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Analysis of secondary makeup characteristics of drill collar joint and prediction of downhole equivalent impact torque of Well SDTK1

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Petroleum Exploration and Development 2024年第3期51卷 697-705页

作者： WANG Chunsheng MING Chuanzhong ZHANG Hao CHEN Jialei QU Hao WANG Wenchang DI Qinfeng PetroChina Tarim Oilfield Company Korla 841000China shanghai Institute of Applied Mathematics and Mechanics Shanghai UniversityShanghai 200072China

Based on the three-dimensional elastic-plastic finite element analysis of the 8"(203.2 mm)drill collar joint,this paper studies the mechanical characteristics of the pin and box of NC56 drill collar joints under complex load conditions,as well as the downhole secondary makeup features,and calculates the downhole equivalent impact torque with the relative offset at the shoulder of internal and external *** the basis of verifying the correctness of the calculation results by using measured results in Well GT1,the prediction model of the downhole equivalent impact torque is formed and applied in the first extra-deep well with a depth over 10000 m in China(Well SDTK1).The results indicate that under complex loads,the stress distribution in drill collar joints is uneven,with relatively higher von Mises stress at the shoulder and the threads close to the *** 203.2 mm drill collar joints pre-tightened according to the make-up torque recommended by American Petroleum Institute standards,when the downhole equivalent impact torque exceeds 65 kN·m,the preload balance of the joint is disrupted,leading to secondary make-up of the *** the downhole equivalent impact torque increases,the relative offset at the shoulder of internal and external threads *** calculation results reveal that there exists significant downhole impact torque in Well SDTK1 with complex loading *** is necessary to use double shoulder collar joints to improve the impact torque resistance of the joint or optimize the operating parameters to reduce the downhole impact torque,and effectively prevent drilling tool failure.

关键词： Well SDTK1 drill tool threaded joint secondary makeup relative offset equivalent impact torque

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Comprehensive identification and potential application of genetic alteration-driven enhancer RNAs for eRNA-targeted therapy in breast cancer

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Genes & Diseases 2024年第5期11卷 59-62页

作者： Hongying Zhao Caiyu Zhang Lin Bo Lixia Wang Wangyang Liu Yaopeng Shu Kailai Liu Ying Liu Meiting Fei Li Wang College of Bioinformatics Science and Technology Harbin Medical UniversityHarbinHeilongjiang 150081China Ninth People’s Hospital Shanghai Jiao Tong University School of MedicineShanghai 200125China shanghai Institute of Precision Medicine Shanghai 200125China

Enhancer RNAs(eRNAs)are a class of non-coding RNA,which play a critical role in tumor progression.1 Previous studies have indicated abundant CpG methylation,somatic mutation,and copy number variation in eRNA regions in cancers.2,3 We constructed a landscape of genetic alteration-driven eRNAs and provided an integrative pipeline to identify drug candidates that affect eRNA ***,we explored the prognostic value of genetic alteration-driven eRNAs.

关键词： alteration breast targeted

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(Parallel) kinetic resolution of 3,3-disubstituted indolines via organocatalyzed reactions with azodicarboxylates

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Science China Chemistry 2024年第3期67卷 973-980页

作者： Qianwen Jiang Dekun Zhang Mengyao Tang Hua Liu Xiaoyu Yang School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China

A novel kinetic resolution(KR) method has been developed for 3,3-disubstituted indolines, whose catalytic asymmetric synthesis remains a significant challenge in organic synthesis. The key to the success of this KR protocol lies in the utilization of chiral phosphoric acid-catalyzed triazane formation reaction with azodicarboxylates, which enables the enantioselective synthesis of various substituted indolines bearing C3-quaternary stereocenters with good to high enantioselectivities(with sfactors up to 70). Moreover, an intriguing parallel kinetic resolution(PKR) has been developed by combining triazane formation and dehydrogenation reactions using different azodicarboxylates. Experimental studies have provided insight into the mechanism of this PKR reaction, demonstrating stereoselectivity in both triazane formation and dehydrogenation steps, favoring the opposite enantiomers. The large-scale synthesis and diverse derivatizations of the products, particularly the imine groupcontaining 3H-indoles, demonstrate the value of these(P)KR methods.

