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Advances in Atmospheric Sciences 2025年第1期42卷 26-35页

作者： Song YANG Fenghua LING Jing-Jia LUO Lei BAI institute of Climate Application research(ICAR)/School of Future Technology/CIC-FEMD/KLME/ILCEC Nanjing University of Information Science and TechnologyNanjing 210044China shanghai Artificial Intelligence Laboratory Shanghai 200232China

Accurate seasonal precipitation forecasts,especially for extreme events,are crucial to preventing meteorological hazards and their potential impacts on national development,social activity,and ***,the intensity of summer precipitation is often largely underestimated in many current dynamic *** study uses a deep learning method called Cycle-Consistent Generative Adversarial Networks(CycleGAN)to improve the seasonal forecasts for June-JulyAugust precipitation in southeastern China by the Nanjing University of Information Science and Technology Climate Forecast System(NUIST-CFS 1.0).The results suggest that the CycleGAN-based model significantly improves the accuracy in predicting the spatiotemporal distribution of summer precipitation compared to the traditional quantile mapping(QM)*** the unpaired bias-correction model,we can also obtain advanced forecasts of the frequency,intensity,and duration of extreme precipitation events over the dynamic model *** study expands the potential applications of deep learning models toward improving seasonal precipitation forecasts.

关键词： bias correction CycleGAN QM NUIST-CFS 1.0 extreme precipitation

Dual-phase medium-entropy diboride–carbide ceramics with metal element exchange during sintering

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Journal of Advanced Ceramics 2025年第1期14卷 91-100页

作者： Pai Peng Ji-Xuan Liu Xiao-Ting Xin Weichao Bao Yongcheng Liang Fangfang Xu Guo-Jun Zhang State Key Laboratory of Advanced Fiber Materials Institute of Functional MaterialsCollege of Materials Science and EngineeringCollege of PhysicsDonghua UniversityShanghai 201620China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China

Multiphase composition design is a strategy for optimizing the microstructures and properties of ceramic materials through mutual inhibition of grain growth, complementary property improvement, or even mutually reinforcing effects. More interesting phenomena can be expected if chemical interactions between the constituent phases exist. In this study, spark plasma sintering was used to prepare fully dense dual-phase (Zr,Hf,Ta)B2–(Zr,Hf,Ta)C ceramics from self-synthesized equimolar medium-entropy diboride and carbide powders. The obtained ceramics were composed of two distinct solid solution phases, the Zr-rich diboride phase and the Ta-rich carbide phase, indicating that metal element exchange occurred between the starting equimolar medium-entropy diboride and carbide phases during sintering. Owing to the mutual grain-boundary pinning effect, fine-grained dual-phase ceramics were obtained. The chemical driving force originating from metal element exchange during the sintering process is considered to promote the densification process of the ceramics. The metal element exchange between the medium-entropy diboride and carbide phases significantly increased the Young’s modulus of the dual-phase ceramics. The dual-phase medium-entropy 50 vol% (Zr,Hf,Ta)B2–50 vol% (Zr,Hf,Ta)C ceramics with the smallest grain size exhibited the highest hardness of 22.4±0.2 GPa. It is inferred that optimized comprehensive properties or performance of dual-phase high-entropy or medium-entropy ceramics of diborides and carbides can be achieved by adjusting both the volume content and the metal element composition of the corresponding starting powders of diborides and carbides.

