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Black radish root extract alleviates sodium valproate-induced liver damage via inhibiting mitochondrial membrane potential collapse and oxidative stress in mice

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Asian Pacific Journal of Tropical Biomedicine 2024年第7期14卷 298-306页

作者： Mohammad Hadi Zarei Sami Akbulut Maryam Zafari Elham Saghaei Zahra Lorigooini Hossein AminiKhoei Somaye Khosravi Elham Bijad Medical Plants Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekordIran Department of Liver Transplant Institute and Biostatistics Inonu University Faculty of Medicine44280MalatyaTurkey Student Research Committee Shahrekord University of Medical SciencesShahrekordIran Physiology and Pharmacology Department School of MedicineShahrekord University of Medical SciencesShahrekordIran Department of Anatomical Sciences School of MedicineShahrekord University of Medical SciencesShahrekordIran

Objective:To explore the effect of black radish(Raphanus sativus *** niger)root extract on liver enzymes,oxidative stress,and histopathological alterations in mice with sodium valproate-induced ***:Thirty-two mice were divided into four groups:the control group received drinking water by gavage,the second group was administered with 100 mg/kg of sodium valproate,the third group received 300 mg/kg of black radish root extract,and the fourth group was given both sodium valproate(100 mg/kg)and black radish root extract(300 mg/kg).After 28 days,the mice were euthanized,and serum levels of aspartate aminotransferase(AST),alanine aminotransferase(ALT),and alkaline phosphatase(ALP),along with liver malondialdehyde(MDA),reactive oxygen species(ROS),mitochondrial parameters,tumor necrosis factor-alpha(TNF-α)gene expression,and histopathological changes were ***:Sodium valproate caused hepatic damage in mice,characterized by elevated serum levels of liver enzymes,increased MDA and ROS levels and TNF-αgene expression,as well as histopathological *** black radish root extract significantly alleviated sodium valproate-caused hepatic injury by decreasing the serum levels of ALT and AST,MDA,ROS,TNF-αgene expression,as well as mitochondrial impairment,but did not have a significant effect on sodium valproate-induced histopathological ***:The black radish root extract demonstrates protective effects against sodium valproate-induced liver injury,possibly through mitigating oxidative stress,mitochondrial impairment,and inflammatory mediator expression.

关键词： Black radish Raphanus sativus Sodium valproate Hepatotoxicity Oxidative stress Anti-inflammation

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An SDN-Based Algorithm for Caching,Routing,and Load Balancing in ICN

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China Communications 2024年第5期21卷 64-76页

作者： MohammadBagher Tavasoli Hossein Saidi Ali Ghiasian Department of Electrical and Computer Engineering Isfahan University of TechnologyIsfahanIran Department of Technology and Engineering Shahrekord UniversityShahrekordIran

One of the challenges of Informationcentric Networking(ICN)is finding the optimal location for caching content and processing users’*** this paper,we address this challenge by leveraging Software-defined Networking(SDN)for efficient ICN *** achieve this,we formulate the problem as a mixed-integer nonlinear programming(MINLP)model,incorporating caching,routing,and load balancing *** explore two distinct scenarios to tackle the ***,we solve the problem in an offline mode using the GAMS environment,assuming a stable network state to demonstrate the superior performance of the cacheenabled network compared to non-cache ***,we investigate the problem in an online mode where the network state dynamically changes over *** the computational complexity associated with MINLP,we propose the software-defined caching,routing,and load balancing(SDCRL)algorithm as an efficient and scalable *** evaluation demonstrates that the SDCRL algorithm significantly reduces computational time while maintaining results that closely resemble those achieved by GAMS.

