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Effects of estrogen receptor modulators on cytoskeletal proteins in the central nervous system

Neural Regeneration Research 2017年第8期12卷 1231-1240页

作者： Julia J.Segura-Uribe Rodolfo Pinto-Almazán Angélica Coyoy-Salgado Claudia E.Fuentes-Venado Christian Guerra-Araiza Unidad de Investigacion Modica en Enfermedades Neurologicas Hospital de Especialidades Centro Medico Nacional Siglo XXI Instituto Mexicano del Seguro Social Mexico City Mexico Seccion de Estudios de Posgrado e Investigacion Escuela Superior de Medicina Instituto Politecnico Nacional Mexico City Mexico Unidad de Investigacion Hospital Regional de Alta Especialidad Ixtapaluca Ixtapaluca Mexico Institute for the developing Mind Children's Hospital Los Angeles Los Angeles CA USA department of Pediatrics Keck School of Medicine University of Southern California Los Angeles CA USA Consejo Nacional de Ciencia y Tecnologia Mexico City Mexico Clinica de Trastornos del Sueno Universidad Autonoma Metropolitana-Iztapalapa Mexico City Mexico servicio de medicina fisica y rehabilitacion Hospital General de Zona No. 197 Texcoco Mexico Unidad de Investigacion Modica en Farmacologla Hospital de Especialidades Centro Medico Nacional Siglo XXI Instituto Mexicano del Seguro Social Mexico City Mexico

Estrogen receptor modulators are compounds of interest because of their estrogenic agonistic/antagonistic effects and tissue specificity. These compounds have many clinical applications, particularly for breast cancer treatment and osteoporosis in postmenopausal women, as well as for the treatment of climacteric symptoms. Similar to estrogens, neuroprotective effects of estrogen receptor modulators have been described in different models. However, the mechanisms of action of these compounds in the central nervous system have not been fully described. We conducted a systematic search to investigate the effects of estrogen receptor modulators in the central nervous system, focusing on the modulation of cytoskeletal proteins. We found that raloxifene, tamoxifen, and tibolone modulate some cytoskeletal proteins such as tau, microtuble-associated protein 1（MAP1）, MAP2, neurofilament 38（NF38） by different mechanisms of action and at different levels： neuronal microfilaments, intermediate filaments, and microtubule-associated proteins. Finally, we emphasize the importance of the study of these compounds in the treatment of neurodegenerative diseases since they present the benefits of estrogens without their side effects.

关键词： estrogen receptor modulators selective estrogen receptor modulators microtubules neurofilaments tibolone tamoxifen raloxifene

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Exercise-induced hypoalgesia in chronic neck pain: A narrative review

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Sports Medicine and Health Science 2024年第1期6卷 37-47页

作者： Fernando Rojas-Galleguillos Cecilia Clark-Hormazabal Eduardo Mendez-Fuentes Francisco Guede-Rojas Cristhian Mendoza Andres Riveros Valdes Claudio Carvajal-Parodi Universidad San Sebastian Programa Magíster en Kinesiología MusculoesqueleticaLientur#1457ConcepcionChile Exercise and Rehabilitation Sciences Laboratory School of Physical TherapyFaculty of Rehabilitation SciencesUniversidad Andres BelloSantiago7591538Chile Universidad San Sebastian Laboratoriode NeurobiologíFacultad de Odontologíay Ciencias dela RehabilitacionLientur#1457ConcepcionChile Universidad San Sebastian Departamento de Ciencias MorfologicasFacultad de MedicinaCienciaLientur#1457ConcepcionChile Universidad San Sebastian Escuelade KinesiologíaFacultad de OdontologíaCiencias dela RehabilitacionLientur#1457ConcepcionChile

Chronic neck pain(CNP)is a worldwide health problem with several risk *** of the most widely used treatments for managing this condition is therapeutic exercise,which could generate a response called exerciseinduced hypoalgesia(EIH).There is no consensus on the best exercise modality to induce ***,this review aims to analyze and synthesize the state-of-the-art about the hypoalgesic effect of exercise in subjects with *** included articles on EIH and CNP in patients older than 18 years,with pain for more than three months,where the EIH response was *** that studied CNP associated with comorbidities or measured the response to treatments other than exercise were *** studies reviewed reported variable *** in healthy subjects has been shown to reduce indicators of pain sensitivity;however,in people with chronic pain,the response is *** investigations reported adverse effects with increased pain intensity and decreased pain sensitivity,others found no clinical response,and some even reported EIH with decreased pain and increased *** is an identifiable,stimulable,and helpful therapeutic response in people with *** research is still needed on subjects with CNP to clarify the protocols and therapeutic variables that facilitate the EIH *** addition,it is necessary to deepen the knowledge of the intrinsic and extrinsic factors that influence EIH in people with CNP.

关键词： Exercise-induced hypoalgesia Neck pain Chronic pain Neck exercise therapy

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