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Glycerol solutions of highly co.centrated biomineral co.nter-ions towards water-responsive mineralization: Demonstration on bacterial cellulose and its application in hard tissue repair

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Nano Research 2024年第3期17卷 2154-2163页

作者： Yunfei Zhao Xiaohao Liu Zhi Zhou Chaobo Feng Nan Luo Jiajun Yan Shuo Tan Yang Lu Feng Chen Bing-Qiang Lu Shisheng He Department of Orthopedic Spinal Pain Research InstituteShanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200072China Department of Preventive Dentistry Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai Research Institute of StomatologyShanghai 200011China

Mineralization has found widespread use in the fabrication of co.posite biomaterials for hard tissue *** current mineralization processes are mainly carried out in neutral aqueous solutions of biomineral co.nter-ions(a pair of cation and anion that form the co.responding minerals at certain co.ditions),which are stable only at very low *** typically results in inefficient mineralization and weak co.trol over biomineral ***,we find that,in the organic solvent glycerol,a variety of biomineral co.nter-ions(e.g.,Ca/PO_(4),Ca/co.(3),Ca/SO_(4),Mg/PO_(4),or Fe/OH)co.responding to distinct biominerals at significantly high co.centrations(up to hundreds-fold greater than those of simulated body fluid(SBF))are able to form translucent and stable solutions(mineralizing solution of highly co.centrated co.nter-ions(MSCIs)),and mineralization can be triggered upon them with external solvents(e.g.,water or ethanol).Furthermore,with pristine bacterial cellulose(BC)membrane as a model,we demonstrate an effective and co.trollable mineralization performance of MSCIs on organic *** approach not only forms the homogeneous biominerals on the BC fibers and in the interspaces,but also provides regulations over mineralization rate,mineral co.tent,phase,and *** resulting mineralized BC membranes(MBCs)exhibit high cytoco.patibility and favor the proliferation of rat bone marrow mesenchymal stem cells(rBMSC).Following this,we prepare a mineralized bone suture(MBS)from MBC for non-weight bearing bone fixation,which then is tested on a rabbit median sternotomy *** shows firm fixation of the rabbit sternum without causing discernible toxicity or inflammatory *** study,by extending the mineralization to the organic solution system of highly co.centrated co.nter-ions,develops a promising strategy to design and build targeted mineral-based co.posites.

关键词： biomineralization organic solvent bacterial cellulose(BC) hard tissue repair

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Enhanced wear resistance,antibacterial performance,and bioco.patibility using nanotubes co.taining nano-Ag and bioceramics in vitro

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Bio-Design and Manufacturing 2024年第5期7卷 670-686页

作者： Qingge Wang Jia Liu Hong Wu Jingbo Liu Yaojia Ren Luxin Liang Xinxin Yan Ian Baker Shifeng Liu V.V.Uglov Chengliang Yang Liqiang Wang State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Affiliated Hospital of Youjiang Medical University for Nationalities Guangxi Key Laboratory for Preclinical and Translational Research on Bone and Joint Degenerative DiseasesGuangxi Zhuang Autonomous Region Engineering Research Center for Biomaterials in Bone and Joint Degenerative DiseasesGuangxi Key Laboratory for Biomedical Material ResearchBaise 533000China Department of Orthopedics The Second Xiangya HospitalCentral South UniversityChangsha 410011China Department of Orthopedics Renmin HospitalWuhan UniversityWuhan 430060China Thayer School of Engineering Dartmouth CollegeHanoverNH 03755-8000USA School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an 710055China Belarusian State University 220030 MinskBelarus State Key Laboratory of Metal Matrix co.posites School of Material Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China

A good Ti-based joint implant should prevent stress shielding and achieve good bioactivity and anti-infection *** meet these requirements,the low-elastic-modulus alloy—Ti–35Nb–2Ta–3Zr—was used as the substrate,and functional co.tings that co.tained bioceramics and Ag ions were prepared for co.ting on TiO_(2)nanotubes(diameter:(80±20)nm and(150±40)nm)using anodization,deposition,and spin-co.ting *** effects of the bioceramics(nano-β-tricalcium phosphate,microhydroxyapatite(micro-HA),and meso-CaSiO_(3))and Ag nanoparticles(size:(50±20)nm)on the antibacterial activity and the triboco.rosion,co.rosion,and early in vitro osteogenic behaviors of the nanotubes were *** triboco.rosion and co.rosion results showed that the wear rate and co.rosive rate were highly dependent on the features of the nanotube ***-HA showed great wear resistance with a wear rate of(1.26±0.06)×10^(−3)mm^(3)/(N·m)due to adhesive and ***-CaSiO_(3)showed enhanced cell adhesion,proliferation,and alkaline phosphatase *** co.tings that co.tained nano-Ag exhibited good antibacterial activity with an antibacterial rate of≥89.5%against Escherichia *** findings indicate that hybrid co.tings may have the potential to accelerate osteogenesis.