关键词： in-network caching information-centric network power efficiency routing software-defined networking

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Synergizing Wind,Solar,and Biomass Power:Ranking Analysis of Off-Grid System for Different Weather Conditions of Iran

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Energy Engineering 2024年第6期121卷 1381-1401页

作者： Razieh Keshavarzi Mehdi Jahangiri Energy and Environment Research Center Shahrekord BranchIslamic Azad UniversityShahrekordIran

Nowadays,the use of renewable energies,especially wind,solar,and biomass,is essential as an effective solution to address global environmental and economic ***,the current study examines the energy-economic-environmental analysis of off-grid electricity generation systems using solar panels,wind turbines,and biomass generators in various weather conditions in *** over 25 years were conducted using HOMER v2.81 software,aiming to determine the potential of each region and find the lowest cost of electricity production per *** the end,to identify the most suitable location,the Technique for Order Preference by Similarity to Ideal Solution(TOPSIS)method was employed to rank different stations based on simulation output parameters and some other influential *** the evaluation of various parameters,the stations in Yazd,Marand,and Dezful achieved the best results,while the stations in Ramsar,shahrekord,and Gonbad presented the least favorable *** Yazd,the wind turbine is an economic priority,and a 100 kW wind turbine is utilized in the optimal *** Yazd,where the simultaneous use of renewable energies is most prominent,the lowest pollutant production occurred with a quantity of 1174 kg/*** energy losses are highest in Jask station and lowest in Yazd.

关键词： Multi-criteria decision-making method residential scale biomass generators normalize weight

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The effect of celastrol in combination with 5-fluorouracil on proliferation and apoptosis of gastric cancer cell lines

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Oncology Research 2024年第7期32卷 1231-1237页

作者： MOHAMMAD-TAGHI MORADI DHIYA ALTEMEMY MAJID ASADI-SAMANI PEGAH KHOSRAVIAN MARZIYEH SOLTANI LEILA HASHEMI AZADEH SAMIEI-SEFAT Medical Plants Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekordIran Department of Pharmaceutics College of PharmacyAl-Zahraa University for WomenKarbalaIraq Cellular and Molecular Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekordIran

Background:Despite the availability of chemotherapy drugs such as 5-ﬂuorouracil(5-FU),the treatment of some cancers such as gastric cancer remains challenging due to drug resistance and side *** study aimed to investigate the effect of celastrol in combination with the chemotherapy drug 5-FU on proliferation and induction of apoptosis in human gastric cancer cell lines(AGS and EPG85-257).Materials and Methods:In this in vitro study,AGS and EPG85-257 cells were treated with different concentrations of celastrol,5-FU,and their *** proliferation was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide(MTT)*** synergistic effect of 5-FU and celastrol was studied using Compusyn *** DNA content at different phases of the cell cycle and apoptosis rate was measured usingﬂow ***:Co-treatment with low concentrations(10%inhibitory concentration(IC10))of celastrol and 5-FU signiﬁcantly reduced IC50(p<0.05)so that 48 h after treatment,IC50 was calculated at 3.77 and 6.9μM for celastrol,20.7 and 11.6μM for 5-FU,and 5.03 and 4.57μM for their combination for AGS and EPG85-257 cells,*** mean percentage of apoptosis for AGS cells treated with celastrol,5-FU,and their combination was obtained 23.9,41.2,and 61.9,and for EPG85-257 cells 5.65,46.9,and 55.7,*** addition,the 5-FU and celastrol-5-FU combination induced cell cycle arrest in the synthesis ***:Although celastrol could decrease the concentration of 5-ﬂuorouracil that sufﬁced to suppress gastric cancer cells,additional studies are required to arrive at conclusive evidence on the anticancer effects of celastrol.

关键词： Gastric cancer Celastrol Terpenoid Cell cycle regulation Apoptosis Synergism

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Effect of virgin olive oil nanoemulsion combined with ajowan(Carum copticum)essential oil on the quality of lamb loins stored under chilled condition

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Food Science and Human Wellness 2022年第4期11卷 904-913页

作者： Sajad Jafarinia Aziz A.Fallah Saied Habibian Dehkordi Department of Food Hygiene and Quality Control Faculty of Veterinary MedicineShahrekord UniversityShahrekord 34141Iran Department of Pharmacology Faculty of Veterinary MedicineShahrekord UniversityShahrekord 34141Iran

