检索结果-南通市图书馆

Cone-beam computed tomography noise reduction method based on U-Net with convolutional block attention module in proton therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第7期35卷 89-100页

作者： Xing-Yue Ruan Xiu-Fang Li Meng-Ya Guo Mei Chen Ming Lv Rui Li Zhi-Ling Chen shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai201800China University of chinese Academy of Sciences Beijing100049China shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China Department of Radiation Oncology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China shanghai Key Laboratory of Proton therapy Shanghai201801China

Cone-beam computed tomography(CBCT) is mostly used for position verification during the treatment process. However,severe image artifacts in CBCT hinder its direct use in dose calculation and adaptive radiation therapy re-planning for proton therapy. In this study, an improved U-Net neural network named CBAM-U-Net was proposed for CBCT noise reduction in proton therapy, which is a CBCT denoised U-Net network with convolutional block attention modules. The datasets contained 20 groups of head and neck images. The CT images were registered to CBCT images as ground truth. The original CBCT denoised U-Net network, sCTU-Net, was trained for model performance comparison. The synthetic CT(SCT) images generated by CBAM-U-Net and the original sCTU-Net are called CBAM-SCT and U-Net-SCT images, respectively. The HU accuracies of the CT, CBCT, and SCT images were compared using four metrics: mean absolute error(MAE), root mean square error(RMSE), peak signal-to-noise ratio(PSNR), and structure similarity index measure(SSIM). The mean values of the MAE, RMSE, PSNR, and SSIM of CBAM-SCT images were 23.80 HU, 64.63 HU, 52.27 dB, and 0.9919, respectively,which were superior to those of the U-Net-SCT images. To evaluate dosimetric accuracy, the range accuracy was compared for a single-energy proton beam. The γ-index pass rates of a 4 cm × 4 cm scanned field and simple plan were calculated to compare the effects of the noise reduction capabilities of the original U-Net and CBAM-U-Net on the dose calculation results. CBAM-U-Net reduced noise more effectively than sCTU-Net, particularly in high-density tissues. We proposed a CBAM-U-Net model for CBCT noise reduction in proton therapy. Owing to the excellent noise reduction capabilities of CBAM-U-Net, the proposed model provided relatively explicit information regarding patient tissues. Moreover, it maybe be used in dose calculation and adaptive treatment planning in the future.

关键词： Proton therapy Cone-beam CT CBAM-U-Net γ-index

Robust neutralization of SARS-CoV-2 variants including JN.1 and BA.2.87.1 by trivalent XBB vaccine-induced antibodies

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第6期9卷 2359-2361页

作者： Xun Wang Shujun Jiang Wentai Ma Yanliang Zhang Pengfei Wang shanghai Pudong hospital Fudan University Pudong Medical CenterState Key Laboratory of Genetic EngineeringMOE Engineering Research Center of Gene TechnologySchool of Life SciencesShanghai Institute of Infectious Disease and BiosecurityFudan UniversityShanghaiChina Department of Infectious Diseases Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing Research Center for Infectious Diseases of Integrated Traditional Chinese and Western MedicineNanjingJiangsuChina Beijing Institute of Genomics Chinese Academy of SciencesUniversity of Chinese Academy of Sciences and China National Center for BioinformationBeijingChina

Dear Editor,The rapid and widespread transmission of SARS-CoV-2 has led to the emergence of multiple variants of concern(VOCs),most notably the Omicron variant,which continues to evolve and diversify into a range of *** previous research has shown that these Omicron sub-lineages,spanning BA.1-BA.2.86,have been evolving to exhibit increased neutralization escape capabilities.

关键词： evolve neutralization variants

Network-based pharmacology and experimental validation to explore the mechanism of action of the Jiawei Pentongling formula(加味盆痛灵方) for the treatment of endometriosis-related pain

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of traditional chinese medicine 2024年第5期44卷 991-999页

作者： YU Siyun ZHANG Shiwen XIA Yu LIU Xiaoqing LIU Yajie FU Jinrong Department of Gynecology Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

