检索结果-南通市图书馆

Bioinspired Scraper-File Type Frequency-Doubling Ultrasonic Exciter

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2024年第4期21卷 1801-1816页

作者： Wenshuai Wu Mingshuo Zhang Zeming Li Guang Yao Xinggang Jiang Deyuan Zhang School of Mechanical Engineering and Automation Beihang UniversityBeijing100191China institute of Bionic and Micro-Nano Systems Beihang UniversityBeijing100191China Guangdong Provincial Key Laboratory of minimally invasive Surgical Instruments and Manufacturing Technology Guangdong University of TechnologyGuangzhou510006China

In the natural world,leaf-cutting ants cause vibrations through their mutual scraping of file-scraper *** this study,we designed a Biomimetic Ultrasonic Exciter(BUE)that imitates leaf-cutting *** operating characteristics of the BUE were studied through experimental testing and finite element *** results showed that the BUE could generate stable ultrasonic vibrations,and that the excitation frequency only needed to be half the Output Frequency(OF).This frequency-doubling phenomenon was conducive to achieving BUE *** further explore the phenomenon of frequency-doubling vibration output,this study designed scrapers of five different sizes,conducted excitation and first-order natural frequency measurement tests,and the corresponding finite element *** was found that each scraper could operate in frequency-doubling mode,but the operating frequency and natural mode frequencies did not correspond with one *** further explicate experimental and simulation results,a two-degrees-of-freedom vibration model was *** was evident that the contact relationship between the dentate disc and scraper introduced strong nonlinear factors into the system,accounting for the frequency-doubling phenomenon and the difference between the BUE’s operating and mode *** BUE could be expected to facilitate the production of high-power micro-ultrasonic generators and has potential application value in the fields of mechanical processing,industrial production,and medical health.

关键词： Leaf-cutting ants Power ultrasound Nonlinear vibration Ultrasonic scalpel Micro vibrator

Exosomal microRNAs in hepatocellular carcinoma,expanding research field

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第20期30卷 2618-2620页

作者： Bo-Hao Zheng Xiao-Jian Ni Hou-Bao Liu Department of Biliary Surgery Zhongshan HospitalFudan UniversityShanghai 200032China Biliary Tract Disease Center of Zhongshan Hospital Fudan UniversityShanghai 200032China Biliary Tract Disease institute Fudan UniversityShanghai 200032China Cancer Center Zhongshan HospitalFudan UniversityShanghai 200032China shanghai Biliary Tract Minimal invasive Surgery and Materials Engineering Research Center Shanghai 200032China

In this editorial we comment on the review by Wang et al published in the recent issue of the World Journal of Gastroenterology in *** extracellular vesicles(exosomes)play important roles in the tumor *** this review,the authors introduce the following points:(1)The composition and function of exosomal microRNAs(miRNAs)of different cell origins in hepatocellular carcinoma(HCC);(2)the crosstalk between exosomal miRNAs from stromal cells and immune cells in the tumor microenvironment and the progression of HCC;and(3)the potential applicability of exosomal miRNAs derived from mesenchymal stem cells in the treatment of *** addition,the potential applicability of exosomal miRNAs derived from mesenchymal stem cells in the treatment of HCC was *** this review,the authors give us an overview of the exosomal RNA and summarize the function of exosomal RNA in HCC,which provides a deeper understanding of exosomal miRNAs to the readers.

关键词： Exosomes MicroRNA Hepatocellular carcinoma Liver cancer Tumor microenvironment

Clinical and molecular significance of homologous recombination deficiency positive non-small cell lung cancer in Chinese population:An integrated genomic and transcriptional analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2024年第3期36卷 282-297页

作者： Yifei Wang Yidan Ma Lei He Jun Du Xiaoguang Li Peng Jiao Xiaonan Wu Xiaomao Xu Wei Zhou Li Yang Jing Di Changbin Zhu Liming Xu Tianlin Sun Lin Li Dongge Liu Zheng Wang Department of Pathology Department of minimally invasive Tumor Therapies Center Department of Thoracic Surgery Department of Oncology Department of Respiratory and Critical Care Medicine Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Amoy Diagnostics Co. Ltd.Xiamen 361027China

