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Correlation analysis of interstitial maturity and prognosis of colorectal cancer:Meta-analysis

World Journal of Gastrointestinal Oncology 2024年第6期16卷 2816-2825页

作者： Zhen-Jun Liu Xu-Wen Zhang Qi-Qi Liu Shao-Zhao Wang department of Gastrointestinal Surgery Feicheng People's HospitalFeicheng 271600Shandong ProvinceChina department of Hepatobiliary Surgery Feicheng People's HospitalFeicheng 271600Shandong ProvinceChina department of Gastrointestinal Surgery Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina department of Anorectal Word Central Hospital Affiliated Shandong First Medical UniversityJinan 250013Shandong ProvinceChina

BACKGROUND To investigate the relationship between interstitial maturity and prognosis of colorectal *** To examine the correlation between interstitial maturity and the prognosis of colorectal *** The paper database PubMed,EMBASE,Cochranelibrary,Springerlink,CNKI,and Wanfang database were searched until December 2023."tumor stroma maturity""desmoplastic stroma reaction""desmoplastic reaction""stroma reaction""degree of stroma reaction""stroma classification""stroma density""colorectal cancer""colon cancer""rectal cancer""prognosis"were searched for the search *** system assessors independently screened the literature quality according to the inclusion exclusion criteria,Quality evaluation and data extraction were performed for the included literatures,and meta-analysis was performed for randomized control trials included at using Review Manager 5.2 *** Finally,data of 9849 patients with colorectal cancer from 19 cosets in 15 literatures were included,including 4339 patients with mature type(control group),3048 patients with intermediate type(intermediate group)and 2456 patients with immature type(immature group).The results of meta-analysis showed:Relapse-free survival[hazard ratio(HR)=2.66,95%confidence interval(CI):2.30-3.08;P<0.00001],disease-free survival(HR=3.68,95%CI:2.33-5.81;P<0.00001)and overall survival(HR=1.70,95%CI:1.53-1.87;P<0.00001)were significantly lower than those in mature group(control group);relapse-free survival(HR=1.36,95%CI:1.17-1.59;P<0.0001)and disease-free survival rate(HR=1.85,95%CI:1.53-2.24;P<0.0001)was significantly lower than the mature group(control group).CONCLUSION There is the correlation between tumor interstitial maturity and survival prognosis of colorectal cancer,and different degrees of tumor interstitial maturity have a certain impact on the quality of life of colorectal cancer patients.

关键词： Colorectal tumor Survival prognosis Tumor interstitial maturity Systematic review Meta-analysis

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Sedimentary Characteristics,Ages,and Environmental Significance of Gravel Deposits and Loess in shandong,Eastern China:Regional Response to Global Change Since the Last Glacial Period

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Acta Geologica Sinica(English Edition) 2024年第2期98卷 491-504页

作者： WANG Min KONG Fanbiao KONG Xianglun CHEN Haitao WANG Jiawei MIAO Xiaodong JIA Guangju HAN Mei XU Shujian department of Geography and Tourism Qilu Normal UniversityJinan 250014China School of Geography and Environment Shandong Normal UniversityJinan 250014China shandong Provincial Key Laboratory of Water and Soil Conservation and Environmental Protection Linyi UniversitySchool of Resources and EnvironmentLinyiShandong 276005China College of Earth Science and Engineering Shandong University of Science and TechnologyQingdaoShandong 266590China

Investigation of rarely studied gravel layers found in the loess in shandong Province,eastern China,reveals the fabric characteristics of two gravel layers(G1,G2)and the sedimentary characteristics of loess at the typical and well-preserved Heiyu section(HY),where,to determine the paleoclimatic changes during Marine Isotope Stage *** stimulated luminescence dates of the HY formation range from 0.26±0.02 ka to 39.00±2.00 *** addition,the ages of G1 and G2 were estimated using the Bayesian model to be 39.60-40.50 and 29.00-29.50 ka.G1 and G2 are mainly composed of fine and medium gravel,both of which were subangular to subrounded limestone,with gravel directions to NE and *** average flow velocity,average depth,and flood peak flow of G1 are 1.10 m/s,0.49 m,and 37.04 m^(3)/s,respectively,calculated using the flow energy method,whereas those of G2 are 0.98 m/s,0.38 m,and 18.38 m^(3)/s,*** of climate proxy indices show that the sedimentary environment of the gravel and loess in HY might be a regional response to global change.

