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Identification of serum immunoglobulin M(IgM)of crucian carp(Carassius auratus gibelio)and immune response to cyprinid herpesvirus 2 infection

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Aquaculture and Fisheries 2024年第2期9卷 172-180页

作者： Shuran Wang Haotian Wu Longlong Wang Pinhua Wang Liqun Lu Yousheng Jiang Ye Zhang Dan Xu National Pathogen Collection Center for Aquatic Animals Shanghai Ocean UniversityShanghai201306China Key Laboratory of Aquatic Genetic Resources of the Ministry of Agriculture Shanghai Ocean UniversityShanghai201306China National Demonstration Center for Experimental Fisheries Science Education Shanghai Ocean UniversityShanghai201306China

Crucian carp(Carassius auratus gibelio),an extensively cultivated freshwater fish,was one of the model species for the study of fish *** antibodies were advantageous molecular tools for studying teleost immune ***,polyclonal antibodies reacting with immunoglobulins(Ig)were used successfully in studies of the teleost *** the present study,we produced polyclonal antibody against CH2 domains of crucian carp IgM,and measured the in vivo dynamics of IgM mRNA caused by CyHV-2 *** recombinant protein IgM with relative molecular weight about 53 KD was correctly expressed in prokaryotic *** specificity of the polyclonal antibody was evaluated by Western blotting and results revealed that the antibody not only specifically recognized crucian carp serum but also cross-reacted with grass carp *** RT-PCR analysis demonstrated the expression of IgM mRNA changed significantly after CyHV-2 *** expression of IgM in the kidney increased and reached a maximum at 6 h post-infection(hpi),while dropped to a low level at 5 days post-infection(dpi).In conclusion,the expression of IgM was significantly upregulated in the kidney of crucian carp infected with CyHV-2,indicating that IgM played a potential role in systemic immunity against viral *** antibody against crucian carp IgM had certain clinical relevance,which might provide insight into the early stage of virus infection and prevention of the disease.

关键词： Immunoglobulin M Crucian carp Polyclonal antibody Cyprinid herpesvirus 2 Immunoprotection

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Diamond-Like Carbon Depositing on the Surface of Polylactide Membrane for Prevention of Adhesion Formation During Tendon Repair

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Nano-Micro Letters 2024年第9期16卷 478-499页

作者： Yao Xiao Zaijin Tao Yufeng Ju Xiaolu Huang Xinshu Zhang Xiaonan Liu Pavel A.Volotovski Chao Huang Hongqi Chen Yaozhong Zhang Shen Liu Department of Orthopaedics Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital600 Yishan RdShanghai 200233People’s Republic of China shanghai Tongji Hospital 389 Xincun RdShanghai 200065People’s Republic of China Key Laboratory for Thin Film and Microfabrication of Ministry of Education Research Institute of Micro/Nano Science and TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Orthopedic Trauma Department Belarus Republic Scientific and Practical Center for Traumatology and OrthopedicsKizhevatova str.60/4220024 MinskBelarus shanghai Haohai Biological Technology Limited Liability Company 1386 Hongqiao RdShanghai 200336People’s Republic of China Department of General Surgery Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital600 Yishan RdShanghai 200233People’s Republic of China shanghai Key Laboratory for High Temperature Materials and Precision Forming School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Post-traumatic peritendinous adhesion presents a significant challenge in clinical *** study proposes the use of diamond-like carbon(DLC)deposited on polylactic acid(PLA)membranes as a biophysical mechanism for anti-adhesion barrier to encase ruptured tendons in tendon-injured *** results indicate that PLA/DLC composite membrane exhibits more efficient anti-adhesion effect than PLA membrane,with histological score decreasing from 3.12±0.27 to 2.20±0.22 and anti-adhesion effectiveness increasing from 21.61%to 44.72%.Mechanistically,the abundant C=O bond functional groups on the surface of DLC can reduce reactive oxygen species level effectively;thus,the phosphorylation of NF-κB and M1 polarization of macrophages are ***,excessive inflammatory response augmented by M1 macrophage-originated cytokines including interleukin-6(IL-6),interleukin-1β(IL-1β),and tumor necrosis factor-α(TNF-α)is largely *** biocompatibility evaluation,PLA/DLC membrane is slowly absorbed within tissue and displays prolonged barrier effects compared to traditional PLA *** studies show the DLC depositing decelerates the release of degradation product lactic acid and its induction of macrophage M2 polarization by interfering esterase and PLA ester bonds,which further delays the fibrosis *** was found that the PLA/DLC membrane possess an efficient biophysical mechanism for treatment of peritendinous adhesion.

