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Transforming growth factor-beta 1 enhances discharge activity of cortical neurons

Neural Regeneration Research 2025年第2期20卷 548-556页

作者： Zhihui Ren Tian Li Xueer Liu Zelin Zhang Xiaoxuan Chen Weiqiang Chen Kangsheng Li Jiangtao Sheng Department of Microbiology and Immunology Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina Department of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system *** neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types ***-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related ***,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain *** this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from *** found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 *** VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical *** findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological ***,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.

关键词： central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transforming growth factor-beta 1 traumatic brain injury voltage-gated sodium currents

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Depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 335-345页

作者： Feng Zhang Chenyang Zhang Linlin Wu Wei Sun Hongliang Zhang Jianhua Chen Yong Pei Songjiang Li Engineering Research Center of Ministry of Education for Carbon Emission Reduction in Metal Resource Exploitation and Utilization Hunan International Joint Research Center for Efficient and Clean Utilization of Critical Metal Mineral ResourcesSchool of Minerals Processing and BioengineeringCentral South UniversityChangsha 410083China State key laboratory of Mineral Processing Beijing General Research Institute of Mining&MetallurgyBeijing 100160China Hunan provincial key laboratory of Micro&Nano Materials Interfaces Science College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China School of Resources Environment and MaterialsGuangxi UniversityNanning 530004China Department of Chemistry Xiangtan UniversityXiangtan 411105China China Railway Resource Group Co.Ltd Beijing 102300China

The depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite still lacked in-depth ***,the depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite was further systematically investigated with experiments and density functional theory(DFT)*** X-ray photoelectric spectroscopy(XPS)results,DFT calculation results,and frontier molecular orbital analysis indicated that sulfite ions were difficult to be adsorbed on sphalerite surface,suggesting that sulfite ions achieved depression effects on sphalerite through other non-adsorption ***,the oxygen content in the surface of sphalerite treated with sulfite ions in creased,which enhanced the hydrophilicity of the sphalerite and further increased the difference in hydrophilicity between sphalerite and ***,sulfite ions were chelated with lead ions to form PbSO_(3)in *** hydrophilic PbSO_(3)was more easily adsorbed on sphalerite than *** interaction between sulfite ions and lead ions could effectively inhibit the activation of *** addition the UV spectrum showed that after adding sulfite ions,the peak of perxanthate in the sphalerite treated xanthate solution was significantly stronger than that in the galena with xanthate solution,indicating that xanthate interacted more readily with sulfite ions and oxygen mo lecules within the sphalerite system,leading to the formation of ***,sulfite ions hardly depressed the flotation of ga lena and could promote the flotation of galena to some *** study deepened the understanding of the depression mechanism o sulfite ions on sphalerite and Pb^(2+)activated sphalerite.

关键词： sphalerite galena sulfite ion density functional theory depression mechanism

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Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming Zhang Bin Liu Limin Rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)key laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

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Impact of the Next-Nearest-Neighbor Interaction on Traffic Flow of Highway with Slopes

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Communications in Theoretical Physics 2012年第10期58卷 590-598页

作者：李志鹏周盈 The key laboratory of embedded system and Service Computing supported by Ministry of Education Tongji University

In this paper,we study the motion course of traffic flow on the slopes of a highway by applying a microscopic traffic model,which takes into account the next-nearest-neighbor interaction in an intelligent transportation system *** common gradients of the highway,which are sag terrain,uphill terrain,and downhill terrain on a single-lane roadway,are selected to clarify the impact on the traffic flow by the next-nearest-neighbor interaction in relative *** obtain the current-density relation for traffic flow on the sag,the uphill and the downhill under the next-nearest-neighbor interaction *** is observed that the current saturates when the density is greater than a critical value and the current decreases when the density is greater than another critical *** the density falls into the intermediate range between the two critical densities it is also found that the oscillatory jam,easily leads to traffic accidents,often appears in the downhill stage,and the next-nearest-neighbor interaction in relative velocity has a strong suppressing effect on this kind of dangerous congestion.A theoretical analysis is also presented to explain this important conclusion.

关键词： traffic flow traffic jam next-nearest-neighbor interaction

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LESO-based Position Synchronization Control for Networked Multi-Axis Servo systems With Time-Varying Delay

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IEEE/CAA Journal of Automatica Sinica 2020年第4期7卷 1116-1123页

作者： Qi Wu Li Yu Yao-Wei Wang Wen-An Zhang the College of Information Engineering Zhejiang University of TechnologyZhejiang Provincial United Key Laboratory of EmbeddedHangzhou 310023China

The position synchronization control(PSC) problem is studied for networked multi-axis servo systems(NMASSs) with time-varying delay that is smaller than one sampling period. To improve the control performance of the system, time-varying delays, modeling uncertainties, and external disturbances are first modeled as a lumped disturbance. Then, a linear extended state observer(LESO) is devised to estimate the system state and the lumped disturbance, and a linear feedback controller with disturbance compensation is designed to perform individual-axis tracking control. After that, a cross-coupled control approach is used to further improve synchronization performance. The bounded-input-bounded-output(BIBO) stability of the closedloop control system is analyzed. Finally, both simulation and experiment are carried out to demonstrate the effectiveness of the proposed method.

