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Cell metabolism pathways involved in the pathophysiological changes of diabetic peripheral neuropathy

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Neural Regeneration research 2024年第3期19卷 598-605页

作者： Yaowei Lv Xiangyun Yao Xiao Li Yuanming Ouyang Cunyi Fan Yun Qian Department of Orthopedics Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina shanghai Engineering research center for Orthopaedic Material Innovation and Tissue Regeneration ShanghaiChina Youth science and Technology Innovation Studio of shanghai Jiao Tong University School of Medicine ShanghaiChina College of Fisheries and Life science Shanghai Ocean UniversityShanghaiChina

Diabetic peripheral neuropathy is a common complication of diabetes *** the pathophysiological metabolic mechanism impels the generation of ideal ***,existing limited treatments for diabetic peripheral neuropathy expose the urgent need for cell metabolism *** the lack of comprehensive understanding of energy metabolism changes and related signaling pathways in diabetic peripheral neuropathy,it is essential to explore energy changes and metabolic changes in diabetic peripheral neuropathy to develop suitable treatment *** review summarizes the pathophysiological mechanism of diabetic peripheral neuropathy from the perspective of cellular metabolism and the specific interventions for different metabolic pathways to develop effective treatment *** metabolic mechanisms(e.g.,polyol,hexosamine,protein kinase C pathway)are associated with diabetic peripheral neuropathy,and researchers are looking for more effective treatments through these pathways.

关键词： cell metabolism diabetic peripheral neuropathy peripheral nerve injury protein kinase C pathway reactive oxygen species.

Trace inequalities, isocapacitary inequalities, and regularity of the complex Hessian equations

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science China Mathematics 2024年第3期67卷 557-576页

作者： Jiaxiang Wang Bin Zhou Beijing International center for mathematical research Peking UniversityBeijing 100871China School of mathematical sciences Peking UniversityBeijing 100871China

In this paper, we study the relations between trace inequalities(Sobolev and Moser-Trudinger types), isocapacitary inequalities, and the regularity of the complex Hessian and Monge-Amp`ere equations with respect to a general nonnegative Borel measure. We obtain a quantitative characterization for these relations through the properties of the capacity-minimizing functions.

关键词： complex Monge-Ampère equations plurisubharmonic functions Sobolev inequality Moser-Trudinger inequality

EPR-Net: constructing a non-equilibrium potential landscape via a variational force projection formulation

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National science Review 2024年第7期11卷 135-147页

作者： Yue Zhao Wei Zhang Tiejun Li center for Data science Peking University Zuse Institute Berlin Department of Mathematics and Computer science Freie Universit?t Berlin Laboratory of Mathematics and Applied Mathematics(LMAM)and School of mathematical sciences Peking University center for Machine Learning research Peking University

We present EPR-Net, a novel and effective deep learning approach that tackles a crucial challenge in biophysics: constructing potential landscapes for high-dimensional non-equilibrium steady-state ***-Net leverages a nice mathematical fact that the desired negative potential gradient is simply the orthogonal projection of the driving force of the underlying dynamics in a weighted inner-product ***, our loss function has an intimate connection with the steady entropy production rate(EPR),enabling simultaneous landscape construction and EPR estimation. We introduce an enhanced learning strategy for systems with small noise, and extend our framework to include dimensionality reduction and the state-dependent diffusion coefficient case in a unified fashion. Comparative evaluations on benchmark problems demonstrate the superior accuracy, effectiveness and robustness of EPR-Net compared to existing methods. We apply our approach to challenging biophysical problems, such as an eight-dimensional(8D)limit cycle and a 52D multi-stability problem, which provide accurate solutions and interesting insights on constructed landscapes. With its versatility and power, EPR-Net offers a promising solution for diverse landscape construction problems in biophysics.

