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The Role of Underlying Boundary Forcing in Shaping the Recent Decadal Change of Persistent Anomalous Activity over the Ural Mountains

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Advances in Atmospheric Sciences 2024年第8期41卷 1496-1510,1661-1667页

作者： Ting LEI Shuanglin LI Climate Change Research center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Beijing meteorological service center Beijing 100089China University of Chinese Academy of Sciences Beijing 100049China Department of Atmospheric Science China University of GeosciencesWuhan 430074China

Observational analyses demonstrate that the Ural persistent positive height anomaly event(PAE) experienced a decadal increase around the year 2000, exhibiting a southward displacement afterward. These decadal variations are related to a large-scale circulation shift over the Eurasian Continent. The effects of underlying sea ice and sea surface temperature(SST) anomalies on the Ural PAE and the related atmospheric circulation were explored by Atmospheric Model Intercomparison Project(AMIP) experiments from the Coupled Model Intercomparison Project Phase 6 and by sensitivity experiments using the Atmospheric General Circulation Model(AGCM). The AMIP experiment results suggest that the underlying sea ice and SST anomalies play important roles. The individual contributions of sea ice loss in the Barents-Kara Seas and the SST anomalies linked to the phase transition of the Pacific Decadal Oscillation(PDO) and Atlantic Multidecadal Oscillation(AMO) are further investigated by AGCM sensitivity experiments isolating the respective *** sea ice decline in Barents-Kara Seas triggers an atmospheric wave train over the Eurasian mid-to-high latitudes with positive anomalies over the Urals, favoring the occurrence of Ural PAEs. The shift in the PDO to its negative phase triggers a wave train propagating downstream from the North Pacific. One positive anomaly lobe of the wave train is located over the Ural Mountains and increases the PAE there. The negative-to-positive transition of the AMO phase since the late-1990s causes positive 500-h Pa height anomalies south of the Ural Mountains, which promote a southward shift of Ural PAE.

关键词： Ural persistent anomaly Pacific decadal oscillation Atlantic multidecadal oscillation sea ice loss in Barents-Kara Seas

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Theoretical Design of Defects as a Driving Force for Ion Transport in Li3OBr Solid Electrolyte

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Energy & Environmental Materials 2024年第3期7卷 147-157页

作者： Xingyun Luo Yanlu Li Xian Zhao State Key Lab of Crystal Materials and Institute of Crystal Materials Shandong University center for Optics Research and Engineering Shandong University

Due to ever-increasing concerns about safety issues in using Li ionic batteries,solid electrolytes have extensively *** Li-rich antiperovskite Li3OBr has been considered as a promising solid electrolyte candidate,but it still suffers challenges to achieve a high ionic conductivity owing to the high intrinsic symmetry of the crystal ***,we presented a design strategy that introduces various point defects and grain boundaries to break the high lattice symmetry of Li3OBr crystal,and their effect and microscopic mechanism of promoting the migration of Li-ion were explored *** has been found that Liiare the dominant defects responsible for the fast Li-ion diffusion in bulk Li3OBr and its surface,but they are easily trapped by the grain boundaries,leading to the annihilating of the Frenkel defect pair V'Li+Li,and thus limits the V'Lidiffusion at the grain *** VBrdefect near the grain boundaries can effectively drive V'Liacross the grain boundary,thereby converting the carrier of Li+migration from Li,in the bulk and surface to V'Liat the grain boundary,and thus improving the ionic conductivity in the whole Li3OBr *** work provides a comprehensive insight into the Li+transport and conduction mechanism in the Li3OBr *** opens a new way of improving the conductivity for all-solid-state Li electrolyte material through the defect design.

