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第十一届全国化学生物学学术会议

作者： Ling Liang Quan Yuan Molecular Sciences and Biomedicine laboratory Hunan University

Nature has constructed complicated living systems that often have elaborate hierarchical structure assemblies arising from weakly interacting,yet readily available building blocks. Constructing an intelligent system that rival the structure and function of living organisms has attracted considerable research interest in self-assembly and bionic science. Photosynthetic bacteria can absorb photons on the submicron scale and efficiently convert light energy into accessible chemical *** photosynthetic bacteria-inspired studies can help researchers improve the ability to precisely manipulate photons and develop more efficient energy transfer pathways. Herein,we designed artificial photoresponsive protocells that mimic the structure and light-harvesting function of photosynthetic bacteria for imaging-guided photodynamic and photothermal *** the specific structure and function,the protocells can efficiently absorb light strongly as well as convert light energy into chemical and heat energy for ablating tumor cells and suppressing the growth of solid *** summary,our demonstration of protocells not only represents a method for fabricating light-harvesting systems based on nanoassembly,but also provides a promising step towards photosynthetic protocells with integrated cell-like structure and light-harvesting function for nanomedicine.

关键词： upconversion black phosphorus near-infrared light theranostics

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Artificial intelligence in pediatrics

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Chinese Medical Journal 2020年第3期133卷 358-360页

作者： Ya-Wen Li Fang Liu Tian-Nan Zhang Fang Xu Yu-Chen Gao Tian Wu School of Economics and Management Beijing University of Posts and TelecommunicationsBeijing 100876China Department of Stomatology Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Pediatrics Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China School of Banking Finance University of International Business and EconomicsBeijing 100029China School of Economics and Management Tsinghua UniversityBeijing 100084China NCMIS Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China School of Economics and Management University of Chinese Academy of SciencesBeijing 100190China key laboratory of Big Data Mining and Knowledge Management Chinese Academy of SciencesBeijing 100190China.

The rapid development of information technology has involved advances in artificial intelligence(AI),big data processing,and cloud computing,with significant and farreaching effects on the structure and efficiency of the traditional healthcare industry,as well as the establishment and maintenance of modern medical management information *** solutions for handling data in the medical field,such as electronic medical records,medical imaging technology,medical big data,intelligent drug design,and smart health management systems have emerged,which improve the standardization and accuracy of clinical decision making,while providing more dimensions of data accumulation for medical knowledge-based *** developments can also support physicians and researchers in the optimization of treatment plans,and decision making about optimal treatment *** review aims to summarize recent advances in the research and clinical use of AI in pediatrics.

关键词： dimensions intelligence advances

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GSH-triggered sequential catalysis for tumor imaging and eradication based on star-like Au/Pt enzyme carrier system

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Nano Research 2020年第1期13卷 160-172页

作者： Amin Zhang Qian Zhang Gabriel Alfranca Shaojun Pan Zhicheng Huang Jin Cheng Qiang Ma Jie Song Yunxiang Pan Jian Ni Lijun Ma Daxiang Cui Institute of Nano Biomedicine and Engineering Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment InstrumentDepartment of Instrument Science and EngineeringSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong University800 Dongchuan RDShanghai200240China National Center for Translational Medicine Collaborative Innovational Center for System BiologyShanghai Jiao Tong University800 Dongchuan RoadShanghai200240China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai200240China Instituto de Ciencia de Materiales de Aragón(ICMA) CSIC/Universidad de ZaragozaC/Pedro Cerbuna 1250009ZaragozaSpain Department of Tumor Xintai People’s HospitalXintai271200China Department of Tumor in Tongren Hospital Shanghai Jiao Tong University School of Medicine1111 XianXia RoadShanghai200336China

