检索结果-南通市图书馆

D-type neuropeptide decorated AIEgen/RENP hybrid nanoprobes with light-driven ROS generation ability for NIR-Ⅱ fluorescence imaging-guided through-skull photodynamic therapy of gliomas

Aggregate

引用

Aggregate 2024年第1期5卷 185-195页

作者： Xuelu He Yuan Luo Yanying Li Yuanbo Pan Ryan T.K.Kwok Lulu He Xiaolin Duan Pengfei Zhang Aiguo Wu Ben Zhong Tang Juan Li Ningbo key laboratory of Biomedical imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Sciences(CAS)Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboP.R.China Guangdong key laboratory of nanomedicine Shenzhen Engineering Laboratory of Nanomedicine and NanoformulationsCAS-HK Joint Lab for BiomaterialsResearch Laboratory for Biomedical Optics and Molecular ImagingShenzhen Key Laboratory for Molecular ImagingCAS Key Lab for Health InformaticsShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenP.R.China Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced StudyThe Hong Kong University of Science and Technology(HKUST)KowloonP.R.China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhenP.R.China

Glioma is one of the most common malignant tumors of the central nervous system,leading high mortality rates in ***-induced emission(AIE)photosensitizers-based photodynamic therapy(PDT)has emerged as a promising therapeutic strategy for least-invasive treatment of glioma,which involves local irradiation of the tumor using an external near-infrared(NIR)***,most AIE photosensitizers suffered from poorly penetration of the visible light excitation,bad spatiotemporal resolution in deep tissues and low efficient blood-brain barrier(BBB)crossing ability,which greatly limited the clinical practice of AIE photosensitizers for especially deep-seated brain tumor *** this work,we developed a multifunctional NIR-driven theranostic agent through hybrid of AIE photosensitizers TIND with rare-earth doping nanoparticles(RENPs)NaGdF4:Nd/Yb/Tm with up/down dual-mode conversion *** theranostic agent was further decorated with D-type neuropeptide DNPY for crossing BBB and targeting *** the 808-nm light irradiation,the down-conversion NIR-II luminescence could indicate the position glioma and the upconversion NIR-I luminescence could trigger the AIE photosensitizers producing reactive oxygen species to inhibit orthotopic glioma tumor growth in *** results demonstrate that the integration of Dtype neuropeptide,AIE photosensitizers and RENPs could be promising candidates for in vivo NIR-II fluorescence image-guided through-skull PDT treatments of brain tumors.

关键词： aggregation-induced emission D-type neuropeptide glioma photodynamic therapy rare-earth doping nanoparticles

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Robust thin-film lithium niobate modulator on a silicon substrate with backside holes

引用

Chinese Optics Letters 2024年第5期22卷 17-21页

作者：王迈祁璐王浩华阮子良陈耿鑫陈斌龚胜琪陈楷旋刘柳 State key laboratory of Extreme Photonics and Instrumentation College of Optical Science and EngineeringInternational Research Center for Advanced PhotonicsZhejiang UniversityHangzhou 310058China Guangdong Provincial key laboratory of Optical Information Materials and Technology South China Academy of Advanced OptoelectronicsSouth China Normal UniversityHigher-Education Mega-CenterGuangzhou 510006China National Center for International Research on Green Optoelectronics South China Normal UniversityGuangzhou 510006China Jiaxing key laboratory of Photonic Sensing&intelligent imaging Intelligent Optics&Photonics Research CenterJiaxing Research InstituteZhejiang UniversityJiaxing 314000China

Recently,Mach–Zehnder modulators based on thin-film lithium niobate have attracted broad interest for their potential for high modulation bandwidth,low insertion loss,high extinction ratio,and high modulation *** periodic capacitively loaded traveling-wave electrode is optimally adopted for ultimate high-performances in this type of ***,such an electrode structure on a silicon substrate still suffers from the velocity mismatch and substrate leakage loss for microwave ***,we introduce a thin-film lithium niobate modulator structure using this periodic capacitively loaded electrode on a silicon *** holes in the silicon substrate are prepared to solve robustly the above *** fabricated device exhibits an insertion loss of 0.9 dB,a halfwave-voltage–length product of 2.18 V·cm,and an ultra-wide bandwidth well exceeding 67 GHz for a 10-mm-long *** transmissions with rates up to 112 Gb/s are *** proposed structure and fabrication strategy are compatible for other types of monolithic and heterogeneous integrated thin-film lithium niobate modulators on a silicon substrate.

