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Targeting PI3K/Akt signal transduction for cancer therapy

Signal Transduction and Targeted Therapy 2022年第1期7卷 95-111页

作者： Yan He Miao Miao Sun Guo Geng Zhang Jing Yang Kui Sheng Chen Wen Wen Xu Bin Li MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes Institute of Life and Health EngineeringCollege of Life Science and TechnologyJinan UniversityGuangzhouChina department of Pathology The First Affiliated Hospital of Zhengzhou UniversityHenan Key Laboratory of Tumor PathologyZhengzhouChina MOE Key Laboratory of Tumor Molecular Biology and Guangdong Provincial Key Laboratory of Bioengineering Medicine National Engineering Research Center of Genetic MedicineInstitute of BiomedicineCollege of Life Science and TechnologyJinan UniversityGuangzhouChina

The phosphatidylinositol 3-kinase(PI3K)/Akt pathway plays a crucial role in various cellular processes and is aberrantly activated in cancers,contributing to the occurrenee and progression of *** the upstream and downstream nodes of this pathway could allow full elucidation of its *** on accumulating evidenee,strategies targeting major components of the pathway might provide new in sights for can cer drug *** have explored the use of some in hibitors targeti ng this pathway to block survival ***,because oncogenic PI3K pathway activation occurs through various mechanisms,the clinical efficacies of these inhibitors are ***,pathway activation is accompanied by the development of therapeutic resista ***,strategies involvi ng pathway in hibitors and other can cer treatments in combinati on might solve the therapeutic *** this review,we discuss the roles of the PI3K/Akt pathway in various cancer phenotypes,review the current statuses of different PI3K/Akt in hibitors,and in troduce combi nation therapies con sisti ng of signaling in hibitors and conven tional cancer *** information presented herein suggests that cascading inhibitors of the PI3K/Akt signaling pathway,either alone or in combi nation with other therapies,are the most effective treatment strategy for can cer.

关键词： PI3K/Akt treatment alone

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Pressure-induced enhancement of optoelectronic properties in PtS2

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Chinese Physics B 2018年第6期27卷 345-349页

作者： Yi-Fang Yuan Zhi-Tao Zhang Wei-Ke Wang Yong-Hui Zhou Xu-Liang Chen Chao An Ran-Ran Zhang Ying Zhou Chuan-Chuan Gu Liang Li Xin-Jian Li Zhao-Rong Yang department of Physics and Laboratory of Material Physics Zhengzhou UniversityZhengzhou 450052China Anhui Provincial Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field LaboratoryChinese Academy of SciencesHefei 230031China Synergetic Innovation Center for Quantum Effects and Application Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of Ministry of EducationCollege of Physics and Information ScienceHunan Normal UniversityChangsha 410081China State Key Laboratory of Material Processing and Die and Mould Technology School of Materials Science and EngineeringHuazhong University of Science and Technology(HUST)Wuhan 430074China Institute of Physical Science and information Technology Anhui UniversityHefei 230601China

PtS2, which is one of the group-10 transition metal dichalcogenides, attracts increasing attention due to its extraordinary properties under external modulations as predicted by theory, such as tunable bandgap and indirect-to-direct gap transition under strain; however, these properties have not been verified experimentally. Here we report the first experimental exploration of its optoelectronic properties under external pressure. We find that the photocurrent is weakly pressuredependent below 3 GPa but increases significantly in the pressure range of 3 GPa–4 GPa, with a maximum ～ 6 times higher than that at ambient pressure. X-ray diffraction data shows that no structural phase transition can be observed up to26.8 GPa, which indicates a stable lattice structure of PtS2 under high pressure. This is further supported by our Raman measurements with an observation of linear blue-shifts of the two Raman-active modes to 6.4 GPa. The pressure-enhanced photocurrent is related to the indirect-to-direct/quasi-direct bandgap transition under pressure, resembling the gap behavior under compression strain as predicted theoretically.

关键词： high pressure optoelectronic properties transition metal disulfide

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Modified Formula for Cotes Rule with Fifths Derivatives of Endpoint

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Chinese Quarterly Journal of Mathematics 2009年第4期24卷 585-589页

作者： SUN Fan HAN Ke-zhong department of Basic Course Henan Quality and Engineering Vocational College Pingdingshan 467000 China Professional college of information and Statistics Zhengzhou Institute of Aeronautical Industry Management Zhengzhou 450011 China

This paper presents a Modified Formula for Cotes rule with fifths derivatives of endpoint and its truncation error. It also displays an analysis on convergence order of compound formula. Though compound modified formula for Cotes rule with endpoint derivatives just calculates a newly-added fifths derivative of the two endpoints for each time compared with compound Cotes formula calculation, there are 2 more ranks of the convergence order in this modified formula. Examples of numerical calculation have validated theoretical analysis.

