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Flexible Graphene Field‑Effect Transistors and Their Application in Flexible Biomedical Sensing

Nano-Micro Letters 2025年第2期17卷 252-313页

作者： Mingyuan Sun Shuai Wang Yanbo Liang Chao Wang Yunhong Zhang Hong Liu Yu Zhang Lin Han institute of Marine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China School of Integrated Circuits Shandong UniversityJinan 250100ShandongPeople’s Republic of China shandong engineering Research Center of Biomarker and Artificial Intelligence Application Jinan250100ShandongPeople’s Republic of China

Flexible electronics are transforming our lives by making daily activities more *** to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and ***,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and *** combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical ***,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning *** ability of FGFETs to sense strains and biomolecular charges opens up diverse application *** specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical ***,we discuss the current challenges and prospects of FGFETs and their applications in biomedical *** review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.

关键词： Flexible Graphene Field-effect transistor Wearable Implantable Biosensor

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Robust interface and excellent as-built mechanical properties of Ti–6Al–4V fabricated through laser-aided additive manufacturing with powder and wire

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 154-168页

作者： Fei Weng Guijun Bi Youxiang Chew Shang Sui Chaolin Tan Zhenglin Du Jinlong Su Fern Lan Ng Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong Engineering&Technology Research Center for Superhard MaterialSchool of Materials Science and EngineeringShandong UniversityJinan 250061China institute of Intelligent Manufacturing Guangdong Academy of SciencesGuangzhou 510095China Singapore institute of Manufacturing Technology 5 Cleantech Loop636732Singapore

The feasibility of manufacturing Ti-6Al-4V samples through a combination of laser-aided additive manufacturing with powder(LAAM_(p))and wire(LAAM_(w))was explored.A process study was first conducted to successfully circumvent defects in Ti-6Al-4V deposits for LAAM_(p) and LAAM_(w),*** the optimized process parameters,robust interfaces were achieved between powder/wire deposits and the forged substrate,as well as between powder and wire *** characterization results revealed the epitaxial prior β grains in the deposited Ti-6Al-4V,wherein the powder deposit was dominated by a finerα′microstructure and the wire deposit was characterized by lamellar α *** mechanisms of microstructure formation and correlation with mechanical behavior were analyzed and *** mechanical properties of the interfacial samples can meet the requirements of the relevant Aerospace Material Specifications(AMS 6932)even without post heat *** fracture occurred within the interfacial area,further suggesting the robust *** findings of this study highlighted the feasibility of combining LAAM_(p) and LAAM_(w) in the direct manufacturing of Ti-6Al-4V parts in accordance with the required dimensional resolution and deposition rate,together with sound strength and ductility balance in the as-built condition.

关键词： laser-aided additive manufacturing powder deposition wire deposition interfacial characteristic mechanical behavior

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The autophagy-lysosome pathway:a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 139-158页

作者： Fengjuan Jiao Lingyan Meng Kang Du Xuezhi Li School of Mental Health Jining Medical UniversityJiningShandong ProvinceChina shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong ProvinceChina

Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in *** one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these *** evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance ofα-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s ***,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately linked to alterations in the autophagy-lysosome ***,this pathway appears to be a promising therapeutic target for treatment of Parkinson’s *** this review,we briefly introduce the machinery of ***,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy-lysosome ***,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy–lysosome pathway and their applications in Parkinson’s disease.

关键词： autophagy chemical therapy gene therapy Parkinson’s disease α-synuclein

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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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A Quantitative Seismic Topographic Effect Prediction Method Based upon BP Neural Network Algorithm and FEM Simulation

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Journal of Earth Science 2024年第4期35卷 1355-1366页

作者： Qifeng Jiang Mianshui Rong Wei Wei Tingting Chen shandong Seismic Hazard Prevention Center Shandong Earthquake AgencyJinan250014China shandong institute of earthquake engineering Jinan250021China Key Laboratory of Urban Security and Disaster engineering of China Ministry of Education Beijing University of TechnologyBeijing100124China Publicity and Education Center Shandong Earthquake AgencyJinan250014China shandong earthquake Station Shandong Earthquake AgencyJinan250014China