关键词： lithium niobate electro-optic modulator high bandwidth backside holes robust structure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gamma/Hadron Separation Method for the HADAR Experiment

引用

Research in Astronomy and Astrophysics 2024年第3期24卷 70-74页

作者： Yang-Zhao Ren Tian-Lu Chen You-Liang Feng Dan-Zeng Luo-Bu Yi-Qing Guo Cheng Liu Qi Gao Mao-Yuan Liu Xiang-Li Qian Ya-Ping Wang Zi-Hao Zhang Xin-Long Li Qing-Yuan Hou Heng-Jiao Liu Qing-Qian Zhou Shan-Jie Shu The key laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China key laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences University of Chinese Academy of Sciences School of intelligent Engineering Shandong Management University

Ground-based arrays of imaging atmospheric Cherenkov telescopes(IACTs)are the most sensitiveγ-ray detectors for energies of approximately 100 Ge V and *** such IACT is the High Altitude Detection of Astronomical Radiation(HADAR)experiment,which uses a large aperture refractive water lens system to capture atmospheric Cherenkov photons(i.e.,the imaging atmospheric Cherenkov technique).The telescope array has a low threshold energy and large field of view,and can continuously scan the area of the sky being observed,which is conducive to monitoring and promptly responding to transient *** process ofγ-hadron separation is essential in very-high-energy(>30 Ge V)γ-ray astronomy and is a key factor for the successful utilization of *** this study,Monte Carlo simulations were carried out to model the response of cosmic rays within the HADAR *** analyzing the Hillas parameters and the distance between the event core and the telescope,the distinction between air showers initiated byγ-rays and those initiated by cosmic rays was ***,a Quality Factor was introduced to assess the telescope’s ability to suppress the background and to provide a more effective characterization of its performance.

关键词： astroparticle physics-telescopes-methods data analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Heptamethine cyanines in bioorthogonal chemistry

引用

Chinese Chemical Letters 2024年第2期35卷 131-137页

作者： Yuanyuan Liao Yuting Liang Yurou Huang Xiaoyan Zeng Tian He Jun Yin National key laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China

Due to their excellent fluorescence properties and biological function,cyanine dyes have been widely applied in biological *** cyanine(Cy7)dyes,as a type of classic near-infrared(NIR)fluorescent dyes,are considered as one of the effective fluorescent tools in the living organisms due to their good biocompatibility and very low background *** reactions performed in living cells and tissues have developed by leaps and bounds in recent *** NIR fluorescent labeling technique involving cyanine has attracted widespread *** review summarizes their recent application in the field of bioorthogonal imaging,mainly concluding Cy7-type dyes,labeling strategy,bioimaging application,*** expect this work can provide some helps for the studies of NIR bioorthogonal reaction in vivo.

关键词： Fluorescent probes Heptamethine cyanines Bioorthogonal reaction imaging Cell

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Anisotropy-free arrayed waveguide gratings on X-cut thin film lithium niobate platform of in-plane anisotropy

引用

Light(Science & Applications) 2024年第7期13卷 1416-1426页

作者： Junjie Yi Changjian Guo Ziliang Ruan Gengxin Chen Haiqiang Wei Liwang Lu Shengqi Gong Xiaofu Pan Xiaowan Shen Xiaowei Guan Daoxin Dai Kangping Zhong Liu Liu State key laboratory of Extreme Photonics and Instrumentation College of Optical Science and EngineeringInternational Research Center for Advanced PhotonicsZhejiang UniversityHangzhou 310058China. Guangdong Provincial key laboratory of Optical Information Materials and Technology South China Academy of Advanced OptoelectronicsSouth China Normal UniversityHigher-Education Mega-CenterGuangzhou 510006China. National Center for International Research on Green Optoelectronics South China Normal UniversityGuangzhou 510006China Photonics Research Institute Department of Electrical and Electronic EngineeringThe Hong Kong Polytechnic UniversityHung HomKowloonHong Kong(SAR)China. Jiaxing key laboratory of Photonic Sensing&intelligent imaging Intelligent Optics&Photonics Research CenterJiaxing Research Institute Zhejiang UniversityJiaxing 314000China