关键词： medium-entropy diboride medium-entropy carbide dual-phase medium-entropy ceramics metal element exchange densification mechanical properties

Influence of phytoplankton,bacteria and viruses on nutrient supply in tropical waters

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Journal of Environmental Sciences 2025年第5期151卷 174-186页

作者： Zhi Yang Sim Kwan Chien Goh Nur Hanisah binte Sukarji Feijian Mao Yiliang He Karina Yew-Hoong Gin National University of Singapore Environmental research institute National University of Singapore1 Create Way#15-02Singapore 138602Singapore institute of Tibetan Plateau research Chinese Academy of Sciences(CAS)Beijing 100101China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Civil and Environmental Engineering National University of SingaporeBlk E1A-07-031 Engineering Drive 2Singapore 117576Singapore

Diel investigations of water environments are one means to holistically understand the dynamics and functional roles of phytoplankton,bacteria and viruses in these *** have the potential to substantially impact carbon(C),nitrogen(N)and phosphorus(P)biogeochemistry through their respective *** study characterizes the phytoplankton,bacteria and virus communities and the elemental composition of various C,N and P nutrients flow over three diel cycles in tropical urban *** results show that ratios of C:N:P fluctuated strongly from the lack of dissolved organic phosphorus(DOP)and PO_(4).Specifically,green algae peaked during day time and exudate dissolved organic matter(DOM)that strongly modulate dissolved organic carbon(DOC):DOP ratio to diel DOP *** linear regression and Stella modelling emphasize the roles of viruses together with Synechococcus as important nutrient recyclers of NH_(4)and PO_(4)in nutrients-limited *** normalised surface PO_(4)and combined surface and bottom NH_(4)concentration selected both viruses and Synechococcus as important *** model of N and P biogeochemical cycles can achieve 69%and 57%similar to observed concentration of NH_(4)and PO_(4),respectively.A short latent period of 9 hr was calculated,in addition to the calibrated high infectivity of viruses to *** together,the rapid turn-over between Synechococcus and viruses has biogeochemical significance,where the rapid recycling of essential nutrients allows for shortcuts in the N and P cycle,supporting a wide range of microbes.

关键词： Diel Phytoplankton Bacteria Virus Nutrients Element ratios

Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration research 2025年第10期20卷 3025-3039页

作者： Jia Fang Zhuangzhuang Li Pengjun Wang Xiaoxu Zhang Song Mao Yini Li Dongzhen Yu Xiaoyan Li Yazhi Xing Haibo Shi Shankai Yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

Intermetallic compounds for nitrogen electrochemistry

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Green Energy & Environment 2025年第2期10卷 268-291页

作者： Haohong Wei Cheng Tang Yanyun Wang Yongcheng Feng Huancong Shi Mingjin Cui Huakun Liu Shixue Dou Laiquan Li institute of Energy Materials Science School of Energy and Power EngineeringUniversity of Shanghai Science and TechnologyShanghai200093China Tsinghua Center for Green Chemical Engineering Electrification(CCEE) Department of Chemical EngineeringTsinghua UniversityBeijing100084China State Grid New Energy Cloud Carbon Neutralization Innovation Center State Grid Zhejiang Electric Power Co.LtdHuzhou Power Supply CompanyZhejiang313000China shanghai Marine Diesel Engine research institute.shanghai 201108China

Electrochemical nitrogen transformation techniques represent a burgeoning avenue for nitrogen pollutant remediation and synthesizing valuable nitrogenous products from atmospheric *** compounds(IMCs)nanocrystals,featured with unique geometric,electronic and functional properties,have emerged as promising *** review discusses various synthesis approaches for IMCs,including thermal annealing,wet chemical synthesis,electrochemical synthesis,and other emerging methods,analyzing their advantages and *** we summarized the recent advances of IMCs in electrocatalytic nitrogen transformation reactions,such as nitrate reduction reaction,nitric oxide reduction reaction,nitrogen reduction reaction,and hydrazine oxidation *** significant progress,challenges remain in the field,particularly in adopting more refined strategies to improve catalyst performance and *** review aims to comprehensively understand the structural properties of IMCs and their structure-performance relationship,guiding the development of more efficient and stable catalysts for future nitrogen electrochemistry.

