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Metabonomic studies of pancreatic cancer response to radiotherapy in a mouse xenograft model using magnetic resonance spectroscopy and principal components analysis

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World Journal of Gastroenterology 2013年第26期19卷 4200-4208页

作者： Xin-Hong He Wen-Tao Li Ya-Jia Gu Bao-Feng Yang Hui-Wen Deng Yi-Hua Yu Wei-Jun Peng Department of Radiology Fudan University Shanghai Cancer Center shanghai key laboratory of functional magnetic resonance imaging Physics Department East China Normal University

AIM: To investigate the metabolic profiles of xenograft pancreatic cancer before and after radiotherapy by high-resolution magic angle spinning proton magnetic resonance spectroscopy (HRMAS 1H NMR) combined with principal components analysis (PCA) and evaluate the radiotherapeutic effect. METHODS: The nude mouse xenograft model of human pancreatic cancer was established by injecting human pancreatic cancer cell SW1990 subcutaneously into the nude mice. When the tumors volume reached 800 mm3 , the mice received various radiation doses. Two weeks later, tumor tissue sections were prepared for running the NMR measurements. 1H NMR and PCA were used to determine the changes in the metabolic profiles of tumor tissues after radiotherapy. Metabolic profiles of normal pancreas, pancreatic tumor tissues, and radiationtreated pancreatic tumor tissues were compared. RESULTS: Compared with 1H NMR spectra of the normal nude mouse pancreas, the levels of choline, taurine, alanine, isoleucine, leucine, valine, lactate, and glutamic acid of the pancreatic cancer group were increased, whereas an opposite trend for phosphocholine, glycerophosphocholine, and betaine was observed. The ratio of phosphocholine to creatine, and glycerophosphocholine to creatine showed noticeable decrease in the pancreatic cancer group. After further evaluation of the tissue metabolic profile after treatment with three different radiation doses, no significant change in metabolites was observed in the 1H NMR spectra, while the inhibition of tumor growth was in proportion to the radiation doses. However, PCA results showed that the levels of choline and betaine were decreased with the increased radiation dose, and conversely, the level of acetic acid was dramatically increased. CONCLUSION: The combined methods were demonstrated to have the potential for allowing early diagnosis and assessment of pancreatic cancer response to radiotherapy.

关键词： High-resolution magic angle spinning proton magnetic resonance spectroscopy Principal components analysis Pancreatic cancer Radiotherapy

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A new dimeric furanocoumarin from Notopterygium incisum

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Chinese Chemical Letters 2008年第8期19卷 940-942页

作者： Shi Biao Wu Yi Hua Yu Ying He Hu Jin Feng Hu Department of Natural Products for Chemical Genetic Research Key Laboratory of Brain Functional Genomics Ministry of Education ＆ Shanghai Key Laboratory of Brain Functional Genomics （MOE ＆ SBFG） East China Normal University Shanghai 200062 China shanghai key laboratory of functional magnetic resonance imaging East China Normal University Shanghai 200062 China

A new dimeric psoralen-type furanocoumarin, notopterol-（18-O-20＇）-notopol （1）, was isolated from Notopterygium incisum for the first time and its structure was elucidated by spectroscopic methods.

关键词： Notopterygium incisum Umbelliferae Dimeric furanocoumarin Structure elucidation

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Quantum key distribution in 50-km optic fibers

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Science China(Physics,Mechanics & Astronomy) 2004年第2期47卷 182-188页

作者： ZHOU Chunyuan WU Guang CHEN Xiuliang LI Hexiang ZENG Heping key laboratory of Optical and magnetic resonance Spectroscopy and Department of Physics East China Normal University Shanghai 200062 China Key Laboratory of Optical and Magnetic Resonance Spectroscopy and Department of Physics East China Normal University Shanghai 200062 China Key Laboratory of Optical and Magnetic Resonance Spectroscopy and Department of Physics East China Normal University Shanghai 200062 China Key Laboratory of Optical and Magnetic Resonance Spectroscopy and Department of Physics East China Normal University Shanghai 200062 China Key Laboratory of Optical and Magnetic Resonance Spectroscopy and Department of Physics East China Normal University Shanghai 200062 China

In this paper, we report our recent experiment of long-distance fiber-optic plug and play quantum cryptography system wherein a Faraday-Mirror was used to compensate for the polarization mode dispersion and phase drifts. The pulse-biased coincident gate single-photon detection technique was used to effectively reduce the noises from the detrimental Rayleigh backscattering. We have achieved a quantum key distribution system with the working distance of 50 km, which was tested to be stable in more than 6 hours continuous work. And we also demonstrated the practical quantum communication in a local area network using the TCP protocol.