关键词： paleoenvironment geochronology gravel layer sedimentology Pleistocene shandong Province

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Nomogram predicting the cardiovascular disease mortality for older patients with colorectal cancer:A real-world population-based study

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World Journal of Cardiology 2024年第8期16卷 458-468页

作者： Jia-Yu Tan Shuo-Hao Shen department of Medical Ultrasound The First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan HospitalJinan 250000Shandong ProvinceChina department of General Surgery Qilu Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina

BACKGROUND Cardio-oncology has received increasing attention especially among older patients with colorectal cancer(CRC).Cardiovascular disease(CVD)-specific mortality is the second-most frequent cause of *** risk factors for CVDspecific mortality among older patients with CRC are still poorly *** To identify the prognostic factors and construct a nomogram-based model to predict the CVD-specific mortality among older patients with *** The data on older patients diagnosed with CRC were retrieved from The Surveillance,Epidemiology,and End Results database from 2004 to *** prognostic factors and a nomogram-based model predicting the CVD-specific mortality were assessed using least absolute shrinkage and selection operator and Cox *** A total of 141251 eligible patients with CRC were enrolled,of which 41459 patients died of CRC and 12651 patients died of *** age at diagnosis,sex,marital status,year of diagnosis,surgery,and chemotherapy were independent prognostic factors associated with CVD-specific mortality among older patients with *** used these variables to develop a model to predict CVD-specific *** calibration curves for CVD-specific mortality probabilities showed that the model was in good agreement with actual *** C-index value of the model in the training cohort and testing cohort for predicting CVD-specific mortality was 0.728 and 0.734,*** The proposed nomogram-based model for CVD-specific mortality can be used for accurate prognostic prediction among older patients with *** model is a potentially useful tool for clinicians to identify high-risk patients and develop personalized treatment plans.

关键词： Older patients Colorectal cancer Cardio-oncology Nomogram Outcome

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Ferroptosis regulating lipid peroxidation metabolism in the occurrence and development of gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2781-2792页

作者： Lan-Mei Wang Wei-Wei Zhang Ying-Yang Qiu Fang Wang department of Clinical Laboratory Anqiu People's HospitalWeifang 262123Shandong ProvinceChina department of Gastroenterology Feicheng People's HospitalTai’an 271600Shandong ProvinceChina Yong Loo Lin School of Medicine National University of Singapore119077Singapore department of Gastroenterology Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013Shandong ProvinceChina

BACKGROUND Gastric cancer is one of the most common malignant tumors in the world,and its occurrence and development involve complex biological *** death,as a new cell death mode,has attracted wide attention in recent ***,the regulatory mechanism of iron death in gastric cancer and its effect on lipid peroxidation metabolism remain *** To explore the role of iron death in the development of gastric cancer,reveal its relationship with lipid peroxidation,and provide a new theoretical basis for revealing the molecular mechanism of the occurrence and development of gastric *** The process of iron death in gastric cancer cells was simulated by cell culture model,and the occurrence of iron death was detected by fluorescence microscopy and flow *** changes of gene expression related to iron death and lipid peroxidation metabolism were analyzed by high-throughput sequencing *** addition,a mouse model of gastric cancer was established,and the role of iron death in vivo was studied by histology and immunohistochemistry,and the level of lipid peroxidation was *** methods comprehensively and deeply reveal the regulatory mechanism of iron death on lipid peroxidation metabolism in the occurrence and development of gastric *** Iron death was significantly activated in gastric cancer cells,and at the same time,associated lipid peroxidation levels increased *** high-throughput sequencing analysis,it was found that iron death regulated the expression of several genes related to lipid *** vivo experiments demonstrated that increased iron death in gastric cancer mice was accompanied by a significant increase in lipid *** This study confirmed the important role of iron death in regulating lipid peroxidation metabolism in the occurrence and development of gastric *** activation of iron death significantly increased lipid peroxidation levels,revealing it

