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Targeted inhibition NCOA4-mediated ferritinophagy limits ferroptosis to ameliorate alcohol-induced liver injury in vivo and in vitro

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food Science and Human Wellness 2024年

作者： Yanan Zhao Bin Li Jiang Liu Fei Yu Lei Chen Hui Teng College of food Science and technology， Guangdong Ocean University Guangdong provincial Key Laboratory of Aquatic Product Processing and Safety Guangdong Province engineering Laboratory for marine Biological Products Guangdong provincial engineering technology research center of Seafood Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution

Alcoholic liver injury (ALD) is a serious liver disease resulting from prolonged and excessive alcohol consumption， with significant morbidity and mortality and closely relate to iron accumulation and ferroptosis. Ferritinophagy is the process of autophagic degradation of ferritin and results in labile iron accumulation and ferroptosis. However， whether ferritinophagy involves in alcohol-induced liver injury and ferroptosis remains unexplored. Here， we demonstrated the involvement of ferroptosis in alcohol-induced liver injury by modulating nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy. Utilizing both in vivo and in vitro models， we observed activation of autophagy and ferroptosis following alcohol administration. Intriguingly， we found that alcohol-induced ferroptosis is autophagy-dependent， because autophagy inhibitor 3-MA (30 mg/kg bw. in vivo， 1 mM in vitro， respectively) profoundly mitigated alcohol-induced ferroptosis. We further demonstrated that alcohol-induced ferritinophagy was derived by iron overload， by showing that iron chelator DFO (100 mg/kg bw. in vivo， 10 μM in vitro， respectively) can abolish alcohol-induced ferritinophagy and ferroptosis. Moreover， we observed an upregulation of NCOA4 expression， and knockdown of NCOA4 significantly reversed alcohol-induced disturbances in iron metabolism and subsequently blocking ferroptosis. Our findings suggest a connection between ferritinophagy and alcohol-induced ferroptosis in mouse liver and HepG2 cells， highlighting NCOA4-mediated ferritinophagy as a novel mechanism of alcohol-induced liver injury. This study enhances our understanding of the molecular mechanisms underlying alcohol-induced liver injury， and targeting ferritinophagy may provide new strategies for preventing or treating ALD.

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Pyropia haitanensis polysaccharide extends lifespan by inhibiting protein aggregation in Caenorhabditis elegans

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Journal of Oceanology and Limnology 2021年第2期39卷 705-713页

作者： Zhongshan ZHANG Xiaomei WANG Yongliang PAN Zhanqi WANG Zhengshun WEN Feng LIU Genxiang MAO Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province Huzhou UniversityHuzhou Central HospitalHuzhou 313000China Zhejiang provincial engineering technology research center of marine Biomedical Products School of Food Science and PharmaceuticsZhejiang Ocean UniversityZhoushan 316022China CAS Key Laboratory of marine Ecology and Environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China Zhejiang provincial Key Lab of Geriatrics Department of GeriatricsZhejiang HospitalHangzhou 310013China

Pyropia haitanensis polysaccharide(LP)have been found for having many excellent functions such as *** Caenorhabditis elegans models,we evaluated the anti-aging activity of LP by observing the lifespan,reproduction,pharyngeal pumping,stress response,quantitative fluorescence of polyglutamic acid,and nuclear localization of DAF-16 of *** results reveal that LP could extend the adult lifespan of wild-type and polyQ nematodes,indicating a connection of its anti-aging benefit with the toxicity-suppressing *** number of polyglutamic acid aggregates in high concentration groups decreased by 24.39%(P<0.05)to the *** high-dose group strongly induced DAF-16 nuclear translocation over intermediate and cytosolic localizations compared with the control(P<0.001).Therefore,we believe that LP could extend the lifespan and reduce the protein aggregation in *** through nuclear DAF-16∷GFP expression.