OBJECTIVE: To investigate the effects and mechanisms of the Jiawei Pentongling formula(加味盆痛灵方, JWPTL) in treating endometriosis-related pain using network pharmacology study and experimental validation. METHODS: Active ingredients and relevant targets of JWPTL, as well as genes for endometriosis-related pain, were collected from public databases. Prediction of core targets and pathways of JWPTL against pain associated with endometriosis by protein-protein interaction(PPI) network work, gene ontology(GO), and Kyoto Encyclopedia of Genes and Genomes(KEGG) functional enrichment analysis. The Sprague-Dawley rat endometriosis model was constructed using the autologous endosomal transplantation method, and the successfully modeled rats were randomly divided into the model group and the JWPTL group, with 8 rats in each group. Another 8 rats were set up in the sham group. Rats in the JWPTL group used the rectal delivery method with the addition of JWPTL(7.77 g·kg-1·d-1) once a day for 28 d. Rats in the model and sham-operated groups were given equal amounts of saline using the same administration method. The 50% paw withdrawal threshold(PWT) of the rats was measured at different time points. After the intervention, the expression of phosphatidylinositol 3-kinase(PI3K) and protein kinase B(Akt) proteins and mRNA in endometriotic tissues was detected by immuneohistochemistry and reverse transcription-polymerase chain reaction. RESULTS: From GeneCards, Online Mendelian Inheritance in Man and other databases, a total of 964 endometriosis(EMs)-related pain targets were screened, 142 active ingredients of JWPTL, 605 targets, and 221 potential targets were obtained by intersection of Venn diagram; 44 core targets were identified by constructing PPI network. KEGG enrichment analysis showed that JWPTL mainly involves the PI3K-Akt signaling pathway, estrogen signaling pathway, hypoxia inducible factor-1 signaling pathway, tumour necrotizing factor signaling pathway, and other signali

关键词： Endometriosis-related pain Jiawei Pentongling formula Signal Transduction network pharmacology phosphatidylinositol 3-kinase proto-oncogene proteins c-akt

Integration of serum pharmacochemistry with network pharmacology to reveal the potential mechanism of Yangqing Chenfei formula(养清尘肺方) for the treatment of silicosis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of traditional chinese medicine 2024年第4期44卷 784-793页

作者： HU Yuanyuan LIU Xinguang ZHAO Peng WU Jinyan YAN Xinhua HOU Runsu WANG Xiangcheng YANG Fan TIAN Xinrong LI Jiansheng Longhua hospital shanghai University of traditional chinese medicine Shanghai University of Traditional Chinese MedicineShanghai 200032China Co-construction Collaborative Innovation Center for chinese medicine and Respiratory Diseases by Henan and Education Ministry of P.R.China.Zhengzhou 450046China Henan Key Laboratory of chinese medicine for Respiratory Disease Henan University of Chinese MedicineZhengzhou 450046China

OBJECTIVE:To explore the mechanisms of Yangqing Chenfei formula(养清尘肺方,YCF)in the treatment of silicosis through a comprehensive strategy consisting of serum pharmacochemistry,network pharmacology analysis,and in vitro ***:An ultrahigh-performance liquid chromatography-tandem mass spectrometry method was used to confirm the active components in YCF-medicated ***,we obtained targets for active components and genes for silicosis from multiple ***,a protein-protein interaction network was constructed,and Kyoto Encyclopedia of Genes and Genomes pathway and biological process analyses were conducted to elucidate the mechanisms of YCF for the treatment of ***,we validated the important components and mechanisms in ***:Altogether,19 active components were identified from rat serum after YCF *** identified 724 targets for 19 components,which were mainly related to inflammation[phosphatidy linositol 3 kinase/protein kinase B,forkhead box O,hypoxia inducible factor,and T-cell receptor signaling pathway,nitric oxide biosynthetic process],fibrotic processes[vascular endothelial growth factor signaling pathway,extracellular signal regulated kinase(ERK)1 and ERK2 cascade,smooth muscle cell proliferation],and apoptosis(negative regulation of apoptotic process).In addition,218 genes for silicosis were identified and were mainly associated with the inflammatory response and immune process[cytokine-cytokine receptor interaction,tumor necrosis factor alpha(TNF-α),toll-like receptor,and nucleotide binding oligomerization domain-like receptor signaling pathway].Taking an intersection of active component targets and silicosis genes,we obtained 61 common genes that were mainly related to the inflammatory response and apoptosis,such as the phosphatidylinositol-3-kinase/protein kinase B signaling pathway,mitogen activated protein kinases signaling pathway,TNF signaling pathway,toll-like receptor signaling pathway,b

