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Geographical features and development models of estuarine cities

Journal of Geographical Sciences 2024年第1期34卷 25-40页

作者： CHEN Mingxing XIAN Yue HUANG Yaohuan SUN Zhigang WU Chengbin Key Laboratory of Regional Sustainable Development Modeling Institute of Geographic Sciences and Natural Resources ResearchCASBeijing 100101China College of Resource and Environment University of Chinese Academy of SciencesBejing 100049China State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchCASBeijing 100101China Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources ResearchCASBeijing 100101China Zhongke shandong Dongying institute of Geography Dongying 257509ShandongChina CAs Engineering Laboratory for Yellow River Delta Modern Agriculture Institute of Geographic Sciences and Natural Resources ResearchCASBeijing 100101China

Cities are the key areas for human beings to achieve sustainable development goals in the *** cities are a special type of coastal city in urgent need of a clear *** paper proposed that estuarine cities are cities developed on the coast where rivers and oceans meet and defined four connotations,including the intersection of rivers and marine water systems,the coordinated development of land and oceans,the location advantages of connecting rivers and seas,and the important fragility of the ecological *** used Hydro SHEDS,OSM,GPW,and urban socioeconomic statistics and selected 50 estuarine cities with large rivers as representatives to summarize the main geographical basis and socioeconomic *** are primarily found in low-altitude,flat regions with average annual temperatures that mainly vary from 10℃to 25℃,relatively abundant precipitation,and extensive biological *** are substantial variations in the socioeconomic features of estuarine *** proposed eight development patterns,including open and inclusive city spirit,high-quality livable cities,high-quality development driven by innovation,integration of internal and external communication with ports and cities,construction of an international financial center,ecological environment protection and restoration,active promotion of cultural tourism,and positive international exchanges.

关键词： estuarine cities great rivers development models sustainability physical geography socioeconomy

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基于铁电-顺电相变增强全固态锂电池高温安全性的新设计（英文）

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Science Bulletin 2024年第1期 22-25页

作者：李文儒崔龙飞公天宇张育涵刘跃辉鞠江伟黄浪马君崔光磊 Qingdao industrial Energy Storage research institute Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences shandong Energy institute Qingdao New Energy shandong Laboratory School of Future technology University of Chinese Academy of Sciences

All-solid-state lithium batteries (ASSLBs) utilizing a nonflowing and low-flammable solid-state electrolyte are considered the most promising candidate to tackle the safety issue of stateof-the-art lithium ion batteries [1].However,recent studies have revealed that ASSLBs may not be as safe as *** high temperatures,various aging and degradation processes evolve inside ASSLBs,such as electrode decay,electrolyte decomposition,

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Fusarium mycotoxins:The major food contaminants

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mLife 2024年第2期3卷 176-206页

作者： Zheng Qu Xianfeng Ren Zhaolin Du Jie Hou Ye Li Yanpo Yao Yi An Agro‐Environmental Protection institute Ministry of Agriculture and Rural AffairsTianjinChina institute of Quality Standard and Testing technology for Agro‐Products Shandong Academy of Agricultural SciencesJinanChina

Mycotoxins,which are secondary metabolites produced by toxicogenic fungi,are natural food toxins that cause acute and chronic adverse reactions in humans and *** genus Fusarium is one of three major genera of mycotoxin‐producing ***,fumonisins,and zearalenone are the major Fusarium mycotoxins that occur *** mycotoxins have the potential to infiltrate the human food chain via contamination during crop production and food processing,eventually threatening human *** occurrence and development of Fusarium mycotoxin contamination will change with climate change,especially with variations in temperature,precipitation,and carbon dioxide *** address these challenges,researchers have built a series of effective models to forecast the occurrence of Fusarium mycotoxins and provide guidance for crop *** mycotoxins frequently exist in food products at extremely low levels,thus necessitating the development of highly sensitive and reliable detection *** successful detection methods have been developed to meet the requirements of various situations,and an increasing number of methods are moving toward highthroughput *** Fusarium mycotoxins cannot be completely eliminated,numerous agronomic,chemical,physical,and biological methods can lower Fusarium mycotoxin contamination to safe levels during the preharvest and postharvest *** theoretical innovations and technological advances have the potential to facilitate the development of comprehensive strategies for effectively managing Fusarium mycotoxin contamination in the future.