关键词： Diamond-like carbon Reactive oxygen species scavenging Foreign body reaction Biodegradation Antioxidant Peritendinous adhesion

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Exosome-encapsulated lncRNA HOTAIRM1 contributes to PM_(2.5)-aggravated COPD airway remodeling by enhancing myofibroblast differentiation

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Science China(Life Sciences) 2024年第5期67卷 970-985页

作者： Huaqi Guo Luo Fei Hengyi Yu Yan Li Yan Feng Shaowei Wu Yan Wang The Ninth People’s Hospital of shanghai Jiao Tong university School of Medicine Shanghai 200011China School of Public Health Shanghai Jiao Tong University School of MedicineShanghai 200020China Department of Occupational and Environmental Health Sciences School of Public HealthXi’an Jiao Tong University Health Science CenterXi’an 710049China

Emphysema,myofibroblast accumulation and airway remodeling can occur in the lungs due to exposure to atmospheric pollution,especially fine particulate matter(PM_(2.5)),leading to chronic obstructive pulmonary disease(COPD).Specifically,bronchial epithelium-fibroblast communication participates in airway remodeling,which results in *** increasing number of studies are now being conducted on the role of exosome-mediated cell-cell communication in disease ***,we investigated whether exosomes generated from bronchial epithelial cells could deliver information to normal stromal fibroblasts and provoke cellular responses,resulting in airway obstruction in *** studied the mechanism of exosome-mediated intercellular communication between human bronchial epithelial(HBE) cells and primary lung fibroblasts(pLFs).We found that PM_(2.5)-induced HBE-derived exosomes promoted myofibroblast differentiation in ***,the exosomal lncRNA expression profiles derived from PM_(2.5)-treated HBE cells and nontreated HBE cells were investigated using an Agilent Human LncRNA *** coculture assays and direct exosome treatment,we found that HBE cell-derived exosomal HOTAIRM1 facilitated the myofibroblast differentiation of ***,we discovered that exosomal HOTAIRM1 enhanced p LF proliferation to secrete excessive collagen secretion,leading to airway obstruction by stimulating the TGF-β/SMAD3 signaling ***,PM_(2.5)reduced FEV1/FVC and FEV1 and increased the level of serum exosomal HOTAIRM1 in healthy people;moreover,serum exosomal HOTAIRM1 was associated with PM_(2.5)-related reductions in FEV1/FVC and *** findings show that PM_(2.5)triggers alterations in exosome components and clarify that one of the paracrine mediators of myofibroblast differentiation is bronchial epithelial cell-derived HOTAIRM1,which has the potential to be an effective prevention and therapeutic target for PM_(2.5)-induced COPD.

关键词： PM2.5 exosomal lncRNAs HOTAIRM1 chronic obstructive pulmonary disease

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Modeling the Interaction between Vacancies and Grain Boundaries during Ductile Fracture

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 2019-2034页

作者： Mingjian Li Ping Yang Pengyang Zhao Department of Engineering Mechanics School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China

The experimental results in previous studies have indicated that during the ductile fracture of pure metals,vacancies aggregate and form voids at grain ***,the physical mechanism underlying this phenomenon remains not fully *** study derives the equilibrium distribution of vacancies analytically by following thermodynamics and the micromechanics of crystal *** derivation suggests that vacancies cluster in regions under hydrostatic compression to minimize the elastic strain ***,a finite element model is developed for examining more general scenarios of interaction between vacancies and grain *** model is first verified and validated through comparison with some available analytical solutions,demonstrating consistency between finite element simulation results and analytical solutions within a specified numerical accuracy.A systematic numerical study is then conducted to investigate the mechanism that might govern the micromechanical interaction between grain boundaries and the profuse vacancies typically generated during plastic *** simulation results indicate that the reduction in total elastic strain energy can indeed drive vacancies toward grain boundaries,potentially facilitating void nucleation in ductile fracture.

关键词： Ductile fracture vacancy grain boundary micromechanical finite element method

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Inflection Point Age in the Middle and Older Women—Jiangxi Province,China,2020-2022

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China CDC weekly 2024年第9期6卷 162-167页

作者： Shanlan Yang Langlang Zhang Helang Huang Jiaofeng Wang Lei Wu Zhijun Bao shanghai Institute of Infectious Disease and Biosecurity Fudan UniversityShanghaiChina Department of Gerontology Huadong Hospital Affiliated to Fudan UniversityShanghai Key Laboratory of Clinical Geriatric MedicineResearch Center on Aging and MedicineFudan UniversityShanghaiChina Jiangxi Provincial Key Laboratory of Preventive Medicine School of Public HealthNanchang UniversityNanchang CityJiangxi ProvinceChina

Summary What is already known about this topic?Previous studies have predominantly examined the micro-level aspects of women aging inflection points,while macro-level research using big data on the inflection points o... 详细信息

