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3d bioprinted breast cancer model reveals stroma-mediated modulation of extracellular matrix and radiosensitivity

Bioactive Materials 2024年第12期42卷 316-327页

作者： Theo desigaux Leo Comperat Nathalie dusserre Marie-Laure Stachowicz Malou Lea Jean-William dupuy Anthony Vial Michael Molinari Jean-Christophe Fricain Francois Paris Hugo Oliveira Univ.Bordeaux Tissue Bioengineering INSERM U1026F-33000BordeauxFrance INSERM U1026 ART BioPrintF-33000BordeauxFrance Univ.Bordeaux Bordeaux ProteomeF-33000BordeauxFrance Univ.Bordeaux CNRSINSERMTBM-CoreUS5UAR 3427OncoProtF-33000BordeauxFrance Univ.Bordeaux CNRSBordeaux INPCBMNUMR 5248F-33600PessacFrance services d’odontologie et de sante buccale CHU BordeauxF-33000BordeauxFrance CRCINA INSERMCNRSUniv.NantesF-44000NantesFrance Institut de Cancerologie de l’Ouest F-44800Saint HerblainFrance

deciphering breast cancer treatment resistance remains hindered by the lack of models that can successfully capture the four-dimensional dynamics of the tumor ***,we show that microextrusion bioprinting can reproducibly generate distinct cancer and stromal compartments integrating cells relevant to human *** findings unveil the functional maturation of this millimeter-sized model,showcasing the development of a hypoxic cancer core and an increased surface *** was also driven by the presence of cancer-associated fibroblasts(CAF)that induced elevated microvascular-like structures *** modulation was concomitant to extracellular matrix remodeling,with high levels of collagen and matricellular proteins deposition by CAF,simultaneously increasing tumor stiffness and recapitulating breast cancer fibrotic ***,our bioprinted model faithfully reproduced response to treatment,further modulated by ***,CAF played a protective role for cancer cells against radiotherapy,facilitating increased paracrine *** model holds promise as a platform to decipher interactions within the microenvironment and evaluate stroma-targeted drugs in a context relevant to human pathology.

关键词： Bioprinting Cancer microenvironment Extracellular matrix

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Factors influencing parent satisfaction with preventive health services for the early detection of speech and language delay in preschool children

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Open Journal of Preventive Medicine 2011年第3期1卷 135-142页

作者： Isabelle Bairati François Meyer Cheikh Bamba dieye Gueye Chantal desmarais Nancie Rouleau Audette Sylvestre Universite Laval QuebecCanada direction regionale de sante publique Agence de la sante et des services sociaux de la Capitale-NationaleQuebecCanada.

The aim of this study was to identify parent and child characteristics which could influence parent satisfaction with preventive health services designed to detect preschool children with speech and language (SL) delay. This study was conducted on 101 children aged 18 to 36 months who participated in an organized SL delay early detection program. Validated instruments were used to assess children’s and parents’ characteristics. Satisfaction was evaluated using the client satisfaction questionnaire for the three activities of the program: 1) a public information session about SL development, 2) parent training sessions for parents concerned by their child SL development, and 3) a child’s SL assessment. Multiple logistic regressions were used to identify all independent factors (p d with satisfaction and to estimate the odds ratios (OR) for satisfaction. Economically disadvantaged parents were less prone to participate in the first two activities of the early detection program. Older parents were more satisfied with the public information session (OR = 1.33 for 1 year increment;p = 0.001). distressed parents were less satisfied with both the parent training sessions (OR = 0.28;p = 0.009) and the SL assessment (OR = 0.43;p = 0.046). Parents whose child had health problems at birth were less satisfied with the public information session (OR = 0.14, p = 0.03) and the SL assessment (OR = 0.33, p = 0.036). There is a need to better adapt the delivery of preventive services for the early detection of SL delay, especially for disadvantaged and distressed parents and for those whose child had suffered from health problems at birth.

关键词： Consumer Satisfaction Preventive Health services Early Intervention Language development disorders

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Transfatty Acids （TFAs） in Cord Blood and Cord Tissue, in France

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Journal of Food Science and Engineering 2017年第9期7卷 413-422页

作者： Claude Billeaud Nicole Combe Leslie Couedelo Wafae Belcadi dominique dallay Jean-Joel Leng Carole Vaysse CIC Pddiatrique CHU Pellegrin Universite de Bordeaux Bordeaux 33000 France ITERG Laboratoire de Nutrition Metabolisme et Sante Universite de Bordeaux Bordeaux 33000 France services de Gynecologie-obstetrique Maternite Pellegrin Universite de Bordeaux Bordeaux 33000 France

