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Cardiovascular prevention in elderly patients

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Journal of Geriatric Cardiology 2022年第5期19卷 377-392页

作者： Clara Bonanad Rosa Fernández-Olmo Sergio García-Blas Jose Antonio Alarcon Pablo Díez-Villanueva Carmen Rus Mansilla Héctor García-Pardo Pablo Toledo Ana Ayesta Eva Pereira Antoni Carol Almudena Castro-Conde Carmen de Pablo-Zarzoso Manuel Martínez-Sellés Vicente Arrarte Raquel Campuzano Albert Ariza-Solé servicio de Cardiología Hospital Clínico Universitario de ValenciaValenciaSpain Instituto de Investigación Sanitaria INCLIVA ValenciaSpain servicio Cardiología Hospital Universitario de Jaén Spain servicio Cardiología Hospital de Donosti Spain servicio de Cardiología Hospital Universitario La Princesa de MadridSpain servicio de Cardiología Hospital Alto Gudalquivir de AndújarJaénSpain servicio de Cardiología Hospital Rio Hortega de ValladolidSpain servicio Cardiología Hospital Clínico San Cecilio de Granada Spain servicio de Cardiología Hospital Universitario Central de AsturiasSpain servicio de Cardiologia Hospital de LugoSpain servicio de Cardiología Hospital Moisés Broggi de BarcelonaSpain servicio de Cardiología Hospital Universitario de la Paz de Madrid Spain servicio de Cardiología Hospital Ramón y Cajal de MadridSpain department of Cardiology.Hospital Universitario Gregorio Marañón CIBERCV.Universidad EuropeaUniversidad Compluten servicio de Cardiología del Hospital General de Alicante Spain servicio de Cardiología Hospital Universitario Fundación de Alcorcón de MadridSpain servicio de Cardiología Hospital Bellvitge de BarcelonaBioheartGrup de Malalties CardiovascularsInstitut d’InvestigacióBiomèdica de BellvitgeIDIBELLL’Hospitalet de LlobregatBarcelonaSpain

In recent decades,life expectancy has been increasing significantly.In this scenario,health interventions are ne-cessary to improve prognosis and quality of life of elderly with cardiovascular risk factors and cardiovascular disease.However,the number of elderly patients included in clinical trials is low,thus current clinical practice guidelines do not include specific re-commendations.This document aims to review prevention recommendations focused in patients≥75 years with high or very high cardiovascular risk,regarding objectives,medical treatment options and also including physical exercise and their inclusion in cardiac rehabilitation programs.Also,we will show why geriatric syndromes such as frailty,dependence,cognitive impair-ment,and nutritional status,as well as comorbidities,ought to be considered in this population regarding their important pro-gnostic impact.

关键词： prevention patients cardiovascular

Stem cells and tissue engineering: an alternative treatment for craniofacial congenital malformations and articular degenerative diseases

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Plastic and Aesthetic Research 2020年第6期7卷 24-37页

作者： Cristina Velasquillo Antonio Madrazo-Ibarra Claudia Gutiérrez-Gómez Marcia Rosario Pérez-Dosal Yaaziel Melgarejo-Ramírez Clemente Ibarra Biotecnología Instituto Nacional de Rehabilitación LGIICiudad de México 14389México Hospital General Manuel Gea González and Instituto Nacional de Rehabilitación LGII Ciudad de México 14080México Médico Adscrito al servicio de Cirugía Plástica Instituto Nacional de PediatríaCiudad de México 04530México Dirección General Instituto Nacional de Rehabilitación LGIICiudad de México 14389México

