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China cdc weekly 2024年第35期6卷 891-895页

作者： Lixin Rao Zheyuan Wu Jing Chen Zhen Ning Xin Shen shanghai Municipal Center for Disease Control and Prevention ShanghaiChina

Summary What is already known about this topic?The World Health Organization(WHO)has recommended the inclusion of the C-reactive protein(CRP)test in active tuberculosis(ATB)screening algorithms among human immunodeficiency virus(HIV)-infected *** performance of the CRP test in African regions has been *** is added by this report?This study analyzed data from a big data platform of shanghai medical records together with infectious disease surveillance systems.

关键词： Infect tuberculosis records

Assessment of the Potential for Cross-Border Transmission of Infectious Diseases via Commercial Air Travel—shanghai Municipality,China,2019-2023

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China cdc weekly 2024年第42期6卷 1093-1097页

作者： Weimin Hao Jieyan Gu Yujue Wang Li Wang Liguang Hou Ting Wang Wei Zhang Yi Zhang Na He Zhengan Tian Department of Epidemiology School of Public HealthFudan UniversityShanghaiChina Division of Health Quarantine Shanghai Customs DistrictShanghaiChina Division of Enterprise Management Shanghai Customs DistrictShanghaiChina Hongqiao Airport Customs House Shanghai Customs DistrictShanghaiChina Pudong International Airport Customs House Shanghai Customs DistrictShanghaiChina shanghai Institute of Infectious Disease and Biosecurity Fudan UniversityShanghaiChina shanghai International Travel Healthcare Center ShanghaiChina

What is already known about this topic?Despite the end of coronavirus disease 2019(COVID-19)as a public health emergency of international concern(PHEIC),the changes in risks of travel-related infectious diseases and their impact on global health quarantine still call for great *** is added by this report?Our study indicated that the pattern of changes in the positive detection rate of arrivals was basically in line with the disease incidence in countries from which travel was *** are the implications for public health practice?Accurate risk assessment at entry-exit ports can significantly enhance the efficiency of targeting highrisk international arrivals,especially in the early stages of epidemic control and prevention when available data are insufficient.

关键词： prevention travel diseases

Salmonella Grumpensis Causing Diarrhea in Children—shanghai Municipality,China,2023

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China cdc weekly 2024年第18期6卷 396-400,I0006,I0007页

作者： Yue Liu Xuebin Xu Wenqin Wang Wenjia Xiao Yi Hu Xin Chen Min Chen shanghai Municipal Center for Disease Control and Prevention ShanghaiChina Pudong New Area Center for Disease Control and Prevention ShanghaiChina Department of Epidemiology Key Laboratory of Public Health Safety of Ministry of EducationSchool of Public HealthFudan UniversityShanghaiChina

Summary What is already known about this topic?Foodborne diseases are a growing public health concern with a notable disease burden in *** is added by this report?Two children with diarrhea visited a healthcare facility within 24 hours on August 1 and 2,*** Grumpensis was detected in their stool samples by the public health *** genome sequencing(WGS)analysis revealed characteristics typical of outbreak *** the origin of the outbreak was unknown,the possibility of a hidden shared infection was deemed feasible.

关键词： diarrhea diseases Whole

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China cdc weekly 2024年第37期6卷 968-971页

作者： Zou Chen Hong Zhang Yifeng Shen Chuchu Ye shanghai Pudong New Area Center for Disease Control and Prevention ShanghaiChina Fudan University Pudong Institute of Preventive Medicine ShanghaiChina

What is already known about this topic?Noroviruses are highly infectious with rapid transmission capabilities,causing illness for an average duration of 12-60 *** China,individuals in educational agencies may return to class 72 hours after symptom *** is added by this report?This outbreak was precipitated by a potential source of infection in a child resuming class after a 72-hour quarantine post-symptom resolution,leading to a cluster of cases within the *** are the implications for public health practice?While extending the quarantine period for children may be considered from a safety perspective,it is a challenge for educational *** outbreak is deemed a low-probability event;however,further investigation into the detoxification period of asymptomatic patients is warranted.

关键词： return break Nor

Inflection Point Age in the Middle and Older Women—Jiangxi Province,China,2020-2022

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China cdc weekly 2024年第9期6卷 162-167页

作者： Shanlan Yang Langlang Zhang Helang Huang Jiaofeng Wang Lei Wu Zhijun Bao shanghai Institute of Infectious Disease and Biosecurity Fudan UniversityShanghaiChina Department of Gerontology Huadong Hospital Affiliated to Fudan UniversityShanghai Key Laboratory of Clinical Geriatric MedicineResearch Center on Aging and MedicineFudan UniversityShanghaiChina Jiangxi Provincial Key Laboratory of Preventive Medicine School of Public HealthNanchang UniversityNanchang CityJiangxi ProvinceChina