关键词： asymmetric organocatalysis kinetic resolution 3 3-disubstituted indolines azodicarboxylate triazanes

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Productivity in the Southern Ocean Antarctic Zone during the Northern Hemisphere Glaciation(NHG)and its link to atmospheric pCO_(2)

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Science China Earth Sciences 2024年第7期67卷 2242-2252页

作者： Yiming WU Jingteng GUO Xiangyu ZHAO Wenshen XIAO Heng LIU Zhifang XIONG Tiegang LI Key Laboratory of Marine Geology and Metallogeny First Institute of OceanographyMinistry of Natural ResourcesQingdao 266061China Laboratory for Marine Geology Laoshan LaboratoryQingdao 266237China School of Oceanography Shanghai Jiao Tong UniversityShanghai 200030China Key Laboratoryof Polar Ecosystem and Climate Change Shanghai Jiao Tong UniversityMinistry of EducationShanghai 200030China State Key Laboratory of Marine Geology Tongji UniversityShanghai 200092China

A decrease in atmospheric CO_(2)partial pressure(pCO_(2))is considered an important prerequisite for the onset and intensification of Northern Hemisphere Glaciation(NHG).However,how the ocean sequestered missing CO_(2)during the NHG is still *** in surface productivity and deep ventilation in the Southern Ocean(SO)have been proposed to explain the variations in atmospheric pCO_(2)over the last eight glacial cycles,but it is unclear whether these mechanisms contributed to the decrease in atmospheric pCO_(2)during the *** titanium-normalized contents and mass accumulation rates of biogenic opal and total organic carbon from the International Ocean Discovery Program(IODP)Expedition 374 Site U1524A,we reconstruct the productivity in the Ross Sea,Antarctica,from 3.3 Ma to 2.4 *** productivity records exhibit a long-term decreasing trend and several distinct phased evolutionary ***,the local productivity fluctuated dramatically during 3.3-3.0 Ma,decreased gradually during 3.0-2.6 Ma,and remained relatively constant during 2.6-2.4 *** comparing productivity with its potential influences,we infer that the phased and long-term evolutions of productivity were mainly controlled by changes in deep ocean *** ice expansion might have decreased productivity during 3.3-3.0 Ma by light *** in eolian dust input have little effect on *** analysis revealed no coupling linkage between productivity and atmospheric pCO_(2),indicating that the productivity in the SO Antarctic Zone(AZ)was not the main factor controlling the atmospheric CO_(2)decrease during the *** improve our understanding of the role of SO processes in the NHG,further studies should focus on the potential influences of deep ocean ventilation on atmospheric pCO_(2)in the AZ,and similar studies should also be extended to the sea area in the Subantarctic Zone.

关键词： Ross Sea Biogenic opal Total organic carbon Deep ocean ventilation Sea ice Ocean carbon cycle

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Hypermethylation of the ALOX12 and CBS promoters in osteoporosis:Potential biomarkers for early diagnosis

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Genes & Diseases 2024年第1期11卷 30-33页

作者： Shang Guo Yue Wu Weekai Chia Peichun Hsu Hongwei Wang Yunliang Wang Biao Zhong Department of Orthopedic Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200023China Institute of Translational Medicine Shanghai General HospitalShanghai Jiao Tong University School of Medicine(SJTU-SM)Shanghai 200025China The university of Chicago Department of MedicineChicagoIL 60637USA Department of Neurology The Second Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450014China

As a bone-confined chronic degenerative disorder,the progression of osteoporosis is characterized by abnormal crosstalk between osteoblasts and osteoclasts,leading to an imbalance of bone remodeling in adults.1 Several studies reported that arachidonic acid ester 12 lipoxygenase(ALOX12)acts as a regulator in bone genesis by participating in the activation of the peroxisome proliferatoractivated receptor(PPARG)pathway through its reaction product.

