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Early Syphilis Presenting as Thickened Penile Plaques With an Embedded Recurrent Ulcer (Chancre Redux): A Case Report

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International Journal of dermatology and Venereology 2024年第3期7卷 160-162页

作者： Stephen C.Davies Rodney Hannaford Joseph Cotter Northern Sydney Sexual Health service Northern Sydney Local Health DistrictSt LeonardsNSW 2065Australia Northern Beaches dermatology Mona ValeNSW 2103Australia

Introduction:The manifestations of syphilis are varied,and serology can establish the diagnosis early,especially in rare *** report a case of chancre redux(a rare recurrence of primary syphilis),which was embedded within a secondary syphilitic penile skin *** were missed opportunities at earlier diagnosis as serology for syphilis was not *** presentation:A 56-year-old man presented with thickened penile plaques for five *** reported a small penile ulcer approximately one month *** was no history of other skin lesions or ***,clinically there was an asymptomatic,indurated ulcer embedded within a plaque which was swab-positive for syphilis by PCR.A punch biopsy of a plaque was spirochaete-positive using an immunoperoxidase *** patient’s lesions resolved three weeks after treatment with intramuscular benzathine ***:Uncommonly reported even in the preantibiotic era,chancre redux is now *** ulcer usually recurs at or near the site of the original chancre,and has similar morphological *** skin lesions of secondary syphilis can exhibit remarkable morphological *** most common skin manifestation,a generalized macular rash,was not present at any time in this ***,there were only a couple of nonspecific penile *** biopsy is performed,histologic findings are variable,though typically the inflammatory infiltrate includes plasma cells.A special immunoperoxidase stain can highlight spirochaetes in biopsy ***:This case highlights the importance of considering syphilis in the differential diagnosis of persistent,atypical penile lesions and underscores the need for appropriate serological testing in such instances.

关键词： primary syphilis secondary syphilis chancre redux immunohistochemistry immunoperoxidase genital rash

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Early results of the integrative epigenomic-transcriptomic landscape of colorectal adenoma and cancer

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 414-435页

作者： You-Wang Lu Zhao-Li Ding Rui Mao Gui-Gang Zhao Yu-Qi He Xiao-Lu Li Jiang Liu Department of dermatology and Venereology The First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina Kunming Biological Diversity Regional Center of Large Apparatus and Equipments Public Technical Service CenterKunming Institute of ZoologyKunming 650223Yunnan ProvinceChina School of Stomatology Kunming Medical UniversityKunming 650500Yunnan ProvinceChina Genome Center of Biodiversity Kunming Institute of ZoologyChinese Academy of ScienceKunming 650223Yunnan ProvinceChina Department of Reproduction and Genetics The First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina

BACKGROUND Aberrant methylation is common during the initiation and progression of colorectal cancer(CRC),and detecting these changes that occur during early adenoma(ADE)formation and CRC progression has clinical *** To identify potential DNA methylation markers specific to ADE and *** Here,we performed SeqCap targeted bisulfite sequencing and RNA-seq analysis of colorectal ADE and CRC samples to profile the epigenomic-transcriptomic *** Comparing 22 CRC and 25 ADE samples,global methylation was higher in the former,but both showed similar methylation patterns regarding differentially methylated gene positions,chromatin signatures,and repeated ***-grade CRC tended to exhibit elevated methylation levels in gene promoter regions compared to those in low-grade *** with RNA-seq gene expression data,we identified 14 methylation-regulated differentially expressed genes,of which only AGTR1 and NECAB1 methylation had prognostic *** Our results suggest that genome-wide alterations in DNA methylation occur during the early stages of CRC and demonstrate the methylation signatures associated with colorectal ADEs and CRC,suggesting prognostic biomarkers for CRC.

关键词： Colorectal cancer Epigenomic alteration Transcriptome Methylation-regulated differentially expressed genes

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Associations of polygenic risk scores with risks of stroke and its subtypes in Chinese

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Stroke & Vascular Neurology 2024年第4期9卷 399-406,I0044-I0065页

