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Effectiveness of C-reactive Protein as a Tuberculosis Screening Test Among HIV-Infected Individuals—shanghai,China,2021-2023

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China CdC weekly 2024年第35期6卷 891-895页

作者： Lixin rao Zheyuan Wu Jing Chen Zhen Ning Xin Shen shanghai Municipal center for disease Control and Prevention ShanghaiChina

Summary What is already known about this topic?The World Health Organization(WHO)has recommended the inclusion of the C-reactive protein(CrP)test in active tuberculosis(ATB)screening algorithms among human immunodeficiency virus(HIV)-infected *** performance of the CrP test in African regions has been *** is added by this report?This study analyzed data from a big data platform of shanghai medical records together with infectious disease surveillance systems.

关键词： Infect tuberculosis records

Laser ablation mechanism and performance of glass fiber-reinforced phenolic composites:An experimental study and dual-scale modelling

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Chinese Journal of Aeronautics 2024年第8期37卷 470-485页

作者： ran BI Pengfei SHEN Longyu ZHU Zhengzheng MA Chuyang LUO Yongfeng LI Lijian PAN shanghai Key Laboratory of Lightweight Composite Donghua UniversityShanghai 201620China shanghai High Performance Fibers and Composites center(Province-Ministry Joint) Center for Civil Aviation CompositesDonghua UniversityShanghai 201620China AVIC Composite Corporation Ltd Beijing 101300China

Both experimental and simulation approaches were employed to investigate the laser ablation mechanism and performances of Glass Fiber reinforced Phenolic Composites(GFrP).during the ablation process,the difference in thermal conductivities of the glass fibers and the resin matrix as well as their discrepant physical and chemical reactions form a conical ablation *** formation of a residual carbon layer effectively mitigates the ablation rate in the thickness direction.A higher power density results in a faster ablation rate,while a longer irradiation time leads to a larger ablation pit *** account for the variation in thermal conductivity between the fiber and resin,a macro-mesoscale model was developed to differentiate the matrix from the fiber *** element analysis revealed that laser irradiation leads to phenolic decomposition,glass fiber melting vaporization,and residual carbon skeleton *** dual-scale model exhibits precise prediction capabilities concerning the laser ablation process of GFrP,and its accuracy is confirmed through the comparison of simulation and experimental results for the GFrP laser ablation *** model provides a feasible method for performance evaluation and lifetime prediction of GFrP subjected to continuous wave laser irradiation.

关键词： Polymer-matrix composites Continuous-wave laser Microstructural analysis Ablation mechanism Finite element method

Efficacy of physiological seawater nasal irrigation for the treatment of children with SArS-CoV-2 Omicron BA.2 variant infection:a randomized controlled trial

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World Journal of Pediatrics 2024年第5期20卷 461-469页

作者： Ji-Lei Lin Fen Zhang Yan-Bo Li Shu-Hua Yuan Jin-Hong Wu Jing Zhang Lei Zhang Yi He Jie Chen Yong Yin department of respiratory Medicine Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong University1678 Dongfang RoadPudong DistrictShanghaiChina University of British Columbia VancouverCanada Information Technology department Shanghai Children’s Medical Center National Children’s Medical CenterSchool of MedicineShanghai Jiao Tong University1678 Dongfang RoadPudong DistrictShanghaiChina department of Otorhinolaryngology Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong University1678 Dongfang RoadPudong DistrictShanghaiChina department of respiratory Medicine Sanya Women and Children’s Hospital Affiliated to Hainan Medical CollegeHainan Branch of Shanghai Children’s Medical CenterSanyaChina department of respiratory Medicine Linyi Maternal and Child Healthcare HospitalLinyiChina shanghai Children’s Medical center Pediatric Medical Complex(Pudong) ShanghaiChina Pediatric AI Clinical Application and research center Shanghai Children’s Medical CenterShanghaiChina