关键词： climate change Fusarium mycotoxin management strategy mycotoxin detection

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Biological Evaluation of Lysionotin:a Novel Inhibitor of 5-Lipoxygenase for Anti-glioma

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Chinese Journal of Integrative Medicine 2024年第9期30卷 826-834页

作者： SHAO Xin-xin CHEN Cong LIU Jie LI Qing-jun HE Shan QI Xiang-hua FU Xian-jun WANG Zhen-guo The First Clinical College of Medicine Shandong University of Traditional Chinese MedicineJinan250355China institute for Literature and Culture of Chinese Medicine Shandong University of Traditional Chinese MedicineJinan250355China Key Laboratory of Classical Theory of Traditional Chinese Medicine Ministry of EducationShandong University of Traditional Chinese MedicineJinan250355China College of Pharmacy Shandong University of Traditional Chinese MedicineJinan250355China Experimental Center Shandong University of Traditional Chinese MedicineJinan250355China Neurology Department Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan250014China Marine Traditional Chinese Medicine research Center Qingdao Academy of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineQingdao266114Shandong ProvinceChina

Objective:To explore the potential mechanism of lysionotin in treating ***:First,target prediction based on Bernoulli Naïve Bayes profiling and pathway enrichment was used to predict the biological activity of *** binding between 5-lipoxygenase(5-LO)and lysionotin was detected by surface plasmon resonance(SPR)and molecular docking,and the inhibitory effects of lysionotin on 5-LO and proliferation of glioma were determined using enzyme inhibition assay in vitro and cell viability analysis,***,the pharmaceutical effect of lysionotin was explored by cell survival rate analysis and liquid chromatography with tandem mass spectrometry(LC-MS/MS).The protein expression,intracellular calcium ion concentration and cytoskeleton detection were revealed by Western blot,flow cytometry and fluorescence labeling,***:Target prediction and pathway enrichment revealed that lysionotin inhibited 5-LO,a key enzyme involved in the arachidonic acid metabolism pathway,to inhibit the proliferation of *** docking results demonstrated that 5-LO can be binding to lysionotin through hydrogen bonds,forming bonds with His600,Gln557,Asn554,and *** analysis further confirmed the interaction between 5-LO and ***,enzyme inhibition assay in vitro and cell survival rate analysis revealed that 50%inhibition concentration of lysionotin and the median effective concentration of lysionotin were 90 and 16.58µmol/L,respectively,and the results of LC-MS/MS showed that lysionotin inhibited the production of 5S-hydroperoxy-eicosatetraenoic acid(P<0.05),and moreover,the LC-MS/MS results indicated that lysionotin can enter glioma cells well(P<0.01)and inhibit their *** blot analysis demonstrated that lysionotin can inhibit the expression of 5-LO(P<0.05)and downstream leukotriene B4 receptor(P<0.01).In addition,the results showed that lysionotin affected intracellular calcium ion concentration by inh

关键词： 5-lipoxygenase inhibitor lysionotin 5-lipoxygenase leukotriene B4 calcium ion cytoskeleton

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Perspective for OER electrocatalysts:Lattice engineering of clay-like frameworks with near-surface cluster active sites

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Science China(Technological Sciences) 2024年第1期67卷 330-334页

作者： ZHANG DanTong QIAN BinBin XUE DongFeng Multiscale Crystal Materials research Center Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Near-surface cluster active centers(NSCAC)are pivotal functional units in the catalysis of oxygen evolution reaction(OER),which exceeds the limitations imposed by the diverse coordination environments experienced in atomic and molecular active centers,thereby serving as an exceptional medium for exploring the dynamic catalytic processes of metal active sites[1,2].In the OER,the NSCAC primarily consist of the catalytic site and the first neighboring coordinating *** investigation of NSCAC surpasses the exclusive reliance on the electron state regulation mechanism at the atomic level.