关键词： high-dimensional potential landscape non-equilibrium system entropy production rate dimensionality reduction deep learning

An anti-aliasing filtering of quantum images in spatial domain using a pyramid structure

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Chinese Physics B 2024年第5期33卷 223-237页

作者：吴凯周日贵罗佳 College of Information Engineering Shanghai Maritime UniversityShanghai 201306China research center of Intelligent Information Processing and Quantum Intelligent Computing Shanghai 201306China School of Mathematics and Computational science Shangrao Normal UniversityShangrao 334001China

As a part of quantum image processing,quantum image filtering is a crucial technology in the development of quantum ***-pass filtering can effectively achieve anti-aliasing effects on ***,most quantum image filterings are based on classical domains and grayscale images,and there are relatively fewer studies on anti-aliasing in the quantum *** paper proposes a scheme for anti-aliasing filtering based on quantum grayscale and color image scaling in the spatial *** achieves the effect of anti-aliasing filtering on quantum images during the scaling ***,we use the novel enhanced quantum representation(NEQR)and the improved quantum representation of color images(INCQI)to represent classical *** aliasing phenomena are more pronounced when images are scaled down,this paper focuses only on the anti-aliasing effects in the case of ***,we perform anti-aliasing filtering on the quantum representation of the original image and then use bilinear interpolation to scale down the image,achieving the anti-aliasing *** constructed pyramid model is then used to select an appropriate image for upscaling to the original image ***,the complexity of the circuit is *** to the images experiencing aliasing effects solely due to scaling,applying anti-aliasing filtering to the images results in smoother and clearer ***,the anti-aliasing filtering allows for manual intervention to select the desired level of image smoothness.

关键词： quantum color image processing anti-aliasing filtering algorithm quantum multiplier pyramid model

Hydrogen-rich surface of MoC catalysts for efficient CO_(2) hydrogenation induced by a coupled hydrogen donator

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Nano research 2024年第8期17卷 7762-7767页

作者： Dong Xu Si-Yuan Xia Qi-Yuan Li Jie-Sheng Chen Xin-Hao Li School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Jiao Tong UniversityShanghai 200240China

Direct CO_(2) hydrogenation offers an important strategy for promoting the global carbon balance,but high thermodynamic and kinetic stability of CO_(2) has restricted its applicability to only a handful of industrial ***,we introduce a proof-of-concept application of the electron-rich Pt surface to promote hydrogen donation for electron-rich MoC particles acting as hydrogen acceptors,thereby constructing hydrogen-rich surface of MoC active ***,the formed hydrogen-rich and electronrich surface could greatly decrease reaction activation energy to boost the efficient CO_(2) hydrogenation into formic acid over the MoC *** optimized MoC@NC/Pt-0.1(NC:nitrogen-doped carbon)catalyst exhibits a high turnover frequency(TOF)value of 1.2 h^(−1) at a lower temperature of 60℃and a TOF of 24.2 h^(−1) under standard reaction conditions widely used in the literature,exceeding 7 times of MoC@NC catalyst and surpassing the benchmark classical non-noble metal active center-based heterogeneous catalyst.

关键词： electron-rich Pt nanoparticles hydrogen donation hydrogen-rich MoC nanoparticles CO_(2) hydrogenation formic acid

Bolstering the Mechanical Robustness of Supramolecular Polymer Network by Mechanical Bond

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Chinese Journal of Polymer science 2024年第10期42卷 1536-1544,I0012页

作者： Yuan-Hao Wang Jing-Xi Deng Jun Zhao Yi Ding Li Yang Zhao-Ming Zhang Xu-Zhou Yan School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai200240China Frontiers science center for Transformative Molecules Shanghai Jiao Tong UniversityShanghai200240China

Supramolecular polymer networks(SPNs)are celebrated for their dynamic nature,yet they often exhibit inadequate mechanical *** far,the quest to bolster the mechanical resilience of SPNs while preserving their dynamic character presents a formidable ***,we introduce[2]rotaxane into SPN to serve as another cross-link,which could effectively enhance the mechanical robustness of the polymer network without losing the dynamic *** with SPN,the dually cross-linked network(DPN)demonstrates superior breaking strength,Young’s modulus,puncture force and toughness,underscoring its superior ***,the cyclic tensile tests reveal that the energy dissipation capacity of DPN rivals,and in some cases surpasses,that of SPN,owing to the efficient energy dissipation pathway facilitated by[2]*** addition,benefiting from stable topological structure of[2]rotaxane,DPN exhibits accelerated recovery from deformation,indicating superior elasticity compared to *** strategy elevates the performance of SPNs across multiple metrics,presenting a promising avenue for the development of high-performance dynamic materials.