关键词： defects density functional theory ionic migration solid electrolyte

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Styrax japonicus functional genomics:an efficient virus induced gene silencing(VIGS)system

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Horticultural Plant Journal 2024年第1期10卷 252-258页

作者： Gangyu Sun Yiqian Ju Cuiping Zhang Lulu Li Xinqiang Jiang Xiaoman Xie Yizeng Lu Kuiling Wang Wei Li College of Landscape Architecture and Forestry Qingdao Agricultural UniversityQingdaoShandong 266109China shandong Provincial center of Forest and Grass Germplasm Resources JinanShandong 250102China

VIGS(Virus-induced gene silencing),a method for posttranscriptional gene silencing,is an effective technique for investigating the activities of genes in *** there is no report for available VIGS system in Styrax japonicus,the application of a VIGS approach that results in a gene knockdown to study gene function is *** this study,we compared the characteristics that could affect the viability of VIGS in ***,including the acetosyringone(AS)concentration,the Agrobacterium’s optical density and the inoculation *** stable reference genes of *** were selected to validate the gene’s knockdown by quantitative *** a result,we successfully constructed 2 VIGS systems based on TRV virus:vacuum with AS concentration of 200μmol·L^(-1)and OD600of 0.5,and friction-osmosis with AS concentration of 200μmol·L^(-1)and OD600of 1.0,which silencing efficiency was 83.33%and 74.19%,*** successfully applied VIGS method provides a rapid and effective reverse gene functional analysis approach in *** to identify unknown gene functions.

关键词： Styrax japonicus VIGS Reference gene

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Advances in regional nodal management of early-stage breast cancer

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Chinese Journal of Cancer Research 2024年第2期36卷 215-225页

作者： Zhao Bi Yongsheng Wang Breast Cancer center Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinan 250017China

With the continuous improvement of systemic treatment, reasonable local regional control of early-stage breast cancer can be translated into survival benefits. The optimization of regional nodal management in patients with limited sentinel lymph node(SLN) metastasis needs to be weighed by surgical complications, regional recurrence risk, and lymph node status, as well as other escalating treatment(systemic/radiotherapy) that may result from deescalating surgery. With the effective support and supplementation of systemic therapy and radiotherapy, the management of axillary surgery is developing in a de-escalating trend. The widespread application of neoadjuvant therapy has contributed to optimizing the management of patients with clinically node-negative/imaging nodepositive disease. In clinical practice, it is necessary to consider the residual tumor burden of regional lymph nodes when formulating the optimal irradiation fields in patients with limited positive SLN without axillary lymph node dissection. The combined application of genomic tests and American College of Surgeons Oncology Group Z0011/AMAROS criteria could provide patients with a better strategy of dual de-escalation treatment, which includes the de-escalation of both axillary surgery and systemic treatment. In the era of sentinel lymph node biopsy(SLNB), the regional nodal management of breast cancer should adhere to the concept of “updating ideas, making bold assumptions, and carefully seeking proof”, make full use of the benefits of systemic therapy and radiotherapy to reduce the scope of surgery and complications, and expand the “net benefit” of efficacy and quality of life. This review discusses the optimization of regional nodal management in the era of SLNB, in order to provide reference information for clinicians.

关键词： Breast cancer sentinel lymph node biopsy internal mammary lymph node radiotherapy surgery

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In-situ analysis of laser-induced breakdown spectra for online monitoring of femtosecond laser machining of sapphire

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Science China(Technological Sciences) 2024年第1期67卷 73-82页

作者： SHANGGUAN ShiYong ZHANG JianGuo LI ZhanZhu SHI Wei WANG WenKe QI DongFeng ZHENG HongYu center for Advanced Laser Manufacturing(CALM) Shandong University of TechnologyZibo 255000China

Laser-induced breakdown spectroscopy(LIBS)is widely used for elemental ***,its application for monitoring and analyzing a laser machining process by examining the changes in spectral information warrants further *** this study,we investigate the effect of laser parameters on the spectra,variations in the time-resolved plasma emission spectra,and the relationship between the morphology of craters and plasma plume evolution during the femtosecond(fs)laser ablation of *** Boltzmann plot method and Stark’s broadening model are employed to estimate the temporal temperature and electron density of the plasma plume,revealing the process of plasma *** study aims to demonstrate the feasibility of LIBS for online monitoring of laser processing through experimental data and theoretical explanations.

