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复发性岛叶胶质细胞瘤再手术的围术期结局分析（英文）

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中华神经外科疾病研究杂志 2018年第6期 572-572页

作者： Morshed RA Young JS Han SJ Hervey-Jumper SL Berger MS Department of Neurological Surgery University of CaliforniaSan FranciscoCalifornia Department of Neurological Surgery Oregon Health & Science University

Objective Greater extent of resection( EOR) improves overall survival and progression-free survival for patients with lowand high-grade glioma. While resection for newly diagnosed insular gliomas can be performed with minimal morbidity,perioperative morbidity is not clearly defined for patients undergoing a repeat resection for recurrent insular gliomas. In this study the authors report on tumor characteristics,tumor EOR,and functional outcomes in patients undergoing reoperation for recurrent insular glioma. Methods Adult patients with insular gliomas( WHO grades Ⅱ-Ⅳ) who underwent index resection followed by reoperation were identified through the university of California San Francisco Brain Tumor center. Treatment history and functional outcomes were collected retrospectively from the electronic medical record. Pre-and postoperative tumor volumes were quantified using software with region-of-interest analysis based on FLAIR and T1-weighted postgadolinium sequences from pre-and postoperative MRI. Results Forty-four patients( 63. 6% male,36. 4% female) undergoing 49 reoperations for recurrent insular tumors were identified with a median follow-up of 741 days. Left-and right-sided tumors comprised 52. 3% and 47. 7% of the cohort,respectively. WHO grade Ⅱ,Ⅲ,and Ⅳ gliomas comprised 46. 9%,28. 6%,and 24. 5% of the cohort,respectively. Ninety-five percent( 95. 9%) of cases involved language and/or motor *** EOR of the insular component of grade Ⅱ,Ⅲ,and Ⅳ tumors were 82. 1%,75. 0%,and 94. 6%,respectively. EOR during reoperation was not impacted by Berger-Sanai insular zone or tumor side. At the time of reoperation,44. 9% of tumors demonstrated malignant transformation to a higher WHO grade. Ninety-day postoperative assessment confirmed that 91. 5% of patients had no new postoperative deficit attributable to surgery. Of those with new deficits,3( 6. 4%) had a visual field cut and 1( 2. 1%) had hemiparesis( strength grade 1-2/5). The presence of a new postoperati

关键词： WHO

Nutritional Challenges of Children with Disabilities in Special Needs center in Mainland, Lagos State, Nigeria

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Journal of Food Science and Engineering 2019年第8期9卷 297-304页

作者： Kemi Priscillia Ogbonna Victoria Omonigho Otobo Felicia Obiageli Maduabum Francisca Nonyelum Onyeka Olatokunboh Ayodele Ashiru Chika Esther Ajuluchi Department of Home Economics&Hospitality Management Education Faculty of Vocational&Technical EducationUniversity of NigeriaNsukka 410001Nigeria Home Economics Department School of Vocational EducationFederal College of Education(Technical)Akoka 100001YabaLagos StateNigeria Department of Fashion Design School of Art Design and PrintingYaba College of TechnologyLagos 101212Nigeria Department of Home Economics Federal College of EducationOkene 260101Kogi StateNigeria

The study determined the nutritional challenges of persons with disability in special needs centers in mainland,Lagos *** research questions guided the *** research design was *** population of the study was *** sampling was done since the population was a manageable *** questionnaire was used for data *** collected were analyzed using mean and standard *** showed that the types of disabilities among children in special need centers in Lagos State included among others:physical disability,learning disability,cerebral palsy,Down syndrome,attention deficit disorder/attention deficit hyperactivity disorder(ADHD),autism and speech and language *** also revealed that the nutritional needs of children with disability included feeding on different foods,drinking water regularly,taking fruits daily,and ensuring that their nutrient requirements are met *** indicated that the nutritional challenges of children with disability included among others:excessive salivation,frequent constipation,inability to feed oneself,depending on care givers for feeding,food dropping from the mouth while being fed and difficulty in chewing and swallowing *** was *** recommendations made was that children with disabilities should be provided with variety of foods daily to meet their nutritional needs and parents/caregivers should devote more feeding time to the disabled child.

关键词： Nutrition challenges disabilities children special needs

CONSONANT DISCRIMINATION IN ELICITED AND SPONTANEOUS SPEECH: A CASE FOR SIGNAL-ADAPTIVE FRONT ENDS IN ASR

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CONSONANT DISCRIMINATION IN ELICITED AND SPONTANEOUS SPEECH:...