Topography can strongly affect ground motion,and studies of the quantification of hill surfaces’topographic effect are relatively *** this paper,a new quantitative seismic topographic effect prediction method based upon the BP neural network algorithm and three-dimensional finite element method(FEM)was *** FEM simulation results were compared with seismic records and the results show that the PGA and response spectra have a tendency to increase with increasing elevation,but the correlation between PGA amplification factors and slope is not obvious for low *** BP neural network models were established for the prediction of amplification factors of PGA and response *** kinds of input variables’combinations which are convenient to achieve are proposed in this paper for the prediction of amplification factors of PGA and response spectra,*** absolute values of prediction errors can be mostly within 0.1 for PGA amplification factors,and they can be mostly within 0.2 for response spectra’s amplification *** input variables’combination can achieve better prediction performance while the other one has better expandability of the predictive ***,the BP models only employ one hidden layer with about a hundred nodes,which makes it efficient for training.

关键词： seismic topographic effect finite element method BP neural network algorithm earthquake disaster prevention

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Three-dimensional simulations of strong ground motion in the Shidian basin based upon the spectral-element method

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earthquake engineering and engineering Vibration 2015年第3期14卷 385-398页

作者： Liu Qifang Yu Yanyan Zhang Xubin institute of engineering Mechanics China Earthquake Administration Key Laboratory of earthquake engineering and engineering Vibration China Earthquake Administration

The strong motion of a small long and narrow basin caused by a moderate scenario earthquake is simulated by using the spectral-element method and the parallel computing technique.A total of five different geometrical profiles within the basin are used to analyze the generation and propagation of surface waves and their relation to the basin structures in both the time and frequency *** amplification effects are analyzed by the distribution of peak ground velocity(PGV)and cumulative kinetic energy(Ek) in the *** results show that in the 3D basin,the excitation of the fundamental and higher surface wave modes are similar to that of the 2D *** bowls in the basin have great influence on the amplification and distribution of strong ground motion,due to their lateral resonances when the wavelengths of the lateral surface waves are comparable to the size of the *** basin edge effects can be seen at the basin edge closer to the source for constructive interference between direct body waves and the basin-induced surface *** Ek distribution maps show very large values in small bowls and some corners in the basin due to the interference of waves propagating in different directions.A high impedance contrast model can excite more surface wave modes,resulting in longer shaking durations as well as more complex seismograms and PGV and Ek distributions.

关键词： 3D Shidian basin spectral element method basin-edg

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Field investigation on severely damaged aseismic buildings in 2014 Ludian earthquake

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earthquake engineering and engineering Vibration 2015年第1期14卷 169-176页

作者： Lin Xuchuan Zhang Haoyu Chen Hongfu Chen Hao Lin Junqi institute of engineering Mechanics China Earthquake Administration Key Laboratory of earthquake engineering and engineering Vibration China Earthquake Administration

The 2014 magnitude 6.5 Ludian earthquake caused a death toll of 617, many landslides and tens of thousands of collapsed buildings. A field investigation to evaluate the damage to buildings was carried out immediately after the occurrence of the earthquake. Severely damaged aseismic buildings, which were basically observed in the downtown of Longtoushan Town, were carefully examined one by one with the aim to improve design codes. This paper summarizes the damage observed to the investigated aseismic buildings in both the structural and local levels. A common failure mode was observed that most of the aseismic buildings, such as RC frame structures and confined masonry structures, were similarly destroyed by severe damage or complete collapse of the first story. The related strong ground motion, which was recorded at the nearby station, had a short duration of less than 20 s but a very large PGA up to 1.0 g. The RC frames based on the new design codes still failed to achieve the design target for ＂strong column, weak beam＂. Typical local failure details, which were related to the interaction between RC columns and infill walls and between constructional columns and masonry walls, are summarized with preliminary analyses.

