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co.bining genome-wide association study and transcriptome analysis to identify molecular markers and genetic basis of population-asynchronous ovarian development in co.lia nasus

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Zoological Research 2024年第3期45卷 491-505页

作者： Yue Yu Shi-Ming Wan Cheng-You Huang Shuang-Meng Zhang Ai-Li Sun Jun-Qi Liu Shun-Yao Li Yong-Fu Zhu Shu-Xin Gu Ze-Xia Gao co.lege of Fisheries Hubei Hongshan Laboratory/Key Lab of Freshwater Animal BreedingMinistry of Agriculture and Rural Affairs/Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic BeltMinistry of EducationHuazhong Agricultural UniversityWuhanHubei 430070China Laboratory for Marine Biology and biotechnology Qingdao Marine Science and Technology CenterQingdaoShandong 266237China Wuhan Hengyuxin Technology Breeding Professional co.perative WuhanHubei 430117China Hubei Provincial Aquatic Science Research Institute WuhanHubei 430208China Zhenjiang Jiangzhiyuan Fishery Technology co. Ltd.ZhenjiangJiangsu 212213China

co.lia nasus,a migratory fish species found in the middle and lower reaches of the Yangtze River and along offshore areas of China,possesses co.siderable aquacultural and eco.omic ***,the species faces challenges due to significant variation in the gonadal development rate among females,resulting in inco.sistent ovarian maturation times at the population level,an extended reproductive period,and limitations on fish growth rate due to ovarian *** the present study,we co.bined genome-wide association study(GWAS)and co.parative transcriptome analysis to investigate the potential single nucleotide polymorphisms(SNPs)and candidate genes associated with population-asynchronous ovarian development in *** of the female population based on whole-genome resequencing yielded 2120695 high-quality SNPs,39 of which were suggestively associated with ovarian *** note,a significant SNP peak on LG21 co.taining 30 suggestively associated SNPs was identified,with cpne5a determined as the causal gene of the ***,single-marker and haplotype association analyses were performed on cpne5a,revealing four genetic markers(P0.9)significantly associated with the *** transcriptome analysis of preco.iously and normally maturing individuals screened out 29 and 426 overlapping differentially expressed genes in the brain and ovary,respectively,between individuals of different body *** the GWAS and transcriptome analysis results,this study identified genes and pathways related to hypothalamic-pituitary-gonadal axis hormone secretion,extracellular matrix,angiogenesis,and gap junctions involved in population-asynchronous ovarian *** insights gained from this study provide a basis for a deeper understanding of the molecular mechanisms underlying ovarian development in fish and may facilitate the genetic breeding of *** strains exhibiting population-synchronous ovarian

关键词： co.lia nasus GWAS Transcriptome Ovarian development SNP

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An Update on the Clinical Pipelines of New Antibacterial Drugs Developed in China

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Engineering 2024年第7期38卷 52-68页

作者： Xinyi Yang co.gran Li Xiukun Wang Zhonghui Zheng Peiyi Sun Chunjie Xu Luni Chen Jiandong Jiang Staffan Normark Birgitta Henriques-Normark Xuefu You Beijing Key Laboratory of Antimicrobial Agents/Laboratory of Pharmaco.ogy Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Division for Medicinal Microorganism-Related Strains CAMS Collection Center of Pathogenic MicroorganismsChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China shandong Xinhua Pharmaceutical co. Ltd.Zibo 255005China Department of Microbiology Tumor and Cell BiologyKarolinska InstitutetStockholm SE-17177Sweden State Key Laboratory of Bioactive Substances and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Institute of Medicinal biotechnology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Clinical Microbiology Karolinska University HospitalBioclinicumStockholm SE-17176Sweden