锆石微量元素对成矿岩体的判别——来自大数据思维的应用

6～(th) International Conference on Spoken language Processing

作者： KemalSonmez MadelainePlauché ElizabethShriberg HoracioFranco Speech Technology and Research Laboratory SRI International Menlo Park CA USA Speech Technology and Research Laboratory SRI International Menlo Park CA USA Department of Linguistics University of California Berkeley CA USA Speech Technology and Research Laboratory SRI International Menlo Park CA USA Speech Technology and Research Laboratory SRI International Menlo Park CA USA

＜正＞The constant frame length in typical ASR front ends is too long to capture transient phenomena in speech, such as stop bursts. However, current HMM systems have consistently outperformed systems based solely on non-uniform units. This work investigates an approach to "add back" such transient information to a speech recognizer, without losing the robustness of the standard acoustic models. We demonstrate a set of phonetically-motivated acoustic features that discriminate a preliminary test set of highly ambiguous voiceless stops in CV contexts. The features are automatically

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地质通报 2019年第12期38卷 1992-1998页

作者：耿厅周永章李兴远王俊陈川王堃屹韩紫奇中山大学地球科学与工程学院广东广州510275 广东省地质过程与矿产资源探查重点实验室广东广州510275 中山大学地球环境与地球资源研究中心广东广州510275 中山大学地理科学与规划学院广东广州510275 Department of Geology University of ReginaReginaSaskatchewan S4S 0A2Canada 广东高质资源环境研究院广东广州510275

华南钦杭结合带燕山期岩浆活动异常活跃,且具有较明显的成矿专属性。近年来微区测试技术日益成熟,积累了大量锆石微量数据。通过全体数据挖掘的思维方法,对前人发表的数据进行了进一步数据挖掘,利用锆石稀土元素对岩体成矿潜力进行判别... 详细信息

华南钦杭结合带燕山期岩浆活动异常活跃,且具有较明显的成矿专属性。近年来微区测试技术日益成熟,积累了大量锆石微量数据。通过全体数据挖掘的思维方法,对前人发表的数据进行了进一步数据挖掘,利用锆石稀土元素对岩体成矿潜力进行判别,探讨有效的找矿地球化学标志。利用Python语言编程,对采用的13种稀土元素及元素比值进行穷举式组合,获得了4095个二元图解及121485个三元图解,并设计筛选算法,自动筛选出能有效区分锆石母岩成矿类型的图解。结果表明,锆石稀土元素含量及比值图解对不同成矿类型岩体的区分程度各异:与Ce、Eu有关的地球化学指标可以较清晰地对斑岩铜矿和钨锡(锡)矿床进行判别,这可能与岩体的氧逸度和含水量有关。此外,还挖掘出一些新的元素组合图解,如Dy/Lu-Er/Lu、Gd/Dy-Er/Yb等,可以有效区分岩体成矿类型,其隐含的地球化学机制尚待进一步解释。地球化学数据挖掘结果可以作为找矿标志使用,为华南燕山期岩浆-热液矿床研究及找矿勘查提供了科学依据,也是大数据技术在矿床学方面应用研究的积极探索。

关键词：锆石微量元素大数据分析地球化学图解钦杭结合带

家庭中照料儿童的保姆所引起的儿童特异性语言能力损害在中国儿童中进行病例对照研究

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世界核心医学期刊文摘（儿科学分册） 2006年第A3期2卷 43-43页

作者： Cheuk D.K.L. Wong V. 王经纬 Department of Pediatrics and Adolescent Medicine Queen Mary Hospital University of Hong Kong Pokfulam Road Hong Kong Hong Kong

Objective: To investigate the relationship between child care by domestic helper and specific language impairment (SLI). Design: Retrospective case-control study. Setting: A Child Assessment center in Hong Kong that receives referrals from primary and secondary care settings. Participants: We reviewed medical records of all new referrals younger than 5 years during a 4-year period (1999-2003) and compared children with SLI (cases) with those referred with other behavioral problems and assessed to have normal language and overall development (controls) using the Griffiths Mental Developmental Scale. Specific language impairment was defined as a language quotient more than 1 SD below the mean and below the general dev-elopmental quotient in children with normal general developmental quotient but without neurological or other organic diseases. Results: Four hundred ninety-six children were included (237 cases and 259 controls). The mean ages of cases and controls were 2.51 and 2.89 years, respectively. Boys predominated (cases=73.4% , controls= 60.2% ). The odds ratio (OR) of SLI for children cared for by a full-time domestic helper was 1.71 (95% confidence interval CI , 1.06-2.77; P=.03), after adjusting for confounding sociodemographic variables. Male gender (OR=1.91; 95% CI, 1.25-2.90), positive family history (OR=2.70; 95% CI, 1.55-4.73), fewer siblings (P=.01), and lower paternal occupational status (P=.01) were also risk factors for an SLI. Child care by a domestic helper was associated with a higher severity of an SLI in ordinal regression analysis (P=.048). Conclusions: Child care by a domestic helper is associated with increasing risk and severity of an SLI. Further studies are required to confirm the association and to evaluate whether avoidance of child care by a domestic helper could be recommended for children with an SLI or prone to develop an SLI.