关键词： laser-induced breakdown spectroscopy plasma plume online monitoring sapphire

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Anomalous valley Hall effect in two-dimensional valleytronic materials

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Chinese Physics B 2024年第4期33卷 2-14页

作者：陈洪欣原晓波任俊峰 School of Physics and Electronics Shandong Normal UniversityJinan 250358China shandong Provincial Engineering and Technical center of Light Manipulations&Institute of Materials and Clean Energy Shandong Normal UniversityJinan 250358China

The anomalous valley Hall effect(AVHE)can be used to explore and utilize valley degrees of freedom in materials,which has potential applications in fields such as information storage,quantum computing and *** exists in two-dimensional(2D)materials possessing valley polarization(VP),and such 2D materials usually belong to the hexagonal honeycomb ***,it is necessary to achieve valleytronic materials with VP that are more readily to be synthesized and applicated *** this topical review,we introduce recent developments on realizing VP as well as AVHE through different methods,i.e.,doping transition metal atoms,building ferrovalley heterostructures and searching for ferrovalley ***,2D ferrovalley systems under external modulation are also discussed.2D valleytronic materials with AVHE demonstrate excellent performance and potential applications,which offer the possibility of realizing novel low-energy-consuming devices,facilitating further development of device technology,realizing miniaturization and enhancing functionality of them.

关键词： anomalous valley Hall effect valley polarization valleytronics two-dimensional materials

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A Quantitative Seismic Topographic Effect Prediction Method Based upon BP Neural Network Algorithm and FEM Simulation

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Journal of Earth Science 2024年第4期35卷 1355-1366页

作者： Qifeng Jiang Mianshui Rong Wei Wei Tingting Chen shandong Seismic Hazard Prevention center Shandong Earthquake AgencyJinan250014China shandong Institute of Earthquake Engineering Jinan250021China Key Laboratory of Urban Security and Disaster Engineering of China Ministry of Education Beijing University of TechnologyBeijing100124China Publicity and Education center Shandong Earthquake AgencyJinan250014China shandong Earthquake Station Shandong Earthquake AgencyJinan250014China

Topography can strongly affect ground motion,and studies of the quantification of hill surfaces’topographic effect are relatively *** this paper,a new quantitative seismic topographic effect prediction method based upon the BP neural network algorithm and three-dimensional finite element method(FEM)was *** FEM simulation results were compared with seismic records and the results show that the PGA and response spectra have a tendency to increase with increasing elevation,but the correlation between PGA amplification factors and slope is not obvious for low *** BP neural network models were established for the prediction of amplification factors of PGA and response *** kinds of input variables’combinations which are convenient to achieve are proposed in this paper for the prediction of amplification factors of PGA and response spectra,*** absolute values of prediction errors can be mostly within 0.1 for PGA amplification factors,and they can be mostly within 0.2 for response spectra’s amplification *** input variables’combination can achieve better prediction performance while the other one has better expandability of the predictive ***,the BP models only employ one hidden layer with about a hundred nodes,which makes it efficient for training.

关键词： seismic topographic effect finite element method BP neural network algorithm earthquake disaster prevention

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DNA methylation drives a new path in gastric cancer early detection:Current impact and prospects

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Genes & Diseases 2024年第2期11卷 847-860页

作者： Xinhui Wang Yaqi Dong Hong Zhang Yinghui Zhao Tianshu Miao Ghazal Mohseni Lutao Du Chuanxin Wang Department of Clinical Laboratory The Second Hospital of Shandong UniversityJinanShandong 250033China Department of Clinical Laboratory Fuling HospitalChongqing UniversityChongqing 402774China Suzhou Research Institute of shandong University SuzhouJiangsu 215123China Department of Biochemistry and Molecular Biology Shandong University School of Basic Medical SciencesJinanShandong 250012China shandong Engineering & Technology Research center for Tumor Marker Detection JinanShandong 250033China shandong Provincial Clinical Medicine Research center for Clinical Laboratory JinanShandong 250033China