The life quality of patients with craniofacial malformations is severely affected by the physical disabilities caused by the malformation itself,but also by being subjected to bullying,which leads to a series of relevant psychological and societal effects that have an economic impact on the health sector.Orofacial clefts,notably cleft lip(CL),cleft palate,and microtia,are the most common craniofacial birth defects in humans and represent a substantial burden,both personal and societal.On the other hand,osteoarthritis is a widespread degenerative disease that is becoming more common due to the extension of the human lifespan and to an increase in injuries in young people as a result of their lifestyle.Advances in tissue engineering as a part of regenerative medicine offer new hope to patients that can benefit from new tissue engineering therapies based on the supportive action of tailored 3D biomaterials and the synergic action of stem cells that can be driven to the process of bone and cartilage regeneration.This review provides an update on recent considerations for stem cells and studies on the use of advanced biomaterials and cell therapies for the regeneration of craniofacial congenital malformations and articular degenerative diseases.

关键词： Mesenchymal stromal cells microtia cartilage cleft lip cleft palate

Effectiveness of sacubitril-varsartan versus angiotensin converting enzyme inhibitors in patients hospitalized for acute heart failure:a retrospective cohort study of the RICA registry

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Journal of Geriatric Cardiology 2022年第11期19卷 802-810页

作者： Llanos Soler-Rangel Manuel Méndez-Bailón JoséPérez-Silvestre JoséMaría Fernández-Rodríguez Beatriz Cuesta García Adrián Argüelles-Curto Álvaro González-Franco Alicia Conde-Martel Sara Carrascosa-García Marta Sánchez-Marteles JoséManuel Cerqueiro-González Noel Lorenzo-Villalba Manuel Montero-Pérez-Barquero Llanos Soler-Rangel Servicio de Medicina InternaHospital Universitario Infanta SofíaFIIB HUIS HHENMadridSpain servicio de Medicina Interna Hospital Clínico San CarlosInstituto de Investigación San Carlos(IdISSC)Spain servicio de Medicina Interna Consorcio Hospital General Universitario de ValenciaSpain servicio de Medicina Interna Hospital Carmen y Severo OchoaCangas del NarceaAsturiasSpain servicio de Medicina Interna Hospital Universitario Central de AsturiasOviedoSpain servicio de Medicina Interna Hospital Universitario de Gran Canaria Dr NegrínSpain servicio de Medicina Interna Hospital Clínico Universitario Lozano Blesa de ZaragozaZaragozaSpain Hospital Universitario Lucus Augusti de Lugo LugoSpain Service de Médecine Interne Diabète et Maladies MétaboliquesHôpitaux Universitaires de StrasbourgFrance servicio de Medicina Interna IMIBIC/Hospital Universitario Reina SofíaCórdobaSpain

BACKGROUND Sacubitril-valsartan has been shown to reduce hospitalizations and mortality in patients with heart failure(HF)and reduced ejection fraction.The PIONEER-HF trial demonstrated that initiation of the drug during acute HF hospitalization reduced NT-proBNP levels and a post-hoc analysis of the trial found a reduction in HF hospitalizations and deaths.Real-life studies in the elderly population are scarce.The aim of our study was to assess the effectiveness of sacubitril-valsartan versus angiotensin converting enzyme inhibitors(ACEI)in elderly patients who initiate this treatment during hospitalization for acute HF.METHODS We conducted a retrospective cohort study using the Spanish acute heart failure registry(RICA)comparing rehospitalizations and deaths at 3 months and 1 year among patients aged 70 years or older who had initiated treatment with sacubitrilvalsartan during hospitalization for acute HF versus those treated with ACEI.RESULTS One hundred and ninety-nine patients hospitalized between October 2016 and November 2020 were included,with a median age of 82 years and high rate of comorbidity.Of these,107 were treated with sacubitril-valsartan and 92 with ACEI.The adjusted OR for readmission for HF at 3 months was 0.906(95%CI:0.241-3.404)and for the combined variable readmission for HF or death at 3 months was 0.696(95%CI:0.224-2.167).The adjusted OR for HF readmission at one year was 0.696(95%CI:0.224-2.167).and for the combined variable HF readmission or death at one year 0.724(95%CI:0.325-1.612).CONCLUSION Treatment with sacubitril-valsartan initiated early in hospitalization for HF in elderly patients with high comorbidity was associated with a trend towards a reduction in readmissions and death due to HF compared to treatment with ACEI,which did not reach statistical significance either at 3 months or 1 year of follow-up.