关键词： Pyropia haitanensis polysaccharide protein aggregation Caenorhabditis elegans

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Structural characterization and immunostimulatory activity of a water-soluble polysaccharide from abalone(Haliotis discus hannai Ino)muscle

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food Science and Human Wellness 2023年第2期12卷 495-502页

作者： Linfan Shi Gengxin Hao Jun Chen Junling Wang Wuyin Weng College of Ocean food and Biological engineering Jimei UniversityXiamen 361021China engineering research center of the Modern technology for Eel Industry Ministry of EducationXiamen 361021China

A water-soluble polysaccharide from abalone muscle(AMPP)was *** contents of carbohydrate,protein,uronic acid,and sulfate in AMPP were 83.5%,0.5%,2.7%,and 2.6%,***-performance liquid chromatography analysis indicated that AMPP was homogeneous and had an average molecular weight of approximately 3.2 *** main monosaccharides of AMPP were glucose(Glc)and mannose with a molar ratio of 99.7:*** structural characteristics of AMPP were elucidated through methylation analysis,Fourier transform infrared spectroscopy,and nuclear magnetic resonance *** linkages of AMPP consisted of terminal,1,4-linked,1,6-linked,and 1,4,6-linked Glcp with a molar ratio of 3.1:7.2:1.0:*** one repeat unit of the proposed AMPP structure,the backbone chain was composed of eight 1→4 glycosidic bonds and one 1→6 glycosidic bond,with three branch chains linked by 1→6 glycosidic *** addition,AMPP was found to possess potent immunostimulatory activity via rising phagocytosis of RAW264.7 cells and promoting secretion of TNF-α.

关键词： Polysaccharide Abalone muscle Structural characterization Immunostimulatory activity Nuclear magnetic resonance spectra

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Evaluation of repeated exposure systemic toxicity test of PVC with new plasticizer on rats via dual parenteral routes

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Regenerative Biomaterials 2018年第1期5卷 9-14页

作者： Li Hou Chunguang Fan Chenghu Liu Qiujin Qu ChunrenWang Yanping Shi Department of Biological Evaluation Key Lab of Biological Evaluation of Medical DevicesShandong Provincial Inspection Center for Medical DevicesJinan 250101China Department of Biomaterials and Tissue engineering National Institutes for Food and Drug Control of ChinaBeijing 100050China

Systemic toxicity caused by repeated exposure to both polar and nonpolar leachables of di(2-ethylhexyl)-1,2-cyclohexane plasticized polyvinyl chloride(PVC)was evaluated with dual routes of parenteral administration method on rats in the *** group and control group were designed by *** intravenous injection with 0.9%sodium chloride injection extracts and intraperitoneal injection with corn oil extracts were conducted to the experimental rats while tail intravenous injection with 0.9%sodium chloride Injection and intraperitoneal injection with corn oil were conducted to the control *** 14 days,blood specimens were collected for clinical pathology(hematology and clinical chemistry)*** organs were weighed and a histopathological examination was *** a result,compared with the control animals,there were no toxicity-related changes on the parameters *** results show that the rats do not show obvious systemic toxicity reaction caused by repeated exposure with dual routes of parenteral administration method on rats after administration with both polar and nonpolar exacts of di(2-ethylhexyl)-1,2-cyclohexane plasticized PVC simultaneously up for 14 days.

关键词： plasticized PVC repeated exposure systemic toxicity test dual routes of parenteral administration method

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Antibiofilm activity and synergistic effects of DNase I and lysostaphinaggainst Staphylococcus aureus biofilms

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food Quality and Safety 2024年第4期8卷 653-664页

作者： Quan Lin Maokun Sheng Yanjun Tian Bing Li Zhaodi Kang Yingying Yang Zhenbo Xu Thanapop Soteyome Liang Guo Huzhi Sun Yan Gao Lingyun Yu Qiang Pan Yulong Tan Special food research Institute Qingdao Agricultural UniversityQingdaoChina shandong technology Innovation center of Special food QingdaoChina Qingdao Special food research Institute QingdaoChina Qingdao NABT PhagePharm Co. Ltd.QingdaoChina marine Science and engineering College Qingdao Agricultural UniversityQingdaoChina School of food Science and engineering Guangdong Province Key Laboratory for Green Processing of Natural Products and Product SafetyEngineering Research Center of Starch and Vegetable Protein Processing Ministry of EducationSouth China University of TechnologyGuangzhouChina Department of Biology Massachusetts Institute of TechnologyCambridgeMAUSA Home Economics technology Rajamangala University of Technology Phra NakhonBangkokThailand China animal husbandry industry Co. Ltd.BeijingChina Key Lab of Preventive Veterinary Medicine in Hubei Province College of Veterinary MedicineHuazhong Agricultural UniversityWuhanChina marine Science research Institute of shandong Provice(National Oceanographic center of Qingdao) QingdaoChina Qingdao PhagePharm bio-tech Co. Ltd.QingdaoChina