关键词： quantum cryptography, single-photon interference, polarization mode dispersion, phase- modula.

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Three-dimensional clogging structures of granular spheres near hopper orifice

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Chinese Physics B 2022年第1期31卷 388-394页

作者： Jing Yang Dianjinfeng Gong Xiaoxue Wang Zhichao Wang Jianqi Li Bingwen Hu Chengjie Xia shanghai key laboratory of magnetic resonance School of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China

The characteristic clogging structures of granular spheres blocking three-dimensional granular flow through hopper outlet are analyzed based on packing structures reconstructed using magnetic resonance imaging *** in clogging structures are arranged in a way with typical features of load-bearing,such as more contacting bonds close to the horizontal plane and more mutually-stabilized contact configurations than packing structures away from the *** requirement of load-bearing inevitably leads to the cooperativity of clogging structures with a correlation length of several particle *** correlation length being comparable with the orifice diameter suggests that a clogging structure is composed of several mutually-stabilized structural motifs to span the orifice perimeter,instead of a collection of independent individual spheres to cover the whole orifice ***,we propose a simple geometric model to explain the unexpected linear dependence of the average size of three-dimensional clogging structures on orifice diameter.

关键词： granular materials clogging magnetic resonance imaging

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Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

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Neural Regeneration Research 2025年第8期20卷 2373-2381页

作者： Lifang Zhao Mingkai Zhang Qimeng Li Xuemin Wang Jie Lu Ying Han Yanning Cai Department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical Research Center BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing key laboratory of magnetic resonance imaging and Brain Informatics BeijingChina key laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina School of Biomedical Engineering Hainan UniversityHaikouHainan ProvinceChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National Clinical Research Center for Geriatric Diseases BeijingChina Institute of Biomedical Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina Department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large *** samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline *** samples were stored at-80°C for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage ***,the level of total tau showed a negative correlation with sample storage ***,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage *** was not observed in individuals with cognitive ***,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage ***,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's ***,in cohort studies,it is important to consider the impact of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plasma biomarkers single molecule array storage time tau

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A Novel Gravito-Optical Surface Trap for Neutral Atoms

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Chinese Physics Letters 2006年第4期23卷 822-825页

作者：解春霞王正岭印建平 key laboratory of Optical and magnetic resonance Spectroscopy Department of Physics East China Normal University Shanghai 200062

We propose a novel gravito-optical surface trap （COST） for neutral atoms based on one-dimensional intensity gradient cooling. The surface optical trap is composed of a blue-detuned reduced semi-Gaussian laser beam （SGB）, a far-blue-detuned dark hollow beam and the gravity field. The SGB is produced by the diffraction of a collimated Gaussian laser beam passing through the straight edge of a semi-infinite opaque plate and then is reduced by an imaging lens. We calculate the intensity distribution of the reduced SGB, and study the dynamic process of the SGB intensity-gradient induced Sisyphus cooling for ^87Rb atoms by using Monte Carlo simulations. Our study shows that the proposed GOST can be used not only to trap cold atoms loaded from a standard magneto-optical trap, but also to cool the trapped atoms to an equilibrium temperature of 3.47μK from ～120μK, even to realize an all-optical two-dimensional Bose-Einstein condensation by using optlcal-potential evaporative cooling.

关键词： BEAM

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Korteweg-de Vries Description of Dark Solitons in Bose-Einstein Condensates

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Chinese Physics Letters 2001年第5期18卷 628-630页

作者： HUANG Guo-Xiang key laboratory for Optical and magnetic resonance Spectroscopy and Department of Physics East China Normal UniversityShanghai 200062

We investigate the dynamics of pulses in a cigar-shaped Bose-Einstein condensate with repulsive atom-atom interactions without using Thomas-Fermi *** the linear level our results give the Bogoliubov excitation spectrum for sound propagation with speed c=c0/√2,where c_(0) is the speed for the case without *** develop a Korteweg-de Vries(KdV)description for dark soliton propagation in the system and show that it is the quantum pressure that contributes the dispersion necessary for the formation of the dark solitons.

