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Epimedin B exhibits pigmentation by increasing tyrosinase family proteins expression,activity,and stability

Journal of Pharmaceutical Analysis 2024年第1期14卷 69-85页

作者： Chen Hong Yifan Zhang Lili Yang Haoyang Xu Kang Cheng Zhi Lv Kaixian Chen Yiming Li Huali Wu Department of TCM Chemistry School of PharmacyShanghai University of Traditional Chinese MedicineShanghai200000China Department of Dermatology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai200000China International Education College Shanghai University of Traditional Chinese MedicineShanghai200000China shanghai Inoherb Cosmetics Co. Ltd.Shanghai200000China

Epimedin B(EB)is one of the main flavonoid ingredients present in Epimedium brevicornum Maxim.,a traditional herb widely used in *** previous study showed that EB was a stronger inducer of melanogenesis and an activator of tyrosinase(TYR).However,the role of EB in melanogenesis and the mechanism underlying the regulation remain ***,as an extension to our previous investigation,we provide comprehensive evidence of EB-induced pigmentation in vivo and in vitro and elucidate the melanogenesis mechanism by assessing its effects on the TYR family of proteins(TYRs)in terms of expression,activity,and *** results showed that EB increased TYRs expression through microphthalmia-associated transcription factor-mediated p-Akt(referred to as protein kinase B(PKB))/glycogen synthase kinase 3β(GSK3β)/β-catenin,p-p70 S6 kinase cascades,and protein 38(p38)/mitogen-activated protein(MAP)kinase(MAPK)and extracellular regulated protein kinases(ERK)/MAPK pathways,after which EB increased the number of melanosomes and promoted their maturation for melanogenesis in melanoma cells and human primary melanocytes/skin ***,EB exerted repigmentation by stimulating TYR activity in hydroquinone-and N-phenylthiourea-induced TYR inhibitive models,including melanoma cells,zebrafish,and ***,EB ameliorated monobenzone-induced depigmentation in vitro and in vivo through the enhancement of TYRs stability by inhibiting TYR misfolding,TYR-related protein 1 formation,and retention in the endoplasmic reticulum and then by downregulating the ubiquitination and proteolysis *** data conclude that EB can target TYRs and alter their expression,activity,and stability,thus stimulating their pigmentation function,which might provide a novel rational strategy for hypopigmentation treatment in the pharmaceutical and cosmetic industries.

关键词： Epimedin B Melanosome Tyrosinase Melanogenesis

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Alternative splicing and related RNA binding proteins in human health and disease

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Signal Transduction and Targeted Therapy 2024年第3期9卷 839-871页

作者： Yining Tao Qi Zhang Haoyu Wang Xiyu Yang Haoran Mu Department of Orthopedics Shanghai General HospitalShanghai Jiao Tong University School of Medicine200000 ShanghaiChina shanghai Bone Tumor Institution 200000 ShanghaiChina Department of Biochemistry and Molecular Cell Biology Shanghai Key Laboratory for Tumor Microenvironment and InflammationShanghai Jiao Tong University School of Medicine200000 ShanghaiChina

Alternative splicing(AS)serves as a pivotal mechanism in transcriptional regulation,engendering transcript diversity,and modifications in protein structure and *** varying tissues,developmental stages,or under specific conditions,AS gives rise to distinct splice *** implies that these isoforms possess unique temporal and spatial roles,thereby associating AS with standard biological activities and *** these,AS-related RNA-binding proteins(RBPs)play an instrumental role in regulating alternative splicing *** physiological conditions,the diversity of proteins mediated by AS influences the structure,function,interaction,and localization of proteins,thereby participating in the differentiation and development of an array of tissues and *** pathological conditions,alterations in AS are linked with various diseases,particularly *** changes can lead to modifications in gene splicing patterns,culminating in changes or loss of protein *** instance,in cancer,abnormalities in AS and RBPs may result in aberrant expression of cancer-associated genes,thereby promoting the onset and progression of *** and RBPs are also associated with numerous neurodegenerative diseases and autoimmune ***,the study of AS across different tissues holds significant *** review provides a detailed account of the recent advancements in the study of alternative splicing and AS-related RNA-binding proteins in tissue development and diseases,which aids in deepening the understanding of gene expression complexity and offers new insights and methodologies for precision medicine.