Background Saline nasal irrigation is an effective therapy for relieving common cold *** study aimed to investigate and explore the efficacy of physiological seawater nasal irrigation(PSNI)on children with mild and asymptomatic infection with *** This randomized controlled trial was conducted in shanghai,China,and 403 children with mild and asymptomatic infection with Omicron were *** children were allocated into the PSNI group and the control *** primary outcome was the duration of viral shedding(dVS),and the secondary outcome was the change in clinical *** The median age of all participants was 5.59(6.26)years *** dVS was significantly shorter in the PSNI group[2.40(1.13)]than in the control group[3.09(2.14)](P=0.014).The multivariable Cox regression model also showed that patients in the PSNI group had an increased probability of shorter dVS compared with patients in the control group[hazard ratio(Hr),1.27;95%confidence interval(CI),1.04–1.55;P=0.017].Subgroup analysis suggested that the dVS of patients without full vaccination was significantly reduced in the PSNI *** proportions of runny nose and stuffy nose were apparently reduced in the first three days in the PSNI group or the control group,but there was no evidence showing that PSNI contributes to the benefit compared with the control *** PSNI can reduce the dVS of patients with mild and asymptomatic infection with SArS-CoV-2 Omicron BA.2 variant.

关键词： Children duration of viral shedding Omicron Physiological seawater nasal irrigation

TCErG1L hypermethylation is a risk factor of diabetic retinopathy in Chinese children with type 1 diabetes

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 537-544页

作者： Yu Qian Ying Xiao Qiu-rong Lin Zhao-Yu Xiang Li-Pu Cui Jia-Qi Sun Si-Cong Li Xin-ran Qin Hai-dong Zou Chen-Hao Yang Pei-Yao Jin department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai First People’s HospitalShanghai 200080China shanghai Eye diseases Prevention&Treatment center Shanghai Eye HospitalShanghai 200040China National Clinical research center for Eye diseases Shanghai Clinical Research Center for Eye DiseasesShanghai Key Clinical SpecialtyShanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghai 200080China department of Ophthalmology Children’s Hospital of Fudan UniversityShanghai 201102China

●AIM:To identify the differential methylation sites(dMS)and their according genes associated with diabetic retinopathy(dr)development in type 1 diabetes(T1dM)children.●METHOdS:This study consists of two surveys.A total of 40 T1dM children was included in the first *** no participant has dr,retina thinning was used as a surrogate indicator for *** lowest 25%participants with the thinnest macular retinal thickness were included into the case group,and the others were *** dNA methylation status was assessed by the Illumina methylation 850K array BeadChip assay,and compared between the case and control *** dMS with a potential role in diabetes were *** second survey included 27 T1dM children,among which four had *** methylation patterns of the four dMS identified by 850K were compared between participants with and without dr by pyrosequencing.●rESULTS:In the first survey,the 850K array revealed 751 sites significantly and differentially methylated in the case group comparing with the controls(|Δβ|>0.1 and Adj.Pd 328 of these were identified with a significance of Adj.Pre hypermethylated and 432 were hypomethylated in the case group relative to the *** revealed that the transcription elongation regulator 1 like(TCErG1L,cg07684215)gene was hypermethylated in the four T1dM children with dr(P=0.018),which was consistent with the result from the first *** methylation status of the other three dMS(cg26389052,cg25192647,and cg05413694)showed no difference(all P>0.05)between participants with and without dr.●CONCLUSION:The hypermethylation of the TCErG1L gene is a risk factor for dr development in Chinese children with T1dM.

关键词： dNA methylation 850K array pyrosequencing diabetic retinopathy type 1 diabetes children

Quantifying the solid electrolyte interphase stress induced capacity fading of lithium-ion batteries via a multiscale mechanical-electrochemical coupling model

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Science China Technological Sciences 2024年第10期67卷 3168-3181页

作者： HE YaoLong XU Peng JIANG dengFeng HU HongJiu LI daWei SHI SiQi shanghai Institute of Applied Mathematics and Mechanics School of Mechanics and Engineering ScienceShanghai University shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai University shanghai Frontier Science center of Mechanoinformatics Shanghai University School of Mechanical Engineering University of Shanghai for Science and Technology School of Materials Science and Engineering Shanghai University Materials Genome Institute Shanghai University

The solid electrolyte interphase（SEI） is widely recognized as a critical factor leading to the capacity fading of lithium-ion batteries（LIBs）. Although SEI stress-related mechanical failure caused by the expansion or contraction of active materials upon cycles is well documented, previously reported SEI components and overpotential varying phenomena due to SEI stress and their effects on the electrochemical performance are poorly understood. Here, we establish a quantitative correlation between capacity fading and the SEI stress by considering its effects on side reactions, especially SEI component evolution, in a multiscale mechanical-electrochemical coupling model. Furthermore, the capacity fading behaviors of two typical cells（Li[NiMnCo]O2as the cathode, and graphite and silicon as the anode, respectively） were adopted as numerical examples to demonstrate its potential utility and applications. Stress within the SEI was indeed found to play a predominant role in the capacity fading of the graphite and silicon anodes, resulting in 27% and 69% of the total capacity loss after 200 and 100 cycles at 1 C, respectively. This study provides valuable mechanical insights into the variations of SEI properties related to the capacity degradation and SEI optimization and design for LIBs.

