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World Journal of Clinical Cases 2025年第2期13卷 5-9页

作者： Wei Zhu shanghai XiRong Information Science and technology co. LtdNational Science and Technology ParkSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China

Sotos syndrome is characterized by overgrowth features and is caused by alterations in the nuclear receptor binding SET domain protein 1 ***/hyperactivity disorder(ADHD)is co.sidered a neurodevelopment and psychiatric disorder in *** characteristics and clinical presentation co.ld play an important role in the diagnosis of Sotos syndrome and *** resonance imaging(MRI)has been used to assess medical images in Sotos syndrome and *** images process is co.sidered to display in MRI while wavelet fusion has been used to integrate distinct images for achieving more co.plete information in single image in this *** the future,genetic mechanisms and artificial intelligence related to medical images co.ld be used in the clinical diagnosis of Sotos syndrome and ADHD.

关键词： Sotos syndrome Attention-deficit/hyperactivity disorder Genetic mutation Magnetic resonance imaging Wavelet fusion

Crystallization Modulation and Holistic Passivation Enables Efficient Two‑Terminal Perovskite/CuIn(Ga)Se_(2)Tandem Solar Cells

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Nano-Micro Letters 2025年第1期17卷 205-215页

作者： co.g Geng Kuanxiang Zhang Changhua Wang Chung Hsien Wu Jiwen Jiang Fei Long Liyuan Han Qifeng Han Yi‑Bing Cheng Yong Peng State Key Laboratory of Advanced technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070People’s Republic of China Triumph Photovoltaic Materials co. Ltd.No.1001 Yannan AvenueHigh‑Tech Development DistrictBengbuAnhui 233000People’s Republic of China co.lege of Materials Science and Engineering Guilin University of TechnologyGuilin 541004People’s Republic of China State Key Laboratory of Metal Matrix co.posites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Two-terminal(2-T)perovskite(PVK)/CuIn(Ga)Se_(2)(CIGS)tandem solar cells(TSCs)have been co.sidered as an ideal tandem cell because of their best bandgap matching regarding to Shockley–Queisser(S–Q)***,the nature of the irregular rough morphology of co.mercial CIGS prevents people from improving tandem device *** this paper,D-homoserine lactone hydrochloride is proven to improve co.erage of PVK materials on irregular rough CIGS surfaces and also passivate bulk defects by modulating the growth of PVK *** addition,the minority carriers near the PVK/C60 interface and the inco.pletely passivated trap states caused interface reco.bination.A surface reco.struction with 2-thiopheneethylammonium iodide and N,N-dimethylformamide assisted passivates the defect sites located at the surface and grain ***,LiF is used to create this field effect,repelling hole carriers away from the PVK and C60 interface and thus reducing *** a result,a 2-T PVK/CIGS tandem yielded a power co.version efficiency of 24.6%(0.16 cm^(2)),one of the highest results for 2-T PVK/CIGS TSCs to our *** validation undersco.es the potential of our methodology in achieving superior performance in PVK/CIGS tandem solar cells.

关键词： PVK/CIGS TSCs Irregular rough surfaces Modulating the growth PVK/C60 interface reco.bination

Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

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Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： Jinmei Ye co.g Duan Jiaxin Han Jinrong Chen Ning Sun Yuan Li Tifei Yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina co.Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing co.pelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it co.stitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications co.bining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

Reco.binant adeno-associated virus 8 vector in gene therapy:Opportunities and challenges

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Genes & Diseases 2024年第1期11卷 283-293页

作者： Liyuan Zhao Zixuan Yang Minhui Zheng Lei Shi Mengyun Gu Gang Liu Feng Miao Yan Chang Fanghua Huang Naping Tang Anhui University of Traditional Chinese Medicine HefeiAnhui 230000China Yangtze Delta Drug Advanced Research Institute Yangtze Delta Pharmaceutical CollegeNantongJiangsu226133China shanghai innostar bio-technology co. LtdChina State Institute of Pharmaceutical IndustryShanghai 201203China innostar bio-tech Nantong co. Ltd.NantongJiangsu 226133China Center for Drug Evaluation National Medical Products AdministrationBeijing 100022China

In recent years,significant breakthroughs have been made in the field of gene ***-associated virus(AAV)is one of the most promising gene therapy vectors and a powerful tool for delivering the gene of *** the AAV vectors,AAV serotype 8(AAv8)has attracted much attention for its efficient and stable gene transfection into specific ***,reco.binant AAv8 has been widely used in gene therapy research on a va-riety of diseases,including genetic diseases,cancers,autoimmune diseases,and viral diseases.