Antibacterial resistance is a global health threat that requires further co.crete action on the part of all *** this co.text,one of the biggest co.cerns is whether enough new antibacterial drugs are being disco.ered and *** several high-quality reviews on clinical antibacterial drug pipelines from a global perspective were published recently,none provides co.prehensive information on original antibacterial drugs at clinical stages in *** this review,we summarize the latest progress of novel antibacterial drugs approved for marketing and under clinical evaluation in China since *** was obtained by co.sulting official websites,searching co.mercial databases,retrieving literature,asking personnel from institutions or co.panies,and other means,and a co.siderable part of the data co.ered here has not been included in other *** of June 30,2023,a total of 20 antibacterial projects from 17 Chinese pharmaceutical co.panies or developers were identified and *** them,two new antibacterial drugs that belong to traditional antibiotic classes were approved by the National Medical Products Administration(NMPA)in China in 2019 and 2021,respectively,and 18 antibacterial agents are in clinical development,with one under regulatory evaluation,five in phase-3,six in phase-2,and six in *** of the clinical candidates are new analogs or monoco.ponents of traditional antibacterial pharmaco.hore types,including two dual-acting hybrid antibiotics and a reco.binant antibacterial ***,despite there being 17 antibacterial clinical candidates,our analysis indicates that there are still relatively few clinically differentiated antibacterial agents in stages of clinical development in ***,Chinese pharmaceutical co.panies and institutions will develop more innovative and clinically differentiated candidates with good market potential in the future research and development(R&D)of original antibacterial drugs.

关键词： Antimicrobial resistance New antibiotics Clinical pipelines WHO priority pathogens National Mega-Project for Innovative Drugs

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Tildrakizumab for moderate-to-severe plaque psoriasis in Chinese patients:A 12-week randomized placebo-co.trolled phase III trial with long-term extension

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Chinese Medical Journal 2024年第10期137卷 1190-1198页

作者： Chen Yu Songmei Geng Bin Yang Yunhua Deng Fuqiu Li Xiaojing Kang Mingye Bi Furen Zhang Yi Zhao Weili Pan Zhongwei Tian Jinhua Xu Zhenghua Zhang Nan Yu Xinsuo Duan Shuping Guo Qing Sun Weiquan Li Juan Tao Zhijun Liu Yuanyuan Yin Gang Wang Department of Dermatology Xijing HospitalThe Fourth Military Medical UniversityXi’anShaanxi 710032China Department of Dermatology The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710004China Department of Dermatology Dermatology Hospital of Southern Medical UniversityGuangzhouGuangdong 510091China Department of Dermatology Tongji HospitalHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Dermatology The Second Hospital of Jilin UniversityChangchunJilin 130041China Department of Dermatology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang 830001China Department of Dermatology Wuxi People’s Hospital of Wuxi CityWuxiJiangsu 214023China Department of Dermatology Shandong Provincial Hospital for Skin Diseases&Shandong Provincial Institute of Dermatology and VenereologyShandong First Medical University&Shandong Academy of Medical SciencesJinanShandong 250022China Department of Dermatology Beijing Tsinghua Changgung HospitalBeijing 102218China Department of Dermatology Zhejiang Provincial People’s HospitalHangzhouZhejiang 310014China Department of Dermatology The First Affiliated Hospital of Xinxiang Medical CollegeXinxiangHenan 453100China Department of Dermatology Huashan Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Dermatology General Hospital of Ningxia Medical UniversityYinchuanNingxia 750000China Department of Dermatology Affiliated Hospital of Chengde Medical UniversityChengdeHebei 067000China Department of Dermatology The First Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China Department of Dermatology Qilu Hospital of Shandong UniversityJinanShandong 250012China Department of Dermatology Yuebei People’s HospitalShaoguanGuangdong 512026China Department of Dermatology Union Hospital Tongji Medical Collage Huazhong University of Science and TechnologyWuhanHubei 430022China Department of Dermatology and Venereal Diseases The First Affiliated Hospit

Background:There is a need for effective and safe therapies for psoriasis that provide sustained *** aim of this study was to assess the efficacy and safety of tildrakizumab,an anti-interleukin-23p19 monoclonal antibody,for treating moderate-to-severe plaque psoriasis in Chinese ***:In this multi-center,double-blind,phase III trial,patients with moderate-to-severe plaque psoriasis were enrolled and randomly assigned(1:1)to receive subcutaneous tildrakizumab 100 mg or placebo at weeks 0 and *** initially assigned to placebo were switched to receive tildrakizumab at weeks 12,16,and every 12 weeks *** in the tildrakizumab group co.tinued with tildrakizumab at week 16,and every 12 weeks until week *** primary endpoint was the Psoriasis Area and Severity Index(PASI 75)response rate at week ***:At week 12,tildrakizumab demonstrated significantly higher PASI 75 response rates(66.4%[73/110]vs.12.7%[14/110];difference,51.4%[95%co.fidence interval(CI),40.72,62.13];Pco.pared to *** 75 response co.tinued to improve over time in both tildrakizumab and placebo-switching to tildrakizumab groups,reaching maximal efficacy after 28 weeks(86.8%[92/106]vs.82.4%[89/108])and maintained up to 52 weeks(91.3%[95/104]vs.87.4%[90/103]).Most treatment-emergent adverse events were mild and not related to ***:Tildrakizumab demonstrated durable efficacy through week 52 and was well tolerated in Chinese patients with moderate-to-severe plaque *** registration:***,NCT05108766.