关键词： Intermetallic compounds Electrocatalysis Nitrogen transformation reactions Synthesis methods Catalyst design

A Geometric Model Simplification Strategy for CFD Simulation of the Cockpit Internal Environment

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Computer Modeling in Engineering & Sciences 2025年第2期142卷 1545-1564页

作者： Meng Zhao Jiaao Liu YudiLiu Zhengwei Long Tianjin Key Lab.of Indoor Air Environmental Quality Control School of Environmental Science and EngineeringTianjin UniversityTianjin300072China Architectural institute China Railway Design CorporationTianjin300308China Environmental Control Oxygen Department Shanghai Aircraft Design and Research InstituteCOMACShanghai201210China

Computational Fluids Dynamics(CFD)simulations are essential for optimizing the design of a cockpit’s internal environment,but the complex geometric models consume a significant amount of computational resources and *** simplification of geometric models may result in inaccurate calculations of physical *** address this issue,this study establishes a geometric model simplification strategy and successfully applies it to a *** implementation of the whole approach is divided into three steps,summarized in three methods,namely Sensitivity Analysis Method(SAM),Detail Suppression Method(DSM),and Evaluation Standards Method(ESM).Sensitivity analysis of the detailed features of the geometric model is performed using the adjoint *** details of the geometric model are suppressed based on the principle of curvature *** evaluation,the suppression degrees of detailed features with different sensitivity levels are *** results demonstrate that this strategy can be employed to achieve precise simplification standards,thereby avoiding excessive deviations caused by arbitrary simplification and reducing the significant costs associated with trial-and-error simplification.

关键词： CFD model simplification cockpit sensitivity analysis detail suppression

Edge computing aileron mechatronics using antiphase hysteresis Schmitt trigger for fast flutter suppression

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Control Theory and Technology 2025年第1期23卷 153-160页

作者： Tangwen Yin Dan Huang Xiaochun Zhang Department of Automation Shanghai Jiao Tong Universityand Key Laboratory of System Control and Information Processing of Ministry of EducationShanghai200240China School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai200240China Control Division Shanghai Aircraft Design and Research InstituteShanghai200210China

An aileron is a crucial control surface for *** jitter or shaking caused by the aileron mechatronics could have catastrophic consequences for the aircraft’s stability,maneuverability,safety,and *** paper presents a robust solution in the form of a fast flutter suppression digital control logic of edge computing aileron mechatronics(ECAM).We have effectively eliminated passive and active oscillating response biases by integrating nonlinear functional parameters and an antiphase hysteresis Schmitt *** findings demonstrate that self-tuning nonlinear parameters can optimize stability,robustness,and *** the same time,the antiphase hysteresis Schmitt trigger effectively rejects flutters without the need for collaborative navigation and *** hardware-in-the-loop simulation results confirm that this approach can eliminate aircraft jitter and shaking while ensuring expected stability and *** conclusion,this nonlinear aileron mechatronics with a Schmitt positive feedback mechanism is a highly effective solution for distributed flight control and active flutter rejection.

关键词： Aileron Edge computing Flutter suppression Mechatronics Nonlinear hysteresis control Positive feedback

Suppression of the Coffee Ring Effect with Undetectable Disturbance of the Deposit

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Chinese Physics Letters 2025年第2期42卷 260-270页

作者： Shiqi Sheng Zhening Fang Shiyu Gao Ruoyang Chen Ying Wang Haijun Yang Haiping Fang School of Physics East China University of Science and TechnologyShanghai 200237China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China shanghai Synchrotron Radiation Facility(SSRF) Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Wenzhou institute University of Chinese Academy of SciencesWenzhou 325001China

Suppressing the coffee ring effect(CRE)of an aqueous suspension through manipulation without affecting the remaining deposit is highly desirable for practical applications;however,this is extremely ***,we demonstrate CRE suppression with undetectable disturbance of the deposit on carbon-based *** was achieved by adding ammonium bicarbonate(NH4HCO_(3)),which benefits from the dissociation of NH_(4)HCO_(3) to produce NH_(4)^(+),as well as its decomposition into NH_(3) and CO_(2) ***,NH_(4)^(+) can also function as Na^(+)/K^(+)to suppress the CRE through cation interactions,although its hydrate state is only partially positively ***,we successfully applied this approach to enhance the morphology,resistance,and color uniformity of deposits of graphene oxide quantum dots,conductive inks,and organic dyes,*** study provides a practical strategy for improving the performance of fabricated devices and paves the way for the development of high-accuracy manufacturing techniques in diverse industries.

