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chinese Journal of Natural medicines 2021年第8期19卷 591-607页

作者： CAO Ning WANG Chang-Hong The MOE Key Laboratory for standardization of chinese medicines Shanghai R&D Centre for Standardization of Chinese MedicinesInstitute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China

Terpenoid indole(TIAs)andβ-carboline alkaloids(BCAs),such as suppressant reserpine,vasodilatory yohimbine,and antimalarial quinine,are natural compounds derived from *** compounds can exert powerful pharmacological effects but be obtained from limited source in *** whole biosynthetic pathway of TIAs and BCAs,The Pictet–Spengler reaction catalyzed by strictosidine synthase(STr;EC:4.***.3.2)is the rate-limiting ***,it is necessary to investigate their biosynthesis pathways,especially the role of STr,and related findings will support the biosynthetic generation of natural and unnatural *** review summarizes the latest studies concerning the function of STr in TIA and BCA biosynthesis,and illustrates the compounds derived from *** substrate specificity of STr based on its structure is also *** that contain sixbladed four-strandedβ-propeller folds in many organisms,other than plants,are *** presence of these folds may lead to similar functions among *** expression of STr gene can greatly influence the production of many *** is mainly applied to product various valuable drugs in plant cell suspension culture and biosynthesis in other carriers.

关键词： Biosynthesis Pictet-Spengler reaction β-Carboline alkaloids Strictosidine synthase Terpenoid indole

Two new alkaloids from the leaves of Uncaria hirsuta Haviland

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chinese Chemical Letters 2008年第8期19卷 931-933页

作者： Wen Bo Xin Gui Xin Chou Zheng Tao Wang Key Laboratory of standardization of chinese medicines Ministry of Education Institute of Chinese Materia Medica of Shanghai University of Traditional Chinese Medicine Shanghai 201203 China shanghai r＆d center for standardization of chinese medicines 1200 Cailun Road Shanghai 201203 China

Two new alkaloids, uncaric acid A and hirsutaside A, were isolated from Uncaria hirsuta. Their structures were determined by spectroscopic evidences and chemical means.

关键词： U. hirsuta Indole alkaloids

Bear bile powder attenuates senecionine-induced hepatic sinusoidal obstruction syndrome in mice

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chinese Journal of Natural medicines 2022年第4期20卷 270-281页

作者： JIANG Kai-Yuan ZHANG Yi YE Xuan-Ling XIONG Fen CHEN Yan JIA Xia-Li ZHANG Yi-Xin YANG Li XIONG Ai-Zhen WANG Zheng-Tao The MOE Key Laboratory for standardization of chinese medicines and the SATCM Key Laboratory for New resources and Quality Evaluation of chinese medicines Institute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China shanghai r&d center for standardization of traditional chinese medicines Shanghai 201203China Institute of Interdisciplinary Integrative Medicine research Shanghai University of Traditional Chinese MedicineShanghai 201203China

Hepatic sinusoidal obstruction syndrome(HSOS)via exposure to pyrrolizidine alkaloids(PAs)is with high mortality and there is no effective treatment in *** bile powder(BBP)is a famous traditional animal drug for curing a variety of hepatobiliary diseases such as cholestasis,inflammation,and ***,we aim to evaluate the protective effect of BBP against HSOS induced by senecionine,a highly hepatotoxic PA *** results showed that BBP treatment protected mice from senecionine-induced HSOS dose-dependently,which was evident by improved liver histology including reduced infiltration of inflammatory cells and collagen positive cells,alleviated intrahepatic hemorrhage and hepatic sinusoidal endothelial cells,as well as decreased conventional serum liver function *** addition,BBP treatment lowered matrix metalloproteinase 9 and pyrrole-protein adducts,two well-known markers positively associated with the severity of PA-induced *** investigation showed that BBP treatment prevents the development of liver fibrosis by decreasing transforming growth factor beta and downstream fibrotic *** treatment also alleviated senecionine-induced liver inflammation and lowered the pro-inflammatory cytokines,in which taurours-odeoxycholic acid played an important ***’s more,BBP treatment also decreased the accumulation of hydrophobic bile acids,such as cholic acid,taurocholic acid,glycocholic acid,as *** concluded that BBP attenuates senecionine-induced HSOS in mice by repairing the bile acids homeostasis,preventing liver fibrosis,and alleviating liver *** present study helps to pave the way to therapeutic approaches of the treatment of PA-induced liver injury in clinics.