关键词： Active-disturbance rejection controller extended state observer networked motion control system(NMCS) timevarying delays

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Detecting Data-flow Errors Based on Petri Nets With Data Operations

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IEEE/CAA Journal of Automatica Sinica 2018年第1期5卷 251-260页

作者： Dongming Xiang Guanjun Liu Chungang Yan Changjun Jiang key laboratory of embedded system and Service Computing Ministry of Education Tongji University Shanghai 201804 China IEEE

In order to guarantee the correctness of business processes, not only control-flow errors but also data-flow errors should be considered. The control-flow errors mainly focus on deadlock, livelock, soundness, and so on. However, there are not too many methods for detecting data-flow errors. This paper defines Petri nets with data operations(PN-DO) that can model the operations on data such as read, write and delete. Based on PN-DO, we define some data-flow errors in this paper. We construct a reachability graph with data operations for each PN-DO, and then propose a method to reduce the reachability graph. Based on the reduced reachability graph, data-flow errors can be detected rapidly. A case study is given to illustrate the effectiveness of our methods.

关键词： Business process modeling data-flow errors Petri nets reachability graph

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Constrained consensuses in disconnected topologies

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Chinese Physics B 2012年第2期21卷 581-590页

作者： Song Hai-Yu Yu Li Hu Hong-Xiang Zhang Wen-An College of Information Engineering Zhejiang University of Technology and Zhejiang Provincial United Key Laboratory of Embedded SystemsHangzhou 310023China

This paper is concerned with the constrained consensuses problem for a group of agents in disconnected topologies. By dividing the communication topology into a combination of directed trees, some necessary and sufficient conditions are derived for all the agents to asymptotically reach a single consensus and multiple consensuses, respectively. The obtained results indicate that arbitrary anticipant consensuses can be achieved, if additional constrained controllers are added to those agents with specific indexes. Some illustrative examples are provided to demonstrate the effectiveness of the proposed theoretical results.

关键词： disconnected topologies single consensus multiple consensuses

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Partition-based Collaborative Tensor Factorization for POI Recommendation

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IEEE/CAA Journal of Automatica Sinica 2017年第3期4卷 437-446页

作者： Wenjing Luan Guanjun Liu Changjun Jiang Liang Qi Department of Computer Science and Technology Tongji University IEEE key laboratory of embedded system and Service Computing Tongji University

The rapid development of location-based social networks(LBSNs) provides people with an opportunity of better understanding their mobility behavior which enables them to decide their next *** example,it can help travelers to choose where to go next,or recommend salesmen the most potential places to deliver advertisements or sell *** this paper,a method for recommending points of interest(POIs)is proposed based on a collaborative tensor factorization(CTF)***,a generalized objective function is constructed for collaboratively factorizing a tensor with several feature ***,a 3-mode tensor is used to model all users' check-in behaviors,and three feature matrices are extracted to characterize the time distribution,category distribution and POI correlation,***,each user's preference to a POI at a specific time can be estimated by using *** order to further improve the recommendation accuracy,PCTF(Partitionbased CTF) is proposed to fill the missing entries of a tensor after clustering its every *** on a real checkin database show that the proposed method can provide more accurate location recommendation.

关键词： Clustering context feature extraction point of interest(POI) recommendation tensor factorization

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Net-structure-based conditions to decide compatibility and weak compatibility for a class of inter-organizational workflow nets

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Science China(Information Sciences) 2015年第7期58卷 128-143页

作者： LIU GuanJun JIANG ChangJun Department of Computer Science Tongji University key laboratory of the Ministry of Education for embedded system and Service Computing Tongji University

Inter-organizational workflow nets(IWF-nets) can well model the interactions among multiple processes by sending/receiving messages. Compatibility and weak compatibility are crucial properties for *** latter guarantees that a system is deadlock-free and livelock-free while the former also guarantees that it has no dead tasks. Our previous work proved that the(weak) compatibility problem is PSPACE-complete for safe IWF-nets. This paper defines a class of IWF-nets in which some simple circuits are allowed. Necessary and sufficient conditions are presented to decide compatibility and weak compatibility for this class, and they are dependent on the net structures only. Algorithms are developed based on these conditions. In addition, we show that the traditional net structures like siphon cannot be easily used to decide the(weak) compatibility of IWF-nets.

关键词： formal method workflow nets compatibility business process model web services composition

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Adaptive walking control of quadruped robots based on central pattern generator (CPG) and reflex

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控制理论与应用（英文版） 2013年第3期11卷 386-392页

作者： Chengju LIU Qijun CHEN Guoxing WANG Department of Electronics and Information Engineering and Key Laboratory of Embedded System and Service Computing Ministry of Education Tongji University

This paper presents a central pattern generator （CPG） and vestibular reflex combined control strategy for a quadruped robot. An oscillator network and a knee-to-hip mapping function are presented to realize the rhythmic motion for the quadruped robot. A two-phase parameter tuning method is designed to adjust the parameters of oscillator network. First, based on the numerical simulation, the influences of the parameters on the output signals are analyzed, then the genetic algorithm （GA） is used to evolve the phase relationships of the oscillators to realize the basic animal-like walking pattern. Moreover, the animal＇s vestibular reflex mechanism is mimicked to realize the adaptive walking of the quadruped robot on a slope terrain. Coupled with the sensory feedback information, the robot can walk up and down the slope smoothly. The presented bio-inspired control method is validated through simulations and experiments with AIBO. Under the control of the presented CPG and vestibular reflex combined control method, AIBO can cope with slipping, falling down and walk on a slope successfully, which demonstrates the effectiveness of the proposed walking control method.

关键词： CPG Walking control Quadruped robot Vestibular reflex

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