Background： Recent studies suggest that dietary transfatty acids （TFAs） at relative high levels （i） increase the risk of coronary heart disease, （ii） inhibit the metabolism of linoleic acid and consequently increase requirement for essential fatty acids （EFAs）. The aim of this prospective study was to estimate TFAs the placental transfer of TFAs to the foetus cord blood and cord tissues in France. Material： TFAs consumption was measured in 59 mother-foetus couples. TFAs transferring across the placenta were estimated by comparative measurement （Capillary Gaz Chromatography） of TFAs in mother＇s blood lipids （n = 59）, cord blood lipids and cord tissue plasma lipids （n = 25） cord red blood tissue （n = 25） and umbilical vessels （n = 15）. Results-discussion： TFA deposition in cord blood is 0.58% slightly lower than mother level. TFAs incorporation in total lips of cord show selectivity of transfer with lower 18：1 t in cord blood and preferential transfer of diene 18：2 tc in cord blood. There is competition between the 18：2 tc in cholesterol esters （CE） with the linolenic acid and a negative correlation in PLT of arterial tissues with the 18：2 tc and C20：4 n-6 or arachidonic acid （AA）, then there is the same competition in PE of venous tissue. But there is no effect on growth in our population of term newborn. Conclusions： Our results confirm the placental TFAs transfer, a better incorporation in the fetus CE; we demonstrated a selective transfer for the 18：2 9 trans 12 cis （18：2 tc） and a negative correlation （r = -0.76） with the linoleic acid and AA （r = 0.98）. This competition, and the presence of these TFAs in cord tissues, even at a low TFAs consumption, remind us to be a potential risk for the fetus concerning EFA metabolism and growth.

关键词： TFAs pregnancy cord blood and tissues neonate diet.

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Factors associated with dAA virological treatment failure and resistance-associated substitutions description in HIV/HCV coinfected patients

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World Journal of Hepatology 2018年第11期10卷 856-866页

作者： dominique Salmon Pascale Trimoulet Camille Gilbert Caroline Solas Eva Lafourcade Julie Chas Lionel Piroth Karine Lacombe Christine Katlama Gilles Peytavin Hugues Aumaitre Laurent Alric Franoois Boué Philippe Morlat Isabelle Poizot-Martin Eric Billaud Eric Rosenthal Alissa Naqvi Patrick Miailhes Firouzé Bani-Sadr Laure Esterle Patrizia Carrieri Franoois dabis Philippe Sogni Linda Wittkop 无 Assistance Publique des Hopitaux de Paris Hopitaux Universitaires Paris CentreHopital Hotel DieuUnitédes Maladies infectieuses et tropicalesParis 75004France Université Paris descartes Sorbonne Paris CitéParis 75006France Trimoulet CHU de BordeauxHopital PellegrinLaboratoire de VirologieBordeaux 33000France Trimoulet CNRS-UMR 5234Microbiologie fondamentale et PathogénicitéUniversitéde BordeauxBordeaux 3000France Philippe Morlat Laure EsterleFrancois DabisLinda WittkopUniv.BordeauxISPEDInsermBordeaux Population Health Research Centerteam MORPH3EUSUMR 1219CIC-EC 1401Bordeaux F-33000France APHM Hopital La TimoneLaboratoire de Pharmacocinétique et ToxicologieMarseille 13005France Centre Hospitalier Universitaire de dijon Département d'InfectiologieDijon cedex 21079France INSERM-CIC 1342 Universitéde Bourgogne Dijon 21000France Assistance Publique des Hopitaux de Paris GHUEP site Saint-AntoineServices Maladies infectieuses et tropicalesParis 75011France UniversitéPierre et Marie Curie UMR S1136Institut Pierre Louis d' Epidémiologie et de SantéPubliqueParis 75646France UniversitéParis-Sorbonne Paris 75005France Assistance Publique des Hopitaux de Paris Hopital PitiéSalpêtrière Services Maladies infectieuses et tropicalesParis 75013France Assistance Publique des Hopitaux de Paris Hopital Bichat-Claude BernardLaboratoire de PharmacologieParis 75877France IAME UMR 1137Sorbonne Paris CitéINSERMUniversitéParis DiderotParis 75890France Centre Hospitalier de Perpignan Service Maladies infectieuses et tropicalesPerpignan 66000Franc Centre Hospitalier Universitaire de Toulouse Hopital PurpanService Médecine interne-Pole DigestifToulouse 31300France UMR 152 IRd UniversitéToulouseⅢ Paul SabatierToulouse 31330France Hopital Antoine-Béclère Assistance Publique des Hopitaux de ParisUniversitéParis SudService Médecine interne et immunologieClamart 92140France Centre Hospitalier Universitaire de Bordeaux Service de médecine interneHopital Saint-AndréBordeaux 33000France Uni