关键词： patients initiated admission

Hepatoprotective properties of oleanolic and ursolic acids in anti-tubercular drug-induced liver damage

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Asian Pacific Journal of Tropical Medicine 2016年第7期9卷 625-632页

作者： Gabriel A.Gutiérrez-Rebolledo Georgina A.Siordia-Reyes Mariana Meckes-Fischer Adelina Jiménez-Arellanes Unidad de Investigación Médica en Farmacología (UIMF) UMAE Hospital de EspecialidadesCentro Médico Nacional-Siglo XXI (CMN-SXXI)Instituto Mexicano del Seguro Social (IMSS) servicio de Patología UMAE Hospital de PediatríaCMN-SXXIIMSS Centro de Diagnóstico en Metabolismo Energético y Medicina Mitocondrial A.C.

Objective:To estimate to what extent the mixture of ursolic acid and oleanolic acid,in addition to the antitubercular standard regime,affects the hepatotoxicity profile.Methods:Liver injury was induced in male BALB/c mice by administering,per os and daily for 11 weeks,a combination of anti-Tubercular(anti-TB) agents Rifampicin(10 mg/kg),Isoniazid(10 mg/kg),and Pyrazinamide(30 mg/kg).The ursolic acid and oleanolic acid mixture at doses of 100 or 200 μg/mouse/day was subcutaneously injected throughout the entire study period(11 weeks).Biochemical and hematological analysis was supplemented by liver histological examination.Results:Animals treated with the mixture of triterpenic acids exhibited significantly decreased aspartate transaminase and alanine aminotransferase levels and amelioration of the histopathological alterations produced by the anti-TB drugs.Conclusions:The triterpene mixture is able to prevent the steatosis induced by the anti-TB drugs.

关键词： Ursolic acid Oleanolic acid Hepatoprotector effect Antitubercular drugs Triterpenes

Inhaler Technique Questionnaire(InTeQ)in pediatric patients with asthma

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世界儿科杂志:英文版 2023年第8期19卷 798-804页

作者： Catalina Lizano‑Barrantes Olatz Garin Alexandra Lelia Dima Karina Mayoral Angels Pont Eva María Ortiz María Araceli Caballero‑Rabasco Manuel Praena‑Crespo Laura Valdesoiro‑Navarrete María Teresa Guerra Alberto Bercedo‑Sanz Gimena Hernández Camila Maroni Inés de Mir MaríaÁngeles Carrasco Marta Ortega Alberto Servan JoséAntonio Castillo Eva Tato Montse Ferrer Health Services Research Group IMIM(Hospital del Mar Medical Research Institute)Barcelona Biomedical Research ParkDoctor Aiguader8808003 BarcelonaSpain department of Medicine and Life Sciences Universitat Pompeu FabraBarcelonaSpain department of Pharmaceutical Care and Clinical Pharmacy Faculty of PharmacyUniversidad de Costa RicaSan JoseCosta Rica Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública CIBERESP MadridSpain Research and development Unit Institut de Recerca Sant Joan de DéuBarcelonaSpain department of pediatrics Obstetrics and Gynaecology and Preventive MedicineUniversitat Autònoma de BarcelonaBarcelonaSpain pediatric Allergy and Pulmonology Unit Pediatric ServiceHospital del MarBarcelonaSpain pediatric Allergy and Pulmonology Unit Pediatric ServiceHospital Universitari Parc TaulíSabadellSpain Centro de Salud La Candelaria Servicio Andaluz de SaludSevilleSpain Grupo de Vías Respiratorias de La Asociación Española de pediatras de Atención Primaria(AEPAP) MadridSpain Centro de Salud Jerez Sur Servicio Andaluz de SaludSevilleSpain Centro de Salud La Sagrera BarcelonaSpain Centro de Salud Los Castros CantabriaSpain Facultat de Medicina Universitat Autònoma de BarcelonaBarcelonaSpain pediatric Allergy and Pulmonology and Cystic Fibrosis UnitHospital Universitari Vall d’HebronBarcelonaSpain Consultorio Sevilla la Nueva MadridSpain Centro de Salud Dos de Mayo MadridSpain Hospital Miguel Servet ZaragozaSpain Hospital Universitario Araba Vitoria-GasteizSpain departamento de Farmacologia Pediatría y RadiologíaUniversidad de SevillaSevilleSpain Institut d’Investigaciói InnovacióParc Taulí SabadellSpain