关键词：病例对照研究中国儿童语言能力特异性医疗记录发育量表阳性家族史语言功能顺序性评价中心

同步放化疗60 Gy对比50 Gy剂量治疗不可手术食管鳞状细胞癌的多中心随机对照研究

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中华医学杂志 2020年第23期100卷 1783-1788页

作者：徐裕金朱卫国 Liao Zhongxing 孔月王万伟李建成黄荣何瀚杨新妹刘利萍孙宗文何慧娟包勇曾铭濮娟胡望远马军江浩刘志刚庄婷婷谭榜宪杜向慧裘国勤周霞季永领胡晓王谨马红莲郑晓黄瑾刘安文梁晓东陶华周菊英刘源陈明中国科学院肿瘤与基础医学研究所中国科学院大学附属肿瘤医院浙江省肿瘤医院胸部放疗科杭州310022 淮安市第一人民医院放疗科淮安223300 Department of Radiation Oncology University of TaxesM.D.Anderson Cancer CenterHouston 77030the United States 福建省肿瘤医院胸部放疗科福州350014 佛山市第一人民医院放疗科佛山528000 嘉兴市第一人民医院肿瘤内科嘉兴314000 济宁市第一人民医院肿瘤科济宁272011 衢州市人民医院放疗科衢州324000 中山大学附属肿瘤医院放疗科广州510080 四川省人民医院放疗科成都610072 涟水市人民医院放疗科涟水223400 金华市中心医院放疗科金华321000 安徽省立医院放疗科合肥230001 蚌埠医学院第一附属医院放疗科蚌埠233004 湖南省肿瘤医院放疗科长沙410013 汕头大学医学院附属肿瘤医院放疗科汕头515031 川北医学院附属医院放疗科南充637000 常州市第一人民医院放疗科常州213003 南昌大学附属第二医院放疗科南昌330006 浙江省人民医院放疗科杭州310014 江苏省肿瘤医院放疗科南京210009 苏州大学附属第一医院放疗科苏州215006 广州医科大学附属肿瘤医院放疗科广州510095 中山大学附属第一医院放疗科中山大学附属第五医院肿瘤中心

目的采用调强放疗(IMRT)技术进行食管鳞状细胞癌同步放化疗,比较60 Gy的放疗剂量是否优于国际标准的50 Gy。方法2013年4月至2017年5月将来自22家医院的331例经病理证实的无法手术的ⅡA~ⅣA期食管鳞状细胞癌患者以随机数字表法分为60 Gy... 详细信息

目的采用调强放疗(IMRT)技术进行食管鳞状细胞癌同步放化疗,比较60 Gy的放疗剂量是否优于国际标准的50 Gy。方法2013年4月至2017年5月将来自22家医院的331例经病理证实的无法手术的ⅡA~ⅣA期食管鳞状细胞癌患者以随机数字表法分为60 Gy和50 Gy两组接受放疗。最后纳入可分析病例305例,其中60 Gy组152例,50 Gy组153例。中位年龄63岁,男242例(79.3%),女63例(20.7%)。原发灶中位长度5.6 cm。两组基础资料具有可比性。所有患者放疗2 Gy/次,每周5次。同步化疗5周,每周1次:多西紫杉醇(25 mg/m2)+顺铂(25 mg/m2);巩固化疗2周期,3周重复:多西紫杉醇(70 mg/m2),d1+顺铂(25 mg/m2),d1~3。首要研究终点为局部区域无进展生存期(LRPFS)。两组分类变量比较采用Pearsonχ^2检验或Fisher精确检验。结果中位随访27.3个月,60 Gy组疾病进展率为37.5%(57/152),50 Gy组为43.8%(67/153),组间差异无统计学意义(χ^2=1.251,P=0.263)。60 Gy组和50 Gy组1、2、3年LRPFS分别为75.4%、56.8%、52.1%和74.2%、58.4%、50.1%(HR:0.95,95%CI:0.69~1.31,P=0.761)。两组1、2、3年总生存率分别为84.1%、64.8%、54.1%和85.4%、62.9%、54.0%(HR:0.98,95%CI:0.71~1.38,P=0.927)。两组1、2、3年无进展生存分别为70.8%、54.2%、48.5%和65.5%、51.9%、45.1%(HR:0.93,95%CI:0.68~1.26,P=0.621)。60 Gy组3级以上肺炎发生率为7.2%,50 Gy组为3.3%,组间差异有统计学意义(χ^2=11.596,P=0.021),其他毒副作用两组相似。结论同步放化疗模式治疗食管癌,50 Gy与60 Gy的疗效无差异,推荐50 Gy为常用放疗剂量。