关键词： numerical integration algebraic precision truncation error order of convergence

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Systematic Cloud-Based Optimization: Twin-Fold Moth Flame Algorithm for VM Deployment and Load-Balancing

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Intelligent Automation & Soft Computing 2024年第3期39卷 477-510页

作者： Umer Nauman Yuhong Zhang Zhihui Li Tong Zhen information Science and engineering college Henan University of TechnologyZhengzhou450001China School of Artificial Intelligence and Big Data Henan University of TechnologyZhengzhou450001China Key Laboratory of Grain information Processing and Control Ministry of EducationHenan University of TechnologyZhengzhou450001China

Cloud computing has gained significant recognition due to its ability to provide a broad range of online services and ***,existing commercial cloud computing models demonstrate an appropriate design by concentrating computational assets,such as preservation and server infrastructure,in a limited number of large-scale worldwide data *** the deployment of virtual machines(VMs)is crucial in this scenario to ensure system dependability,performance,and minimal latency.A significant barrier in the present scenario is the load distribution,particularly when striving for improved energy consumption in a hypothetical grid computing *** design employs load-balancing techniques to allocate different user workloads across several virtual *** address this challenge,we propose using the twin-fold moth flame technique,which serves as a very effective optimization *** intentionally designed the twin-fold moth flame method to consider various restrictions,including energy efficiency,lifespan analysis,and resource *** provides a thorough approach to evaluating total costs in the cloud computing *** assessing the efficacy of our suggested strategy,the study will analyze significant metrics such as energy efficiency,lifespan analysis,and resource *** investigation aims to enhance cloud computing techniques by developing a new optimization algorithm that considers multiple factors for effective virtual machine placement and load *** proposed work demonstrates notable improvements of 12.15%,10.68%,8.70%,13.29%,18.46%,and 33.39%for 40 count data of nodes using the artificial bee colony-bat algorithm,ant colony optimization,crow search algorithm,krill herd,whale optimization genetic algorithm,and improved Lévy-based whale optimization algorithm,respectively.

关键词： Optimizing cloud computing deployment of virtual machines load-balancing twin-fold moth flame algorithm grid computing computational resource distribution data virtualization

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New approach to extract phase feature of 3-D objects by wavelength-scanning digital holography

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Optoelectronics Letters 2006年第2期2卷 136-138页

作者： SHEN Jin-yuan LI Xian-guo M. K. Kim CHANG Sheng-jiang college of information engineering Zhengzhou UniversityZhengzhou 450052China department of Physics University of South Florida Tampa Florida 33620 USA Key Laboratory of Opto-electronics information Technical Science EMC Institute of Modern Optics Nankai UniversityTianjin 300071 China

A new approach to extract phase feature of 3-D objects based on wavelength-scanning digital holography and numerical reconstruction technique is proposed in this paper.A number of holograms are recorded on a digital camera and reconstructed numerically by a computer with different wavelengths spaced at regular *** theoretical analysis and computer simulations demonstrate that those pixels with the same phase of a 3-D object can focus on the same reconstruction *** those pixels with different phase of a 3-D object focus on the different reconstruction *** the phase information of a 3-D object can be described by a series of reconstructed images on different planes.

关键词：数字全息术波长扫描数字相机三维重建

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The analysis and solutions in Game Transplantation on Mobile Phone Base on J2ME

The analysis and solutions in Game Transplantation on Mobile...

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2011 International Conference on information Management and engineering(ICIME 2011)

作者： Yin Guangli Binzhou Vocational college The Department of Information Engineering

ISBN: (纸本)9781612842387

This paper analyzes the problems encountered, Based on transplantation of different mobile phone and development. Through in-depth analysis, this article present the specific problems that we rely on a simple PC system in the software system architecture design, it is difficult to reuse the same model agencies in the next mobile platform system. Therefore, the idea of abandoning the inherent design patterns, by introducing the directive, the classification of project resources, as well as automatic construction of pre-project and release propose a new design concept, the development of of mobile phone game transplantation has a very important reference value.

关键词： J2ME mobilegame MIDP MIDP transplantation

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Recent advances in enzyme-free and enzyme-mediated single-nucleotide variation assay in vitro

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National Science Review 2024年第5期11卷 365-384页

作者： Erhu Xiong Pengfei Liu Ruijie Deng Kaixiang Zhang Ronghua Yang Jinghong Li Key Laboratory of Chemical Biology &Traditional Chinese Medicine Research Ministry of EducationCollege of Chemistry and Chemical Engineering Hunan Normal University college of Biomass Science and engineering Healthy Food Evaluation Research CenterSichuan University School of Pharmaceutical Sciences Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases Zhengzhou University department of Chemistry Center for Bioanalytical Chemistry Key Laboratory of Bioorganic Phosphorus Chemistry& Chemical BiologyTsinghua University Beijing Institute of Life Science and Technology