关键词： cluster centers exceptional

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H-and J-aggregation of conjugated small molecules in organic solar cells

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Journal of Energy Chemistry 2024年第6期93卷 174-192,I0005页

作者： Qiaoqiao Zhao Feng He State Key Laboratory of Biobased Material and Green Papermaking Qilu University of TechnologyShandong Academy of SciencesJinan 250353ShangdongChina Shenzhen Grubbs institute and Department of Chemistry Southern University of Science and TechnologyShenzhen 518055GuangdongChina Guangdong Provincial Key Laboratory of Catalysis Southern University of Science and TechnologyShenzhen 518055GuangdongChina

As H-and J-aggregation receive more and more attention in the research of organic solar cells(OSCs),especially in small molecular systems,deep understanding of aggregation behavior is needed to guide the design of conjugated small molecular structure and the fabrication process of OSC *** this end,this review is ***,the review firstly introduced the basic information about H-and J-aggregation of conjugated small molecules in ***,the characteristics of H-and J-aggregation and the methods to identify them were ***,it reviewed the research progress of H-and J-aggregation of conjugated small molecules in OSCs,including the factors influencing H-and J-aggregation in thin film and the effects of H-and J-aggregation on OPV performance.

关键词： H-aggregation J-aggregation Organic solar cells Small molecules Efficiency Stability

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Cu nanowire array with designed interphases enabling high performance Si anode toward flexible lithium-ion battery

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Nano research 2024年第3期17卷 1516-1524页

作者： Pengfei Su Ziqi Zhang Linshan Luo Zhiyong Zhang Chaofei Lan Yahui Li Shaowen Xu Shanpeng Pei Guangyang Lin Cheng Li Xiang Han Wei Huang Songyan Chen Fujian Provincial Key Laboratory of Semiconductors and Applications Collaborative Innovation Center for Optoelectronic Semiconductors and Efficient DevicesDepartment of PhysicsXiamen UniversityXiamen 361005China College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037China Science and technology on Analog Integrated Circuit Laboratory Chongqing 400060China shandong Electric Power Engineering Consulting institute Co. Ltd.Jinan 250013China

To meet the growing demand for wearable smart electronic devices,the development of flexible lithium-ion batteries(LIBs)is *** is an ideal candidate for the anode material of flexible lithium-ion batteries due to its high specific capacity,low working potential,and earth *** largest challenge in developing a flexible silicon anode is how to maintain structural integrity and ensure stable electrochemical reactions during external *** this work,we propose a novel design for fabricating core–shell electrodes based on a copper nanowire(CuNW)array core and magnetron sputtered Si/C *** nanowire array structure has characteristics of bending under longitudinal stress and twisting under transverse stress,which helps to maintain the mechanical stability of the structure during electrode bending and *** low-temperature annealing generates a small amount of Cu3Si alloy,which enhances the connection strength between Si and the conductive network and solves the poor conductivity problem of Si,which is known as a semiconductor *** unique configuration design of CuNW@Si@C-400℃ leads to stable long cycle performance of 1109 mAh∙g^(-1) after 1000 cycles and excellent rate performance of 500 mAh∙g^(-1) at a current density of 10 A∙g^(-1).Furthermore,the CuNW@Si@C-400℃||LiFePO_(4)(LFP)full battery demonstrates excellent flexibility,with a capacity retention of more than 96%after 100 *** study provides a promising strategy for the development of flexible lithium-ion batteries.

关键词： flexible lithium-ion battery silicon anode magnetron sputtering core–shell electrode Cu nanowire array

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Metal coordination-driven assembly of stimulator of interferon genes-activating nanoparticles for tumor chemo-immunotherapy

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BMEMat(BioMedical Engineering Materials) 2024年第2期2卷 118-133页

作者： Guiqiang Zhang Ning Wang Yuan Ma Shumei Zhai To Ngai Shilei Ni Xinyi Jiang Jianwei Jiao Jiwei Cui Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education School of Chemistry and Chemical EngineeringShandong UniversityJinanChina Medical Science and technology innovation Center Shandong First Medical University&Shandong Academy of Medical SciencesJinanChina Department of Neurosurgery Qilu Hospital and Institute of Brain and Brain-Inspired ScienceCheeloo College of MedicineShandong UniversityJinanChina Department of Chemistry The Chinese University of Hong KongHong KongChina Department of Pharmaceutics School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinanChina

Activating the stimulator of interferon genes(STING)signaling pathway is critical for enhancing antitumor immunity and remodeling the immunosuppressive tumor microenvironment(TME).Herein,we report the preparation of STING-activating nanoparticles via metal coordination-driven assembly of a synthetic STING agonist(i.e.,SR717)and a chemotherapeutic drug(i.e.,curcumin).After intravenous administration,the assembled nanoparticles could efficiently accumulate in tumors to improve the bioavailability of SR717 and trigger potent STING pathway activation for effective immune ***,the released curcumin evokes immunogenic cell death in tumors and regulates amino acid metabolism by inhibiting the activation of indoleamine 2,3-dioxygenase 1,leading to the reversal of the immunosuppressive *** antitumor immunity induced by nanoparticles significantly inhibits the growth of primary,recurrent,and metastatic *** assembled nanoparticles are promising for the co-delivery of STING agonists and drugs in improved tumor chemo-immunotherapy.