关键词：食管肿瘤鳞状细胞癌放射治疗放射剂量预后

基于数据库驱动技术的土壤图注记自动配置系统的设计与实现

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土壤学报 2018年第2期55卷 293-303页

作者：雷秋良朱阿兴武淑霞张认连徐爱国张维理孙福军农业部面源污染控制重点实验室中国农业科学院农业资源与农业区划研究所北京100081 江苏省地理信息资源开发与利用协同创新中心南京师范大学地理科学学院南京210023 中国科学院地理科学与资源研究所资源与环境信息系统国家重点实验室北京100101 Department of Geography University of Wisconsin-MadisonMadisonWI 53706USA 沈阳农业大学土地与环境学院沈阳110161

土壤注记是土壤图制图表达的重要内容,对于理解土壤的发生、分布具有重要意义。在基于全国第二次土壤普查资料进行大比例尺土壤图分幅制图过程中,若对拥有海量土壤空间信息的多分幅大比例尺土壤图实现注记表达,不可能再依赖于传统的制... 详细信息

土壤注记是土壤图制图表达的重要内容,对于理解土壤的发生、分布具有重要意义。在基于全国第二次土壤普查资料进行大比例尺土壤图分幅制图过程中,若对拥有海量土壤空间信息的多分幅大比例尺土壤图实现注记表达,不可能再依赖于传统的制图方式生成注记。为了实现注记上图的自动化和以交互方式解决多个步骤判断问题,构建了土壤图注记自动配置系统。该系统采用图廓边界注记压盖检测与处理技术,解决了注记压盖图廓边界的问题;采用图层、分级码、要素对象的三级控制方法,实现了注记在图层级别上进行整个图层以及背景层注记的设置,在分级码级别上结合统计结果,实现了注记的条件判别与阈值过滤,在要素级别上实现了特殊要素注记的生成。基于数据库驱动技术并以人机交互的方式进行土壤图注记的自动化配置,实现了批量土壤图分幅注记的快速生成,不仅具有较强的灵活性,可适用于不同比例尺土壤图及其他类型地图的注记表达,而且大大提高了数据生产的效率和自动化处理程度。该研究为今后不同比例尺土壤图制图实现注记的自动化配置提供参考。

关键词：土壤图注记自动配置图层分级码要素数据库驱动

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进行性失语的临床和病理学特征

世界核心医学期刊文摘（神经病学分册） 2006年第5期2卷 6-6页

作者： Knibb J.A Xuereb J.H Patterson K Hodges J.R 周永 university of Cambridge Department of Clinical Neurosciences R3 Neurosciences Addenbrooke's Hospital Cambridge CB2 2QQ United KingdomDr.

Objective: The clinical and neuropathological categorization of patients presenting with progressive aphasia is an area of controversy. This study aimed to characterize a large group of progressive aphasic patients from a single center (n = 38), first clinically by case note review, and then pathologically. Methods: Hierarchical cluster analysis of the cases according to their clinical language deficits was used to establish an unbiased, data-driven classification. Results: This analysis revealed two groups of cases corresponding to the syndromes of progressive nonfluent aphasia (n = 23) and semantic dementia (n = 15). Postmortem analysis showed a majority in both groups of pathologies from the spectrum of frontotemporal lobar degeneration: the most frequent were non-Alzheimer’s disease (AD) tauopathy in the nonfluent cases (10 of 23) and frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions in the fluent cases (8 of 15). Despite rigorous exclusion of cases with clinically significant memory deficits or other cognitive impairments, the pathology of AD was present in approximately one third of each group (overall 12 of 38), although often with an atypical neuroanatomical distribution. Interpretation: Progressive aphasia is best seen as a composite of two conditions, on both clinical and pathological levels: progressive nonfluent aphasia and semantic dementia.

