutamine repeat undergoes misfolding and forms aggregates in the brain,which precipitate selective neuronal loss in specific brain regions.Animal models play an important role in elucidating the pathogenesis of neurodegenerative disorders such as HD and in identifying potential therapeutic targets.Due to the marked species differences between rodents and larger animals,substantial efforts have been directed toward establishing large animal models for HD research.These models are pivotal for advancing the discovery of novel therapeutic targets,enhancing effective drug delivery methods,and improving treatment outcomes.We have explored the advantages of utilizing large animal models,particularly pigs,in previous reviews.Since then,however,significant progress has been made in developing more sophisticated animal models that faithfully replicate the typical pathology of HD.In the current review,we provide a comprehensive overview of large animal models of HD,incorporating recent findings regarding the establishment of HD knock-in(KI)pigs and their genetic therapy.We also explore the utilization of large animal models in HD research,with a focus on sheep,non-human primates(NHPs),and pigs.Our objective is to provide valuable insights into the application of these large animal models for the investigation and treatment of neurodegenerative disorders.

关键词： Huntington's disease Large animal models Sheep Non-human primates Transgenic pigs

Hypomethylation of glycine dehydrogenase promoter in peripheral blood mononuclear cells is a new diagnostic marker of hepatitis B virus-associated hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 35-42页

作者： Li-Li Miao Jing-Wen Wang Hui-Hui Liu Shuai Gao Yu-Chen Fan Kai Wang Department of Hepatology Qilu Hospital of Shandong UniversityJinan 250012China Experimental Center Shandong University of Traditional Chinese MedicineJinan 250355China institute of Hepatology Shandong UniversityJinan 250012China

Background: Glycine dehydrogenase(GLDC) plays an important role in the initiation and proliferation of several human cancers. In this study, we aimed to detect the methylation status of GLDC promoter and its diagnostic value for hepatitis B virus-associated hepatocellular carcinoma(HBV-HCC). Methods: We enrolled 197 patients, 111 with HBV-HCC, 51 with chronic hepatitis B(CHB), and 35 healthy controls(HCs). The methylation status of GLDC promoter in peripheral mononuclear cells(PBMCs) was identified by methylation specific polymerase chain reaction(MSP). The mRNA expression was examined using real-time quantitative polymerase chain reaction(q PCR). Results: The methylation frequency of the GLDC promoter was significantly lower in HBV-HCC patients(27.0%) compared to that in CHB patients(68.6%) and HCs(74.3%)( P < 0.001). The methylated group had lower alanine aminotransferase level( P = 0.035) and lower rates of tumor node metastasis(TNM) Ⅲ/Ⅳ( P = 0.043) and T3/T4( P = 0.026). TNM stage was identified to be an independent factor for GLDC promoter methylation. GLDC mRNA levels in CHB patients and HCs were significantly lower than those in HBV-HCC patients( P = 0.022 and P < 0.001, respectively). GLDC mRNA levels were significantly higher in HBV-HCC patients with unmethylated GLDC promoters than those with methylated GLDC promoters( P = 0.003). The diagnostic accuracy of alpha-fetoprotein(AFP) combined with GLDC promoter methylation for HBV-HCC was improved compared with that of AFP alone(AUC: 0.782 vs. 0.630, P < 0.001). In addition, GLDC promoter methylation was an independent predictor for overall survival of HBV-HCC patients( P = 0.038). Conclusions: The methylation frequency of GLDC promoter was lower in PBMCs from HBV-HCC patients than that from patients with CHB and HCs. The combination of AFP and GLDC promoter hypomethylation significantly improved the diagnostic accuracy of HBV-HCC.

关键词： Hepatocellular carcinoma Glycine dehydrogenase DNA methylation Peripheral blood mononuclear cells

Advances in the differentiation of pluripotent stem cells into vascular cells

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World Journal of Stem Cells 2024年第2期16卷 137-150页

作者： Yi-Chang Jiao Ying-Xin Wang Wen-Zhu Liu Jing-Wen Xu Yu-Ying Zhao Chuan-Zhu Yan Fu-Chen Liu Department of Neurology Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina research institute of Neuromuscular and Neurodegenerative Diseases Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Mitochondrial Medicine Laboratory Qilu Hospital(Qingdao)of Shandong UniversityQingdao 266103Shandong ProvinceChina Brain Science research institute Shandong UniversityJinan 250012Shandong ProvinceChina

Blood vessels constitute a closed pipe system distributed throughout the body,transporting blood from the heart to other organs and delivering metabolic waste products back to the lungs and kidneys.Changes in blood vessels are related to many disorders like stroke,myocardial infarction,aneurysm,and diabetes,which are important causes of death worldwide.Translational research for new appro-aches to disease modeling and effective treatment is needed due to the huge socio-economic burden on healthcare systems.Although mice or rats have been widely used,applying data from animal studies to human-specific vascular physiology and pathology is difficult.The rise of induced pluripotent stem cells(iPSCs)provides a reliable in vitro resource for disease modeling,regenerative medicine,and drug discovery because they carry all human genetic information and have the ability to directionally differentiate into any type of human cells.This review summarizes the latest progress from the establishment of iPSCs,the strategies for differentiating iPSCs into vascular cells,and the in vivo trans-plantation of these vascular derivatives.It also introduces the application of these technologies in disease modeling,drug screening,and regenerative medicine.Additionally,the application of high-tech tools,such as omics analysis and high-throughput sequencing,in this field is reviewed.