关键词： deposit adding desirable

A logistic-Lasso-regression-based seismic fragility analysis method for electrical equipment considering structural and seismic parameter uncertainty

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Earthquake Engineering and Engineering Vibration 2025年第1期24卷 169-186页

作者： Cui Jiawei Che Ailan Li Sheng Cheng Yongfeng Key Lab of Structures Dynamic Behavior and Control of the Ministry of Education School of Civil EngineeringHarbin Institute of TechnologyHarbin 150094China School of Ocean and Civil Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China China Electric Power research institute Beijing 100055China

Damage to electrical equipment in an earthquake can lead to power outage of power *** fragility analysis is a common method to assess the seismic reliability of electrical *** further guarantee the efficiency of analysis,multi-source uncertainties including the structure itself and seismic excitation need to be considered.A method for seismic fragility analysis that reflects structural and seismic parameter uncertainty was developed in this *** proposed method used a random sampling method based on Latin hypercube sampling(LHS)to account for the structure parameter uncertainty and the group structure characteristics of electrical ***,logistic Lasso regression(LLR)was used to find the seismic fragility surface based on double ground motion intensity measures(IM).The seismic fragility based on the finite element model of an±1000 kV main transformer(UHVMT)was analyzed using the proposed *** results show that the seismic fragility function obtained by this method can be used to construct the relationship between the uncertainty parameters and the failure *** seismic fragility surface did not only provide the probabilities of seismic damage states under different IMs,but also had better stability than the fragility ***,the sensitivity analysis of the structural parameters revealed that the elastic module of the bushing and the height of the high-voltage bushing may have a greater influence.

关键词： seismic fragility uncertainty logistic lasso regression ±1000 kV main transformer sensitivity analysis

AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China(Life Sciences) 2025年第1期68卷 204-218页

作者： Chen Xiong Hong Ling Yingdan Huang Hanzhi Dong Bangxiang Xie Qian Hao Xiang Zhou Fudan University shanghai Cancer Center and institutes of Biomedical Sciences Fudan UniversityShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan UniversityShanghai 200032China Department of Oncology First Affiliated Hospital of Nanchang UniversityNanchang 330006China Beijing institute of Hepatology Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Beijing Engineering research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Beijing 100069China Key Laboratory of Breast Cancer in shanghai Fudan University Shanghai Cancer CenterFudan UniversityShanghai 200032China shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)Institutes of Biomedical SciencesFudan UniversityShanghai 200032China

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies,including WEE1 *** that p53 activation can also lead to multiple types of cell death,the role of this tumor suppressor in WEE1 inhibitor-based therapies remains *** this study,we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer *** findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake,an action similar to that of ***,inhibition of WEE1 by the WEE1 inhibitors or siRNAs induced compensatory upregulation of SLC7A11,which conferred resistance to ***,AZD1775 prevented the enrichment of H3K9me3,a histone marker of transcriptional repression,on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1,thereby enhancing NRF2-mediated SLC7A11 *** finding was also validated using the H3K9me3 inhibitor ***,we found that the nucleolar stress-inducing agent Actinomycin D(Act.D)inhibited SLC7A11 expression by activating p53,thus augmenting AZD1775-induced ***,the combination of AZD1775 and Act.D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in ***,our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription,and inhibition of SLC7A11 by Act.D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

关键词： p53 NRF2 SLC7A11 WEE1 AZD1775 ferroptosis nucleolar stress