作者： Songchun Yang Zhijia Sun Dong Sun Canqing Yu Yu Guo Dianjianyi Sun Yuanjie Pang Pei Pei Ling Yang Iona Y Millwood Robin G Walters Yiping Chen Huaidong Du Yan Lu Sushila Burgess Daniel Avery Robert Clarke Junshi Chen Zhengming Chen Liming Li Jun Lv On behalf of the China Kadoorie Biobank Collaborative Group Department of Epidemiology&Biostatistics School of Public HealthPeking UniversityBeijingChina Department of dermatology Xiangya HospitalCentral South UniversityChangshaHunanChina Peking University Center for Public Health and Epidemic Preparedness&Response BeijingChina Key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of EducationBeijingChina Fuwai Hospital Chinese Academy of Medical Sciences BeijingChina Medical Research Council Population Health Research Unit at the University of Oxford OxfordUK Clinical Trial service Unit&Epidemiological Studies Unit(CTSU) Nuffield Department of Population HealthUniversity of OxfordOxfordUK NCDs Prevention and Control Department Suzhou CDCSuzhouJiangsuChina China National Center for Food Safety Risk Assessment BeijingChina State Key Laboratory of Vascular Homeostasis and Remodeling Peking UniversityBeijingChina 不详

Background and purpose Previous studies,mostly focusing on the European population,have reported polygenic risk scores(PRSs)might achieve risk stratification of *** aimed to examine the association strengths of PRSs with risks of stroke and its subtypes in the Chinese *** Participants with genome-wide genotypic data in China Kadoorie Biobank were split into a potential training set(n=22191)and a population-based testing set(n=72150).Four previously developed PRSs were included,and new PRSs for stroke and its subtypes were *** PRSs showing the strongest association with risks of stroke or its subtypes in the training set were further evaluated in the testing *** proportional hazards regression models were used to estimate the association strengths of different PRSs with risks of stroke and its subtypes(ischaemic stroke(IS),intracerebral haemorrhage(ICH)and subarachnoid haemorrhage(SAH)).Results In the testing set,during 872919 person-years of follow-up,8514 incident stroke events were *** PRSs of any stroke(AS)and IS were both positively associated with risks of AS,IS and ICH(p<0.05).The HR for per SD increment(HR_(SD))of PRSAS was 1.10(95%CI 1.07 to 1.12),1.10(95%CI 1.07 to 1.12)and 1.13(95%CI 1.07 to 1.20)for AS,IS and ICH,*** corresponding HR_(SD) of PRS_(IS) was 1.08(95%CI 1.06 to 1.11),1.08(95%CI 1.06 to 1.11)and 1.09(95%CI 1.03 to 1.15).PRS_(ICH) was positively associated with the risk of ICH(HR_(SD)=1.07,95%CI 1.01 to 1.14).PRSS_(AH) was not associated with risks of stroke and its *** addition of current PRSs offered little to no improvement in stroke risk prediction and risk *** In this Chinese population,the association strengths of current PRSs with risks of stroke and its subtypes were moderate,suggesting a limited value for improving risk prediction over traditional risk factors in the context of current genome-wide association study under-representing the East Asia

关键词： testing prediction increment

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Herbal Medicines Prevent the Development of Atopic Dermatitis by Multiple Mechanisms

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Chinese Journal of Integrative Medicine 2019年第2期25卷 151-160页

作者： MAN Mao-qiang HU Li-zhi Peter M.Elias dermatology service Veterans Affairs Medical Center Department of dermatology University of California San Francisco School of Basic Medical Sciences Tianjin Medical University

Atopic dermatitis(AD) is among the most common skin disorders in humans. Although a variety of regimens are available for the treatment of AD, preventive approaches are limited. Recent studies have demonstrated that certain naturally-occurring herbal medicines are effective in preventing the development of AD via divergent mechanisms, such as inhibiting cytokine and chemokine expression, IgE production, inflammatory cell infiltration, histamine release, and/or enhancement of epidermal permeability barrier function. Yet, they exhibit few adverse effects. Since herbal medicines are widely available, inexpensive and generally safe, they could represent an ideal approach for preventing the development of AD, in both highly developed and developing countries.

关键词： herbal medicines T cells cytokines permeability barrier dermatitis

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Hemorrhagic Fever with Renal Syndrome Associated with Acute Pancreatitis

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Virologica Sinica 2012年第3期27卷 214-217页

作者： Edmond Puca Arben Pilaca Pellumb Pipero Dhimiter Kraja Entela Y Puca service of Infectious Diseases University Hospital Center "Mother Teresa" Department of Infection Diseases and dermatology University of Tirana service of Endocrinilogy American Hospital No2

Hemorrhagic fever with renal syndrome (HFRS) is a systemic infectious disease caused by Hantaviruses and characterized by fevers, bleeding tendencies, gastrointestinal symptoms and renal failure. It encompasses a broad spectrum of clinical presentations, ranging from unapparent or mild illnesses to fulminant hemorrhagic processes. Among the various complications of HFRS, acute pancreatitis is a rare find. In this report, based on clinical data, laboratory and radiologic examination findings, we describe a clinical case, with HFRS from Dobrava virus, associated with acute pancreatitis. The patient was successfully treated by supportive management. Clinicians should be alert to the possibility of HFRS when examining patients with epidemiological data and symptoms of acute pancreatitis.