关键词： Induced pluripotent stem cell Blood vessels Vascular organoids Endothelial cells Smooth muscle cells Pericytes Tissue engineering vascular graft

One-step construction of strongly coupled Co_(3)V_(2)O_(8)/Co_(3)O_(4)/MXene heterostructure via in-situ Co-F bonds for high performance all-solid-state asymmetric supercapacitors

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Rare Metals 2024年第2期43卷 682-691页

作者： Ji Zhou Bin-Bin Liu Hu Zheng Wen-Qing Ma Qian Li Cai-Xia Xu institute for Advanced Interdisciplinary research(iAIR) Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of ShandongSchool of Chemistry and Chemical EngineeringUniversity of JinanJinan250022China

Co_(3)V_(2)O_(8)/Co_(3)O_(4)/Ti_(3)C_(2)T_(x) composite was easily synthesized via one-step succinct-operated hydrothermal process.The interconnected Co_(3)V_(2)O_(8)/Co_(3)O_(4) nanowires network can in-situ grow and anchor on the surface of Ti_(3)C_(2)T_(x) via the strong Co-F bonds and contribute tremendously to depress Ti_(3)C_(2)T_(x) self-restacking.Profiting from the synergistically interplayed effect among the multiple interfaces and high conductivity of Ti_(3)C_(2)T_(x) as well as outstanding stability of the as-designed nanostructure,the optimum Co_(3)V_(2)O_(8)/Co_(3)O_(4)/Ti_(3)C_(2)T_(x)electrode reaches a commendable specific capacitance(up to 3800 mF·cm^(−2)),great rate capability(80%capacitance retention after 20-times current increasing),and preeminent cycling stability(95.4%/85.5%retention at 7000th/20,000th cycle).Moreover,the all-solid-state asymmetric supercapacitor based on Co_(3)V_(2)O_(8)/Co_(3)O_(4)/Ti_(3)C_(2)T_(x) and active carbon can deliver a high energy density of 84.0μWh·cm^(−2) at the power energy of 3.2 mW·cm^(−2),and excellent cycling durability with 87.0%of initial capacitance retention upon 20,000 loops.This work provides a practicable pathway to tailor MXene-based composites for high-performance supercapacitor.

关键词： Ti_(3)C_(2)T_(x) Co_(3)V_(2)O_(8)/Co_(3)O_(4) Heterostructure Cathode Supercapacitor

Fabrication of patterned transparent conductive glass via laser metal transfer for efficient electrical heating and antibacteria

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Nano research 2024年第3期17卷 1578-1584页

作者： Xiaoyan Liu Ting Zhang Mengchen Xu Yang Li Haiqing Wang Yuke Chen Xuzihan Zhang Zenan Wang Xiaoyan Li Weijia Zhou Hong Liu institute for Advanced Interdisciplinary research(iAIR) School of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China School of Physics and Technology University of JinanJinan 250024China Department of Endodontics School and Hospital of StomatologyCheeloo College of MedicineShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Laboratory for Dental Materials and Oral Tissue RegenerationJinan 250012China School of Information Science and Engineering University of JinanJinan 250022China Shenzhen institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China

Vapor deposition and three-dimensional(3D)printing technology are considered to be conventional methods to achieve patterned metal film preparation through the assistance of masks and high temperature.Therefore,there are still some challenges in fabricating metal films in template-free and normal temperature environment.In this work,we report a flexible and rapid laser metal transfer(LMT)technique for fabricating the various metal films(Cu,Ni,Sn,Al,Fe,and Ag)with different patterns without templates on arbitrary substrates(glass,polyimide(PI)films,and aluminum nitride(AlN)ceramic).Especially,the obtained transparent conductive glass displays high transmittance(more than 90%)and adjustable resistances(≈5Ω).According to the Joule effect,the interface resistance between Cu particles and copper oxide coating produces the high temperature approximately 280℃ at 2 V in a short time(≈60 s)and remains stable at 120℃ over 12 h.At last,the multifunctional glass with Cu patterns also shows excellent bactericidal activity(≈95%).This work demonstrates that laser metal transfer is an exceeding effective means of fabricating the micro/nano structures with potential applications in functional devices.

关键词： laser metal transfer(LMT) transparent conductive glass electrical heating copper pattern antibacterial