关键词： osteoporosis diagnosis remodeling

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Application of immune checkpoint inhibitors and microsatellite instability in gastric cancer

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World Journal of Gastroenterology 2024年第21期30卷 2734-2739页

作者： Shi-Yan Yan Jian-Gao Fan Department of Gastroenterology Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai 200092China

In this editorial we comment on the article by Li published in the recent issue of the World Journal of *** focus specifically on the application of immune checkpoint inhibitors(ICIs)and microsatellite instability(MSI)in gastric cancer(GC).The four pillars of GC management have long been considered,including surgery,chemotherapy,radiotherapy and targeted ***,immunotherapy has recently emerged as a“fifth pillar”,and its use is rapidly *** are four principal strategies for tumor immunotherapy:ICIs,tumor vaccines,adoptive immunotherapy and nonspecific *** them,ICIs are the most advanced and widespread type of cancer immunotherapy for *** breakthrough results for ICIs have paved the way to a new era of cancer *** particular,inhibition of the PD-1/PD-L1 axis with ICIs,including nivolumab and pembrolizumab,has emerged as a novel treatment strategy for advanced ***,these therapies are sometimes associated with often subtle,potentially fatal immune-related adverse events(irAEs),including dermatitis,diarrhea,colitis,endocrinopathy,hepatotoxicity,neuropathy and *** must be aware of these irAEs and improve the detection of these processes to prevent inappropriate discharges,emergency department revisits,and downstream *** studies have revealed that MSI-high or mismatch-repair-deficient tumors,regardless of their primary site,have a promising response to ***,it is important to detect MSI before applying ICIs for treatment of GC.

关键词： Gastric cancer Immune checkpoint inhibitors Microsatellite instability Immunotherapy Immune-related adverse events

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Real-Time Co-optimization of Gear Shifting and Engine Torque for Predictive Cruise Control of Heavy-Duty Trucks

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 294-317页

作者： Hongqing Chu Xiaoxiang Na Huan Liu Yuhai Wang Zhuo Yang Lin Zhang Hong Chen School of Automotive studies Tongji UniversityShanghaiChina Department of Engineering University of CambridgeCambridgeUK State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchunChina Qingdao Automotive Research Institute Jilin UniversityQingdaoChina Dongfeng Commercial Vehicle Technology Center Dongfeng Motor CorporationWuhanChina

Fuel consumption is one of the main concerns for heavy-duty *** cruise control(PCC)provides an intriguing opportunity to reduce fuel consumption by using the upcoming road *** this study,a real-time implementable PCC,which simultaneously optimizes engine torque and gear shifting,is proposed for heavy-duty *** minimize fuel consumption,the problem of the PCC is formulated as a nonlinear model predictive control(MPC),in which the upcoming road elevation information is *** the solution of the nonlinear MPC is time consuming;thus,a real-time implementable solver is developed based on Pontryagin’s maximum principle and indirect shooting *** programming(DP)algorithm,as a global optimization algorithm,is used as a performance benchmark for the proposed ***,hardware-in-the-loop and real-truck experiments are conducted to verify the performance of the proposed *** results demonstrate that the MPC-based solution performs nearly as well as the DP-based solution,with less than 1%deviation for testing ***,the proposed co-optimization controller is implementable in a real-truck,and the proposed MPC-based PCC algorithm achieves a fuel-saving rate of 7.9%without compromising the truck’s travel time.

关键词： Heavy-duty truck Predictive cruise control Model predictive control Pontryagin’s maximum principle Real-truck implementation

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Status and trends in the stability of the three largest ice shelves in Antarctica

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Science China Earth Sciences 2024年第8期67卷 2615-2632页

作者： Rongxing LI Guojun LI Lu AN Menglian XIA Da LV Yuan CHENG Aiguo ZHAO Tian CHANG Xiangbin CUI Shengkai ZHANG Shijie LIU Yixiang TIAN Weian WANG Center for Spatial Information Science and Sustainable Development Applications Tongji UniversityShanghai 200092China College of Surveying and Geo-informatics Tongji UniversityShanghai 200092China Postdoctoral Research Station of shanghai Surveying and Mapping Institute Shanghai 200063China Key Laboratory of Spatial-temporal Big Data Analysis and Application of Natural Resources in Megacities Shanghai 200063China Institute for Conservation of Cultural Heritage School of Cultural Heritage and Information ManagementShanghai UniversityShanghai 200444China Polar Research Institute of China Shanghai 200136China Chinese Antarctic Center of Surveying and Mapping Wuhan UniversityWuhan 430079China