Summary What is already known about this topic?Previous studies have predominantly examined the micro-level aspects of women aging inflection points,while macro-level research using big data on the inflection points o... 详细信息

关键词： Middle Jiangxi currently

Hydrolysis mechanism of YbB_(2)C_(2)and the microstructure of the carbon derived from the hydrolysis reaction

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Journal of Materials Science & Technology 2024年第4期171卷 209-221页

作者： Zhihui Li Hao Zhang Jixin Chen Jiemin Wang Xiaohui Wang Jinxing Yang Chao Zhang Zerong Zhang Hongyang Liu Fei Huang Meishuan Li Fei Li Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China shanghai Key Laboratory for High Temperature Materials and Precision Forming School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Carbide-derived carbon(cdc)materials have gained great attention due to the excellent properties for various potential ***,graphite crystal is formed during a room-temperature hydrolysis pro-cess of layered compound YbB_(2)C_(2).The formation mechanism can be demonstrated by a YbB_(2)C_(2)molecular cell:Yb^(3+)acts as a cathode where H_(2)O molecule is reduced to H atom and OH^(−)ion,while(B_(2)C_(2))^(3−)acts as an anode where OH−ion is oxidized to O ***,YbB_(2)C_(2)molecular cell begins to disintegrate,i.e.,Yb^(3+)ion,B and C atoms dissociate from the molecular *** as-produced C atoms combine to form graphite *** initial graphite crystal is a cabbage-like microsphere,and then it gradually disintegrates and transforms into layered *** addition,YbB_(6),Yb_(3)(OH)_(3)n(BO_(3))_((3-n))sol,hydrogen,hydrocarbons,and carbon oxides form *** method provides a general and inexpensive route to obtain carbide-derived graphite crystal.

关键词： Carbide-derived carbon YbB_(2)C_(2) Hydrolysis Molecular cell First-principles calculations

Hepatitis B virus core protein as a Rab-GAP suppressor driving liver disease progression

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Science Bulletin 2024年第16期69卷 2580-2595页

作者： Yu Su Fan Bu Yuanfei Zhu Le Yang Qiong Wu Yuan Zheng Jianjin Zhao Lin Yu Nan Jiang Yongxiang Wang Jian Wu Youhua Xie Xinxin Zhang Yueqiu Gao Ke Lan Qiang Deng Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesShanghai Institute of Infectious Disease and BiosecurityFudan UniversityShanghai 200032China shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection Fudan UniversityShanghai 200032China Department of Infectious Diseases Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Laboratory of Cellular Immunity Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China State Key Laboratory of Virology College of Life SciencesWuhan UniversityWuhan 430072China

Chronic hepatitis B virus(HBV)infection can lead to advanced liver ***,we establish a transgenic murine model expressing a basic core promoter(BCP)-mutated HBV *** previous studies on the wild-type virus,the BCP-mutated HBV transgenic mice manifest chronic liver injury that culminates in cirrhosis and tumor development with ***,agonistic anti-Fas treatment induces fulminant hepatitis in these mice even at a negligible *** the BCP mutant exhibits a striking increase in HBV core protein(HBc)expression,we posit that HBc is actively involved in hepatocellular ***,HBc interferes with Fis1-stimulated mitochondrial recruitment of Tre-2/Bub2/cdc16 domain family member 15(TBC1D15).HBc may also inhibit multiple Rab GTPase-activating proteins,including Rab7-specific TBC1D15 and TBC1D5,by binding to their conserved catalytic *** cells under mitochondrial stress,HBc thus perturbs mitochondrial dynamics and prevents the recycling of damaged ***,sustained HBc expression causes lysosomal consumption via Rab7 hyperactivation,which further hampers late-stage autophagy and substantially increases apoptotic cell ***,we show that adenovirally expressed HBc in a mouse model is directly cytopathic and causes profound liver injury,independent of antigen-specific immune *** findings reveal an unexpected cytopathic role of HBc,making it a pivotal target for HBV-associated liver disease *** BCP-mutated HBV transgenic mice also provide a valuable model for understanding chronic hepatitis B progression and for the assessment of therapeutic strategies.

关键词： Apoptosis Basic core promoter Mitophagy Rab7 Transgenic mice

Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell(cdc1)activation and tumor infiltration

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2804-2818页

作者： Fenglian He Zhongen Wu Chenglong Liu Yuanyuan Zhu Yan Zhou Enming Tian Rina Rosin-Arbesfeld Dehua Yang Ming-Wei Wang Di Zhu Department of Pharmacology Minhang Hospitaland Key Laboratory of Smart Drug DeliveryShanghai Engineering Research Center of Immune TherapySchool of PharmacyFudan UniversityShanghai 201203China The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research Shanghai Institute of Materia MedicaChinese Academy of Sciences(CAS)Shanghai 201203China Department of Microbiology and Immunology Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Department of Pharmacology School of Basic Medical SciencesFudan UniversityShanghai 200032China Research Center for Deepsea Bioresources SanyaChina Department of Chemistry School of ScienceThe University of TokyoTokyoJapan Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education School of PharmacyHainan Medical UniversityHaikouChina Shandong Academy of Pharmaceutical Science JinanChina