AIMTo describe factors associated with treatment failure and frequency of resistance-associated substitutions （RAS）.MetHOdSHuman immunodefciency virus （HIV）/hepatitis C virus （HCV） coinfected patients starting a first direct-acting antiviral （dAA） regimen before February 2016 and included in the French ANRS CO13 HEPAVIH cohort were eligible. Failure was defned as：（1） non-response [HCV-RNA remained detectable during treatment, at end of treatment （EOT）]; and （2） relapse （HCV-RNA suppressed at EOT but detectable thereafter）. Sequencing analysis was performed to describe prevalence of drug class-specifc RAS. Factors associated with failure were determined using logistic regression *** 559 patients, 77% had suppressed plasmaHIV-RNA 〈 50 copies/mL at dAA treatment initiation41% were cirrhotic, and 68% were HCV treatmentexperienced. Virological treatment failures occurred in22 patients and were mainly relapses （17, 77%） thenundefined failures （3, 14%） and non-responses （29%）. Mean treatment duration was 16 wk overall. Posttreatment NS3, NS5A or NS5B RAS were detected in10/14 patients with samples available for sequencinganalysis. After adjustment for age, sex, ribavirin useHCV genotype and treatment duration, low platelecount was the only factor signifcantly associated with ahigher risk of failure （OR： 6.5; 95%CI： 1.8-22.6）. CONCLUSIONOnly 3.9% HIV-HCV coinfected patients failed dAAregimens and RAS were found in 70% of those failingLow platelet count was independently associated withvirological failure.

关键词： Human immunodeficiency virus Hepatitis C virus direct-acting antiviral Treatment virological failure Resistant associated mutations

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Social services for Mobile Pastoralists： Cross-sector Strategy Based on ＂One Health＂

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Sociology Study 2012年第9期2卷 705-714页

作者： Mahamat Bechir Zinsstag Jakob Mahamat Abdoulaye Schelling Esther Kessely Hamit Fokou Gilbert Moto daugla Bonfoh Bassirou Tanner Marcel University of N'djamena Chad Centre de Support en sante lnternationale Chad Swiss Tropical and Public Health Institute/University ofBasel Swiss Centre Suisse de Recherche Scientifique Cite d'Ivoire

Mobile pastoralist communities in Sahel countries have serious problems of access to social services. Classic strategies for social services were always based on a single sector, focused on settled populations, and hardly reached mobile communities. This paper aims to show a cross-sector approach as a part of solutions to provide social services for mobile pastoralist communities and describes the ongoing scaling-up process. The method used is based on a transdisciplinary approach which involves target communities and authorities in all processes through workshops and site visits. Interventions adopted the concept of ＂one health＂ benefiting of an added value of closer cooperation between human and animal health. This approach was tested with joint interventions between human and animal health, which provided access to health services for unreached communities and saved resource when compared with single sector intervention. Such approaches could be extended to other social services within cross-sector interventions such as the delivery of basic education in nomadic areas. Such a strategy was validated by the communities and authorities and was further transformed into a national programme after a series of six national stakeholders＇ seminars. The cross-sector intervention will provide a minimum package of services （MPS） without compromising the structural services.

关键词： Mobile pastoralists integrated cross-sector approach transdisciplinary one health Chad

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在布基纳法索肺结核症状者就诊于医疗卫生机构后能得到妥善的管理吗?

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国际结核病与肺部疾病杂志 2006年第2期1卷 81-84页

作者： S.M.dembele H.Z.Ouedraogo A.I.Combary B.Sondo J.Macq B.dujardin 徐敏杨振旦张立兴 Programme National de Lutte Antituberculeuse Ouagadougou Institut de Recherche en Sciences de la sante(IRSS) OuagadougouBurkina Faso Ecole de sante Publique.Universite Libre de Bruxelles Brussels.Belgium

地点:从布基纳法索53个卫生服务中选择的6个地市。目的:评价布基纳法索医疗卫生机构发现传染性肺结核病人(PTB)的水平。设计:回顾2001年一级卫生服务中心和实验室的初诊病人登记本和结核病诊断治疗中心(CdTs)的治疗登记本。结果:涂阳肺... 详细信息

地点:从布基纳法索53个卫生服务中选择的6个地市。目的:评价布基纳法索医疗卫生机构发现传染性肺结核病人(PTB)的水平。设计:回顾2001年一级卫生服务中心和实验室的初诊病人登记本和结核病诊断治疗中心(CdTs)的治疗登记本。结果:涂阳肺结核病人的发现率是11.7/100000。248730例成年病人中有10.6%是由于咳嗽就医;1.1%有慢性咳嗽症状。在慢性咳嗽病人中,66%已被转诊并作痰涂片镜检,其中69.7%已被登记在CdT。转诊并追踪到位于CdT的病人中,有22.5%的病人为阳性诊断结果。在这些阳性病人中,87.1%者已在同一CdT接受治疗。结论:由于病人丢失发生在结核病诊断的各个阶段,所以布基纳法索的肺结核病人发现率较低。病人发现依赖卫生医疗机构人员的工作效力和向CdT转诊可疑症状者的情况。

关键词：选择转诊病人发现结核病布基纳法索

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