Asthma in school-aged children is a major public health problem worldwide[1,2].Inhaled medications are the mainstay of its pharmacological management[2],but only 8%-22%of children with asthma use their inhalers correc... 详细信息

关键词： asthma pediatric patients

Multi-tissue transcriptomics of a unique monozygotic discordant twin case of severe progressive osseous heteroplasia

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Genes & Diseases 2024年第3期11卷 22-25页

作者： Alberto Gomez-Carballa Maria Jose Curras-Tuala Sara Pischedda Miriam Cebey-Lopez Jose Gomez-Rial Irene Rivero-Cale Jacobo Pardo-seco Xabier Bello Sandra Viz-Lasheras Antonio Justicia-Grande Julian Montoto-Louzao Alba Camino-Mera Isabel Ferreiros-Vidal Maximo Fraga Jose RAntunez Rodolfo Gomez Federico Martinon-Torres Antonio Salas Genetics Vaccines and Infections Research Group(GENVIP)Instituto de Investigacion Sanitaria de SantiagoSantiagode CompostelaGalicia 15706Spain Translational pediatrics and Infectious Diseases Department of PediatricsHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Laboratorio de Inmunologia Servicio de Andlisis ClinicosHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Unidade de Xenetica Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstituto de Investigacion SanitariaHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Musculoskeletal Pathology Group Instituto de Investigacion Sanitaria de SantiagoServicio Galego de Saude(SERGAS)Santiago de CompostelaGalicia 15706Spain department of Pathology Hospital Clinico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain Unidad Integrada de BiobancosBiomodelos 3D y Modelos Animales IDIS(lnstituto de Investigacion Sanitaria de Santiagode Compostela)Galicia15706Spain Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias(CIBER-ES) MadridSpain

Progressive osseous heteroplasia(POH)is an ultra-rare autosomal dominant disabling disorder characterized by heterotopic ossification(HO).It is caused by heterozygous inactivating mutations in the GNAS(guanine nucleotide-binding protein alpha-stimulating activity polypeptide)gene.However,the molecular mechanisms underlying HO remain poorly understood.As a treatment for POH is not yet available,the identification of the mechanisms driving POH in affected tissues using gene expression may be of great help to underestand the molecular basis of POH and develop new therapeutic approaches.

关键词： stimulating driving asi

Inflammatory bowel disease and celiac disease:Overlaps and differences

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World Journal of Gastroenterology 2014年第17期20卷 4846-4856页

作者： Virginia Pascual Romina Dieli-Crimi Natalia López-Palacios Andrés Bodas Luz María Medrano Concepción Nú?ez UGC de Inmunología Hospital Clínico San CarlosInstituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC)28040 MadridSpain servicio de Digestivo Hospital Clínico San CarlosInstituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC)28040 MadridSpain Servicio de Pediatría Hospital Clínico San CarlosInstituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC)28040 MadridSpain