关键词： organs alterations thereby

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A novel complex-high-order graph convolutional network paradigm:ChyGCN

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Chinese Physics B 2024年第5期33卷 665-672页

作者：郑和翔苗书宇顾长贵 Business School University of Shanghai for Science and TechnologyShanghai 200093China Ant Group Shanghai 200000China

In recent years,there has been a growing interest in graph convolutional networks(GCN).However,existing GCN and variants are predominantly based on simple graph or hypergraph structures,which restricts their ability to handle complex data correlations in practical *** limitations stem from the difficulty in establishing multiple hierarchies and acquiring adaptive weights for each of *** address this issue,this paper introduces the latest concept of complex hypergraphs and constructs a versatile high-order multi-level data correlation *** model is realized by establishing a three-tier structure of ***,we start by establishing hyperedge clusters on a foundational network,utilizing a second-order hypergraph structure to depict potential *** this second-order structure,truncation methods are used to assess and generate a three-layer composite *** the construction of the composite structure,an adaptive learning strategy is implemented to merge correlations across different *** evaluate this model on several popular datasets and compare it with recent state-of-the-art *** comprehensive assessment results demonstrate that the proposed model surpasses the existing methods,particularly in modeling implicit data correlations(the classification accuracy of nodes on five public datasets Cora,Citeseer,Pubmed,Github Web ML,and Facebook are 86.1±0.33,79.2±0.35,83.1±0.46,83.8±0.23,and 80.1±0.37,respectively).This indicates that our approach possesses advantages in handling datasets with implicit multi-level structures.

关键词： raph convolutional network complex modeling complex hypergraph

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An Improved Bounded Conflict-Based Search for Multi-AGV Pathfinding in Automated Container Terminals

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2705-2727页

作者： Xinci Zhou Jin Zhu shanghai Maritime University Logistics Science and Engineering Research InstituteShanghai200000China

As the number of automated guided vehicles(AGVs)within automated container terminals(ACT)continues to rise,conflicts have becomemore *** point and edge conflicts ofAGVs,amulti-AGVconflict-free path planning model has been formulated to minimize the total path length of AGVs between shore bridges and *** larger terminalmaps and complex environments,the grid method is employed to model AGVs’road *** improved bounded conflict-based search(IBCBS)algorithmtailored to ACT is proposed,leveraging the binary tree principle to resolve conflicts and employing focal search to expand the search *** experiments involving 60 AGVs indicate a reduction in computing time by 37.397%to 64.06%while maintaining the over cost within 1.019%.Numerical experiments validate the proposed algorithm’s efficacy in enhancing efficiency and ensuring solution quality.

关键词： Automated terminals multi-AGV multi-agent path finding(MAPF) conflict based search(CBS) AGV path planning

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Multifunctional role of oral bacteria in the progression of nonalcoholic fatty liver disease

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World Journal of Hepatology 2024年第5期16卷 688-702页

作者： En-Hua Mei Chao Yao Yi-Nan Chen Shun-Xue Nan Sheng-Cai Qi shanghai Medical College Fudan UniversityShanghai 200000China Department of Prothodontics Shanghai Stomatological HospitalFudan UniversityShanghai 200000China shanghai Key Laboratory of Craniomaxiofacial Development and Diseases Fudan UniversityShanghai 200000China

Non-alcoholic fatty liver disease(NAFLD)encompasses a spectrum of liver disorders of varying severity,ultimately leading to *** spectrum primarily consists of NAFL and non-alcoholic *** pathogenesis of NAFLD is closely associated with disturbances in the gut micr-obiota and impairment of the intestinal ***-gut commensal flora,particularly bacteria,play a pivotal role in the progression of ***,Porphyromonas gingivalis,a principal bacterium involved in periodontitis,is known to facilitate lipid accumulation,augment immune responses,and induce insulin resistance,thereby exacerbating fibrosis in cases of periodontitis-associated *** influence of oral microbiota on NAFLD via the“oral-gut-liver”axis is gaining recognition,offering a novel perspective for NAFLD management through microbial imbalance *** review endeavors to encapsulate the intricate roles of oral bacteria in NAFLD and explore underlying mechanisms,emphasizing microbial control strategies as a viable therapeutic avenue for NAFLD.