关键词：病理学特征失语患者临床资料进行性 tau蛋白病语义性痴呆神经解剖学系统聚类分析阿尔茨海默病认知功能障碍

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阿尔茨海默病居家筛查专家共识

阿尔茨海默病及相关病杂志 2024年第3期7卷 176-183页

作者：徐群 JWesson Ashford 陈彪陈树斌 Jeffrey Cummings 顾柏俊郭起浩韩璎花迎雪金华 Nagaendran Kandiah 李海雁刘晓蕾刘新卢佩琳裴中施晓耕孙凯汤彬 Goerge Vradenburg 王惠芳王军王晓明王艳蕊王艳梅王玉林翁文锋辛美哲张玉兰赵禾欣周显波王虹峥上海交通大学医学院附属仁济医院上海200127 Stanford university Palo AltoCA美国首都医科大学宣武医院北京100053 上海市安达医院上海201204 university of Nevada Las VegasNV美国澳大利亚墨尔本大学Florey研究所墨尔本澳大利亚上海市第六人民医院 200233上海上海市新场社区卫生服务中心上海200065 university of California San DiegoCA美国 Nanyang Technological university 新加坡大理市第一人民医院云南大理671013 昆明医科大学第一附属医院昆明650032 成都大学附属医院成都610040 浙江大学医学院附属邵逸夫医院杭州310009 中山大学附属第一医院广州510080 广东省干部保健中心广州510080 汕头大学医学院龙岗影像研究所广东汕头515041 上海剪爱公益发展中心上海201824 Davos Alzheimer's Collaborative WaynePA美国同济大学附属养志康复医院(上海市阳光康复中心) 上海201613 北京交通大学生命科学与生物工程研究院北京100044 川北医学院附属医院四川南充637002 北京市石景山区乐龄老年社会工作服务中心北京100040 昆明市中医医院昆明650011 深圳龙城医院深圳518100 广州市白云区新市街社区卫生服务中心广州510410 中华预防医学会北京100021 中国人民解放军总医院北京100039 北京医院北京100730 华盛顿临床研究学院阿尔茨海默研究中心(美国) 阿斯诺来(上海)医药科技有限公司上海200131 阿尔茨海默病防治协会北京100027

老年人痴呆或认知障碍多由一种以上年龄相关的常见脑部疾病所致。阿尔茨海默病(Alzheimer's disease,AD)是其中最常见的神经变性疾病,且是全球前10位死因中唯一无法治愈或缺乏长期对症疗效的疾病,给个人、家庭和全球经济都带来了巨大的... 详细信息

老年人痴呆或认知障碍多由一种以上年龄相关的常见脑部疾病所致。阿尔茨海默病(Alzheimer's disease,AD)是其中最常见的神经变性疾病,且是全球前10位死因中唯一无法治愈或缺乏长期对症疗效的疾病,给个人、家庭和全球经济都带来了巨大的负担。早期及时发现和干预是对抗AD的最佳策略。在过去的30年中,许多研究都提出了降低痴呆风险的方法,2020年《柳叶刀》杂志的痴呆预防报告已阐明通过应对风险因素可以预防或延缓超过40%的痴呆。然而,目前全球医疗体系尚未具备早期或及时发现AD的足够能力。最近的一项研究发现,只有不到10%的轻度认知障碍(mild cognitive impairment,MCI)是在初级医疗机构中诊断出来的。近来,抗淀粉样蛋白β(Amyloid beta,Aβ)抗体药物lecanemab和donanemab被批准上市用于早期AD治疗,以及30年的随访研究证明改善风险因素显著减少AD痴呆的发病率并延长了寿命,使得人们对AD早期识别的关注迅速增加。阿尔茨海默病防治协会(China Association for Alzheimer's Disease,CAAD)认识到居家早期和及时发现AD的重要性,并成立了一个由协会成员、临床医生和研究人员组成的全球AD多领域专家团队,就以下目标达成共识:①为个人、家庭、社区、协会和组织提供专家指导意见;②介绍用于认知障碍和痴呆居家筛查的数字工具和可用资源,并为AD高危人群或疑似患者制定下一步应对策略;③讨论现有可用或将来可能的居家筛查适宜AD生物标志物;④为未来的改进和全球应用建立可行性框架。专家组对于当前可用的证据、工具和资源进行综述,并进一步考量其在AD居家筛查中的价值。

关键词：认知评估阿尔茨海默病认知障碍痴呆居家筛查