Arrayed waveguide grating is a versatile and scalable integrated light dispersion device,which has been widely adopted in various applications,including,optical communications and optical ***,thin-film lithium niobate emerges as a promising photonic integration platform,due to its ability of shrinking largely the size of typical lithium niobate based optical *** would also enable multifunctional photonic integrated chips on a single lithium niobate ***,due to the intrinsic anisotropy of the material,to build an arrayed waveguide grating on X-cut thin-film lithium niobate has never been ***,a universal strategy to design anisotropyfree dispersive components on a uniaxial in-plane anisotropic photonic integration platform is introduced for the first *** leads to the first implementation of arrayed waveguide gratings on X-cut thin-film lithium niobate with various configurations and *** best insertion loss of 2.4 dB and crosstalk of−24.1 dB is obtained for the fabricated arrayed waveguide grating *** of such arrayed waveguide gratings as a wavelength router and in a wavelength-division multiplexed optical transmission system are also demonstrated.

关键词： waveguide arrayed lithium

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

RGB-guided hyperspectral image super-resolution with deep progressive learning

引用

CAAI Transactions on Intelligence Technology 2024年第3期9卷 679-694页

作者： Tao Zhang Ying Fu Liwei Huang Siyuan Li Shaodi You Chenggang Yan School of Computer Science and Technology Beijing Institute of TechnologyBeijingChina Satellite Information intelligent Processing and Application Research laboratory Beijing Institute of Remote SensingBeijingChina key laboratory of Spectral imaging Technology Xi'an Institute of Optics and Precision Mechanics of Chinese Academy of SciencesXi'anChina Institute of Informatics University of AmsterdamAmsterdamNetherlands School of Communication Engineering Hangzhou Dianzi UniversityHangzhouChina

Due to hardware limitations,existing hyperspectral(HS)camera often suffer from low spatial/temporal ***,it has been prevalent to super-resolve a low reso-lution(LR)HS image into a high resolution(HR)HS image with a HR RGB(or mul-tispectral)image *** approaches for this guided super-resolution task often model the intrinsic characteristic of the desired HR HS image using hand-crafted ***,researchers pay more attention to deep learning methods with direct supervised or unsupervised learning,which exploit deep prior only from training dataset or testing *** this article,an efficient convolutional neural network-based method is presented to progressively super-resolve HS image with RGB image ***-ically,a progressive HS image super-resolution network is proposed,which progressively super-resolve the LR HS image with pixel shuffled HR RGB image ***,the super-resolution network is progressively trained with supervised pre-training and un-supervised adaption,where supervised pre-training learns the general prior on training data and unsupervised adaptation generalises the general prior to specific prior for variant testing *** proposed method can effectively exploit prior from training dataset and testing HS and RGB images with spectral-spatial *** has a good general-isation capability,especially for blind HS image *** experimental results show that the proposed deep progressive learning method out-performs the existing state-of-the-art methods for HS image super-resolution in non-blind and blind cases.

关键词： computer vision deep neural networks image processing image resolution unsupervised learning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Unimolecular Self-Assembled Hemicyanine-Oleic Acid Conjugate Acts as a Novel Succinate Dehydrogenase Inhibitor to Amplify Photodynamic Therapy and Eliminate Cancer Stem Cells

引用

Research 2024年第2期6卷 449-461页

作者： Qiang Wang Tian Yang Shiyou Li Chen Xu Chong Wang Yuxuan Xiong Xing Wang Jiangling Wan Xiangliang Yang Zifu Li National Engineering Research Center for nanomedicine College of Life Science and Technology.Huazhong University of Science and TechnologyWuhan 430074P.R.China key laboratory of Molecular Biophysics of Ministry of Education College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074P.R.China .3Hubei key laboratory of Bioinorganic Chemistry and Materia Medical Huazhong University of Science and TechnologyWuhan 430074P.R.China Hubei Engineering Research Center for Biomaterials and Medical Protective Materials Huazhong University of Science and TechnologyWuhan 430074P.R.China Hubei Bioinformatics and Molecular imaging key laboratory College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074P.R.China