关键词： AAV8 Adeno-associated virus Gene therapy Primates

Protein arginine methyltransferase-6 regulates heterogeneous nuclear ribonucleoprotein-F expression and is a potential target for the treatment of neuropathic pain

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Neural Regeneration Research 2025年第9期20卷 2682-2696页

作者： Xiaoyu Zhang Yuqi Liu Fangxia Xu Chengcheng Zhou Kaimei Lu Bin Fang Lijuan Wang Lina Huang Zifeng Xu Department of Anesthesiology International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Anesthesiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina shanghai Key Laboratory of Embryo Original Diseases ShanghaiChina

Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal ***,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this *** this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic co.striction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic *** results showed that protein arginine methyltransferase-6 mostly co.localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic co.striction injury and bone cancer *** addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain ***,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 ***,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was ***,protein arginine methyltransferase-6 appeared to co.tribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ***,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical H3R2 *** findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain.

关键词： dorsal root ganglion heterogeneous nuclear ribonucleoprotein F neuropathic pain protein arginine methyltransferase-6 sensory neurons

Role of iron ore in enhancing gasification of iron co.e:Structural evolution,influence mechanism and kinetic analysis

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 58-69页

作者： Jie Wang Wei Wang Xuheng Chen Junfang Bao Qiuyue Hao Heng Zheng Runsheng Xu School of Chemistry and Materials Science Hubei Engineering UniversityXiaogan 432000China Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081China Institue of Ironmaking technology Baosteel Central Research InstituteShanghai 201999China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

The utilization of iron co.e provides a green pathway for low-carbon *** unco.er the influence mechanism of iron ore on the behavior and kinetics of iron co.e gasification,the effect of iron ore on the microstructure of iron co.e was ***,a co.parative study of the gasification reactions between iron co.e and co.e was co.ducted through non-isothermal thermogravimetric *** findings indicate that co.pared to co.e,iron co.e exhibits an augmentation in micropores and specific surface area,and the micropores further extend and *** provides more adsorption sites for co.(2) molecules during the gasification process,resulting in a reduction in the initial gasification temperature of iron *** the heating rate in non-isothermal gasification can enhance the reactivity of iron *** metallic iron reduced from iron ore is embedded in the carbon matrix,reducing the orderliness of the carbon structure,which is primarily responsible for the heightened reactivity of the carbon *** kinetic study indicates that the random pore model can effectively represent the gasification process of iron co.e due to its rich pore ***,as the proportion of iron ore increases,the activation energy for the carbon gasification gradually decreases,from 246.2 kJ/mol for co.e to 192.5 kJ/mol for iron co.e 15wt%.

关键词： low-carbon ironmaking iron co.e gasification structural evolution kinetic model

Microstructures and mechanical properties of Cu/Al co.pound materials during thermal cycle

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Rare Metals 2022年第11期41卷 3911-3918页

作者： Bing Wang Ping Liu Xin-Kuan Liu Zi-Yan Wang Yan-Yan Wang Xiao-Hong Chen Xiao-Zhi Liu School of Materials Science and Engineering University of Shanghai for Science and TechnologyShanghai200093China Automobiles Science and technology(shanghai)co. LtdShanghai200433China

Cu/Al co.pound materials,named as co.perclad aluminum bus bars,are widely used in heat dissipation of modern *** thermal cycle tests were co.ducted at 200,250 and 300℃for different cycle times,*** of thermal cycle temperatures and thermal cycle times on micro structures and mechanical properties of the interface were *** results show that the width of bonding layer and bond strength are significantly affected by thermal cycle temperatures and ***,the variety or the quantity of intermediate co.pounds is scarcely ***_(2)Cu,Cu_(9) Al_(4)and CuAl were identified on the *** the increase in cycle times,grains of the material grew ***,grains of the interface grew up more apparently than those of Cu and *** knowledge may be applied in the establishment of service co.dition and quality evaluation of material.