关键词： Non-alcoholic fatty liver disease Oral bacteria Gut bacteria Periodontitis Non-alcoholic steatohepatitis

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Dominant negative effect as a novel mechanism of SPAST gene mutation in a large family with hereditary spastic paraplegia

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Genes & Diseases 2024年第5期11卷 74-77页

作者： Ke Deng Haibo Ruan Feifei Yu Zhenle Pei Congjian Xu Shuo Zhang shanghai Ji Ai Genetics&IVF Institute Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200000China shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai 200000China The First People’s Hospital of Wenling WenlingZhejiang 317500China Rushan Hospital of Traditional Chinese Medicine RushanShandong 264599China Department of Obstetrics and Gynecology Fudan UniversityShanghai 200000China.

Hereditary spastic paraplegia(HSP)is a group of disorders with genetic heterogeneity,lower-extremity weakness,and spasticity are the most common signs and *** is the most frequently disease-causing *** is a microtubule-severing enzyme encoded by SPAST that cleaves long microtubules into short fragments by interacting with other proteins or *** spastic paraplegia type 4(SPG4),which is autosomal dominant,is the clinical subtype associated with SPAST ***4 accounts for up to one-third of all HSP cases and usually presents with isolated lower extremity spasticity,with or without bladder or sensory dysfunction.1 The main cause of SPG4 is believed to be spastin haploinsufficiency,which results from mutations in the SPAST gene.

关键词： bladder insufficiency clinical

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The Variation of Plankton Community Structure in Artificial Reef Area and Adjacent Waters in Haizhou Bay

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Journal of Ocean University of China 2024年第1期23卷 264-276页

作者： GAO Shike SHI Yixi LU Yanan ZHANG Shuo College of Marine Sciences Shanghai Ocean UniversityShanghai 201306China Joint Laboratory for Monitoring and Conservation of Aquatic Living Resources in the Yangtze Estuary Shanghai 200000China

Plankton are an important component of marine protected areas(MPAs),and its communities would require much smaller interpatch distances to ensure connection among *** to the survey from MPAs dominated by artificial reefs and adjacent waters(estuary area(EA),aquaculture area(AA),artificial reef area(ARA),natural area(NA)and comprehensive effect area(CEA))in Haizhou Bay in spring and autumn,we analyzed phyto-zooplankton composition,abundance and biomass,and correlation with hydrologic variables to gain information about the forces that structure the *** results showed that the dominant zooplankton were copepods(spring,98.9%;autumn,94.2%),while the phytoplankton were mainly composed of Bacillariophyta(spring,61.8%;autumn,95.6%).The RDA results showed that temperature,salinity and depth highly associated with the distribution and composition of plankton species among the habitats than other factors in spring;temperature,Chla and DO had the strongest influence in *** zooplankton in the ARA and AA ecosystems basically contained the same species as those in other habitats,and each habitat also exhibited a relatively unique combination of plankton *** structures of the EA zooplankton in spring and the EA phytoplankton in both seasons were much different than other habitats,which may have been caused by factors such as currents and *** concluded that there exists similarity of the plankton community between artificial reef area and adjacent waters,whereas the EAs may be relatively independent ***,these interaction between plankton community should be considered when designing MPA networks,and ocean circulations should be considered more than the environmental factors.

关键词： zooplankton phytoplankton seasonal variation environmental factor artificial reef

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Treatment of a femoral neck fracture combined with ipsilateral femoral head and intertrochanteric fractures: A case report

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World Journal of Orthopedics 2024年第10期15卷 973-980页

作者： Xiang Yu Yu-Zhi Li Hai-Jian Lu Bing-Li Liu Department of Orthopedics Shanghai Seventh People's HospitalShanghai 200000China

BACKGROUND This article presents a rare case of a complex hip fracture involving the ipsilateral femoral neck,trochanter,and femoral head,that was accompanied by hip ***,there is no established standard treatment method for this specific type of ***,it is crucial to comprehensively consider factors such as patient age,fracture type,and degree of displacement to achieve a successful *** SUMMARY A 38-year-old man sustained a comminuted fracture of his right hip as a result of a car *** injuries included a fracture of the femoral head,a fracture of the femoral neck,an intertrochanteric fracture of the femur,and a posterior dislocation of the hip on the same *** opted for a treatment approach combining the use of a proximal femoral locking plate,cannulated screws,and Kirschner *** the surgery,we developed an individualized rehabil-itation program to restore patient limb *** For this complex fracture,we selected appropriate internal fixation and for-mulated individualized rehabilitation,which ultimately achieved good results.