Photodynamic therapy with reactive oxygen species production is a prospective treatment to combat cancer stem cells(CSCs).However,the innate drawbacks,including short lifetime and diffusion distance of reactive oxygen species and hypoxia within solid tumors,have become bottlenecks for clinical applications of photodynamic ***,we develop a mitochondria-targeting hemicyanine-oleic acid conjugate(CyOA),which can self-assemble into supramolecular nanoparticles(NPs)without any exogenous *** is also shown for targeting the mitochondrial complex II protein succinate dehydrogenase to inhibit oxidative phosphorylation and reverse tumor hypoxia,resulting in 50.4-fold higher phototoxicity against breast cancer stem cells(BCSCs)compared to SO_(3)-CyOA NPs that cannot target to *** 4T1 and BCSC tumor models,CyOA NPs achieve higher tumor inhibition and less lung metastasis nodules compared to the clinically used photosensitizer *** study develops a self-assembled small molecule that can serve as both oxidative phosphorylation inhibitor and photosensitizer for eradication of CSCs and treatment of solid tumors.

关键词： cyanine oxidative treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

MMAE-loaded PLGA nanomedicine with improved biosafety to achieve efficient antitumor treatment

引用

Journal of Innovative Optical Health Sciences 2024年第2期17卷 79-93页

作者： Changqiang Xie Yan Wang Zhenzhen Cai Jianghai Du Zhengyu Chen Junjie Wang Xingzhou Peng State key laboratory of Digital Medical Engineering School of Biomedical Engineering Hainan University Haikou 570228P.R.China key laboratory of Biomedical Engineering of Hainan Province One Health Institute Hainan University Haikou 570228P.R.China key laboratory of Hainan Trauma and Disaster Rescue The First Affiliated Hospital of Hainan Medical University Hainan Medical University Haikou 571199P.R.China Engineering Research Center for Hainan Bio.Smart Materials and Bio-Medical Devices Key Laboratory of Emergency and Trauma Ministry of EducationKey Laboratory of Hainan Functional Materials and Molecular ImagingCollege of Emergency and Trauma Hainan Medical UniversityHaikou 571199P.R.China

Monomethyl auristatin E(MMAE)is a derivative of the marine peptide Dolastatin 10,which has therapeutic effects against various cancers according to its antimitotic activity in multiple clinical *** antibody drug conjugate(ADC)of MMAE is currently used in clinical ***,the safety issues of MMAE-based ADC,such as high drug toxicity and poor bioavailability,still exist when using it for anticancer therapy.A sustained release of drug delivery approach should be used to reduce toxicity and achieve sufficient anticancer ***,PLGA-b-PEG 2000 with excellent biocompatibility and slow degradation ability was adopted to construct MMAE-loaded nanoparticles for safe and effective *** sustained release effect and the immunogenic cell death(ICD)effect of PLGA-MMAE nanoparticles were assessed by in vitro *** PLGA-MMAE nanoparticles effectively accumulated in the tumor through the enhanced permeability and retention(EPR)effect,inducing cell apoptosis and causing a certain degree of immune *** sustained drug release of PLGA-MMAE improved the bioavailability and effectively reduced the toxicity and development of the tumor compared to the effect of free MMAE or ***,this study provides a safe and effective chemotherapeutic approach,as well as a simple and effective synthetic process for MMAE-based nanoparticles,improving their therapeutic efficacy and safety.