Background:In recent years,food safety has become a global public health *** contamination is one of the most common food safety *** aureus is a common foodborne pathogen that can form biofilms on the surface of food processing equipment,leading to greater resistance to antimicrobial agents than occurs with planktonic *** and methods:In this work,recombinant Escherichia coli BL21(DE3)cells expressing optimized lysostaphin(Lst)were constructed,recombinant Lst was produced and purified,and Lst enzymatic assays were performed,followed by antimicrobial testing of ***,a mixtureof Lst and DNase I was tested for ***:The protein content of purified Lst was 0.6 mg/mL and the enzyme activity was 240 U/*** minimum inhibitory concentration(MiC)of Lst against *** was O.1μg/*** 1 MiC,Lst exerted an effect on the growth,cell wall integrity and cell membrane permeability of ***:Although Lst alone also showed good inhibition and disruption of *** biofilms,the inhibition and disruption of *** biofilms were significantly greater when Lst was mixed with DNase *** is probably because DNase I removes extracellular DNA,affecting biofilm formation and dispersing mature biofilms,and thereby facilitating the penetration of Lst.

关键词： Biofilm foodborne pathogen lysostaphin DNase I Staphylococcus aureus

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A Minireview of marine Algal Virus-Coccolithoviruses

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Journal of Ocean University of China 2015年第2期14卷 293-300页

作者： LIU Jingwen XU Miaomiao ZHENG Tianling College of food and Bioengineering Jimei University research center of food Microbiology and Enzyme engineering technology of Fujian Province State Key Laboratory for marine Environmental Sciences and Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystem School of Life Sciences Xiamen University

Coccolithophorid is unicellular marine microalgae with a global distribution in temperate and sub-temperate oceanic regions and has the ability to produce ＇the coccoliths＇. It is considered to be the second most productive calcifying organism on earth and becoming an important factor in the global carbonate cycle. Emiliania huxleyi is one of the only two bloom-forming coccolithophores and becomes a species crucial to the study of global biogeochemical cycles and climate modeling. Coccolithoviruse is a recently discovered group of viruses infecting the marine coceolithophorid E. huxleyi. They are a major cause of coceolithophore bloom termination, and DMSP concentration is increasing in the process of viral lysis. Phylogenetic evidences support that some genes are functional both in E. huxleyi and its virus （EhV）. Horizontal gene transfer （HGT） of multiple functionally coupled enzymes occurs in E. huxleyi and its DNA virus EhV has been confirmed, which contributes to the diversification and adaptation of plankton in the oceans and also critically regulates virus-host infection by allowing viruses to control host metabolic pathways for their repli- cation. Therefore, it is of particular interest to understand this host-virus interaction. On this issue, we have made a minireview of coeeolithoviruses focusing on the basic characteristics, phylogenesis, horizontal gene transfer and the interaction between the host and its viruses, as well as its important role in global biogeochemical cycling.

