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Oral cancer epidemiology in mato Grosso State

中国口腔颌面外科杂志 2008年第B5期6卷 132-132页

作者： Fabiano Tonaco Borges Artur Aburad de Carvalhosa Paulo Henrique de Souza Castro Luiz Evaristo Ricci Volpato Lidia Hidalgo Clea Adas Saliba Garbin Department of Oral Pathology Mato Grosso State Public Health School. Cuiabo Mato Grosso State - Brazil Department of Oral and maxillofacial Surgery Mato Grosso State Cancer Hospital. Cuiaba Mato Grosso State - Brazil Department of pediatrics Mato Grosso State Cancer Hospital. Cuiabop Mato Grosso State - Brazil Department of Oral Public Health School of Dentistry Sao Paulo State University - UNESP. Aracatuba Saop Paulo State Brazil

Purpose: To analyze the register of oral cancer cases diagnosed on public laboratory of mato Grosso State。methods: It's a longitudinal epidemiologic study。The studied object was the histopathological award, being 1.324 emitted awards between January 2005 and December 2006。The oral cancer cases were verified through the analysis of following variables: percentage of oral cancer among oral lesions, histological type, age, and the local where the patients come from (interior or capital of State)。Results: After analysis of data, 44 lesions of oral cancer were found, representing 3% of all diagnosis。The histological type more incident were oral squamous cell carcinoma。The majority of diagnosis was referent to men with age between 5th and 6th decade of life that were resident in interior of State。Conclusion: We can conclude with this study that during the period of two years of historic series, the public service of pathology registered a considerable number of oral cancer cases。

关键词：口腔癌治疗方法诊断技术流行病学

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Genetic mechanisms of critical illness in Covid-19

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四川生理科学杂志 2020年第4期42卷 455-455页

作者： Erola Pairo-Castineira Roslin Institute University of Edinburgh Edinburgh UK mRC Human Genetics Unit Institute of Genetics and Molecular Medicine University of Edinburgh Western General Hospital Edinburgh UK Genomics England London UK Centre for Inflammation Research The Queen’s Medical Research Institute University of Edinburgh Edinburgh UK Centre for Genomic and Experimental medicine Institute of Genetics and Molecular Medicine University of Edinburgh Western General Hospital Edinburgh UK Edinburgh Clinical Research Facility Western General Hospital University of Edinburgh Edinburgh UK Intensive Care National Audit & Research Centre London UK Institute for molecular Bioscience The University of Queensland Brisbane Queensland Australia Biostatistics Group School of Life Sciences Sun Yat-sen University Guangzhou China The Crick Institute London UK Intensive Care Unit Royal Infirmary of Edinburgh Edinburgh UK School of Life Sciences Westlake University Hangzhou China Westlake Laboratory of Life Sciences and Biomedicine Hangzhou China Wellcome Centre for Human Genetics University of Oxford Oxford UK Department of medicine University of Cambridge Cambridge UK Department of Intensive Care medicine Guy’s and St Thomas’ NHS Foundation Trust London UK School of Immunology and microbial Sciences King’s College London London UK NIHR Health Protection Research Unit for Emerging and Zoonotic Infections Institute of Infection Veterinary and Ecological Sciences University of Liverpool Liverpool UK mRC-University of Glasgow Centre for Virus Research Institute of Infection Immunity and Inflammation College of Medical Veterinary and Life Sciences University of Glasgow Glasgow UK William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK Centre for Tropical medicine and Global Health Nuffield Department of Medicine University of Oxford Oxford UK Clinical Research Centre at St Vincent’s University Hospital Un

Host-mediated lung inflammation is present,1 and drives mortality,2 in critical illness caused by *** genetic variants associated with critical illness may identify mechanistic targets for therapeutic development.3 Here we report the results of the GenOmICC(Genetics Of mortality In Critical Care)genome-wide association study(GWAS)in 2244 critically ill Covid-19 patients from 208 UK intensive care units(ICUs).We identify and replicate novel genome-wide significant associations,on chr12q24.13(rs10735079,p=1.65[Formula:see text]10-8)in a gene cluster encoding antiviral restriction enzyme activators(OAS1,OAS2,OAS3),on chr19p13.2(rs2109069,p=2.3[Formula:see text]10-12)near the gene encoding tyrosine kinase 2(TYK2),on chr19p13.3(rs2109069,p=3.98[Formula:see text]10-12)within the gene encoding dipeptidyl peptidase 9(DPP9),and on chr21q22.1(rs2236757,p=4.99[Formula:see text]10-8)in the interferon receptor gene *** identify potential targets for repurposing of licensed medications:using mendelian randomisation we found evidence in support of a causal link from low expression of IFNAR2,and high expression of TYK2,to life-threatening disease;transcriptome-wide association in lung tissue revealed that high expression of the monocyte/macrophage chemotactic receptor CCR2 is associated with severe *** results identify robust genetic signals relating to key host antiviral defence mechanisms,and mediators of inflammatory organ damage in *** mechanisms may be amenable to targeted treatment with existing ***-scale randomised clinical trials will be essential before any change to clinical practice.

关键词： lung drugs critical

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