关键词： Middle Jiangxi currently

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Long-Term Survival Trend of Gynecological Cancer:A Systematic Review of Population-Based Cancer Registration Data

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Biomedical and Environmental Sciences 2024年第8期37卷 897-921页

作者： Xiaohui Zhou Danni Yang Yixin Zou Dandan Tang Jun Chen Zhuoying Li Qiuming Shen Qun Xu Yongbing Xiang Department of Epidemiology&State Key Laboratory of Systems Medicine for Cancer Shanghai Cancer InstituteRenji HospitalShanghai Jiaotong University School of MedicineShanghai 200032China School of Public Health Shanghai Jiaotong University School of MedicineShanghai 200025China School of Public Health Fudan UniversityShanghai 200025China Health Management Center Renji HospitalShanghai Jiaotong University School of MedicineShanghai 200127China

Gynecological cancer significantly affect the health of *** review aimed to describe the global patterns and trends in the survival of patients with gynecological *** searched PubMed,Embase,Web of Science,SinoMed,and SEER for survival analyses of cancer registration data of cervical,endometrial,and ovarian cancers published between 1980 and ***,the highest 5-year observed survival rate for cervical cancer was 76.5% in Anshan,Liaoning,China(2008-2017).The 5-year observed survival rates of endometrial and ovarian cancers were higher in Finland(1995-1999,82.5%)and Singapore(1988-1992,62.0%).The 5-year relative survival rate of cervical cancer patients was higher in Haining,Zhejiang,China(2011-2014,85.8%).Korea ranked first at 89.0% and 64.5% for endometrial and ovarian cancers,*** rates have improved for cervical,endometrial,and ovarian *** aged≥75 years and those with advancedstage disease had the worst 5-year survival *** rates were better for squamous cell carcinoma in cervical cancer,for endometrial carcinoma and mucinous adenocarcinoma in endometrial cancer,and for germ cell and sex-cord stromal tumors in ovarian *** the past four decades,the survival rates of gynecological cancers have increased globally,with notable increases in cervical and endometrial *** rates are higher in developed countries,with a slow-growing *** studies should focus on improving survival,especially in ovarian cancer patients.

关键词： Survival Cancer globally

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Weakly Supervised Network with Scribble-Supervised and Edge-Mask for Road Extraction from High-Resolution Remote Sensing Images

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Computers, Materials & Continua 2024年第4期79卷 549-562页

作者： Supeng Yu Fen Huang Chengcheng Fan College of Artificial Intelligence Nanjing Agricultural UniversityNanjing210095China Innovation Academy for Microsatellites of CAS Shanghai201210China shanghai Engineering Center for Microsatellites Shanghai201210China Key Laboratory of Satellite Digital Technology Shanghai201210China

Significant advancements have been achieved in road surface extraction based on high-resolution remote sensingimage processing. Most current methods rely on fully supervised learning, which necessitates enormous humaneffort to label the image. Within this field, other research endeavors utilize weakly supervised methods. Theseapproaches aim to reduce the expenses associated with annotation by leveraging sparsely annotated data, such asscribbles. This paper presents a novel technique called a weakly supervised network using scribble-supervised andedge-mask (WSSE-net). This network is a three-branch network architecture, whereby each branch is equippedwith a distinct decoder module dedicated to road extraction tasks. One of the branches is dedicated to generatingedge masks using edge detection algorithms and optimizing road edge details. The other two branches supervise themodel’s training by employing scribble labels and spreading scribble information throughout the image. To addressthe historical flaw that created pseudo-labels that are not updated with network training, we use mixup to blendprediction results dynamically and continually update new pseudo-labels to steer network training. Our solutiondemonstrates efficient operation by simultaneously considering both edge-mask aid and dynamic pseudo-labelsupport. The studies are conducted on three separate road datasets, which consist primarily of high-resolutionremote-sensing satellite photos and drone images. The experimental findings suggest that our methodologyperforms better than advanced scribble-supervised approaches and specific traditional fully supervised methods.

关键词： Semantic segmentation road extraction weakly supervised learning scribble supervision remote sensing image

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Shock Formation for 2D Isentropic Euler Equations with Self-similar Variables

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Chinese Annals of Mathematics,Series B 2024年第3期45卷 349-412页

作者： Wenze SU School of Mathematical Sciences Fudan UniversityShanghai 200433China

The author studies the 2D isentropic Euler equations with the ideal gas *** exhibits a set of smooth initial data that give rise to shock formation at a single point near the planar *** solutions to the 2D isentropic Euler equations are associated with non-zero vorticity at the shock and have uniform-in-time-1/3-Holder ***,these point shocks are of self-similar type and share the same profile,which is a solution to the 2D self-similar Burgers *** proof of the solutions,following the 3D construction of Buckmaster,Shkoller and Vicol(in 2023),is based on the stable 2D self-similar Burgers profile and the modulation method.