Single-nucleotide variants(SNVs) are the most common type variation of sequence alterations at a specific location in the genome, thus involving significant clinical and biological information. The assay of SNVs has engaged great awareness, because many genome-wide association studies demonstrated that SNVs are highly associated with serious human diseases. Moreover, the investigation of SNV expression levels in single cells are capable of visualizing genetic information and revealing the complexity and heterogeneity of single-nucleotide mutation-related diseases. Thus, developing SNV assay approaches in vitro, particularly in single cells, is becoming increasingly in demand. In this review, we summarized recent progress in the enzyme-free and enzyme-mediated strategies enabling SNV assay transition from sensing interface to the test tube and single cells, which will potentially delve deeper into the knowledge of SNV functions and disease associations, as well as discovering new pathways to diagnose and treat diseases based on individual genetic profiles. The leap of SNV assay achievements will motivate observation and measurement genetic variations in single cells, even within living organisms, delve into the knowledge of SNV functions and disease associations, as well as open up entirely new avenues in the diagnosis and treatment of diseases based on individual genetic profiles.

关键词： single-nucleotide variant point mutation in vitro enzyme-free assay enzyme-mediated assay

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Asymptotic Behavior of Global Solutions for Double Degenerate Nonlinear Parabolic Equation

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Chinese Quarterly Journal of Mathematics 2005年第4期20卷 390-394页

作者：叶耀军刘秋香 department of information and Computational Science Henan Agricultural University Zhengzhou 450002 ChinaBeijing Graduate School of Chinese Academy of Engineering Physics Bejing 100088China Prosecutor college of Henan Province Zhengzhou 450003 China

In this paper we study the decay estimate of global solutions to the initial-boundary value problem for double degenerate nonlinear parabolic equation by using a dif-ference inequality.

关键词： double degenerate parabolic equations initial-boundary value problem global solutions asymptotic property

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Time domain analysis for discrete difference equation on discrete linear system controllable problem's research

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商丘师范学院学报 2008年第9期24卷 34-37页

作者： DENG Shu-xian DING Yu college of information Science and Technology Donghua University Shanghai 201620 China department of Mathematical Physics Henan Engineering CollegeZhengzhou 450007 China The Third Senior School in Luohe Luohe 462000China

We usually describle a comparatively more complex control system,especially a multi-inputs and multi-outputs system by time domation analytical *** the system's controllability means whether the system is controllable according to certain *** involves not only the system's outputs' controllability but also the controllability of the system's partial or total *** movement is described by difference equation in the linear discrete-time ***,the problem of controllability of the linear discrete-time system has been converted into a problem of the controllability of discrete-time difference *** thesis makes out the determination method of the discrete-time system's controllability and puts forward the sufficient and necessary conditions to determine it's controllability by making a study on the controllability of the linear discrete-time equation.

关键词：离散差分方程计算方法线性系统数学分析

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Hybrid quantum-classical convolutional neural networks

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Science China(Physics,Mechanics & Astronomy) 2021年第9期64卷 1-8页

作者： Junhua Liu Kwan Hui Lim Kristin LWood Wei Huang Chu Guo He-Liang Huang information Systems Technology and Design Singapore University of Technology and DesignSingapore 487372Singapore Forth AI Singapore 487372Singapore college of engineering Design and ComputingUniversity of Colorado DenverColorado 80208USA Guangxi Key Laboratory of Optoelectronic information Processing Guilin University of Electronic TechnologyGuilin 541004China Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Department of Physics and Synergetic Innovation Center for Quantum Effects and ApplicationsHunan Normal UniversityChangsha 410081China Hefei National Laboratory for Physical Sciences at Microscale and department of Modern Physics University of Science and Technology of ChinaHefei 230026China Shanghai Branch CAS Centre for Excellence and Synergetic Innovation Centre in Quantum Information and Quantum PhysicsUniversity of Science and Technology of ChinaHefei 201315China Henan Key Laboratory of Quantum information and Cryptography Zhengzhou 450000China

Deep learning has been shown to be able to recognize data patterns better than humans in specific circumstances or *** parallel,quantum computing has demonstrated to be able to output complex wave functions with a few number of gate operations,which could generate distributions that are hard for a classical computer to *** we propose a hybrid quantum-classical convolutional neural network(QCCNN),inspired by convolutional neural networks(CNNs)but adapted to quantum computing to enhance the feature mapping *** is friendly to currently noisy intermediate-scale quantum computers,in terms of both number of qubits as well as circuit’s depths,while retaining important features of classical CNN,such as nonlinearity and *** also present a framework to automatically compute the gradients of hybrid quantum-classical loss functions which could be directly applied to other hybrid quantum-classical *** demonstrate the potential of this architecture by applying it to a Tetris dataset,and show that QCCNN can accomplish classification tasks with learning accuracy surpassing that of classical CNN with the same structure.

关键词： quantum computing quantum machine learning hybrid quantum-classical algorithm convolutional neural network

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