关键词： Monomethyl auristatin E poly(lactic-co-glycolic acid)nanoparticles sustained release chemotherapy immunogenic cell death

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acidic/hypoxia dual-alleviated nanoregulators for enhanced treatment of tumor chemo-immunotherapy

引用

Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 136-152页

作者： Xiaoju Guo Xiaoxiao Chen Jiayi Ding Feng Zhang Shunyang Chen Xin Hu Shiji Fang Lin Shen Chenying Lu Zhongwei Zhao Jianfei Tu Gaofeng Shu Minjiang Chen Jiansong Ji Lishui Central Hospital Shaoxing UniversityShaoxing 312000China Zhejiang key laboratory of imaging and Interventional Medicine Imaging Diagnosis and Interventional Minimally Invasive InstituteThe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000China Clinical College of The Affiliated Central Hospital School of MedicineLishui UniversityLishui 323000China key laboratory of Precision Medicine of Lishui Lishui 323000China

Chemotherapy plays a crucial role in triple-negative breast cancer (TNBC) treatment as it not only directly kills cancer cells but also induces immunogenic cell death. However, the chemotherapeutic efficacy was strongly restricted by the acidic and hypoxic tumor environment. Herein, we have successfully formulated PLGA-based nanoparticles concurrently loaded with doxorubicin (DOX), hemoglobin (Hb) and CaCO3 by a CaCO3-assisted emulsion method, aiming at the effective treatment of TNBC. We found that the obtained nanomedicine (DHCaNPs) exhibited effective drug encapsulation and pH-responsive drug release behavior. Moreover, DHCaNPs demonstrated robust capabilities in neutralizing protons and oxygen transport. Consequently, DHCaNPs could not only serve as oxygen nanoshuttles to attenuate tumor hypoxia but also neutralize the acidic tumor microenvironment (TME) by depleting lactic acid, thereby effectively overcoming the resistance to chemotherapy. Furthermore, DHCaNPs demonstrated a notable ability to enhance antitumor immune responses by increasing the frequency of tumor-infiltrating effector lymphocytes and reducing the frequency of various immune-suppressive cells, therefore exhibiting a superior efficacy in suppressing tumor growth and metastasis when combined with anti-PD-L1 (αPD-L1) immunotherapy. In summary, this study highlights that DHCaNPs could effectively attenuate the acidic and hypoxic TME, offering a promising strategy to figure out an enhanced chemo-immunotherapy to benefit TNBC patients.

关键词： CaCO3-based nanoparticles Hypoxia attenuation Acidity neutralization Reversal of chemotherapy resistance Enhanced chemo-immunotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

界面工程与等离激元效应协同作用增强的ZnO微米线同质结自驱动紫外探测器

引用

Science China Materials 2024年第3期67卷 842-851页

作者：唐楷沙树林万鹏翟亚林阚彩侠施大宁姜明明 College of Physics MIIT Key Laboratory of Aerospace Information Materials and PhysicsKey Laboratory for Intelligent Nano Materials and DevicesNanjing University of Aeronautics and AstronauticsNanjing 211106China

高灵敏度的自驱动紫外探测器在许多应用中都大有可为.本研究提出了一种一维ZnO基同结光电探测器,它包括表面覆盖着Ag纳米线的锑掺杂ZnO微米线(AgNWs@ZnO:Sb MW)、MgO缓冲纳米层和ZnO薄膜.该探测器在0 V偏压下对紫外光非常敏感,其性能参... 详细信息

高灵敏度的自驱动紫外探测器在许多应用中都大有可为.本研究提出了一种一维ZnO基同结光电探测器,它包括表面覆盖着Ag纳米线的锑掺杂ZnO微米线(AgNWs@ZnO:Sb MW)、MgO缓冲纳米层和ZnO薄膜.该探测器在0 V偏压下对紫外光非常敏感,其性能参数包括约7个量级的开关比、292.2 mA W^(-1)的响应度、6.9×10^(13)Jones的比探测率,以及微秒量级的快速响应速度(上升时间16.4μs,下降时间465.1μs).特别是10μW cm^(-2)的微弱紫外光时接近99.3%的外量子效率.此外,本文系统研究了MgO纳米薄膜和表面修饰AgNWs对探测器件性能增强的机理.作为自驱动光接收器,该光电二极管被进一步集成到能够实时传输信息的紫外通信系统中.此外,基于AgNWs@p-ZnO:Sb MW/i-MgO/n-ZnO的同质结9×9阵列显示出均匀的光响应分布,可用作具有良好空间分辨率的成像传感器.这项研究有望为设计高性能紫外光检测器提供一条具有低功耗和可大规模建造的途径.

关键词： interface engineering p-type ZnO:Sb microwire selfpowered photodetector imaging sensor UV optical communication plasmonic effect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：