关键词： co.per-clad aluminum bus bars Thermal cycle Interface Bonding Microstructure Intermetallic

Nonlinear Dynamic Modeling for a Diesel Engine Propeller Shafting Used in Large Marines

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Chinese Journal of Mechanical Engineering 2014年第5期27卷 937-948页

作者： ZHANG Qinglei DUAN Jianguo ZHANG Suohuai FU Yumin School of Mechanical Engineering University of Shanghai for Science and Technology Central Academe shanghai Electric Group co. Ltd School of Mechanical and Automation Engineering shanghai Institute of technology

Longitudinal vibration,torsional vibration and their co.pled vibration are the main vibration modes of the crankshaft-sliding bearing ***,these vibrations of the propeller-crankshaft-sliding bearing system generated by the fluid exciting force on the propeller are much more ***,the torsional and longitudinal vibrations have been studied separately while the research on their co.pled vibration is few,and the influence of the propeller structure to dynamic characteristics of a crankshaft has not been studied *** order to describe the dynamic properties of a crankshaft accurately,a nonlinear dynamic model is proposed taking the effect of torsional-longitudinal co.pling and the variable inertia of propeller,co.necting rod and piston into *** simulation cases are carried out to calculate the response data of the system in time and frequency domains under the working speed and over-speed,*** of vibration analysis of the propeller and crankshaft system co.pled in torsional and longitudinal direction indicate that the system dynamic behaviors are relatively co.plicated especially in the co.ponents of the frequency *** example,the 4 times of an exciting frequency acting on the propeller by fluid appears at 130 r/min,while not yield at 105 r/*** the possible abnormal vibration at over-speed just needs to be *** when designing the propeller shafting used in marine diesel engines,strength calculation and vibration analysis based only on linear model may cause great errors and the proposed research provides some references to design diesel engine propeller shafting used in large marines.

关键词： nonlinear dynamics propeller shafting marine engine numerical simulation

Effect of different bending shapes on thermal properties of flexible light-emitting diode filament

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Chinese Physics B 2018年第11期27卷 430-436页

作者： Liping Wang Wenbo Li Yichao Xu Bobo Yang Mingming Shi Jun Zou Yang Li Xinglu Qian Fei Zheng Lei Yang School of Materials Science and Engineering Shanghai Institute of TechnologyShanghai 201418China School of Science Shanghai Institute of TechnologyShanghai 201418China Zhejiang Emitting Optoelectronic technology co. LTDJiaxing 310000China

Heat dissipation is an important part of light-emitting diode(LED)filament research and has aroused co.stant *** this paper,we studied the thermal performance of flexible LED filament by numerical simulation and through *** heat dissipation characteristics of spring-like structure flexible LED filament were co.puted by finite volume method,and it was found that the chip junction temperature was closely related to the pitch and the bending *** effect of inclination angle of lighting LED filament was discussed because it is relevant to the spring-like structure flexible LED filament in *** results demonstrated that the temperature of the filament increases as the inclination angle improves.

关键词： flexible light-emitting diode filament heat dissipation numerical simulation spring-like

Removal of sulfamethoxazole by nanofiltration membrane

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第11期11卷 868-878页

作者： Su-hua WU Hua-qiang CHU Bing-zhi DONG Jun-ru ZHOU Yu HUANG School of Environmental Science and Engineering Tongji University Shanghai 200092 China shanghai Purge Filtration technology co. Ltd Shanghai 200444 China

The retention of sulfamethoxazole (SMZ) by nanofiltration (NF) membranes is strongly influenced by the pH value of the solution. The retention of SMZ reaches its peak value when the solution pH rises above its pKa2 value as the co.pound transforms into a negatively charged species. Charge repulsion is the main mechanism involved in SMZ removal by NF membranes. In this study, the removal of SMZ by NF membranes, as a function of solution chemistry, was examined at pH 8.9 to investigate the effect of solution co.ditions on charge repulsion. The results show that the retention of negatively charged SMZ is relatively independent of SMZ co.centration, and an increase in the ionic strength of the solution causes a relatively small reduction in retention. A small effect of humic acid (HA) on SMZ retention was noticed at pH 8.9, which can be explained by a small but insignificant improvement in the zeta potential of the membrane caused by HA at high pH values. However, it was found that SMZ co.centration in the feed decreased significantly in solutions co.taining tannic acid (TA). The Adams-Bohart model was applied to our experimental data and was found to be suitable for describing the initial part of the breakthrough curves. The adsorptive parameters of the membrane were determined.

关键词： Pharmaceutically active co.pounds (PhACs) Nanofiltration (NF) membrane Electronic exclusion Adsorption Sulfamethoxazole (SMZ)