关键词： eoccolithoviruses phylogenetic characteristics virus-host interaction horizontal gene transfer (HGT) global climatechange

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Evaluating the Effect of Subsurface Structures on Freshwater Lenses in Coral Reefs

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Journal of Ocean University of China 2024年第6期23卷 1551-1560页

作者： ZHANG Zhenchao WANG Han GUO Xiujun Key Laboratory of marine Environmental Science and Ecology Ministry of EducationQingdao 266100China Ocean University of China Sanya Oceanographic InstitutionSanya 572000China shandong provincial Key Laboratory of marine Environment and Geological engineering Qingdao 266100China

Freshwater groundwater lenses(FGLs)serve as an important water resource for remote coral atoll islands,and different hydrogeological data of the islands determine the growth and decay of the *** study conducted a three-dimensional(3D)numerical model using hydrogeological data from a reclaimed island to evaluate the effects of different locations and sizes of subsurface structures on the formation and macroscale stability of the *** results revealed that freshwater formation begins earlier than the base model when the subsurface structures are *** underground structures in Pleistocene aquifers leads to a significant increase in freshwater volume with the enlargement of the structure's *** these structures are built within Holocene aquifers,as the burial site moves from the edge towards the center of the area,the maximum freshwater volume decreases slightly,with the largest difference being approximately 4×10^(5) m^(3).When the structure constructed in the Holocene aquifer and its central axis does not coincide with the center of the simulated area,the maximum thickness of the FGLs will be shifted from the center of the simulated area to 20-25 m on the side of the *** constructed in the Pleistocene aquifer,the thickness of the FGLs *** study provides methodology for planning and management of reclaimed lands for water sustainability in the future in coastal areas.

关键词： freshwater lens numerical simulation Yongshu Island subsurface structures formation process steady-state water volume

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Effects of Rhodiola rosea and its major compounds on insulin resistance in Caenorhabditis elegans

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Journal of Future foods 2022年第4期2卷 365-371页

作者： Hui Teng Hongting Deng Yanzi Wu Chang Zhang Chao Ai Hui Cao Jianbo Xiao Lei Chen Guangdong provincial Key Laboratory of Aquatic Product Processing and Safety Guangdong Province Engineering Laboratory for Marine Biological ProductsGuangdong Provincial Engineering Technology Research Center of SeafoodKey Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education InstitutionCollege of Food Science and TechnologyGuangdong Ocean UniversityZhanjiang 524088China College of food Science Fujian Agriculture and Forestry UniversityZhuzhou 350002China

By establishing insulin resistance model of Caenorhabditis elegans,the effects of Rhodiola rosea extract and its compounds on glucose level,insulin signal intensity,antioxidant enzymes and cell apoptosis of *** were investigated in present *** mRNA expression of DAF-2,DAF-16,AkT-1,SKN-1,AAK-2 and SOD-3 were detected by *** results revealed that *** extract contain salidroside,kaempferol,chlorogenic acid,kaemphenol-7-O-glucoside,caffeic acid,and quercetin,*** the concentration of 200μg/mL,*** extract treated *** showed increased insulin signal intensity by 52.46%compared with the normal group,while,glucose content decreased by 72.13%and reactive oxygen species(ROS)level decreased by 36.84%.Compared with high glucose model group,the activities of superoxide dismutase(SOD),catalase(CAT)and glutathione peroxidase(GSH-Px)increased by 10.9,14.2 and 27.9,*** *** extract intervention,the expression levels of DAF-2,AkT-1,AAK-2,SKN-1 and other genes significantly *** results also indicated that *** extract could activate insulin receptor substrate(IRS)and adenosine 5′-monophosphate(AMP)-activated protein kinase(AMPK)pathways to enhance insulin signaling,promote nutrient metabolism,and achieve the effect for improving insulin resistance of ***.

关键词： Rhodiola rosea Caenorhabditis elegans Insulin resistance

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Mechanisms of Exogenous Nitric Oxide and 24-Epibrassinolide Alleviating Chlorosis of Peanut Plants Under Iron Deficiency

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Pedosphere 2018年第6期28卷 926-942页

作者： SONG Yiling DONG Yuanjie TIAN Xianyi WANG Wanwan Zhenli HE College of Resources and Environment National Engineering Laboratory for Efficient Utilization of Soil and Fertilizer Shandong Agricultural University Indian River research and Education center Institute of Food and Agricultural Sciences University of Florida