关键词： amino acid metabolism immunotherapy nanoparticles self-assembly STING

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Experimental distillation of tripartite quantum steering with an optimal local filtering operation

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Photonics research 2024年第3期12卷 552-562页

作者： QIAN-XI ZHANG XIAO-XU FANG HE LU School of Physics State Key Laboratory of Crystal MaterialsShandong UniversityJinan 250100China Shenzhen research institute of shandong University Shenzhen 518057China

Multipartite Einstein-Podolsky-Rosen(EPR)steering admits multipartite entanglement in the presence of uncharacterized verifiers,enabling practical applications in semi-device-independent *** applications generally require stronger steerability,while the unavoidable noise weakens steerability and consequently degrades the performance of quantum information ***,we propose the local filtering operation that can maximally distill genuine tripartite EPR steering from N copies of three-qubit generalized Greenberger-Horne-Zeilinger states,in the context of two semi-device-independent *** optimal filtering operation is determined by the maximization of assemblage *** and numerical results indicate the advantage of the proposed filtering operation when N is finite and the steerability of initial assemblages is ***,a proof-of-principle demonstration of two-copy distillation is realized with the optical *** advantage of the optimal local filtering operation is confirmed by the distilled assemblage in terms of higher assemblage fidelity with perfectly genuine tripartite steerable assemblages,as well as the greater violation of the inequality to witness genuine tripartite steerable *** results benefit the distillation of multipartite EPR steering in practice,where the number of copies of initial assemblages is generally finite.

关键词： filtering distillation optimal

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Cellular atlases of ovarian microenvironment alterations by diet and genetically-induced obesity

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Science China(Life Sciences) 2024年第1期67卷 51-66页

作者： Yonghui Jiang Xueying Gao Yue Liu Xueqi Yan Huangcong Shi Rusong Zhao Zi-Jiang Chen Fei Gao Han Zhao Shigang Zhao Center for Reproductive Medicine Shandong UniversityJinan 250012China research Unit of Gametogenesis and Health of ART-Offspring Chinese Academy of Medical Sciences(No.2021RU001)Jinan 250012China Key Laboratory of Reproductive Endocrinology of Ministry of Education Shandong UniversityJinan 250012China shandong Key Laboratory of Reproductive Medicine Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250012China shandong Provincial Clinical research Center for Reproductive Health Jinan 250012China National research Center of Assisted Reproductive technology and Reproductive Genetics Shandong UniversityJinan 250012China The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215000China Center for reproductive medicine Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics Shanghai 200127China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of ScienceBeijing 100101China

Obesity,which can arise from genetic or environmental factors,has been shown to cause serious damages to the reproductive *** ovary,as one of the primary regulators of female fertility,is a complex organ comprised of heterogeneous cell types that work together to maintain a normal ovarian microenvironment(OME).Despite its importance,the effect of obesity on the entire ovary remains poorly *** this study,we performed ovary single-cell and nanoscale spatial RNA sequencing to investigate how the OME changed under different kinds of obesity,including high-fat diet(HFD)induced obesity and Leptin ablation induced obesity(OB).Our results demonstrate that OB,but not HFD,dramatically altered the proportion of ovarian granulosa cells,theca-interstitial cells,luteal cells,and endothelial ***,based on the spatial dynamics of follicular development,we defined four subpopulations of granulosa cell and found that obesity drastically disrupted the differentiation of mural granulosa cells from small to large antral ***,HFD enhanced follicle-stimulating hormone(FSH)sensitivity and hormone conversion,while OB caused decreased sensitivity,inadequate steroid hormone conversion,and impaired follicular *** differences can be explained by the differential expression pattern of the transcription factor ***,our study provides a powerful and high-resolution resource for profiling obesity-induced OME and offers insights into the diverse effects of obesity on female reproductive disorders.

关键词： obesity ovarian microenvironment snRNA-seq Stereo-seq Foxo1

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