关键词： Tildrakizumab Interleukin 23 Plaque psoriasis Chinese Randomized co.trolled trial

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我国自主开发的抗菌新药临床管线最新进展（英文）

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Engineering 2024年第7期 52-68页

作者：杨信怡李聪然王秀坤郑忠辉孙培译许春杰陈鲁妮蒋建东 Staffan Normark Birgitta Henriques-Normark 游雪甫 Beijing Key Laboratory of Antimicrobial Agents/Laboratory of Pharmaco.ogy Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences & Peking Union Medical College Division for Medicinal Microorganism-Related Strains CAMS Collection Center of Pathogenic Microorganisms Chinese Academy of Medical Sciences & Peking Union Medical College State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences & Peking Union Medical College shandong Xinhua Pharmaceutical co. Ltd. Department of Microbiology Tumor and Cell Biology Karolinska Institutet State Key Laboratory of Bioactive Substances and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College Institute of Medicinal biotechnology Chinese Academy of Medical Sciences & Peking Union Medical College Clinical Microbiology Karolinska University Hospital

Antibacterial resistance is a global health threat that requires further co.crete action on the part of all *** this co.text,one of the biggest co.cerns is whether enough new antibacterial drugs are being disco.ered and *** several high-quality reviews on clinical antibacterial drug pipelines from a global perspective were published recently,none provides co.prehensive information on original antibacterial drugs at clinical stages in *** this review,we summarize the latest progress of novel antibacterial drugs approved for marketing and under clinical evaluation in China since *** was obtained by co.sulting official websites,searching co.mercial databases,retrieving literature,asking personnel from institutions or co.panies,and other means,and a co.siderable part of the data co.ered here has not been included in other *** of June 30,2023,a total of 20 antibacterial projects from 17 Chinese pharmaceutical co.panies or developers were identified and *** them,two new antibacterial drugs that belong to traditional antibiotic classes were approved by the National Medical Products Administration (NMPA) in China in 2019 and 2021,respectively,and 18antibacterial agents are in clinical development,with one under regulatory evaluation,five in phase-3,six in phase-2,and six in *** of the clinical candidates are new analogs or monoco.ponents of traditional antibacterial pharmaco.hore types,including two dual-acting hybrid antibiotics and a reco.binant antibacterial ***,despite there being 17 antibacterial clinical candidates,our analysis indicates that there are still relatively few clinically differentiated antibacterial agents in stages of clinical development in ***,Chinese pharmaceutical co.panies and institutions will develop more innovative and clinically differentiated candidates with good market potential in the future research and development (R&D) of original antibacterial drug

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Dynamics of molecular alignment steered by a few-cycle terahertz laser pulse

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Chinese Physics B 2022年第10期31卷 377-383页

作者：程起元宋玉志李登旺刘治平孟庆田 Medical Engineering Department Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China School of Physics and Electronics Shandong Normal UniversityJinan 250358China shandong Laibo biotechnology co. Ltd.Jinan 250101China School of co.trol Science and Engineering Shandong UniversityJinan 250061China

The field-free alignment of molecule Cl CN is investigated by using a terahertz few-cycle pulse(THz FCP)based on the time-dependent density matrix *** is shown that a high degree of molecular alignment can be obtained by changing the matching number of the THz FCPs in the adiabatic regime and the non-adiabatic *** matching number can affect both the maximum value of the alignment and the time at which it is *** is also found that a higher degree of alignment can be achieved by using the THz FCP at lower intensity and there exists an optimal threshold of molecular alignment with the increase of the field *** found is the frequency sensitive region in which the degree of maximum alignment can be enhanced greatly by modulating the center frequencies of different THz *** investigation demonstrates that co.paring with a THz single-cycle pulse,a better result of the field-free alignment can be created by a THz FCP at a co.stant rotational temperature of molecule.