Gastric cancer(GC)is one of the most common and deadly cancers *** detection offers the best chance for curative treatment and reducing its ***,the optimal population-based early screening for GC remains *** DNA methylation occurs in the early stage of GC,exhibiting cancer-specific genetic and epigenetic changes,and can be detected in the media such as blood,gastric juice,and feces,constituting a valuable biomarker for cancer early ***,DNA methylation is a stable epigenetic alteration,and many innovative methods have been developed to quantify it rapidly and ***,large-scale clinical validation of DNA methylation serving as tumor biomarkers is still lacking,precluding their implementation in clinical *** conclusion,after a critical analysis of the recent existing literature,we summarized the evolving roles of DNA methylation during GC occurrence,expounded the newly discovered noninvasive DNA methylation biomarkers for early detection of GC,and discussed its challenges and prospects in clinical applications.

关键词： Biomarkers DNA methylation Early detection Gastric cancer Translation

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Quantum dot-enabled infrared hyperspectral imaging with single-pixel detection

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Light(Science & Applications) 2024年第6期13卷 1112-1121页

作者： Heyan Meng Yuan Gao Xuhong Wang Xianye Li Lili Wang Xian Zhao Baoqing Sun School of Information Sciences and Engineering Shandong UniversityQingdaoChina center for Optics Research and Engineering(CORE) Key Laboratory of Laser&Infrared System(Shandong University)Ministry of EducationShandong UniversityQingdaoChina School of Mechanical Electrical and Information EngineeringShandong UniversityWeihaiChina

Near-infrared(NIR)hyperspectral imaging is a powerful technique that enables the capture of three-dimensional(3D)spectra-spatial information within the NIR spectral range,offering a wide array of ***,the high cost associated with InGaAs focal plane array(FPA)has impeded the widespread adoption of NIR hyperspectral *** this challenge,in this study,we adopt an alternative approach—single-pixel detection for NIR hyperspectral *** investigation reveals that single-pixel detection outperforms conventional FPA,delivering a superior signal-to-noise ratio(SNR)for both spectral and imaging *** implement this strategy,we leverage self-assembled colloidal quantum dots(CQDs)and a digital micromirror device(DMD)for NIR spectral and spatial information multiplexing,complemented by single-pixel detection for simultaneous spectral and image *** experimental results demonstrate successful NIR hyperspectral imaging with a detection window about 600 nm and an average spectral resolution of 8.6 nm with a pixel resolution of 128×*** resulting spectral and spatial data align well with reference instruments,which validates the effectiveness of our *** circumventing the need for expensive and bulky FPA and wavelength selection components,our solution shows promise in advancing affordable and accessible NIR hyperspectral imaging technologies,thereby expanding the range of potential applications.

关键词： spectral Quantum mirror

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Application of Fusobacterium nucleatum as a biomarker in gastrointestinal malignancies

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2271-2283页

作者： Long-Chen Yu Ya-Ping Li Yue-Ming Xin Mai Mao Ya-Xin Pan Yi-Xuan Qu Zheng-Dong Luo Yi Zhang Xin Zhang Department of Clinical Laboratory Qilu Hospital of Shandong UniversityShandong Engineering Research Center of Biomarker and Artificial Intelligence ApplicationJinan 250012Shandong ProvinceChina

The morbidity and mortality of gastrointestinal(GI)malignancies are among the highest in the world,posing a serious threat to human *** of the insidious onset of the cancer,it is difficult for patients to be diagnosed at an early stage,and it rapidly progresses to an advanced stage,resulting in poor treatment and *** nucleatum(***)is a gram-negative,sporefree anaerobic bacterium that primarily colonizes the oral cavity and is implicated in the development of colorectal,esophageal,gastric,and pancreatic cancers via various intricate *** development in novel research suggests that *** may function as a biomarker in GI *** the abundance of *** in stool,saliva,and serum samples of patients may aid in the diagnosis,risk assessment,and prognosis monitoring of GI *** editorial systematically describes the biological roles and mechanisms of *** in GI malignancies focusing on the application of *** as a biomarker in the diagnosis and prognosis of GI malignancies to promote the clinical translation of *** and GI tumors-related research.

关键词： Gastrointestinal malignancies Fusobacterium nucleatum Biomarker Diagnosis Prognosis

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