关键词： Ludian earthquake field investigation aseismic buildings structural collapse local failure

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Damage characteristics and seismic capacity of buildings during Nepal M_s 8.1 earthquake

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earthquake engineering and engineering Vibration 2015年第3期14卷 571-578页

作者： Sun Baitao Yan Peilei institute of engineering Mechanics China Earthquake Administration Key Laboratory of earthquake engineering and engineering Vibration China Earthquake Administration

The extensive damage to buildings caused by the Nepal Ms8.1 earthquake has attracted much attention by the international *** preliminary scientific investigations on the different affected areas inNepal,the construction and damage characteristics of five different types of buildings commonly existing in Nepal were discussed and the reasons of their disaster performance were *** of buildings investigated include reinforced concrete(RC) frame structures,rubble structures,brick-wood structures,raw soil structures,and brick-wood structures of historic *** addition,the weak links of the seismic design were pointed out,which was very important for the post-earthquake reconstruction and recovery,and gave a preliminary explanations for the damage experienced.

关键词： Nepal earthquake seismic damage of building seismi

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Shear strength of frozen clay under freezing-thawing cycles using triaxial tests

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earthquake engineering and engineering Vibration 2018年第4期17卷 761-769页

作者： Wang Miao Meng Shangjiu Sun Yiqiang Fu Haiqing institute of engineering Mechanics China Earthquake Administration Harbin 150080 China Key Laboratory of earthquake engineering and engineering Vibration China Earthquake Administration College of Civil engineering andArchitecture Harbin University of Science and Technology Harbin 150080 China shandong earthquake Administration Jinan 250014 China

Using a new low-temperature dynamic triaxial apparatus, the influence law of freezing-thawing cycles on clay shear strength is studied. In this research, the concept of correction coefficients of freezing-thawing cycles on clay static strength, cohesion and internal friction angles is proposed, and the change patterns, correction curves and regressive formulae of clay static strength, cohesion and internal friction angles under freezing-thawing cycles are given. The test results indicate that with increasing numbers of freezing-thawing cycles, the clay static strength and cohesion decrease exponentially but the internal friction angle increases exponentially. The performance of static strength, cohesion and internal friction angles are different with increasing numbers of freezing-thawing cycles, i.e., the static strength decreases constantly until about 30% of the initial static strength prior to the freezing-thawing cycling and then stays basically stable. After 5-7 freezing-thawing cycles, the cohesion decreases gradually to about 70% of the initial cohesion. The internal friction angle increases about 20% after the first freezing-thawing cycle, then increases gradually close to a stable value which is an increase of about 40% of the internal friction angle. The freezing-thawing process can increase the variation of the density of the soil samples; therefore, strict density discreteness standards of frozen soil sample preparation should be established to ensure the reliability of the test results.

关键词： seasonally frozen soil freezing-thawing cycles cohesion internal friction angle correction coefficient

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Design and development of safety evaluation system of buildings on a seismic field based on the network platform

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earthquake engineering and engineering Vibration 2015年第1期14卷 157-167页

作者： Sun Baitao Zhang Lei Chen Xiangzhao Zhang Xinghua institute of engineering Mechanics China Earthquake Administration Key Laboratory of earthquake engineering and engineering Vibration China Earthquake Administration

This paper describes a set of on-site earthquake safety evaluation systems for buildings, which were developed based on a network platform. The system embedded into the quantitative research results which were completed in accordance with the provisions from Post-earthquake Field Works, Part 2： Safety Assessment of Buildings, GB18208.2 -2001, and was further developed into an easy-to-use software platform. The system is aimed at allowing engineering professionals, civil engineeing technicists or earthquake-affected victims on site to assess damaged buildings through a network after earthquakes. The authors studied the function structure, process design of the safety evaluation module, and hierarchical analysis algorithm module of the system in depth, and developed the general architecture design, development technology and database design of the system. Technologies such as hierarchical architecture design and Java EE were used in the system development, and MySQL5 was adopted in the database development. The result is a complete evaluation process of information collection, safety evaluation, and output of damage and safety degrees, as well as query and statistical analysis of identified buildings. The system can play a positive role in sharing expert post-earthquake experience and promoting safety evaluation of buildings on a seismic field.

关键词： safety evaluation of buildings seismic field algorithm model database evaluation system

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