关键词： molecular alignment few-cycle terahertz pulse density matrix theory

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Network pharmaco.ogy analysis to explore mechanism of Three Flower Tea against nonalco.olic fatty liver disease with experimental support using high-fat diet-induced rats

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Chinese Herbal Medicines 2022年第2期14卷 273-282页

作者： Peixuan Wu Shufei Liang Yanping He Rui Lv Bendong Yang Meng Wang Chao Wang Yong Li Xinhua Song Wenlong Sun Institute of Biomedical Research School of Life Sciences and MedicineShandong University of TechnologyZibo 255000China shandong Qingyujiangxing biotechnology co. Ltd.Zibo 255000China shandong Tianyin biotechnology co. Ltd.Zibo 255000China

Objective:Nonalco.olic fatty liver disease(NAFLD)has beco.e a co.mon chronic liver disease that is harmful to human ***,there is currently no FDA-approved first-line drug for the treatment of nonalco.olic steatohepatitis(NASH)or *** Chinese medicine(TCM)is widely used to ameliorate liver diseases,such as the traditional ancient recipe called Three Flower Tea(TFT),which co.sists of double rose(Rosa rugosa),white chrysanthemum(Chrysanthemum morifolium),and Daidaihua(Citrus aurantium).However,the mechanisms of the action of TFT are not ***,this study aimed to elucidate the mechanisms of TFT against NAFLD in high-fat diet(HFD)-induced ***:This study utilized bioinformatics and network pharmaco.ogy to establish the active and potential ingredient-target networks of ***,a protein–protein interaction(PPI)network was co.structed,and enrichment analysis was performed to determine the key targets of TFT against ***,an animal experiment was co.ducted to evaluate the therapeutic effect and co.firm the key targets of TFT against ***:A total of 576 NAFLD-related genes were searched in Gene Cards,and under the screening criteria of oral bioavailability(OB)≥30%and drug-likeness(DL)≥0.18,a total of 19 active ingredients and 210 targets were identified in *** pharmaco.ogy analysis suggested that 55 matching targets in PPIs were closely associated with roles for NAFLD *** the evaluation of network topology parameters,four key central genes,PPARγ,SREBP,AKT,and RELA,were ***,animal experiments indicated that TFT co.ld reduce plasma lipid profiles,hepatic lipid profiles and hepatic fat accumulation,improve liver function,suppress inflammatory factors,and reduce oxidative *** immunoblotting and immunofluorescence analysis,PPARγ,SREBP,AKT,and RELA were co.firmed as targets of TFT in HFD-induced ***:In summary,our results indicate that TFT can pr

关键词： network pharmaco.ogy nonalco.olic fatty liver disease Three Flower Tea

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Dietary supplemental co.ted essential oils and organic acids mixture improves growth performance and gut health along with reduces Salmonella load of broiler chickens infected with Salmonella Enteritidis

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Journal of Animal Science and biotechnology 2023年第6期14卷 2554-2577页

作者： Zeqiong Hu Lin Liu Fangshen Guo Jia Huang Jianing Qiao Ruichen Bi Jinyu Huang Kaichen Zhang Yuming Guo Zhong Wang State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijingChina. Shanghai Meinong biotechnology co. Ltd.ShanghaiChina. shandong Heyi Food co. Ltd.Zaozhuang CityShandong ProvinceChina.

Background Reducing Salmonella infection in broiler chickens by using effective and safe alternatives to antibiotics is vital to provide safer poultry meat and minimize the emergence of drug-resistant Salmonella and the spread of salmonellosis to *** study was to first evaluate the protective efficacy of feeding co.ted essential oils and organic acids mixture(EOA)on broiler chickens infected with Salmonella Enteritidis(***,SE),and then its action mechanism was further *** A total of 4801-day-old Arbor Acres male chickens were randomly assigned into five treatments with six replicates,including non-challenged co.trol fed with basal diet(A),SE-challenged co.trol(B),and SE-infected birds fed a basal diet with 300 mg/kg of EOA(BL),500 mg/kg of EOA(BM)and 800 mg/kg of EOA(BH),*** birds on challenged groups were infected with Salmonella Enteritidis on d *** Feeding EOA showed a reversed ability on negative effects caused by SE infection,as evidenced by decreasing the feed co.version rate(FCR)and the ratio of villus height to crypt depth(VH/CD)(Pco.bined effect size measurements analysis(LEfSe)showed that the relative abundance of g_Butyricico.cus,g_Anaerotruncus and g_unclassified_f_Bacillaceae significantly was enriched in infected birds given ***,phylogenetic investigation of co.munities by reco.struct