关键词： Hemorrhagic fever with renal syndrome (HFRS) Pancreatitis, Dobrava virus

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Advances in the function of traditional medicine for vitiligo treatment

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Traditional Medicine Research 2024年第3期9卷 43-51页

作者： Jun Liu Jia-Yi Li Jing-Jing Xu Ling-Jun Li Wang Cheng Sheng-Tao Yuan Wei Zhang Hong-Yang Li Institute of dermatology Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjing 210042China Jiangsu Center for Pharmacodynamics Research and Evaluation China Pharmaceutical UniversityNanjing 210009China School of Basic Medicine and Clinical Pharmacy China Pharmaceutical UniversityNanjing 210042China Department of dermatology Zhongda Hospital Southeast UniversityNanjing 210009China

Vitiligo has a significant impact on a substantial number of individuals *** Chinese medicine has a long history of serving as a therapeutic treatment for ***,given the increasing volume of research on the utilization of traditional Chinese medicine for vitiligo treatment,it is imperative to conduct a comprehensive review that elucidates the efficacy of Chinese traditional medicine and other active ingredients in the treatment of *** paper presents a comprehensive overview of the clinical preparations used to treat vitiligo,while also highlighting the potential monomers and extracts derived from traditional Chinese medicine for vitiligo treatment.A thorough analysis of the pharmacological effects of traditional Chinese medicine on vitiligo treatment will provide valuable insights and reliable information for the development of new treatment strategies.

关键词： vitiligo traditional Chinese medicine melanogenesis

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Detection of β-Glucuronidase Activity within Actinomadura madurae Grains of Human Actinomycetoma

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Advances in Microbiology 2014年第6期4卷 317-323页

作者： Alejandro Palma-Ramos Samantha Reyes-Mayén Laura Estela Castrillón-Rivera Silvia Elena Fernández-López Carmen Padilla-Desgarennes María Elisa Vega-Memije Roberto Arenas-Guzmán María Elisa Drago-Serrano Teresita Sainz-Espunes Department of Biological Systems Universidad Autónoma Metropolitana-XochimilcoMexico CityMéxico dermatology Center“Dr.Ladislao de la Pascua” Mycology ServiceMexico City Health SecretaryMexico CityMéxico General Hospital“Manuel Gea González” Dermatology ServiceMexico City Health SecretaryMexico CityMéxico General Hospital“Manuel Gea González” Mycology ServiceMexico City Health SecretaryMexico CityMéxico

Actinomycetoma syndrome by Actinomadura (A.) madurae is characterized by a subcutaneous chronic lesion that affects fascia, muscle and bone. A. madurae produces colonies that form grains of less than 1 mm in diameter. Grains are surrounded and infiltrated by neutrophils involved in the grain disruption by enzymes like β-glucuronidase released after the neutrophil degranulation. The aim of this work was to evaluate the polysaccharide degradation of grains treated with β-glucuronidase and to detect the presence and activity of β-glucuronidase within the A. madurae grains. Actinomadura madura grains from patients infected were processed to quantify the total content of polysaccharide with the phenol-sulfuric acid reaction. Grains were treated with β-glucuronidase at different conditions to evaluate the optimal polysaccharide degradation. Grains were analyzed to detect the enzyme by using anti-human β-glucuronidase antibody while enzymatic activity was assessed by evaluating the release of reduced sugars and by in situ enzymatic activity. Optimal degradation of polysaccharide in the grains treated with β-glucuronidase was found with 300 units/ml of enzyme and 24 hr of incubation at 37°C. Presence and activity of β-glucuronidase enzyme within the grains were detected. Results suggested that β-glucuronidase present within A. madurae grain resulted from degranulated neutrophils surrounding and/or infiltrated within the grain.

关键词： Actinomycetoma A. madurae β-Glucuronidase

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Topical Applications of Thiosulfinate-Enriched Allium sativum Extract Accelerates Acute Cutaneous Wound Healing in Murine Model

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Chinese Journal of Integrative Medicine 2020年第11期26卷 812-818页

作者： Juan Luis Santiago Eva Maria Galan-Moya Jose Ramon Munoz-Rodriguez Miguel Angel de la Cruz-Morcillo Francisco Javier Redondo-Calvo Ignacio Gracia-Fernandez Peter M.Elias Jose Manuel Perez-Ortiz Mao-Qiang Man dermatology service Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Research Unit Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Oncology Laboratory Centro Regional de Investigaciones BiomedicasUniversidad de Castilla-La ManchaAlbacete(02008)Spain Instituto de Tecnologia Quimica y Medioambiental Universidad de Castilla-La ManchaCiudad Real(13004)Spain dermatology service Vetera ns Affairs Medical Centerand Department of DermatologyUniversity of CaliforniaSan FranciscoCA(94121)USA dermatology Hospital Southern Medical UniversityGuangzhou(510091)China