关键词： Einstein soliton propagation

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Vacuum-Induced Quantum Interference in a Trapped Λ-Configuration Three-Level System

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Chinese Physics Letters 2005年第11期22卷 2820-2823页

作者：王正岭印建平 key laboratory of Optical and magnetic resonance Spectroscopy Department of Physics East China Normal University Shanghai 200062

In consideration of quantization of centre-of-mass motion, we derive the second-order solution of the dynamic equation of a Λ-configuration three-level atom confined in an approximately harmonic trap by using the timedependent perturbation theory. It is found that there are a series of dark lines in the second-order probability spectrum with multi-peak structures, which is the result of the quantum interference from the same vacuum mode in the spontaneous decay process of the trapped atom from the upper level to the two nearby lower levels. Our study shows that the second-order spectrum may be modified by the oscillation frequency Ω of the trap and the frequency difference △ between two lower levels of the three-level atom, and the depth of the dark lines from the vacuum-induced quantum interference effect is strongly dependent on the above two parameters （Ω and △ ）.

关键词： Vacuum-Induced Quantum Interference in a Trapped Λ-Configuration Three-Level System

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Controllable magnetic Focusing of Cold Atoms on a Chip

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Chinese Physics Letters 2006年第7期23卷 1698-1701页

作者：刘泱恽旻印建平 key laboratory for Optically and magnetic resonance Spectroscopy Department of Physics East China Normal University Shanghai 200062

We propose a new lens scheme to focus cold atoms by using a controllable inhomogeneous magnetic field from a square current-carrying wire fabricated on a chip. The spatial distributions of the magnetic field are calculated, and the results show that the generated magnetic field is a two-dimensional （2D） quadrupole one and can be used to focus cold atoms or a cold atomic beam. The dynamic processes of cold atoms passing through our square wire layout and its focusing properties are studied by using Monte Carlo simulations. Our study shows that the atomic clouds can be focused effectively by our magnetic lens scheme, and the focal length of the atomic lens and its radius of focused spot can be continuously changed by adjusting the current in the wires.

关键词： BOSE-EINSTEIN CONDENSATION NEUTRAL ATOMS HOLLOW-BEAM LIGHT MICROMANIPULATION FORCES MIRROR OPTICS FUNNEL TRAPS

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Crystalline inclusion complexes formed between the drug diflunisal and block copolymers

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Chinese Chemical Letters 2017年第6期28卷 1268-1275页

作者： Zhi Zhong Xiaotong Yang Xiao-Bin Fu Ye-Feng Yao Bao-Hua Guo Yanbin Huang Jun Xu key laboratory of Advanced Materials(MOE) Department of Chemical EngineeringTsinghua University shanghai key laboratory of magnetic resonance Institute of Functional MaterialsSchool of Physics and Materials ScienceEast China Normal University

The solid form of drugs plays a central role in optimizing the physicochemical properties of drugs,and new solid forms will provide more options to achieve the desirable pharmaceutical profiles of ***,certain drugs have been found to form crystalline inclusion complexes（ICs） with multiple types of linear polymers,representing a new subcategory of pharmaceutical *** this study,we used diflunisal（DIF） as the model drug host and extended the guest of drug/polymer ICs from homopolymers to block copolymers of poly（ethylene glycol）（PEG） and poly（s-caprolactone）（PCL）.The block length in the guest copolymers showed a significant influence on the formation,thermal stability and dissolution behavior of the DIF *** the PEG block could hardly be included alone,it could indeed be included in the DIF ICs when the PCL block was long *** increase of the PCL block length produced IC crystals with improved thermal *** dissolution profiles of DIF/block copolymer ICs exhibited gradually decreased aqueous solubility and dissolution rate with the increasing PCL block *** results demonstrate the possibility of using drug/polymer ICs to modulate the desired pharmaceutical profiles of drugs in a predictable and controllable manner.

关键词： Pharmaceutical solid forms Inclusion complexes Drugs Block copolymers Thermal stability Aqueous solubility Dissolution profiles

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