Iron(Fe) is a crucial transition metal for all living organisms including plants; however, Fe deficiency frequently occurs in plant because only a small portion of Fe is bioavailable in soil in recent years. To cope with Fe deficiency, plants have evolved a wide range of adaptive responses from changes in morphology to altered physiology. To understand the role of nitric oxide(NO) and 24-epibrassinolide(EBR) in alleviating chlorosis induced by Fe deficiency in peanut(Arachis hypogaea L.) plants, we determined the concentration of chlorophylls, the activation, uptake, and translocation of Fe, the activities of key enzymes, such as ferric-chelate reductase(FCR),proton-translocating adenosine triphosphatase(H^+-ATPase), and antioxidant enzymes, and the accumulation of reactive oxygen species(ROS) and malondialdehyde(MDA) of peanut plants under Fe sufficiency(100 μmol L^(-1)ethylenediaminetetraacetic acid(EDTA)-Fe) and Fe deficiency(0 μmol L^(-1)EDTA-Fe). We also investigated the production of NO in peanut plants subjected to Fe deficiency with foliar application of sodium nitroprusside(SNP), a donor of NO, and/or EBR. The results showed that Fe deficiency resulted in severe chlorosis and oxidative stress, significantly decreased the concentration of chlorophylls and active Fe, and significantly increased NO production. Foliar application of NO and/or EBR increased the activity of antioxidant enzymes, superoxide dismutase,peroxidase, and catalase, and decreased the ROS and MDA concentrations, thus enhancing the resistance of plants to oxidative *** of NO also significantly increased Fe translocation from the roots to the shoots and enhanced the transfer of Fe from the cell wall fraction to the cell organelle and soluble fractions. Consequently, the concentrations of available Fe and chlorophylls in the leaves were elevated. Furthermore, the activities of H^+-ATPase and FCR were enhanced in the Fe-deficient plants. Simultaneously,there was a significant in

关键词： active iron antioxidant enzyme subcellular structure chlorophyll oxidative stress reactive oxygen species sodium nitroprusside

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Development of environmentally friendly biological algicide and biochemical analysis of inhibitory effect of diatom Skeletonema costatum

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Chinese Chemical Letters 2022年第3期33卷 1358-1364页

作者： Jie Yang Qingzheng Zhu Jinlong Chai Feng Xu Yunfei Ding Qiang Zhu Zhaoxin Lu Kuan Shiong Khoo Xiaoying Bian Shujun Wang Pau Loke Show Jiangsu Key Laboratory of marine Bioresources and Environment/Jiangsu Key Laboratory of marine Biotechnology Jiangsu Ocean UniversityLianyungang 222005China Jiangsu marine Resources Development research Institute Lianyungang 222005China Co-Innovation center of Jiangsu marine Bio-industry technology Jiangsu Ocean UniversityLianyungang 222005China Helmholtz Institute of Biotechnology State Key Laboratory of Microbial TechnologyShandong UniversityQingdao 266237China College of food Science and technology Nanjing Agricultural UniversityNanjing 210095China Department of Chemical and Environmental engineering Faculty of Science and EngineeringUniversity of Nottingham MalaysiaJalan Broga43500 SemenyihMalaysia

Skeletonema costatum is a diatom widely distributed in red tide microalgae blooms and as one of the main algae causing harmful algal blooms,because of their rapid reproduction and production of toxic and harmful substances,often play a negative role in aquatic ecosystems,and human health and *** D is a nonribosomal cyclic antifungal lipopeptide in the iturins *** this study,Bacillomycin D was tested for its ability to inhibit the growth of *** EC_(50 24h) of Bacillomycin D on *** was 24.70μg/*** chlorophyll fluorescence parameters F_(v)/F_(m),F_(v)/F_(o),and yield of the diatoms decreased significantly with increasing concentrations of Bacillomycin *** of the mechanism showed that Bacillomycin D induced cell death by changing cell membrane permeability,promoting the release of cellular *** this study,transcriptomic analysis showed Bacillomycin D significantly inhibited the photosynthesis and metabolism of *** findings investigated the inhibitory effect of Bacillomycin D on the growth of *** and provided a theoretical foundation for the development of new environmentally friendly biological algicide.

关键词： Bacillomycin D Skeletonema costatum Transcriptome Growth inhibition Photosynthesis

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