Objective:The clinical significance of homologous recombination deficiency(HRD)in breast cancer,ovarian cancer,and prostate cancer has been established,but the value of HRD in non-small cell lung cancer(NSCLC)has not been fully *** study aimed to systematically analyze the HRD status of untreated NSCLC and its relationship with patient prognosis to further guide clinical ***:A total of 355 treatment-naïve NSCLC patients were retrospectively *** status was assessed using the AmoyDx Genomic Scar Score(GSS),with a score of≥50 considered ***,transcriptomic,tumor microenvironmental characteristics and prognosis between HRD-positive and HRDnegative patients were ***:Of the patients,25.1%(89/355)were *** to HRD-negative patients,HRDpositive patients had more somatic pathogenic homologous recombination repair(HRR)mutations,higher tumor mutation burden(TMB)(Ptherapy(first-and third-generation EGFR-TKIs)(P=0.042).Additionally,HRDpositive,EGFR/ALK wild-type patients showed a numerically lower response to platinum-free immunotherapy ***:Unique genomic and transcriptional characteristics were found in HRD-positive *** prognosis and poor response to EGFR-TKIs and immunotherapy were observed in HRD-positive *** study highlights potential actionable alterations in HRD

关键词： Non-small cell lung cancer homologous recombination deficiency genetic alterations transcriptional analysis tumor microenvironment prognosis

Efficacy of graphene nanocomposites for air disinfection in dental clinics: A randomized controlled study

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第28期12卷 6173-6179页

作者： Ya-Qiong Ju Xiang-Hua Yu Jing Wu Ying-Hui Hu Xiang-Yong Han Dan Fang Department of Nursing Minhang District Dental ClinicShanghai 201107China Department of Medical Sciences Minhang District Dental ClinicShanghai 201107China Department of Orthopedics Center for Spinal Minimally Invasive ResearchShanghai Jiao Tong UniversityShanghai 201107China

BACKGROUND Aerosols containing disease-causing microorganisms are produced during oral diagnosis and treatment can cause secondary *** To investigate the use of graphene material for air disinfection in dental clinics by leveraging its adsorption and antibacterial *** Patients who received ultrasonic cleaning at our hospital from April 2023 to April *** were randomly assigned to three groups(n=20 each):Graphene nanocomposite material suction group(Group A),ordinary filter suction group(Group B),and no air suction device group(Group C).The air quality and air colony count in the clinic rooms were assessed before,during,and after the ***,bacterial colony counts were obtained from the air outlets of the suction devices and the filter screens in Groups A and *** Before ultrasonic cleaning,no significant differences in air quality PM2.5 and colony counts were observed among the three ***,significant differences in air quality PM2.5 and colony counts were noted among the three groups during ultrasonic cleaning and after ultrasonic ***,the number of colonies on the exhaust port of the suction device and the surface of the filter were significantly lower in Group A than in Group B(P=0.000 and P=0.000,respectively).CONCLUSION Graphene nanocomposites can effectively sterilize the air in dental clinics by exerting their antimicrobial effects and may be used to reduce secondary pollution.

关键词： Graphene Nanocomposites Oral clinic Air disinfection Secondary contamination

Transfer force perception skills to robot‐assisted laminectomy via imitation learning from human demonstrations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CAAI Transactions on Intelligence Technology 2024年第4期9卷 903-916页

作者： Meng Li Xiaozhi Qi Xiaoguang Han Ying Hu Bing Li Yu Zhao Jianwei Zhang Harbin institute of Technology ShenzhenChina Shenzhen institute of Advanced Technology Chinese Academy of SciencesShenzhenChina Shenzhen Key Laboratory of minimally invasive Surgical Robotics and System Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenChina Beijing Jishuitan Hospital Capital Medical UniversityBeijingChina Department of Orthopedics Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina University of Hamburg Hamburg22527Germany