关键词： Hepatic sinusoidal obstruction syndrome Pyrrolizidine alkaloids Bear bile powder Liver disease Bile acids

Identification and Kinetics Study on the Transformation of Mevinolin in Acidic Alcohol Solution by High-performance Liquid Chromatography with Photodiode Array detector or Mass Spectrometry

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Chemical research in chinese Universities 2006年第4期22卷 500-504页

作者： LI Yong-guo LIU Hong ZHANG Fang WANG Zheng-tao HU Zhi-bi Key Laboratory of standardization of chinese medicines of Ministry of Education Institute of Chinese Materia Medica Shanghai University of Traditional Chinese Medicine Shanghai 201203 P.R. China shanghai r ＆ d center for standardization of traditional chinese medicines Shanghai 201203 P.R. China State Key Laboratory of drug research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 P. R. China

Mevinolin is one of the earlier statin drugs which is effective for the treatment of hypercholesterolemia, as an inhibitor of the HMG-CoA reductase. The transformations of mevinolin in acidic alcohol（ such as ethanol, methanol and isopropanol） solutions caused by solvent effects were revealed in the present article. The solvates, that is, mevinolinic methyl ester, mevinolinic ethyl ester and mevinolinic isopropyl ester, were identified by LC/PdA and LC/MS. The kinetics parameters of the transformations caused by solvent effects, such as the observed rate constant of mevinolin （kobs）, the maximum concentration（ Cmax ）, and its corresponding maximum time（ t time for the acid form to reach the maximum concentration） of mevinolinic acid, are discussed. The influencing factors, such as the kind of solvents, the acidic concentration, the initial mevinolin concentration, and the water content as well as temperature were investigated. Two kinds of comparative reactions, hydrolysis and alcoholysis, of mevinolin in solution were studied. This detailed study on the kinetics of mevinolin transformations is valuable and meaningful for the purification, preparation, injection manufacturing, extraction, storage, etc. , of mevinolin or other similar compounds. This work provides useful information for the quality control of mevinolin and mevinolin-like drugs as well.

关键词： Identification Kinetic study Solvates Mevinolin LC-PdA-ESI-MS

Abietane diterpenoids and iridoids from Caryopteris mongolica

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chinese Journal of Natural medicines 2023年第12期21卷 927-937页

作者： ZHANG Shanshan MAO Xudong XU Hongtao WEI Xiaohui CHOU Guixin Institute of chinese Materia Medica Shanghai University of Traditional Chinese MedicineShanghai 201203China shanghai r&d center for standardization of chinese medicines Shanghai 201203China State Key Lab of New drug and Pharmaceutical Process Shanghai Institute of Pharmaceutical IndustryChina State Institute of Pharmaceutical IndustryShanghai 201203China

Six new abietane diterpenoids(1−6)and five undescribed iridoids(7−11)have been isolated from the aerial parts of Caryopteris *** intricate structural characterization of these compounds was meticulously undertaken using an array of advanced spectroscopic *** process was further enhanced by the application of dP4+probability analyses and electronic circular dichroism(ECd)*** isolation and structural elucidation,the cytotoxicity of these compounds was *** them,compound 3 stood out,displaying significant cytotoxic activity against HeLa cells with an IC50 value of 7.83±1.28μmol·L^(−1).Additionally,compounds 1,2,4,9,and 10 manifested moderate cytotoxic effects on specific cell lines,with IC50 values ranging from 11.7 to 20.9μmol·L^(−1).

关键词： Caryopteris mongolica Abietane diterpenoids Spectroscopic analysis Cytotoxicity

Chiral resolution of furofuran lignans and their derivatives from the stems of dendrobium'Sonia'

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chinese Journal of Natural medicines 2024年第10期22卷 937-944页

作者： QIU Kaimei QIU Hao XIE Yanqiao ZHANG Siyu ZHANG Qian WANG Zhengtao HAN Zhuzhen YANG Li The MOE Key Laboratory of standardization of chinese medicines The SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese MedicinesThe Shanghai Key Laboratory for Compound Chinese MedicinesInstitute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China

Five new furofuran lignans and their derivatives,(-)-glaberide I 4-O-β-d-glucopyranoside(1a),(+)-glaberide I 4-O-β-d-glucopyranoside(1b),(+)-glaberide I 7'-ethoxy-4-O-β-d-glucopyranoside(2a),(-)-glaberide I 7'-ethoxy-4-O-β-d-glucopyranoside(2b),and(-)-isoeucommin A(3b),along with fifteen known analogs were isolated from the stems of dendrobium'Sonia'.These compounds were classified into ten pairs of enantiomers or diastereoisomers via chiral resolution,and their structures were determined based on extensive spectroscopic *** absolute configurations were determined by hydrolysis,comparison of experimental and calculated electronic circular dichroism(ECd)data,and single-crystal X-ray diffraction *** isolates were evaluated for their ability to inhibit nitric oxide(NO)production in rAW264.7 *** them,syringaresinol(5)exhibited prominent inhibition activity,with an IC50 value of 28.4±3.0μmol·L~(-1),and there was a slight difference between 5a,5b and the racemic mixture 5.