关键词： silicosis network treatment

chinese herbal medicine Ginkgo biloba *** for ischemic stroke:An overview of systematic reviews and meta-analyses

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative medicine 2024年第2期22卷 163-179页

作者： Tian-tian Meng Ya-ping You Min Li Jian-bo Guo Xin-bin Song Jing-yi Ding Xiao-long Xie An-qi Li Shang-jin Li Xiang-jun Yin Peng Wang Zhe Wang Bao-liang Wang Qing-yong He Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100032China Department of Rehabilitation Dongfang HospitalBeijing University of Chinese MedicineBeijing 100071China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of chinese medicine the University of Hong KongHong KongChina Graduate School Henan University of Chinese MedicineZhengzhou 450008Henan ProvinceChina Department of Acupuncture and Moxibustion Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100010China Department of Cardiology Guang’anmen HospitalChina Academy of Chinese Medical SciencesZhengzhou 450008Henan ProvinceChina School of Integrated traditional chinese and western medicine Southwest Medical UniversityHangzhou 310053Zhejiang ProvinceChina School of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhu 310053Zhejang ProvinceChina Department of Neurology the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450003Henan ProvinceChina

Background:Ginkgo biloba ***(GBLPs)are a class of chinese herbal medicine used in the adjuvant treatment of ischemic stroke(IS).Recently,several systematic reviews(SRs)and meta-analyses(MAs)of GBLPs for IS have been ***:This overview aims to assess the quality of related SRs and *** strategy:Pub Med,Embase,Cochrane Library,Web of Science,chinese Biological medicine,China National Knowledge Infrastructure,Wanfang,and chinese Science and Technology Journals databases were searched from their inception to December 31,*** criteria:SRs and MAs of randomized controlled trials(RCTs)that explored the efficacy of GBLPs for patients with IS were *** extraction and analysis:Two independent reviewers extracted data and assessed the methodological quality,risk of bias(ROB),reporting quality,and credibility of evidence of the included SRs and MAs using A Measurement Tool to Assess Systematic Reviews 2(AMSTAR 2),Risk of Bias in Systematic Reviews(ROBIS),the Preferred Reporting Items for Systematic Reviews and Meta-analyses(PRISMA),and the Grading of Recommendations Assessment,Development and Evaluation(GRADE),***,descriptive analysis and data synthesis were ***:Twenty-nine SRs/MAs involving 119 outcomes were included in this *** overall methodological quality of all SRs/MAs was critically low based on AMSTAR 2,and 28 had a high ROB based on the *** to the PRISMA statement,the reporting items of the included SRs/MAs are relatively *** results based on GRADE showed that of the 119 outcomes,8 were rated as moderate quality,24 as low quality,and 87 as very low *** on the data synthesis,GBLPs used in conjunction with conventional treatment were superior to conventional treatment alone for decreasing neurological function ***:GBLPs can be considered a beneficial supplemental therapy for ***,because of the low quality of the existing eviden

关键词： statement synthesis alone

The role of m^(6)A RNA methylation in autoimmune diseases: Novel therapeutic opportunities

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第1期11卷 252-267页

作者： Yunan Shan Wei Chen Yanbin Li The First Clinical Medical College Shandong University of Traditional Chinese MedicineJinanShandong 250013China Department of Neurology The First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qjanfoshan HospitalShandong Institute of NeuroimmunologyShandong Key Laboratory of Rheumatic Disease and Translational MedicineJinanShandong 250013China Department of Gastroenterology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China

N6-methyladenosine m^(6)A modifications,as one of the most common forms of in-ternal RNA chemical modifications in eukaryotic cells,have gained increasing attention in recent *** m^(6)A RNA modifications exert various crucial roles in various biological pro-cesses,such as embryonic development,neurogenesis,circadian rhythms,and *** advances have highlighted that m^(6)A RNA modification plays an important role in im-mune response,especially in the initiation and progression of autoimmune *** this re-view,we summarized the regulatory mechanisms of m^(6)A methylation and its biological functions in the immune system and mainly focused on recent progress in research on the po-tential role of m^(6)A RNA methylation in the pathogenesis of autoimmune diseases,thus providing possible biomarkers and potential targets for the prevention and treatment of auto-immunediseases.