关键词： Rotaxane cross-links Dually cross-linked network Supramolecular polymer network Host-guest recognition Dynamic materials

Azobenzene-based ultrathin peptoid nanoribbons for the potential on highly efficient artificial light-harvesting

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science China Chemistry 2024年第5期67卷 1680-1686页

作者： Zichao Sun Lingrong Zhu Jingze Liu Fan Liu Pengchao Wu Pengliang Sui Haibao Jin Shaoliang Lin shanghai Key Laboratory of Advance Polymeric Materials Frontiers Science Center for Materiobiology and Dynamic ChemistrySchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China

The development of artificial light-harvesting systems based on long-range ordered ultrathin organic nanomaterials(i.e., below3 nm), which were assembled from stimuli-responsive sequence-controlled biomimetic polymers, remains challenging. Herein,we report the self-assembly of azobenzene-containing amphiphilic ternary alternating peptoids to construct photo-responsive ultrathin peptoids nanoribbons(UTPNRs) with a thickness of ~2.3 nm and the length in several micrometers. The pendants hydrophobic conjugate stacking mechanism explained the formation of one-dimensional ultrathin nanostructures, whose thickness was highly dependent on the length of side groups. The photo-isomerization of azobenzene moiety endowed the aggregates with a reversible morphology transformation from UTPNRs to spherical micelles(46.5 nm), upon the alternative irradiation with ultraviolet and visible light. Donor of 4-(2-hydroxyethylamino)-7-nitro-2,1,3-benzoxadiazole(NBD) and acceptor of rhodamine B(RB) were introduced onto the hydrophobic and hydrophilic regions, respectively, to generate photocontrollable artificial light-harvesting systems. Compared with the spheres-based systems, the obtained NBD-UTPNRs@RB composite proved a higher energy transfer efficiency(90.6%) and a lower requirement of RB acceptors in water. A proof-ofconcept use as fluorescent writable ink demonstrated the potential of UTPNRs on information encryption.

关键词： azobenzene-based peptoid ultrathin nanoribbon photo-responsive light-harvesting information encryption

Weak type(1, 1) of the Riesz transform on some direct product manifolds with exponential volume growth

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science China Mathematics 2024年第7期67卷 1599-1622页

作者： Hong-Quan Li Jie-Xiang Zhu School of mathematical sciences Fudan UniversityShanghai200433China center for Applied Mathematics Tianjin UniversityTianjin300072China

In this paper, we are concerned with the Riesz transform on the direct product manifold H^(n)× M,where H^(n) is the n-dimensional real hyperbolic space, and M is a connected complete non-compact Riemannian manifold satisfying the volume doubling property and generalized Gaussian or sub-Gaussian upper estimates for the heat kernel. We establish its weak type(1, 1) property. In addition, we obtain the weak type(1, 1) of the heat maximal operator in the same setting. Our arguments also work for a large class of direct product manifolds with exponential volume growth. Particularly, we provide a simpler proof of weak type(1, 1) boundedness of some operators considered in the work of Li et al.(2016).

关键词： Riesz transform heat kernel direct product real hyperbolic space

Designing High-Porosity Porous Structures with Complex Geometries for Enhanced Thermal Conductivity Using Selective Laser Melting and Heat Treatment

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Acta Metallurgica Sinica(English Letters) 2024年第5期37卷 808-824页

作者： Hulin Tang Xiang Zhang Chenping Zhang Tian Zhou Shiyue Guo Gaopeng Xu Rusheng Zhao Boyoung Hur Xuezheng Yue School of Materials science and Engineering University of Shanghai for Science and TechnologyShanghai 200082China National center for Stomatology National Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyDepartment of Oral Maxillofacial-Head and Neck OncologyShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityShanghai 200011China Longzhong Lab Wuhan of Science and TechnologyYancheng 224000China Tokyo Metropolitan University TokyoJapan Gyeongsang National University JinjuKorea

Rapid advancements in the aerospace industry necessitate the development of unified,lightweight and thermally conductive *** complex geometries,including bionic and porous structures,is paramount in thermally conductive structures to attain improved thermal *** design of two high-porosity porous lattice structures was inspired by pomelo peel structure,using Voronoi parametric *** combining characteristic elements of two high-porostructuressity porous lattice structures designed,a novel high-porosity porous gradient structure is *** structure is based on gradient *** selective laser melting(SLM),fabrication comprises ***-state thermal characteristics are evaluated via finite element analysis(FEA).The experimental thermal conductivity measurements correlate well with simulation results,validating the sequence of K_L as the highest,followed by D_K_L and then D_*** treatment significantly improves thermal conductivity,enhancing the base material by about 45.6%and porous structured samples by approximately 43.7%.

关键词： Selective laser melting Porous lattice structure Thermal conductivity Heat treatment