The Ross,Filchner-Ronne,and Amery ice shelves are the three largest ice shelves in Antarctica,playing a crucial role in supporting the Antarctic ice ***,current studies on the stability of the three largest ice shelves primarily focus on singular or limited factors,lacking a comprehensive assessment of multiple *** systematically and in-depth study the stability and trend of the three largest ice shelves,we comprehensively collected and analyzed key parameters,including elevation changes,basal melting,surface meltwater,major rifts propagation rate,suture zones,ice front area change rate,grounding lines,ice velocity,and mass ***,we selected the collapsed Larsen B Ice Shelf(LBIS),the rapidly changing and structurally weakened Pine Island Ice Shelf(PIIS),and the accelerating Totten Ice Shelf(TIS)as reference ice *** comparing and analyzing the key parameters between these reference ice shelves and the three largest ice shelves,we find the status and trends in the stability of the *** findings reveal that most key parameters of the three largest ice shelves present relatively minor variations compared to those of the reference ice ***,50%of the parameters are smaller than those of the accelerating TIS,88%are smaller than those of the rapidly changing PIIS,and all parameters are smaller than those of the collapsed ***,after analyzing parameters that are not smaller than those of the TIS,it is observed that they remain in a stable ***,the three largest ice shelves are currently undergoing natural changes that do not threaten their stability in the short ***,the evolution of the ice shelves under global climate change remains uncertain,making long-term observation and monitoring essential to assess their impact on sea level rise.

关键词： Three largest ice shelves in Antarctica Key parameters Remote sensing monitoring Ice shelf stability Sea level change

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Identification of marker genes associated with N6-methyladenosine and autophagy in ulcerative colitis

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World Journal of Clinical Cases 2024年第10期12卷 1750-1765页

作者： Xiao-Yan Liu Dan Qiao Ya-Li Zhang Zi-Xuan Liu You-Lan Chen Ren-Ye Que Hong-Yan Cao Yan-Cheng Dai Department of Gastroenterology Shanghai Traditional Chinese Medicine-Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai 200082China Institute of Digestive Diseases Long Hua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China Department of Gastroenterology Shu Guang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China

BACKGROUND Both N6-methyladenosine(m6A)methylation and autophagy are considered relevant to the pathogenesis of ulcerative colitis(UC).However,a systematic exploration of the role of the com-bination of m6A methylation and autophagy in UC remains to be *** To elucidate the autophagy-related genes of m6A with a diagnostic value for *** The correlation between m6A-related genes and autophagy-related genes(ARGs)was ***,gene set enrichment analysis(GSEA)was performed on the characteristic ***,the expression levels of four characteristic genes were verified in dextran sulfate sodium(DSS)-induced colitis in *** GSEA indicated that BAG3,P4HB and TP53INP2 were involved in the inflammatory response and TNF-αsignalling via nuclear factor ***,polymerase chain reaction results showed significantly higher mRNA levels of BAG3 and P4HB and lower mRNA levels of FMR1 and TP53INP2 in the DSS group compared to the control *** This study identified four m6A-ARGs that predict the occurrence of UC,thus providing a scientific reference for further studies on the pathogenesis of UC.

关键词： Ulcerative colitis m6A Autophagy Characteristic genes Immune infiltration

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Advances in non-invasive imaging of proteinopathies in animal models of neurodegenerative diseases

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Neural Regeneration Research 2024年第10期19卷 2115-2116页

作者： Lei Cao Bin Ji Ruiqing Ni Changes Technology Corporation Ltd. ShanghaiChina Fudan university ShanghaiChina School of Pharmacy Fudan UniversityShanghaiChina Institute for Biomedical Engineering University of Zurich&ETH Zurich Institute for Regenerative MedicineUniversity of ZurichZurichSwitzerland

Neurodegenerative diseases,including Alzheimer's disease(AD),frontotemporal dementia,Parkinson's disease,and dementia with Lewy bodies,represent tremendous unmet clinical needs.A common feature of these diseases is the aberrant cerebral accumulation of pathological protein aggregates,affecting selectively vulnerable circuits in a disease-specific *** studies have established a relationship between abnormal aggregation and neuronal dysfunction or loss,suggesting multifactorial pathogenesis mechanisms in these neurodegenerative disorders.

关键词： diseases degenerative clinical

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