关键词： Broiler chickens Essential oils and organic acids mixture Gut health Salmonella Enteritidis

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Application of acid protease in the industrial production of co.n ethanol

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Systems Microbiology and Biomanufacturing 2022年第2期2卷 361-368页

作者： Liangliang Wang Qi Yao Jun Yue Xirui Jiang Fangfang Li Linyi Jiayun biotechnology co. LTDLinyi 273306ShandongChina Research Institute of Jilin Petrochemical co. LTDPetroChinaJilin 132021JilinChina Wuxi Jiangda Yizhong Biological Engineering co. LTDWuxi 214062JiangsuChina School of Food Science and Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353ShandongChina

Bioethanol is a renewable,clean energy and a very important basic chemical raw material,improving production efciency and reducing production co.t are the goals pursued by ethanol *** acid protease in the process of producing ethanol from grain will have many efects on fermentation,one of the most co.cerned efects is to increase liquor *** protease can hydrolyze the protein in cereals to produce free amino acids that can be used directly by yeast,thus reducing the amount of sugar co.sumed for amino acid metabolism,and allowing more sugar to be co.verted to *** application method and efect of acid protease in the industrial production of ethanol from co.n were studied in this study,the results showed that the addition of acid protease at the dosage of 10 U/g(raw material)during yeast seeding co.ld replace urea,promote yeast proliferation,reduce the infection rate,shorten the fermentation period by 7.5 h and increase the alco.ol yield of raw materials by 0.33 percentage *** acid protease was used in ethanol production line with an annual output of 180,000 tons,the net proft increased by at least US$4900/day co.pared with the co.trol *** is hoped that this study can lay a foundation for the application of acid protease in ethanol industry.

关键词： Acid protease Ethanol co.n Application Industrial production

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Erratum to:Regulation of different light co.ditions for efficient biomass production and protein accumulation of Spirulina platensis

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Journal of Oceanology and Limnology 2024年第2期42卷 695-695页

作者： Yufei ZHANG Xianjun LI Yuhui LI Shiqi LIU Yanrui CHEN Miao JIA Xin WANG Lu ZHANG Qiping GAO Liang ZHANG Daoyong YU Baosheng GE State Key Laboratory of Heavy Oil Processing and Center for Bioengineering and biotechnology China University of Petroleum(East China)Qingdao 266580China Tongwei co. Ltd.Healthy Aquaculture Key Laboratory of Sichuan ProvinceChengdu 610093China

In this article,the legend for Fig.3 f&g was inadvertently *** figure below shows the wrong *** figure should have appeared as shown below.

关键词： figure wrong labeled

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co.y number variation of B1 co.trols awn length in wheat

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The Crop Journal 2023年第3期11卷 817-824页

作者： Jinlong Li Xin Xin Fangyao Sun Zhenzhen Zhu Xiangru Xu Jiatian Yang Xiaoming Xie Jiazheng Yu Xiaobo Wang Sen Li Shilin Tian Baoyun Li Chaojie Xie Jun Ma co.lege of Agronomy and biotechnology China Agricultural UniversityBeijing 100193China State Key Laboratory of Crop Biology College of Life SciencesShandong Agricultural UniversityTai’an 271018ShandongChina Novogene Bioinformatics Technology co. Ltd.Beijing 100015China

Wheat awns co.tribute to photosynthesis and grain *** this study,an F2population and F2:3families from a cross between the awned line 7D12 and the Chinese awnless variety Shiyou 20(SY20)were used to identify loci associated with awn ***-segregant RNA sequencing and linkage mapping identified a single dominant locus in a 0.3 cM interval on chromosome *** genes were in the interval,including the recently cloned awn inhibitor *** a single co.y of the B1 gene was detected in 7D12,SY20 carried five co.ies of the *** co.y number of B1 in SY20enhanced gene *** on sequence variation among the promoter regions of five B1 gene co.ies in SY20,two dominant markers were developed and found to co.egregate with B1 in a population of 931 wheat *** 77 awnless accessions harbored sequence variations in the B1 promoter regions similar to those of SY20 and thus carried multiple co.ies of the gene,whereas 15 randomly selected awned wheats carried only one *** results suggest that an increase in co.y number of the B1 gene is associated with inhibition of awn length.

关键词： Wheat Awn Awnless,B1 gene co.y number variation

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