关键词： Ferroptosis Lipid peroxidation Gastric cancer Lipid metabolism Systematic review

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Boeravinone B ameliorates allergic nasal inflammation by modulating the GATA-3/T-bet signaling pathway in a mouse model of allergic rhinitis

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Asian Pacific Journal of Tropical Biomedicine 2024年第6期14卷 245-252页

作者： Ben Ye Ji-Zhe Wang department of Otorhinolaryngology Second Hospital of Dalian Medical UniversityDalian116000China department of Otorhinolaryngology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan250000China

Objective:To evaluate the anti-allergic effect of boeravinone B against ovalbumin-induced allergic rhinitis in mice and explore its possible ***:For the induction of allergic rhinitis,mice were intraperitoneally sensitized and intranasally challenged with ovalbumin,as well as orally received various concentrations of boeravinone *** mucosal inflammation,and the levels of nitric oxide,β-hexosaminidase,IFN-γ,LTC-4,myeloperoxidase,Nrf2,HO-1,GATA-3,ROR-γ,T-bet,antioxidant parameters,and allergen-specific cytokines were ***:Boeravinone B markedly reduced ovalbumin-induced increase in the number of episodes of nasal sneezing,rubbing,and discharge,as well as the levels of IgE,IgG1,andβ-hexosaminidase(P<0.05).It also significantly reduced differential cell count,myeloperoxidase,oxide-nitrosative stress,and the levels of IL-1β,IL-4,IL-5,IL-6,IL-13,IL-17,tumor necrosis factor-α,GATA-3,and ROR-γwhile enhancing the level of ***:Boeravinone B is a potential therapeutic agent for allergic rhinitis by modulating various inflammatory mediators and immune responses.

关键词： Allergic reaction Boeravinone B Oxidative stress Inflammation Ovalbumin

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Special electromyographic features in a child with paramyotonia congenita: A case report and review of literature

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World Journal of Clinical Cases 2024年第3期12卷 587-595页

作者： Hui Yi Chen-Xiang Liu Shu-Xin Ye Yu-Lin Liu department of Neuroelectrophysiology Qilu Children’s Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina department of Neuroelectrophysiology University of Health and Rehabilitation Sciences(Qingdao Municipal Hospital)Qingdao 266000Shandong ProvinceChina

BACKGROUND Paramyotonia congenita(PMC)stands as a rare sodium channelopaty of skeletal muscle,initially identified by *** identification of PMC often relies on electromyography(EMG),a diagnostic *** child’s needle EMG unveiled trains of myotonic discharges with notably giant amplitudes,alongside irregular wave trains of myotonic *** distinctive observation had not surfaced in earlier *** SUMMARY We report the case of a 3-year-old female child with PMC,who exhibited la-ryngeal stridor,muffled speech,myotonia from ***,exposure to cool water,crying,and physical activity exacerbated the myotonia,which was relieved in warmth,yet never *** myotonia was observable in bilateral *** symptoms remained unchanged after potassium-rich food consumption like *** periodic paralysis was *** magnetic resonance imaging yielded normal *** potassium remained within normal range,while creatine kinase showed slight ***-wide genetic testing pinpointed a heterozygous mutation on chromosome SCN4A:c.3917G>A(p.G1306E).After a six-month mexiletine regimen,symptoms *** In this case revealed the two types of myotonic discharges,and had not been documented in other *** underscore two distinctive features:Giant-amplitude potentials and irregular waves.