Distinctively different metabolism between tumor cells and normal cells endows tumor tissues unique *** this regard,we have successfully prepared a sequential catalytic platform based on Au/Pt star for tumor *** multifunctional probes consisted of a gold/platinum star-shaped core(Au/Pt star)conjugated with a GSH-sensitive disulfide bond(S–S),a targeting ligand(rHSA-FA),a near-infrared fluorophore(IR780)and glucose oxidase(GOx).When systemically administered in a xenografted murine model,the probes specifically targeted the tumor *** the disulfide linker was cleaved by intracellular GSH,the IR780 molecules could be released for photo-thermal therapy&photodynamic therapy(PTT&PDT)and ***,the Pt nanolayer of the Au/Pt star and the GOx formed a sequential catalytic system:GOx effectively catalyzed intracellular glucose by consuming oxygen to generate H2O2 and enhance the local acidity,and the Pt layer exhibited peroxidase-like property to catalyze H2O2 producing toxic·OH for tumor oxidative *** we demonstrated that our probes simultaneously possessed a GSH-sensitive release,real-time imaging ability,and synergetic cancer starving-like therapy/enzyme oxidative therapy/PTT/PDT features,which provides a potential strategy for effective tumor theragnostic.

关键词： Au/Pt star GSH-responsive GOx peroxidase sequential nanocatalyst cancer starving-like therapy enzyme oxidative therapy photo-thermal therapy&photodynamic therapy(PTT&PDT)

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A Preliminary Study on the Theory of Polar Coordinates Digital Photogrammetry and the Coordinate System of Spatial Information

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Journal of Geodesy and Geoinformation Science 2018年第1期1卷 61-79页

作者： Lei YAN Ruihua ZHANG Yanbiao SUN Beijing key Lab of Spatial Information Integration and Its Applications Peking UniversityBeijing 100871China Department of Civil Environmental&Geomatic EngineeringUniversity College London(UCL)LondonUK

The development of new aeronautics and astronautics technologies has been constrained by strict mathematical rules for data processing among the diverse methods used to obtain spatial *** acquisition of spatial information has been affected by various choices including the applied technologies(e.g.,push broom sensors),techniques(e.g.,zoom imaging),and equipment settings(e.g.,swing angle,aerial platform attitude,camera angle)in terms of the convergence,efficiency,and accuracy of the *** on the principle of the bionic machine parallax angle and pyramidal projection of the aerial space platform to the surface,this study explored solutions for high-resolution image sparsity,ill-conditioned singularity,and non-convergence by building a set of mathematical models to process the polar coordinates of the parallax angular *** study also formed a polar information theory for initial spatial *** method improved the ranges of accuracy,efficiency,and anti-interference in close-range photogrammetry and the free net bundle adjustment model by several orders of *** open source code was made globally available more than 3 years ago,and has received positive *** method’s effectiveness was verified using aerophotogrammetry and absolute network adjustment model experiments,and its performance was better than that of the Cartesian coordinate processing ***,the higher-order solution characteristics of various applications and spaceflight platforms were provided,which are expected to provide a foundation for construction of a new polar coordinate system for aerospace multi-scale all-attitude spatial information acquisition,organization,management,storage,processing,and application.

关键词： astringency bionic machine vision convergence precision intelligent photogrammetry polar coordinates vector spatial information

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Detection of defect on navel orange using hyperspectral reflectance image

Detection of defect on navel orange using hyperspectral refl...

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The 2011 International Conference on key Engineering Materials and Computer Science(KEMCS 2011)

作者： Jing LI Long XUE Muhua LIU Xiao WANG Chunsheng LUO Optics-Electrics Application of Biomaterials Lab Jiangxi Agricultural University School of Mechanical and Electrical Engineering Departments East China Jiaotong University key lab of nondestructive testing ministry of educationNanchang Hangkong University

A hyperspectral imaging system for detecting defect on navel orange was demonstratedThe hyperspectral imaging system, which was a line-scan imaging system, consisted of a hyperspectral camera, a halogen lighting unit, a computer and a translation stageThe imaging system operated from 400 to 1000 nmPrincipal component analysis（PCA） was performed using the hyperspectral images data（from 500 to 700nm）;2nd principal component（PC） image exhibited differential responses between normal and defect spots on the surface of navel orangeThe combined use of the PC-2 images demonstrated the detection of defect spots with minimal false positivesBased on the PC-2 weighing coefficients, the dominant wavelengths were 528,529,530,673,674 and 675 nmThis research demonstrated the potential of multispectral image for online applications for detection of defect on navel oranges.

关键词： Hyperspectral reflectance image principal component analysis defect detection navel orange

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