Objective To determine whether topical applications of thiosulfinate-enriched Allium sativum extract(TASE)can accelerate acute cutaneous wound healing(WH)in a murine *** Keratinocyte viability and in vitro wound closure were assessed in keratinocyte *** of topical TASE(0.5μg/mL of allicin in 97%ethanol)on acute cutaneous WH were determined in a murine model of acute cutaneous *** mice were alternately assigned to the vehicle-and TASE-treated groups(n=6 per group).Expression levels of mRNA for keratinocyte differentiation marker-related proteins(filaggrin,loricrin and involucrin)and lipid synthetic enzymes(elongation of very long chain fatty acids protein 4(ELOVL4),fatty acid synthase(FA2H),3-hydroxy-3-methyl-glutaryl-coenzyme A reductase(HMGCoA),and serine palmitoyltransferase(SPT))were assessed using real-time quantitative polymerase chain reaction on day 3 and 8 after wounding,while transepidermal water loss(TEWL)rates were measured in wounded *** TASE accelerated WH both in vivo(40%vs.22%reduction in wound area,P<0.01)and in vitro(90%vs.65%reduction in wound area,P<0.01).Moreover,topical applications of TASE upregulated the expression levels of epidermal mRNA for ELOVL4,HMGCoA,SPT,filaggrin,loricrin and involucrin(P<0.05 ***-treated controls)on day 3 after ***,TASE significantly lowered TEWL rates in comparison with vehicle alone on day 8(33.06±2.09 g/(m^2·h)vs.24.60±2.04 g/(m^2·h),P<0.01).Conclusions Topical applications of TASE stimulated keratinocyte proliferation and formation of epidermal permeability barrier function,leading to acceleration of acute cutaneous *** products containing TASE could be used to manage acute cutaneous WH.

关键词： Allium sativum thiosulfinate wound healing permeability barrier keratinocytes proliferation

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Hemorrhagic Fever with Renal Syndrome Complicated by Orchitis

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Virologica Sinica 2011年第4期26卷 285-288页

作者： Edmond Puca Arben Pilaca Pellumb Pipero Silva Bino Majlinda Kote Elton Rogozi Entela Puca Dhimiter Kraja service of Infectious Diseases University Hospital Center "Mother Teresa" Department of Infection Diseases and dermatology University of Tirana Institute of Public Health TiranaAlbania Neo-Style Clinic TiraneAlbania

Hemorrhagic fever with renal syndrome (HFRS) is a disease caused by viruses of the family Bunyaviridae,genus *** from Dobrava virus (DOBV) is a seldom reported disease in *** HFRS is manifested as mild,moderate,or ***,the number of cases of Hantavirus' infection may be underestimated,and should be included in the differential diagnosis of many acute infections,hematologic diseases,acute abdominal diseases and renal diseases complicated by acute renal *** report here an atypical presentation of HFRS from Dobrava virus complicated by orchitis with a positive outcome.

关键词： Fever Dobrava virus Orchitis

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Efficacy and safety of herbal medicines in treating gastric ulcer:A review

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World Journal of Gastroenterology 2014年第45期20卷 17020-17028页

作者： Wei-Ping Bi Hui-Bin Man Mao-Qiang Man Department of Internal Medicine Wendeng Central Hospital dermatology service Veterans Affairs Medical Center Department of dermatology University of California

Gastric ulcer is a common disorder of the digestive *** therapeutic regimens largely rely on Western ***,numerous studies have demonstrated that herbal medicines can effectively treat gastric ulcer in humans and various animal models via divergent *** review updates the efficacy and safety of herbal medicines in treating gastric ulcer,and the mechanisms of their action in humans and animal *** have demonstrated that the efficacy of herbal medicines is comparable or superior to that of drugs such as omeprazole or cimetidine in humans and animal models,and herbal medicines display fewer adverse *** mechanisms by which herbal medicines benefit gastric ulcer include stimulation of mucous cell proliferation,anti-oxidation,and inhibition of gastric acid secretion and H(+)/K(+)-ATPase *** herbal medicines also exhibit antimicrobial *** of herbal medicines could be a valuable alternative to treat gastric ulcer in humans effectively,with few adverse effects.

关键词： Herbal medicines Gastric ulcer Mechanism of action

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