关键词： βTi alloy Surface modification Wear resistance co.rosion resistance Osteogenic behavior Antibacterial activity

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Simple-structured hydrophilic sensors for sweat uric acid detection with laser-engraved polyimide electrodes and cellulose paper substrates

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Chinese Chemical Letters 2024年第3期35卷 443-448页

作者： Linhe Xu Xueshan Hu Shuang Zhou Ze Zhang Junxian Zhang Chao Li Daxian Zuo Hao Liu Gang Chen Jiayu Wan Jinsong Tao State Key Lab of Pulp and Paper Engineering South China University of TechnologyGuangzhou 510640China Future Battery Research Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240China

Accurate detection of uric acid(UA)is crucial for diagnosing gout,yet traditional sweat-based UA sensors co.tinue to face challenges posed by co.plex and co.tly electrode fabrication methods,as well as weakly hydrophilic ***,we designed and developed simple,low-co.t,and hydrophilic sweat UA detection sensors co.structed by carbon electrodes and cellulose paper *** carbon electrodes were made by carbonized polyimide films through a simple,one-step laser engraving *** electrodes are porous,possess a large specific surface area,and are flexible and *** substrates were co.posed of highly hydrophilic cellulose paper that can effectively co.lect,store,and transport *** co.structed electrodes demonstrate high sensitivity of 0.4μA Lμmol^(-1)cm^(-2),wide linear range of 2–100μmol/*** addition,our electrodes demonstrate high selectivity,excellent reproducibility,high flexibility,and outstanding stability against mechanical bending,temperature variations,and extended storage ***,our sensors have been proven to provide reliable results when detecting UA levels in real sweat and on real human *** envision that these sensors hold enormous potential for use in the prognosis,diagnosis,and treatment of gout.

关键词： Laser-engraved carbon Polyimide Cellulose paper Hydrophilicity Sweat uric acid

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Development of a low-co.t GPS/INS integrated system for tractor automatic navigation

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International Journal of Agricultural and Biological Engineering 2017年第2期10卷 123-131页

作者： Xiongzhe Han Hak-Jin Kim Chan Woo Jeon Hee Chang Moon Jung Hun Kim Dept.of Biosystems and biomaterials Engineering College of Agriculture and Life SciencesSeoul National University.Seoul 08826Republic of Korea Unmanned Solutions co. Seoul 06643Republic of Korea R&D Institute Tong Yang Moolsan Co.LTDChungcheongnam-do 32530Republic of Korea

The use of low-co.t single GPS receivers and inertial sensors for auto-guidance applications has been limited by their reduced accuracy and signal drift over time co.pared to real-time kinematic(RTK)differential GPS units and fiber-optic gyrosco.e(FOG)*** this study,a prototype low-co.t GPS/INS integrated system co.sisting of a triangle-shaped array of three Garmin 19x GPS receivers and an Xsens inertial measurement unit(IMU)to improve the accuracy of position and heading angle measured with a single GPS receiver was developed.A triangular algorithm that uses data co.lected from the three single GPSs mounted on the angular points of a triangular frame was designed.A sensor fusion algorithm based on the Kalman filter co.bining the GPS and IMU data was developed by integrating position data and heading angles of a triangular array of GPS *** optimized values of two noise co.ariance matrixes(Q and R)for the Kalman filtering were determined using the Central co.posite Design(CCD)*** co.pared to the use of a single Garmin GPS receiver,use of the developed GPS/INS system showed improved accuracy performance in terms of both position and heading angle,with reductions in root mean square errors(RMSEs)from 2.7 m to 0.64 m for position and from 8.9ºto 2.1ºfor heading *** accuracy improvements show new potential for agricultural auto-guidance applications.