关键词： solid electrolyte interphase capacity fading multiscale mechanical-electrochemical coupling stress analysis

Open-vessel Synthesis of Poly-N-methoxyethylglycine

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Chemical research in Chinese Universities 2024年第1期40卷 153-158页

作者： LIU Guojan MA Ke CHEN Qi ZHANG donghui LIU runhui State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai200237P.R.China Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic ChemistryShanghai Frontiers Science Center of Optogenetic Techniques for Cell MetabolismResearch Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237P.R.China School of Biotechnology East China University of Science and TechnologyShanghai200237P.R.China

Polypeptoids are widely used in biological applications owing to their diverse functions and proteolytic *** type of polypeptoids,poly-N-methoxyethylglycine(P-Nmeg),has been found to possess remarkable hydrophilicity and notable properties in terms of protein,cell,and bacterial ***,the currently known synthesis methods of P-Nmeg include solid-phase synthesis,which is time-consuming and difficult to scale up,and N-substituted N-carboxyanhydride(NNCA)ring-opening polymerization,whose monomers were difficult to *** this study,we used the chemical stable Nmeg N-phenoxycarbonyl(NPC)as the monomer,which was obtained without the use of highly toxic reactants,such as phosgene or phosphorus halide,to synthesize P-Nmeg under open-vessel *** adding BnNH_(2) as an initiator at 80℃,we can obtain controllable short chain length P-Nmeg with narrow dispersity.

关键词： Open-vessel Polypeptoid synthesis Poly-N-methoxyethylglycine Stable monomer Narrow dispersity

MicrorNA (let-7b-5p)-targeted dArS2 regulates lung adenocarcinoma growth by PI3K/AKT signaling pathway

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Oncology research 2024年第3期32卷 517-528页

作者： YUANYUAN XU XIAOKE CHEN department of Oncology Surgery Shanghai Lung Cancer CenterShanghai Chest HospitalShanghai Jiao Tong UniversityShanghaiChina

Background:The aberrant intraellular expression of a mitochondrial aspartyl trNA synthetase 2(dArS2)has been reported in human *** its critical role and detailed mechanism in lung adenocarcinoma(LUAd)remain ***:Initially,The Cancer Genome Atlas(TCGA)based Gene Expression Profiling Interactive Analysis(GEPIA)database (http:/***/)was used to analyze the prognostic relevance of dArS2 expression in ***,cell counting kit(CCK)8,immunostaining,and transwell invasion assays in LUAd cell lines in vitro,as well as dArS2 silence on LUAd by tumorigenicity experiments in wivo in nude mice,were ***,we analyzed the expression levels of p-PI3K(phosphorylated Phosphotylinosital3 kinase),PI3K,AKT(Protein Kinase B),p-AKT(phosphorylated Protein Kinase B),PCNA(proliferating cell nudear antigen),cleaved-caspase 3,E cadherin,and N-cadherin proteins using the Westem blot ***:LUAd tissues showed higher dArS2 expression compared to normal *** of dArS2 could be related to Tumor-Node-Metastasis(TNM)stage,high lymph node metastasis,and inferior ***2 silence decreased the proliferation,migration,and invasion abilities of LUAd *** addition,the dArS2 downregulation decreased the PCNA and N-cadherin expression and increased cleaved:caspase 3 and E cadherin expressions in LUAd cells,coupled with the inactivation of the PI3K/AKT signaling ***,dArS2 silence impaired the tumonigenicity of LUAd in ***,let:7b-5p could recognize dArS2 through a complementary ***,the increased let 7b 5p expression attenuated the promo oncogenic action of dArS2 during LUAd progression,which were inversely correlated to each other in the LUAd tssues Conclusion:In summary,let 7b-5p,downregulated dArS2 expression,regulating the progression of LUAd cells by the PI3K/AKT signaling pathway.