Conventional type 1 dendritic cells(cdc1)are the essential antigen-presenting DC subset in antitumor *** B-cell lymphoma 9 and B-cell lymphoma 9-like(BCL9/BCL9L)inhibits tumor growth and boosts immune responses against ***,whether oncogenic BCL9/BCL9L impairs antigen presentation in tumors is still not completely ***,we show that targeting BCL9/BCL9L enhanced antigen presentation by stimulating cdc1 activation and infiltration into *** inhibition of BCL9/BCL9L with a novel inhibitor hsBCL9z96 or Bcl9/Bcl9l knockout mice markedly delayed tumor growth and promoted antitumor CD8^(+)T cell ***,targeting BCL9/BCL9L promoted antigen presentation in *** is due to the increase of cdc1 activation and tumor infiltration by the XCL1-XCR1 ***,using single-cell transcriptomics analysis,we found that Bcl9/Bcl9l deficient cdc1 were superior to wild-type(WT)cdc1 at activation and antigen presentation via NF-κB/IRF1 ***,we demonstrate that targeting BCL9/BCL9L plays a crucial role in cdc1-modulated antigen presentation of tumor-derived antigens,as well as CD8^(+)T cell activation and tumor *** BCL9/BCL9L to regulate cdc1 function and directly orchestrate a positive feedback loop necessary for optimal antitumor immunity could serve as a potential strategy to counter immune suppression and enhance cancer immunotherapy.

关键词： immunity Targeting markedly

Accelerating the Control and Elimination of Major Parasitic Diseases in China—On World NTD Day 2024

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China cdc weekly 2024年第6期6卷 95-99页

作者： Yuwan Hao Tian Tian Zelin Zhu Yijun Chen Jing Xu Shuai Han Menbao Qian Yi Zhang Shizhu Li Qiang Wang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute of Parasitic DiseasesChinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)Key Laboratory on Parasite and Vector BiologyMinistry of HealthWHO Centre for Tropical Diseases National Center for International Research on Tropical Diseases Ministry of Science and TechnologyShanghaiChinaSchool of Global HealthChinese Center for Tropical Diseases Research-Shanghai Jiao Tong University School of MedicineShanghaiChina

Neglected tropical diseases(NTDs)are a group of diseases associated with poverty that affect over 1 billion people worldwide(1).On May 31,2021,the World Health Assembly(WHA)officially recognized January 30 as World Neglected Tropical Diseases Day through decision WHA74(18).This designation aims to raise awareness about the severe impact of NTDs on disadvantaged populations and to mobilize support for control,elimination,and eradication efforts.

关键词： Diseases diseases disadvantage

Genome Analysis of Plasmodium falciparum:A Preliminary Observation-Sierra Leone,2022-2023

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China cdc weekly 2024年第17期6卷 368-373页

作者： Tianyu Wang Haimo Shen Bin Xu Wanxuan Yang Shenbo Chen Junhu Chen National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Centre for International Research on Tropical DiseasesShanghaiChina School of Basic Medical Sciences and Forensic Medicine Hangzhou Medical CollegeHangzhou CityZhejiang ProvinceChina School of Global Health Chinese Centre for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiChina Hainan Tropical Diseases Research Center(Hainan Sub-Center Chinese Center for Tropical Diseases Research)Haikou CityHainan ProvinceChina.

What is already known about this topic?Sierra Leone,with a gross domestic product(GDP)per capita below$300 and significant poverty,ranks among the world’s least developed countries(LDCs).Despite its modest population of 8.6 million,the nation reports approximately 2.6 million malaria cases ***,there has been no reporting on the malaria genome data from this *** is added by this report?In this study,we present the first reported wholegenome sequence analysis of 19 high parasite-density Plasmodium falciparum isolates from Sierra Leone,providing insights into the genomic epidemiology of this high-prevalence *** found a high degree of relatedness among infections and substantial genetic diversity,consistent with the gradual reduction in overall case ***,our whole-genome analysis revealed that,beyond drug-resistance genes,gene families related to blood cell invasion,immune evasion,and others are undergoing directional *** suggests that the population in Sierra Leone has developed a relatively strong acquired *** are the implications for public health practice?The genomic data not only facilitate the creation of single nucleotide polymorphism barcodes for case tracking but also enable the analysis of evolving transmission dynamics and selection ***,the samples from Sierra Leone exhibited higher selective pressures on resistance genes compared to those from Asia,a trend not commonly observed in other African *** suggests that less stringent healthcare systems and inconsistent treatment strategies can subject parasites to increased drug pressure,thereby accelerating the development of resistant strains.

关键词： epidemiology invasion Observation