关键词： global positioning system tractor automatic navigation sensor fusion Kalman filter inertial sensor heading angle

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RETRACTED ARTICLE Recent progress in AFM studies of biodegradable poly(lactic acid) materials

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Chinese Science Bulletin 2012年第27期57卷 3660-3660页

作者： ZENG Chao Zhang NaiWen REN jie Institute of Nano- and Bio-polymeric Materials School ~fMaterials Science and Engineering Tongji University Shanghai 200092 China shanghat tong-jie-hang biomaterials co. Ltd Shanghai 200438 China Key Laboratory of Advanced Civil Engineering Materials Ministry nfEducation Tongji University Shanghai 200092 China

The authors have voluntarily retracted article [Zeng C,Zhang N W,Ren *** progress in AFM studies of biodegradable poly(lactic acid) *** Sci Bull,doi:10.1007/s11434-012-5052-z] because of portions of the article are si... 详细信息

关键词：原子力显微镜可生物降解聚乳酸材料回条解聚 PLA DOI

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Cytoco.patibility Evaluation of Grafted IKVAV PLEOF Hydrogels with Bone Marrow Mesenchymal Stem Cells

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Journal of Wuhan University of Technology(Materials Science) 2014年第4期29卷 824-831页

作者：李宾斌 Zhang Ping YIN Yixia QIU tong TAO Yuan WANG Xinyu 李世普 State Key Laboratory of Advanced Technology for Materials Synthesis and Processing and Biomaterials Science and Engineering Research Center Wuhan University of Technology

The novel hydrogels-grafted IKVAV poly（lactide-co.ethylene oxide-co.fumarate）（PLEOF） hydrogels（GIPHs） were developed. The rat bone marrow mesenchymal stem cells（BMMSCs） were employed, and the cell vitality and apoptosis assays were carried out to evaluate the cytoco.ptibility of GIPHs. Our data demonstrated that the infl uence of GIPHs on the proliferation of BMMSCs was in a co.centration and time dependent manner. The proliferative ability of BMMSCs in GIPHs-treated group（100 μg/mL） after 72 h presented a maximum response which was 30.1% more than that of co.trol group. The numbers of apoptotic cells in GIPHs-treated group（100 μg/mL） were just as much as that of co.trol group after 24 h treatment. The GIPHs are able to provide an appropriate environment for BMMSCs survival and proliferation.

关键词： proliferation IKVAV hydrogels vitality apoptosis

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biomaterials affect cell-cell interactions in vitro in tissue engineering

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Journal of Materials Science & Technology 2021年第4期63卷 62-72页

作者： Dan He Haiyan Li Shanghai Jiao tong University Affiliated Sixth People’s Hospital School of Biomedical EngineeringShanghai Jiao Tong University1954 Huashan RoadShanghai 200030China Med-X Research Institute School of Biomedical EngineeringShanghai Jiao Tong University1954 Huashan RoadShanghai200030China

The facts that most tissues or organs co.sist of a variety of cells suggest that interactions between different types of cells play critical roles in tissue or organ *** tissue engineering,the effects of biomaterials on cell-cell interactions have recently attracted increasing attention for better elucidating the mechanisms through which biomaterials promote tissue *** studies have focused on these effects of biomaterials on cell-cell *** this review,co.prehensive information was provided about the existing cell co.culture technologies and the main behavioral modes of cell-cell *** effects of biomaterials on the cell-cell interactions in various types of tissue regeneration have been summarized and *** the end,the existing problems and future perspectives that would help promote the research of biomaterials in tissue engineering have been *** article can help researchers to understand the progress and importance of studying the effects of biomaterials on cell-cell interactions in tissue engineering and to choose the optimal cell-cell co.culture models for designing experiments.

关键词： organs biomaterials culture

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co.trolled release of hydrogen by implantation of magnesium induces P53-mediated tumor cells apoptosis

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Bioactive Materials 2022年第3期7卷 385-396页

作者： Rui Zan Hao Wang Weijie Cai Jiahua Ni Berengere J.C.Luthringer-Feyerabend Wenhui Wang Hongzhou Peng Weiping Ji Jun Yan Jiazeng Xia Yang Song Xiaonong Zhang State Key Laboratory of Metal Matrix co.posites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200240China Institute of Metallic biomaterials Department of Biological CharacterisationHelmholtz-Zentrum Geesthacht(HZG)Geesthacht21502Germany Department of General Surgery and Translational Medicine Center Wuxi No.2 People’s HospitalAffiliated Wuxi Clinical College of Nantong UniversityJiangsu214002China Orthopaedic Department Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai200233China Department of General Surgery Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai200233China Suzhou Origin Medical Technology co.Ltd. Suzhou215513China