关键词： Paramyotonia congenita Channelopathy Electromyography Child Case report

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Systemic immune-inflammation index combined with pediatric appendicitis score in assessing the severity and prognosis for paediatric appendicitis

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2565-2573页

作者： Li-Ming Guo Zhi-Hui Jiang Hong-Zhen Liu department of General Surgery Qingdao Women and Children’s HospitalQingdao 266000Shandong ProvinceChina department of Pediatric Surgery Children's Hospital Affiliated to Shandong UniversityJinan 250022Shandong ProvinceChina department of Pediatric Surgery Jinan Children's HospitalJinan 250022Shandong ProvinceChina

BACKGROUND Pediatric appendicitis is a common cause of abdominal pain in children and is recognized as a significant surgical emergency.A prompt and accurate diagnosis is essential to prevent complications such as perforation and *** To investigate the predictive value of the systemic immune-inflammation index(SII)combined with the pediatric appendicitis score(PAS)for the assessment of disease severity and surgical outcomes in children aged 5 years and older with *** Clinical data of 104 children diagnosed with acute appendicitis were *** participants were categorized into the acute appendicitis group and chronic appendicitis group based on disease presentation and further stratified into the good prognosis group and poor prognosis group based on *** SII and PAS were measured,and a joint model using the combined SII and PAS was constructed to predict disease severity and surgical *** Significant differences were observed in the SII and PAS parameters between the acute appendicitis group and chronic appendicitis *** analysis showed associations among the SII,PAS,and disease severity,with the combined SII and PAS model demonstrating significant predictive value for assessing disease severity[aera under the curve(AUC)=0.914]and predicting surgical outcomes(AUC=0.857)in children aged 5 years and older with *** The study findings support the potential of integrating the SII with the PAS for assessing disease severity and predicting surgical outcomes in pediatric appendicitis,indicating the clinical utility of the combined SII and PAS model in guiding clinical decision-making and optimizing surgical management strategies for pediatric patients with appendicitis.

关键词： Systemic immune-inflammation index Pediatric appendicitis score Disease severity Surgical outcomes Risk factor Logistic regression Receiver operating characteristic analysis

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Intestinal tuberculosis with small bowel stricture and hemorrhage as the predominant manifestation: Three case reports

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 248-256页

作者： Gang Huang Kang-Kang Wu Xiao-Na Li Jing-Hua Kuai Ai-Jun Zhang department of Gastroenterology Qilu Hospital(Qingdao)Cheeloo College of MedicineShandong UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Intestinal tuberculosis is a chronic disease caused by Mycobacterium tuberculosis that mainly affects the ileum and *** bowel tuberculosis,characterized by predominant involvement of the small intestine,is an extremely rare condition with highly atypical clinical presentations,making diagnosis even more *** SUMMARY We report three cases of small intestinal tuberculosis,two of the patients pre-sented primarily with abdominal pain,and one presented with gastrointestinal *** patients underwent blood tests and imaging *** bowel endoscopy(SBE)revealed that the main lesions in these patients were in-testinal stenosis or gastrointestinal bleeding caused by small intestinal *** patient ultimately underwent surgical *** a complex diagnostic process and comprehensive analysis,all patients were confirmed to have small intestinal tuberculosis and received standard antituberculosis treatment,leading to an improvement in their *** Patients with SBTs present with nonspecific symptoms such as abdominal pain,weight loss,and occasional gastrointestinal *** diagnosis requires a thorough evaluation of clinical symptoms and various tests to avoid misdiagno-sis and complications.