关键词： Adaptive immunity Autoimmune diseases Innate immunity Immune response m^(6)A RNA methylation

Clinical practice guideline for acupuncture and moxibustion: Female urinary incontinence

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative medicine 2024年第3期22卷 258-269页

作者： Chao Yang Shan-ze Wang Sheng Chen Shuo Du Guan-qun Wang Wei Guo Xiao-long Xie Bi-hui Peng Shi-hao Du Ji-ping Zhao Department of Acupuncture and Moxibustion Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Department of Acupuncture and Moxibustion Guangdong provincial hospital of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina shanghai Ninth People’s hospital Shanghai Jiao Tong University School of MedicineShanghai 200011China Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing 100700China

Urinary incontinence (UI) is a common problem *** has a major impact on physical and social activities and interpersonal *** is common in women,but is under-reported and *** affects the quality of life of female patients *** and moxibustion have been proposed as potentially effective interventions for female ***,for the benefit of acupuncture practitioners around the world,the World Federation of Acupuncture-moxibustion Societies initiated a project to develop a clinical practice guideline (CPG) for the use of acupuncture and moxibustion to treat female *** CPG was developed according to the Grading of Recommendations Assessment,Development,and Evaluation (GRADE) methodology,referring to the principles of the World Health Organization Handbook for Guideline *** the development of the CPG,the guideline development group (GDG) played an important *** clinical questions,recommendations and therapeutic protocols were all formulated by GDG using the modified Delphi *** CPG contains ten recommendations about the use of acupuncture and moxibustion interventions for ten clinical questions,which include nine conditional recommendations for the intervention and one conditional recommendation for either the intervention or the *** CPG also provides one protocol for conventional filiform needle therapy,two therapy protocols for deep needling stimulation on lumbosacral acupoints,and four moxibustion therapy protocols,based on the protocols presented in randomized controlled trials reviewed by the GDG.

关键词： Acupuncture Clinical practice guideline Female urinary incontinence Moxibustion GRADE

Dominant negative effect as a novel mechanism of SPAST gene mutation in a large family with hereditary spastic paraplegia

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第5期11卷 74-77页

作者： Ke Deng Haibo Ruan Feifei Yu Zhenle Pei Congjian Xu Shuo Zhang shanghai Ji Ai Genetics&IVF Institute Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200000China shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai 200000China The First People’s hospital of Wenling WenlingZhejiang 317500China Rushan hospital of traditional chinese medicine RushanShandong 264599China Department of Obstetrics and Gynecology Fudan UniversityShanghai 200000China.

Hereditary spastic paraplegia(HSP)is a group of disorders with genetic heterogeneity,lower-extremity weakness,and spasticity are the most common signs and *** is the most frequently disease-causing *** is a microtubule-severing enzyme encoded by SPAST that cleaves long microtubules into short fragments by interacting with other proteins or *** spastic paraplegia type 4(SPG4),which is autosomal dominant,is the clinical subtype associated with SPAST ***4 accounts for up to one-third of all HSP cases and usually presents with isolated lower extremity spasticity,with or without bladder or sensory dysfunction.1 The main cause of SPG4 is believed to be spastin haploinsufficiency,which results from mutations in the SPAST gene.

关键词： bladder insufficiency clinical

Host cyclophilin A facilitates SARS-CoV-2 infection by binding and stabilizing spike on virions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第1期9卷 36-39页

作者： Xiangpeng Sheng Fang Zhu Hong Peng Fan Yang Yi Yang Cong Yang Zhen Wang Wei Chen Deyin Guo Ronggui Hu State Key Laboratory of Molecular Biology Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghaiChina MOE Key Laboratory of Tropical Disease Control Centre for Infection and Immunity StudySchool of MedicineSun Yat-sen UniversityShenzhenChina ICU Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghaiChina

Dear Editor,The novel coronavirus SARS-CoV-2 rapidly evolutes to increase its infectivity and transmissibility,facilitates its immune escape,impairs vaccine efficacy,and currently causes repeated infections in human,which is mainly determined by the accumulated mutations in spike(S).1 Transmembrane S is a heavily glycosylated protein on the surface of the virion as homotrimer,responsible for binding to human angiotensin-converting enzyme 2(hACE2)receptor.2 While the architecture of S trimers has been well studied,how the stability of S is regulated by potential host factors remains unknown.

关键词： ACE2 vaccine infection