关键词： 2D isentropic Euler equations Shock formation Self-similar solution

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Emission and optical characteristics of brown carbon in size-segregated particles from three types of Chinese ships

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Journal of Environmental Sciences 2024年第8期142卷 248-258页

作者： Fengqin Yang Fan Zhang Zeyu Liu Yingjun Chen Yan Zhang Can Wu Yali Lei Shijie Liu Binyu Xiao Xinyi Wan Yubao Chen Yong Han Min Cui Cheng Huang Gehui Wang Key Lab of Geographic Information Science of the Ministry of Education School of Geographic SciencesEast China Normal UniversityShanghai 200241China Institute of Eco-Chongming 20 Cuiniao Rd.ChongmingShanghai 202150China State Environmental Protection Key Laboratory of Formation and Prevention of the Urban Air Pollution Complex Shanghai Academy of Environmental SciencesShanghai 200233China shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention(LAP3) Department of Environmental Science and EngineeringFudan UniversityShanghai 200438China shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China Department of Civil and Environmental Engineering and State Key Laboratory of Marine Pollution The Hong Kong Polytechnic UniversityKowloon 100872Hong KongChina College of Environmental Science and Engineering Yangzhou UniversityYangzhou 225009China

Brown carbon(BrC)is one of the important light absorption substances that have high light absorption ability under short wavelength ***,limit studies have focused on the BrC emission from *** this study,size-segregated particulate matters(PM)were collected from three different types of ships,light absorption characteristics and size distribution of methanol-soluble BrC and water-soluble BrC in PM from ship exhausts were *** showed that four-stroke low-power diesel fishing boat(4-LDF)had the highest mass concentrations of methanol-soluble organic carbon(MSOC)and water-soluble organic carbon(WSOC),followed by 2-stroke high-power heavy-fuel-oil vessel(2-HHV),and fourstroke high-power marine-diesel vessel(4-HMV).While 2-HHV had obviously higher light absorption coefficients of methanol-soluble BrC(Abs365,M)and water-soluble BrC(Abs365,W)in unit weight of PM than the other two types of *** tested ships presented comparable or higher absorption efficiency of BrC in water extracts(MAE365,W)compared with other BrC emission *** of BrC was concentrated in fine particles,and the particle size distributions of both Abs365,Mand Abs365,Wshowed bimodal patterns,peaking at0.43–0.65μm and 4.7–5.8μm,***,different particle size distributions were found for MAE365,Mbetween diesel and heavy fuel oil ***,different wavelength dependence in particles with different size were also *** exhaust could be confirmed as a non-ignorable BrC emission source,and complex influencing factor could affect the light absorption characteristics of ship *** size should also be considered when light absorption ability of BrC was evaluated.

关键词： Ship emission Brown carbon Light absorption Size distribution

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Buckling Properties of Water-Drop-Shaped Pressure Hulls with Various Shape Indices Under Hydrostatic External Pressure

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China Ocean Engineering 2024年第1期38卷 1-17页

作者： DING Xiao-de ZHANG Jian WANG Fang JIAO Hui-feng WANG Ming-lu School of Mechanical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China shanghai Engineering Research Center of Marine Renewable Energy College of Engineering Science and Technol-ogyShanghai Ocean UniversityShanghai 201306China China Ship Scientific Research Center Wuxi 214082China

The water-drop-shaped pressure hull has a good streamline,which has good application prospect in the underwater ***,this study conducted analytical,experimental and numerical investigation of the buckling properties of water-drop-shaped pressure hulls under hydrostatic pressure.A water-drop experiment was conducted to design water-drop-shaped pressure hulls with various shape *** critical loads for the water-drop-shaped pressure hulls were resolved by using Mushtari’s *** numerical simulations including linear buckling analysis and nonlinear buckling analysis including eigenmode imperfections were *** results indicated that the critical loads resolved by Mushtari's formula were in good agreement with the linear buckling loads from the numerical *** formula can be extended to estimate the buckling capacity of water-drop-shaped pressure *** addition,three groups of pressure hulls were fabricated by using stereolithography,a rapid prototyping ***,three groups of the pressure hulls were subjected to ultrasonic measurements,optical scanning,hydrostatic testing and numerical *** experimental results were consistent with the numerical *** results indicate that the sharp end of the water-drop-shaped pressure hulls exhibited instability compared with the blunt *** paper provides a new solution to the limitations of experimental studies on the water-drop-shaped pressure hulls as well as a new configuration and evaluation method for underwater observatories.

关键词： buckling pressure hull water drop underwater observatory

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