Hydrogen has been used to suppress tumor growth with co.siderable *** of hydrogen gas and oral ingestion of hydrogen-rich saline are two co.mon systemic routes of hydrogen *** have developed a topical delivery method of hydrogen at targeted sites through the degradation of magnesium-based ***,the underlying mechanism of hydrogen’s role in cancer treatment remains ***,we investigate the mechanism of tumor cell apoptosis triggered by the hydrogen released from magnesium-based *** find that the localized release of hydrogen increases the expression level of P53 tumor suppressor proteins,as demonstrated by the in vitro RNA sequencing and protein expression ***,the P53 proteins disrupt the membrane potential of mitochondria,activate autophagy,suppress the reactive oxygen species in cancer cells,and finally result in tumor *** anti-tumor efficacy of magnesium-based biomaterials is further validated in vivo by inserting magnesium wire into the subcutaneous tumor in a *** also disco.ered that the minimal hydrogen co.centration from magnesium wires to trigger substantial tumor apoptosis is 91.2μL/mm^(3)per day,which is much lower than that required for hydrogen *** together,these findings reveal the release of H2 from magnesium-based biomaterial exerts its anti-tumoral activity by activating the P53-mediated lysosome-mitochondria apoptosis signaling pathway,which strengthens the therapeutic potential of this biomaterial as localized anti-tumor treatment.

关键词： Biodegradable magnesium Hydrogen Tumor apoptosis Underlying mechanism P53

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High-purity magnesium pin enhances bone co.solidation in distraction osteogenesis via regulating Ptch protein activating Hedgehog-alternative Wnt signaling

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Bioactive Materials 2021年第6期6卷 1563-1574页

作者： Musha Hamushan Weijie Cai Yubo Zhang Zun Ren Jiafei Du Shaoxiang Zhang Changli Zhao Pengfei Cheng Xiaonong Zhang Hao Shen Pei Han Orthopaedic Department Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai200233China Suzhou Origin Medical Technology co.Ltd Suzhou215513China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai200240China

Magnesium alloys are promising biomaterials for orthopedic implants because of their degradability,osteogenic effects,and *** has been proven to promote distraction ***,its mechanism of promoting distraction osteogenesis is not thoroughly *** this work,a high-purity magnesium pin developed and applied in rat femur distraction *** test,radiological and histological analysis suggested that high-purity magnesium pin can promote distraction osteogenesis and shorten the co.solidation *** RNA sequencing investigation found that alternative Wnt signaling was *** further bioinformatics analysis,it was found that the Hedgehog pathway is the upstream signaling pathway of the alternative Wnt *** found that Ptch protein is a potential target of magnesium and verified by molecular dynamics that magnesium ions can bind to Ptch *** co.clusion,HP Mg implants have the potential to enhance bone co.solidation in the DO application,and this process might be via regulating Ptch protein activating Hedgehog-alternative Wnt signaling.

关键词： magnesium purity co.solidation

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Biodegradable magnesium implants:a potential scaffold for bone tumor patients

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Science China Materials 2021年第4期64卷 1007-1020页

作者： Rui Zan Weiping Ji Shuang Qiao Hongliu Wu Wenhui Wang Tianjiao Ji Bangcheng Yang Shaoxiang Zhang co.gfeng Luo Yang Song Jiahua Ni Xiaonong Zhang State Key Laboratory of Metal Matrix co.posites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Orthopedic Surgery Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China Laboratory for biomaterials and Drug Delivery Department of AnesthesiologyBoston Children’s HospitalHarvard Medical SchoolBostonMassachusetts 02115USA Engineering Research Center in biomaterials Sichuan UniversityChengdu 610064China Suzhou Origin Medical Technology co.Ltd. Suzhou 215513China Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMassachusetts 02139USA

Relapse and metastasis of tumor may occur for osteosarco.a(OS)patients after clinical *** metallic scaffolds provide sufficient mechanical support to the defected bone but fail to eradicate recurring *** we report that biodegradable magnesium(Mg)wirebased implant can inhibit OS *** brief,the Mg wires release Mg ions to activate the transport of zinc finger protein Snail1 from cytoplasm to cell nucleus,which induces apoptosis and inhibits proliferation of OS cells through a parallel antitumor signaling pathway of miRNA-181d-5p/TIMP3 and miRNA-181c-5p/NLK ***,the hydrogen gas evolution from Mg wires eliminates intracellular excessive reactive oxygen species,by which the growth of bone tumor cells is *** subcutaneous tumor-bearing experiment of OS cells in nude mice further co.firms that Mg wires can effectively inhibit the growth of tumors and prolong the survival of tumor-bearing *** addition,Mg wires have no toxicity to normal cells and *** results suggest that Mg implant is a potential anti-tumor scaffold for OS patients.

关键词： magnesium wire osteosarco.a inhibition hydrogen evolution Snail1 miRNA-181

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