A comparative study of two force perception skill learning approaches for robot‐assisted spinal surgery,the impedance model method and the imitation learning(IL)method,is *** impedance model method develops separate models for the surgeon and patient,incorporating spring‐damper and bone‐grinding *** surgeons'feature parameters are collected and mapped using support vector regression and image navi-gation *** imitation learning approach utilises long short‐term memory networks(LSTM)and addresses accurate data labelling challenges with custom *** results demonstrate skill recognition rates of 63.61%-74.62%for the impedance model approach,relying on manual feature ***,the imitation learning approach achieves a force perception recognition rate of 91.06%,outperforming the impedance model on curved bone *** findings demonstrate the potential of imitation learning to enhance skill acquisition in robot‐assisted spinal surgery by eliminating the laborious process of manual feature extraction.

关键词： learning(artificial intelligence) medical applications medical signal processing robotics

Advanced rehabilitation in ischaemic stroke research

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Stroke & Vascular Neurology 2024年第4期9卷 328-343页

作者： Jixian Wang Yongfang Li Lin Qi Muyassar Mamtilahun Chang Liu Ze Liu Rubing Shi Shengju Wu Guo-Yuan Yang Department of Rehabilitation Medicine Ruijin HospitalShanghai Jiao Tong University School of MedicalShanghaiChina Med-X Research institute and School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghaiChina

At present,due to the rapid progress of treatment technology in the acute phase of ischaemic stroke,the mortality of patients has been greatly reduced but the number of disabled survivors is increasing,and most of them are elderly *** and rehabilitation therapists pay attention to develop all kinds of therapist techniques including physical therapy techniques,robot-assisted technology and artificial intelligence technology,and study the molecular,cellular or synergistic mechanisms of rehabilitation therapies to promote the effect of rehabilitation ***,we discussed different animal and in vitro models of ischaemic stroke for rehabilitation studies;the compound concept and technology of neurological rehabilitation;all kinds of biological mechanisms of physical therapy;the significance,assessment and efficacy of neurological rehabilitation;the application of brain–computer interface,rehabilitation robotic and non-invasive brain stimulation technology in stroke rehabilitation.

关键词： stimulation mortality acute

Acidic/hypoxia dual-alleviated nanoregulators for enhanced treatment of tumor chemo-immunotherapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 136-152页

作者： Xiaoju Guo Xiaoxiao Chen Jiayi Ding Feng Zhang Shunyang Chen Xin Hu Shiji Fang Lin Shen Chenying Lu Zhongwei Zhao Jianfei Tu Gaofeng Shu Minjiang Chen Jiansong Ji Lishui Central Hospital Shaoxing UniversityShaoxing 312000China Zhejiang Key Laboratory of Imaging and Interventional Medicine Imaging Diagnosis and Interventional Minimally Invasive InstituteThe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000China Clinical College of The Affiliated Central Hospital School of MedicineLishui UniversityLishui 323000China Key Laboratory of Precision Medicine of Lishui Lishui 323000China

Chemotherapy plays a crucial role in triple-negative breast cancer (TNBC) treatment as it not only directly kills cancer cells but also induces immunogenic cell death. However, the chemotherapeutic efficacy was strongly restricted by the acidic and hypoxic tumor environment. Herein, we have successfully formulated PLGA-based nanoparticles concurrently loaded with doxorubicin (DOX), hemoglobin (Hb) and CaCO3 by a CaCO3-assisted emulsion method, aiming at the effective treatment of TNBC. We found that the obtained nanomedicine (DHCaNPs) exhibited effective drug encapsulation and pH-responsive drug release behavior. Moreover, DHCaNPs demonstrated robust capabilities in neutralizing protons and oxygen transport. Consequently, DHCaNPs could not only serve as oxygen nanoshuttles to attenuate tumor hypoxia but also neutralize the acidic tumor microenvironment (TME) by depleting lactic acid, thereby effectively overcoming the resistance to chemotherapy. Furthermore, DHCaNPs demonstrated a notable ability to enhance antitumor immune responses by increasing the frequency of tumor-infiltrating effector lymphocytes and reducing the frequency of various immune-suppressive cells, therefore exhibiting a superior efficacy in suppressing tumor growth and metastasis when combined with anti-PD-L1 (αPD-L1) immunotherapy. In summary, this study highlights that DHCaNPs could effectively attenuate the acidic and hypoxic TME, offering a promising strategy to figure out an enhanced chemo-immunotherapy to benefit TNBC patients.