关键词： Locking plate Femoral neck fracture Femoral head fracture Intertrochanteric fracture Open reduction and internal fixation Case report

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Colonoscopy-assisted removal of an impaction foreign body at the rectosigmoid junction: A case report

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World Journal of Clinical Cases 2024年第11期12卷 1990-1995页

作者： Peng-Fei Zhou Jin-Gen Lu Jia-Dong Zhang Jia-Wen Wang Department of Anorectal Surgery Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200000China

BACKGROUND When an anorectal foreign body is found,its composition and shape should be evaluated,and a timely and effective treatment plan should be developed based on the patient's symptoms to avoid serious complications such as intestinal perforation caused by displacement of the foreign *** SUMMARY A 54-year-old male was admitted to our outpatient clinic on June 3,2023,due to a rectal foreign body that had been embedded for more than 24 *** patient reported using a glass electrode tube to assist in the recovery of prolapsed hemorrhoids,however,the electrode tube was inadvertently inserted into the anus and could not be removed by the *** hospitalization,the patient underwent surgery,and the foreign body was dragged into the rectum with the aid of *** anus was dilated with a comb-type pulling hook and an anal fistula pulling hook to widen the anus and remove the foreign body,and the local anal symptoms were then relieved with topical *** patient was allowed to eat and drink,and an entire abdominal Computed tomography(CT)and colonoscopy were reviewed 3 d after *** revealed no foreign body residue and colonoscopy showed no metal or other residues in the colon and rectum,and no apparent intestinal tract *** The timeliness and rationality of the surgical and therapeutic options for this patient were based on a literature review of the clinical signs and conceivable conditions in such *** type,material and the potential risks of rectal foreign bodies should be considered.

关键词： Foreign body impaction Surgical therapy Rectum-sigmoid colon Colonoscopy Case report

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Re-entry rocket basic flow characteristics and thermal environment of different retro-propulsion modes

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Chinese Journal of Aeronautics 2024年第7期37卷 190-203页

作者： Yifei SU Peijie SUN Yangwen CUI Guigao LE School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China shanghai Institute of Aerospace System Engineering Shanghai 200000China Southwest Institute of Technology and Engineering Chongqing 400039China

During the supersonic re-entry of multi-nozzle heavy rockets into the atmosphere,the basic flow state becomes increasingly complex due to the coupling effect between the retropropulsion plumes and the freestream.A numerical method using the hybrid Reynolds-Averaged Navier-Stokes and Large Eddy Simulation(RES)method and discrete coordinate method is developed to accurately estimate the thermal *** addition,finite rate chemical kinetics is used to calculate the afterburning *** numerical results agree well with wind tunnel data,which confirms the validity and accuracy of the numerical *** are conducted for the heavy carrier rocket re-entry from 53.1 km to 39.5 km altitude with 180°angle of attack by using three different Supersonic Retro-Propulsion(SRP)*** numerical results reveal that these three SRP flow fields are all Short Penetration Models(SPM).As the re-entry altitudes decrease,both the plume-plume interaction and the plume-freestream interaction become *** highest temperatures in the plume shear layers of the three SRP modes increase by 8.36%,7.33%and 6.92%respectively after considering afterburning reactions,and all occur at a reentry altitude of 39.5 *** the rocket re-enters the atmosphere,the maximum heat flux on the rocket base plate of three SRP modes stabilizes at 290,170 and 200 kW/m^(2) respectively,but the maximum heat flux on the side wall increases *** the altitude declines to 39.5 km,the extreme heat flux of the three modes increase by 84.16%,49.45%and 62.97%respectively compared to that at 53.1 km.

关键词： Re-entry rocket Multi-nozzle Supersonic retro propulsion Thermal environment Afterburning effect

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