This survey was conducted to evaluate the impact of virgin olive oil nanoemulsion(ONE) combined with ajowan(Carum copticum) essential oil(AEO) on quality of lamb loin under refrigerated condition. The treatments were control, ONE, ONE + 1% AEO, and ONE + 2% AEO. The treatments caused a delay in growth of mesophilic and psychrotrophic bacteria, Enterobacteriaceae, and lactic acid bacteria during chilled storage. The increasing rate of total volatile nitrogen content, lipid and protein oxidation, metmyoglobin formation, and color deterioration was more retarded in treatment groups. The treatments including ONE + 1% AEO and ONE + 2% AEO were more efficient than ONE alone to delay microbial flora growth, slow down oxidative processes, and improve color in the loins. According to the results of microbial, chemical, and sensory parameters, shelflife of lamb loins was 4 days in control, 8 days in ONE, and at least 16 days in ONE + 1% AEO and ONE + 2% AEO groups. In conclusion, combination of ONE and AEO is appropriate as natural preservative to extend the shelflife of lamb loins stored under chilled condition.

关键词： Olive oil Nanoemulsion Carum copticum Meat Shelf-life

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Antibacterial,antioxidative and sensory properties of Ziziphora clinopodioides–Rosmarinus officinalis essential oil nanoencapsulated using sodium alginate in raw lamb burger patties

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Food Bioscience 2022年第3期47卷 848-857页

作者： Pourya Karimifar S.Siavash Saei-Dehkordi Zahra Izadi Department of Food Hygiene and Quality Control Faculty of Veterinary MedicineShahrekord UniversityShahrekord34141Iran Department of Mechanical Engineering of Biosystems Faculty of AgricultureShahrekord University34141ShahrekordIran

This study was aimed to encapsulate Ziziphora clinopodioides –Rosmarinus officinalis essential oil (Z-REO) using sodium alginate (NaAlg) and to evaluate its performance on antimicrobial and antioxidative activities and sensory attributes in lamb burger patties during cold storage for 12 ***-MS analysis of Z-REO indicated carvacrol (21.5%) and thymol (16.9%) were the major *** images showed the formation of encapsulated *** presence of encapsulated Z-REO in NaAlg was proved based on the increase in band intensity of FTIR *** increasing mass ratios of NaAlg:Z-REO from 1:1 to 2:1,and 4:1,encapsulation efficiency was *** zeta-potential values (mV) of the mass ratios 4:1 and 2:1 were −48.67 and −44.83,indicating the stability of encapsulated *** average size of particles ranged from 159.14 nm to 256.14 *** results showed that the encapsulated nanoparticles could markedly decrease the growth of inoculated Escherichia coli O157:H7 and Staphylococcus aureus and delay the lipid oxidation of lamb patties compared to the control samples and in samples with free ***,nanoparticles efficiently decreased discoloration and off-odor development in the ***,NaAlg-Z-REO nanoparticles could efficiently reduce bacterial growth and oxidative or sensory deterioration of lamb patties during storage.

关键词： Encapsulation Ziziphora clinopodioides essential oil Rosmarinus officinalis essential oil Sodium alginate Antibacterial and antioxidative activities Sensory evaluation

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Design and manufacture of emulsion liquid membrane based on various amine extractants for separation and extraction of succinic acid from fermentation broth

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Chinese Journal of Chemical Engineering 2023年第9期61卷 173-179页

作者： Elham Ameri Ali Aghababai Beni Zahra Pournuroz Nodeh Department of Chemical Engineering Najafabad BranchIslamic Azad UniversityNajafabadIran Department of Chemical Engineering Shahrekord BranchIslamic Azad UniversityShahrekordIran Department of Chemistry Lahijan BranchIslamic Azad UniversityLahijanIran

The aim of this study was to design a new emulsion liquid membrane(ELM)system for the separation of succinic acid from aqueous *** concentration of succinic acid varied from 20 to 60 mmol·L^(-1).The prepared ELM system includes tributylamine(TBA)as a carrier,commercial kerosene as a solvent,Span 80 as a surfactant,and Na2CO3as a stripping *** order to control the membrane swelling,different values of cyclohexanone were added to the membrane *** effect of various empirical variables on the extraction of the succinic acid such as acid concentration in the feed solution,initial feed concentration,carrier concentration,the stirring speed of the extraction,Na2CO3,surfactant,and cyclohexanone concentrations,and treat ratio in the ELM *** best result was obtained when TBA was used as the *** final acid extraction efficiency was independent of pH variations of the aqueous feed *** extraction of succinic acid solution with a concentration of 40 mmol·L^(-1)was improved by increasing the treat ratio 1:7-1:3,stripping phase concentration 0.5-1.5 mol·L^(-1),stirring speed 300-500 r·min^(-1)and cyclohexanone concentration in the membrane phase 1.2-1.6 mol·L^(-1).No considerable effect on the extraction rate was observed for the carrier concentration in the membrane ***,the surfactant concentration in the feed phase showed a dual effect on the extraction efficiency.