关键词： CaCO3-based nanoparticles Hypoxia attenuation Acidity neutralization Reversal of chemotherapy resistance Enhanced chemo-immunotherapy

Mesenchymal stem cell-derived extracellular vesicles in skin wound healing:roles,opportunities and challenges

在线全文

学校读者我要写书评

暂无评论

Military Medical Research 2024年第3期11卷 400-429页

作者： Jia-Yi Ding Min-Jiang Chen Ling-Feng Wu Gao-Feng Shu Shi-Ji Fang Zhao-Yu Li Xu-Ran Chu Xiao-Kun Li Zhou-Guang Wang Jian-Song Ji Key Laboratory of Imaging Diagnosis and minimally invasive Intervention Research Institute of Imaging Diagnosis and Minimally Invasive Intervention Researchthe Fifth Affiliated Hospital of Wenzhou Medical UniversityZhejiangLishui 323000China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhou 325035ZhejiangChina Clinical College of the Affiliated Central Hospital School of MedicineLishui UniversityLishui 323000ZhejiangChina Department of Overseas Education College Jimei UniversityXiamen 361021FujianChina Department of Medicine Ⅱ Internal MedicineCardio-Pulmonary Institute(CPI)Universities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Justus-Liebig University Giessen35392 GiessenGermany Pulmonary and Critical Care Department of Medicine VInternal MedicineInfectious Diseases and Infection ControlUniversities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Justus-Liebig University Giessen35392 GiessenGermany

Skin wounds are characterized by injury to the skin due to trauma,tearing,cuts,or *** such injuries are common to all human groups,they may at times represent a serious socioeconomic ***,increasing numbers of studies have focused on the role of mesenchymal stem cell(MSC)-derived extracellular vesicles(EVs)in skin wound *** a cell-free therapy,MSC-derived EVs have shown significant application potential in the field of wound repair as a more stable and safer option than conventional cell *** based on MSC-derived EVs can significantly promote the repair of damaged substructures,including the regeneration of vessels,nerves,and hair *** addition,MSC-derived EVs can inhibit scar formation by affecting angiogenesis-related and antifibrotic pathways in promoting macrophage polarization,wound angiogenesis,cell proliferation,and cell migration,and by inhibiting excessive extracellular matrix ***,these structures can serve as a scaffold for components used in wound repair,and they can be developed into bioengineered EVs to support trauma *** the formulation of standardized culture,isolation,purification,and drug delivery strategies,exploration of the detailed mechanism of EVs will allow them to be used as clinical treatments for wound *** conclusion,MSCderived EV-based therapies have important application prospects in wound *** we provide a comprehensive overview of their current status,application potential,and associated drawbacks.

关键词： Mesenchymal stem cell(MSC) Extracellular vesicles(EVs) Wound repair Engineered nanoparticles

Advances in non-invasive imaging of proteinopathies in animal models of neurodegenerative diseases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第10期19卷 2115-2116页

作者： Lei Cao Bin Ji Ruiqing Ni Changes Technology Corporation Ltd. ShanghaiChina Fudan University ShanghaiChina School of Pharmacy Fudan UniversityShanghaiChina institute for Biomedical Engineering University of Zurich&ETH Zurich Institute for Regenerative MedicineUniversity of ZurichZurichSwitzerland

Neurodegenerative diseases,including Alzheimer's disease(AD),frontotemporal dementia,Parkinson's disease,and dementia with Lewy bodies,represent tremendous unmet clinical needs.A common feature of these diseases is the aberrant cerebral accumulation of pathological protein aggregates,affecting selectively vulnerable circuits in a disease-specific *** studies have established a relationship between abnormal aggregation and neuronal dysfunction or loss,suggesting multifactorial pathogenesis mechanisms in these neurodegenerative disorders.

关键词： diseases degenerative clinical