关键词： Furofuran lignans Chiral resolution Enantiomers diastereoisomers dendrobium'Sonia' Anti-inflammatory

Scutellarein alleviates the dysfunction of inner blood-retinal-barrier initiated by hyperglycemia-stimulated microglia cells

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International Journal of Ophthalmology(English edition) 2020年第10期13卷 1538-1545页

作者： Han Li Xi-Yu Mei Meng-Na Wang Tian-Yu Zhang Yue Zhang Bin Lu Yu-Chen Sheng The MOE Key Laboratory for standardization of chinese medicines Shanghai Key Laboratory of Compound Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese MedicinesInstitute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China center for drug Safety Evaluation and research Innovation Research Institute of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai 201203China

AIM:To investigate the alleviation of scutellarein(SN)against inner blood-retinal-barrier(iBrB)dysfunction in microglia cells stimulated by hyperglycemia and to elucidate the engaged ***:Microglia BV2 cells were stimulated by using 25 mmol/L *** same concentration of mannitol(25 mmol/L)was applied as an isotonic ***-time PCr,Western-blot assay and immunofluorescence staining assay was *** dysfunction of iBrB in vitro was detected by using transendothelial electrical resistance(TEEr)***,the leakage of fluorescein isothiocyanate(FITC)-conjugated dextran(70 kda)was ***:SN abrogated microglia BV2 cells activation and reduced the phosphorylated activation of extracellular signal-regulated protein kinase(ErK)1/*** also decreased the transcriptional activation of nuclear factorκB(NFκB)and the elevated expression of tumor necrosis factorα(TNFα),interleukin(IL)-6 and IL-1βin BV2 cells treated with d-glucose(25 mmol/L).SN attenuated iBrB dysfunction in human retinal endothelial cells(HrECs)or choroid-retinal endothelial rF/6 A cells when those cells were treated with TNFα,IL-1βor IL-6,or co-cultured with microglia cells stimulated by ***,SN restored the decreased protein expression of tight junctions(TJs)in TNFα-treated HrECs and rF/6 A ***:SN not only alleviate iBrB dysfunction via directly inhibiting retinal endothelial injury caused by TNFα,IL-1βor IL-6,but also reduce the release of TNFα,IL-1βand IL-6 from microglia cells by abrogating hyperglycemia-mediated the activation of microglia cells.

关键词： scutellarein blood-retinal-barrier tight junctions inflammation tumor necrosis factorα

Two new triterpenoids from Psidium guajava

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chinese Chemical Letters 2012年第7期23卷 827-830页

作者： Ji Cheng Shu Jian Qun Liu Gui Xin Chou Zheng Tao Wang The MOE Key Laboratory for standardization of chinese medicines and SATCM Key Laboratory for New resources and Quality Evaluation of chinese medicines Institute of Chinese Materlaz Medica of Shanghai University of Traditional Chinese MedicineShanghai 201203China Key Laboratory of Modern Preparation of traditional chinese medicines Ministry of EducationNanchang 330004China

Two new triterpenoids,named as 2 α,3 β,23-trihydroxylurs-12,20（30）-dien-28-oic acid β-d-glucopyranoside（1）,and 2 α,3 β,6 β,20 β,23,30-hexahydroxyurs-12-en-28-oic acid（2）,together with four known triterpenoids were isolated from the leaves of Psidium guajava *** structures were elucidated on the basis of mass and spectral evidence.

关键词： Psidium guajava Triterpcnoid

A novel cytotoxic neophysalin from Physalis alkekengi ***

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chinese Chemical Letters 2009年第11期20卷 1327-1330页

作者： Chu Hang Zhang Zheng Tao Wang Yi Ping Yang Qi Shi Sun School of traditional chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China Key Laboratory of standardization of chinese medicines of Ministry of Education Institute of chinese Materia Medica Shanghai University of Traditional Chinese Medicine Shanghai 201203 China

A new neophysalin, named 5α-hydroxy-25,27-dihydro-4,7-didehydro-7-deoxyneophysalin A（1）, along with three other known neophysalins （2-4） were isolated from the calyxes of Physalis alkekengi L. *** （Mast.） Makino. The structure of 1 was determined by means of 1d and 2d NMr, UV, Ir and mass spectra. Compound 1 displayed potent cytotoxicities in vitro against PC- 3 and LNCaP cell lines.

关键词： Physalis alkekengi var. francheti Neophysalin Cytotoxicity

New Triterpene Saponins and Flavonol Glycosides from the Leaves of Ilex cornuta

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chinese Journal of Chemistry 2006年第4期24卷 577-579页

作者：李颜吴弢程志红王峥涛 Key Laboratory of standardization of chinese medicines Ministry of Education Insititute of Chinese Materia Medica Shanghai University of Traditional Chinese Medicine Shanghai 201203 China shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China

A new triterpene glycoside, pomolic acid 3-O-6″-methyl-β-d-glucuronopyranosyl-（1→3）-α-L-arabino- pyranoside, and a new flavonol glycoside, quercetin 3-O-β-d-glucopyranosyl-（1→2）-α-L-arabinopyranoside together with three known triterpene saponins and two flavonol glycosides, were isolated from the leaves of Ilex cornuta. Their structures were established on the basis of spectroscopic analysis.

关键词： Ilex cornuta aquifoliaceae triterpene glycoside flavonol glycoside