关键词： Design Membranes Separation Emulsion liquid Succinic acid Fermentation broth

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Bifurcations of a discrete-time SIR epidemic model with logistic growth of the susceptible individuals

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生物数学学报:英文版 2023年第6期16卷 289-312页

作者： Z.Eskandari R.Khoshsiar Ghaziani Z.Avazzadeh Department of Mathematics Faculty of Science Fasa UniversityFasaIran Department of Mathematical Sciences shahrekord university ShahrekordIran Department of Mathematical Sciences university of South Africa FloridaSouth Africa

This study focuses on the stability and local bifurcations of a discrete-time SIR epidemic model with logistic growth of the susceptible individuals analytically,and *** analytical results are obtained using thenormal form technique and numerical results are obtained using the numerical continuation *** this model,a number of bifurcations are studied,including the transcritical(pitchfork)and fip bifurcations,the Neimark-Sacker(NS)bifurcations,and the strong resonance *** especially determine the dynamical behaviors of the model for higher iterations up to *** simulation is employed to present a closed invariant curve emerging about an NS point,and its breaking down to several closed invariant curves and eventuality giving rise to a chaotic strange attractor by increasing the bifurcation parameter.

关键词： SIR epidemic model stability,bifurcation critical normal form coefficient numerical continuation method

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Numerical simulation of squeezing Cu-Water nanofluid flow by a kernel-based method

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International Journal of Modeling, Simulation, and Scientific Computing 2022年第1期13卷 175-191页

作者： Mojtaba Fardi Yasir Khan Department of Applied Mathematics Faculty of Mathematical Science shahrekord university shahrekord P.O.Box 115 Iran Department of Mathematics university of Hafr Al-Batin Hafr Al-Batin 31991 Saudi Arabia

The main aim of this paper is to propose a kernel-based method for solving the problem of squeezing Cu–Water nanofluid flow between parallel *** method is based on Gaussian Hilbert–Schmidt SVD(HS-SVD),which gives an alternate basis for the data-dependent subspace of“native”Hilbert space without ever forming kernel *** well-conditioning linear system is one of the critical advantages of using the alternate basis obtained from *** simulations are performed to illustrate the efficiency and applicability of the proposed method in the sense of *** results obtained by the proposed method are assessed by comparing available results in *** results demonstrate that the proposed method can be recommended as a good option to study the squeezing nanofluid flow in engineering problems.

关键词： Nanofluid flow Hilbert-Schmidt SVD ill-conditioning well-conditioning

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Effects of strain-induced melt activation treatment on the microstructure and properties of Zn sacrificial anodes

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International Journal of Minerals,Metallurgy and Materials 2021年第10期28卷 1693-1704页

作者： Behrooz Shayegh Boroujeny Payam Raiesi Goojani Ehsan Akbari Department of Engineering Shahrekord UniversityShahrekordIran

The microstructural properties and electrochemical performance of zinc(Zn)sacrificial anodes during strain-induced melt activation(SIMA)were investigated in this *** samples were subjected to a compressive ratio of 20%-50% at various temperatures(425-435℃)and durations(5-30 min).Short-term electrochemical tests(anode tests)based on DNV-RP-B401 and potentiodynamic polarization tests were performed in 3.5wt%NaCl solution to evaluate the electrochemical efficiency and corrosion behavior of the samples,*** electrochemical test results for the optimum sample confirmed that the corrosion current density declined by 90% and the anode efficiency slightly decreased relative to that of the raw ***-dispersive X-ray spectroscopy,scanning electron microscopy,metallographic images,and microhardness profiles showed the accumulation of alloying elements on the boundary and the conversion of uniform corrosion into localized corrosion,hence the decrease of the Zn sacrificial anode’s efficiency after the SIMA process.

关键词： strain-induced melt activation process zinc sacrificial anode corrosion resistance anode test

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