关键词： Lung adenocarcinoma Prognosis PI3K/AKT pathway Mitochondrial asparty-trNA synthetase MicrorNAs

Calcification-associated molecular traits and therapeutic strategies in hormone receptor-positive HEr2-negative breast cancer

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Cancer Biology & Medicine 2024年第5期21卷 400-415页

作者： Yuwei Li Yuzheng Xu Caijin Lin Xi Jin ding Ma Zhiming Shao department of Breast Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Key Laboratory of Breast Cancer in shanghai Fudan University Shanghai Cancer CenterShanghai 200032China department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China

Objective:Mammographic calcifications are a common feature of breast cancer,but their molecular characteristics and treatment implications in hormone receptor-positive(Hr+)/human epidermal growth factor receptor 2-negative(HEr2−)breast cancer remain ***:We retrospectively collected mammography records of an Hr+/HEr2−breast cancer cohort(n=316)with matched clinicopathological,genomic,transcriptomic,and metabolomic *** the basis of mammographic images,we grouped tumors by calcification status into calcification-negative tumors,tumors with probably benign calcifications,tumors with calcification of lowmoderate suspicion for maligancy and tumors with calcification of high suspicion for *** then explored the molecular characteristics associated with each calcification status across multiple ***:Among the different statuses,tumors with probably benign calcifications exhibited elevated hormone receptor immunohistochemical staining scores,estrogen receptor(Er)pathway activation,lipid metabolism,and sensitivity to endocrine *** with calcifications of high suspicion for malignancy had relatively larger tumor sizes,elevated lymph node metastasis incidence,Ki-67 staining scores,genomic instability,cell cycle pathway activation,and may benefit from cyclin-dependent kinase 4 and 6(CdK4/6)***:Our research established links between tumor calcifications and molecular features,thus proposing potential precision treatment strategies for Hr+/HEr2−breast cancer.

关键词： Hr+/HEr2−breast cancer mammographic calcifications molecular features precision treatment

Synchronous deprotonation–protonation for mechanically robust chitin/aramid nanofibers conductive aerogel with excellent pressure sensing, thermal management, and electromagnetic interference shielding

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Nano research 2024年第3期17卷 2038-2049页

作者： Xinxin Zhang Kunpeng Qian Jianhui Fang Sineenat Thaiboonrod Miao Miao Xin Feng department of Chemistry College of SciencesShanghai UniversityShanghai 200444China research center of Nano Science and Technology College of SciencesShanghai UniversityShanghai 200444China School of Materials Sciences and Engineering Shanghai UniversityShanghai 200444China National Nanotechnology center(NANOTEC) National Science and Technology Development Agency(NSTDA)Thailand Science ParkPathum Thani 12120Thailand

Aerogels with regularly porous structure and uniformly distributed conductive networks have received extensive attention in wearable electronic sensors,electromagnetic shielding,and so ***,the poor mechanical properties of the emerging nanofibers-based aerogels are limited in practical *** this work,we developed a synchronous deprotonation–protonation method in the KOH/dimethyl sulfoxide(dMSO)system at room temperature for achieving chitin cross-linked aramid nanofibers(CANFs)rather than chitin nanofibers(ChNFs)and aramid nanofibers(ANFs)separately by using chitin and aramid pulp as raw *** freeze-drying process,the cross-linked chitin/aramid nanofibers(CA)aerogel exhibited the synergetic properties of ChNF and ANF by the dual-nanofiber compensation *** mechanical stress of CA aerogel was 170 kPa at 80%compressive strain,increased by 750%compared with pure ChNF ***,the compressibility of CA aerogel was somewhat improved compared to ANF *** enhancement verified that the crosslinking reaction between ANF and ChNF during the synchronous deprotonation process was ***,the conductive aerogels with uniform porous structure(CA-M)were successfully obtained by vacuum impregnating CA aerogels in Ti_(3)C_(2)T_(x) MXene solution,displaying low thermal conductivity(0.01 W/(m·K)),high electromagnetic interference(EMI)shielding effectiveness(SE)(75 dB),flame retardant,and heat ***,the as-obtained CA-M aerogels were also applied as a pressure sensor with excellent compression cycle stability and superior human motion monitoring *** a result,the dual-nanofiber based conductive aerogels have great potentials in flexible/wearable electronics,EMI shielding,flame retardant,and heat insulation.

关键词： synchronous deprotonation–protonation electromagnetic interference(EMI)shielding flame retardant heat insulation pressure sensing