Recent findings demonstrate the common genetic basis for many immune-mediated diseases,and consequently,the partially shared pathogenesis.We collected these findings and reviewed the extension of these overlaps to other disease characteristics.Two autoimmune diseases were selected that also share the specific target organ,the bowel.The etiology and immunopathogenesis of both conditions characterized by chronic intestinal inflammation,inflammatory bowel disease(IBD)and celiac disease(CeD),are not completely understood.Both are complex diseases with genetics and environment contributing to dysregulation of innate and adaptive immune responses,leading to chronic inflammation and disease.CeD constitutes a particular disease because the main environmental and genetic triggers are largely known.IBD comprises two main clinical forms,Crohn’s disease and ulcerative colitis,which most likely involve a complex interplay between some components of the commensal microbiota and other environmental factors in their origin.These multifactorial diseases encompass a broad spectrum of clinical phenotypes and ages of onset,although the clinical presentation often differs depending on childhood or adult onset,with greater heterogeneity commonly observed in adults.

关键词： Disease susceptibility Gene-environment interactio

Encephalitis with convulsive status in an immunocompetent pediatric patient caused by Bartonella henselae

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Asian Pacific Journal of Tropical Medicine 2016年第6期9卷 591-594页

作者： Rosario Cerpa Polar Gabriela Orellana Wilmer Silva Caso José Sánchez Carbonel Javier Santisteban Juana del Valle Mendoza Javier Santisteban Infectogía Pediátrica Servicio de Pediatría Especializada Hospital Edgardo Rebagliati Martins Neurologia Pediátrica Hospital Edgardo Rebagliati Martins School of Medicne Faculty of Health Sciences Universidad Peruana de Ciencias Aplicadas Faculty of Health Sciences Research Center of the Faculty of Health Sciences Universidad Peruana de Ciencias Aplicadas Clínica pediatrica Hospital Edgardo Rebagliati Martins

Cat scratch's disease caused by Bartonella henselae, is known to be a self-limited benign process in immunocompetent children. The association with neurologic manifestations is very uncommon especially in patient with no immunologic defects and in cases without specific treatment. A 7 years old male patient, without any immunocromised defect, presented an atypic presentation of the cat scratch disease. The patient came to the hospital in two opportunities in a status epilepticus, in both cases the diagnosis was encephalitis by Bartonella henselae and the evolution with treatment was monitored with PCR(polymerase chain reaction) in cerebrospinal fluid and blood, as well as IFI(IgM, IgG) serology(indirect immunofluorescence). The patient had a favorable clinical and laboratory evolution for 6 months showing no recurrence of the disease.

关键词： Bartonella henselae Encephalitis Immunocompetent pediatric patient Convulsive status Cat scratch’s disease

Thrombin activation and liver inflammation in advanced hepatitis C virus infection

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World Journal of Gastroenterology 2016年第18期22卷 4427-4437页

作者： Emilio González-Reimers Geraldine Quintero-Platt Candelaria Martín-González Onán Pérez-Hernández Lucía Romero-Acevedo Francisco Santolaria-Fernández servicio de Medicina Interna Hospital Universitario de Canarias Universidad de La Laguna

Hepatitis C virus(HCV) infection is associated with increased thrombotic risk. Several mechanisms are involved including direct endothelial damage by the HCV virus, with activation of tissue factor, altered fibrinolysis and increased platelet aggregation and activation. In advanced stages, chronic HCV infection may evolve to liver cirrhosis, a condition in which alterations in the portal microcirculation may also ultimately lead to thrombin activation, platelet aggregation, and clot formation. Therefore in advanced HCV liver disease there is an increased prevalence of thrombotic phenomena in portal vein radicles. Increased thrombin formation may activate hepatic stellate cells and promote liver fibrosis. In addition, ischemic changes derived from vascular occlusion by microthrombi favor the so called parenchymal extinction, a process that promotes collapse of hepatocytes and the formation of gross fibrous tracts. These reasons may explain why advanced HCV infection may evolve more rapidly to end-stage liver disease than other forms of cirrhosis.

关键词： Coagulation Liver cirrhosis Hepatitis C virus Fibrogenesis Parenchymal extinction Portal thrombosis