关键词： Intestinal tuberculosis Gastrointestinal hemorrhage Small bowel endoscopy Case report

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Carrimycin in the treatment of acute promyelocytic leukemia combined with pulmonary tuberculosis: A case report

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World Journal of Clinical Cases 2024年第3期12卷 623-629页

作者： Fu-Yu Yang Lei Shao Jie Su Zhen-Meng Zhang department of Infectious Diseases The Affiliated Central Hospital of Shandong First Medical UniversityJinan 250013Shandong ProvinceChina

BACKGROUND Pulmonary tuberculosis(PTB)is prevalent in immunocompromised populations,including patients with hematologic malignancies,human immunodeficiency virus infections,and chronic *** treatment for acute promyelocytic leukemia(APL)combined with PTB is *** patients show an extremely poor ***,studies should establish efficient treatment options to improve patient survival and *** SUMMARY A 60-year-old male with pain in the right side of his chest and a fever for 4 d visited the outpatient department of our *** blood smear revealed 54%*** bone marrow examinations,variant APL with TNRC18-RARA fusion gene was *** computed tomography scan showed bilateral pneumonitis with bilateral pleural effusions,partial atelectasis in the lower lobes of both lungs,and the bronchoalveolar lavage fluid gene X-Pert test was positive,indicative of ***,ethambutol(EMB),and isoniazid(INH)were administered since he could not receive chemotherapy as the WBC count decreased *** one week of treatment with carrimycin,the patient recovered from fever and received *** was very effective and his white blood cells counts got back to *** being given five months with rifampin,EMB and INH and chemotherapy,the patient showed complete remission from pneumonia and *** We report a case of PTB treated successfully with carrimycin with APL that requires chemotherapy.

关键词： Carrimycin Hematologic disease Acute myeloid leukemia Acute promyelocytic leukemia Pulmonary tuberculosis Case report

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Injectable“cocktail”hydrogel with dual-stimuli-responsive drug release,photothermal ablation,and drug-antibody synergistic effect

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SmartMat 2024年第2期5卷 43-53页

作者： Li Zhao Jiawen Xu Yao Tong Pengyu Gong Fucheng Gao Hui Li Yanyan Jiang Key Laboratory for Liquid-Solid Structural Evolution&Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinanChina department of Pathology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanChina department of Clinical Laboratory The Second HospitalCheeloo College of MedicineShandong UniversityJinanChina

The combination of the first-line standard chemotherapeutic drug doxorubicin hydrochloride(DOX)and the molecular-targeted drug Herceptin(HCT)has emerged as a promising strategy for human epidermal growth receptor 2(HER-2)overexpressing breast cancer ***,insufficient drug accumulation and severe cardiotoxicity are two major challenges that limit its clinical ***,an in situ forming gold nanorods(AuNRs)-sodium alginate(ALG)hybrid hydrogel encapsulating DOX and HCT was engineered for tumor synergistic therapy involving injectable,dual-stimuli-responsive drug release,photothermal ablation,and drug-antibody synergistic *** photothermal agent AuNRs,anticancer drug DOX,and anticancer antibody HCT were mixed in ALG solution,and after injection,the soluble ALG was quickly transformed into a hydrogel in the presence of Ca^(2+)in the ***,the hybrid hydrogel exhibits an extremely high photothermal conversion efficiency of 70%under 808 nm laser *** thermal effect can also provide photothermal stimulation to trigger the drug release from the gel *** addition,the drug release rate and the releasing degree are also sensitive to the *** vitro studies demonstrated that the PEI-AuNR/DOX/HCT/ALG hydrogel has facilitated the therapeutic efficiency of each payload and demonstrated a strong synergistic killing effect on SK-BR-3 *** vivo imaging results showed that the local drug delivery system can effectively reduce the nonspecific distribution in normal tissues and increase drug concentration at tumor *** proposed hydrogel system shows significant clinical implications by easily introducing a sustainable photothermal therapy and a potential universal carrier for the local delivery of multiple drugs to overcome the challenges faced in HER-2 overexpressing cancer therapy.

关键词： dual-stimuli-responsive drug release HER-2 overexpressing breast cancer injectable hydrogel photothermal therapy synergistic effect

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