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Diagnostic neuroradiology for the interventional neuroradiologist

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World Journal of Radiology 2013年第11期5卷 386-397页

作者： Vitor Mendes Pereira Maria Isabel Vargas Ana Marcos Philippe Bijlenga Ana Paula Narata Sven Haller Karl-Olof Lvblad service neuro-diagnostique et neuro-interventionnel Geneva University Hospitals service de neurochirurgie HUG Geneva University Hospitals

In order to further improve the impact of the continuously evolving neurointerventional techniques, the interventional neuroradiologist needs to have at his disposal more powerful techniques to image the central nervous system. With the recent development of diagnostics techniques that are computed tomography and magnetic resonance based we are now able to assess not just morphology, but also physiology, physiopathology and function. This review discusses the place of diagnostic techniques in the evaluation that the interventional neuroradiologist hast to make when confronted with patients. We provide an overview of current techniques for the brain and spine.

关键词： neuroradiology Brain Imaging Magnetic resonance Interventional radiology

Involvement of CRF2 signaling in enterocyte differentiation

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World Journal of Gastroenterology 2017年第28期23卷 5127-5145页

作者： Benjamin Ducarouge Marjolaine Pelissier-Rota Rebecca Powell Alain Buisson Bruno Bonaz Muriel Jacquier-Sarlin Equipe de l’apoptose du cancer et du développementCentre Léon Bérard Equipes des"neuro-pathologies et Dysfonctions synaptiques"et du"Stress et des interactions neurodigestives" UniversitéGrenoble Alpes Equipes des"neuropathologies et dysfonctions synaptiques"et du"Stress et des interactions neurodigestives" Université Grenoble Alpes and Grenoble Institut des Neurosciences-Inserm U1216 service d’hépato-gastroentérologie Centre Hospitalier Universitaire de Grenoble

To determine the role of corticotropin releasing factor receptor (CRF2) in epithelial permeability and enterocyte cell *** this purpose, we used rat Sprague Dawley and various colon carcinoma cell lines (SW620, HCT8R, HT-29 and Caco-2 cell lines). Expression of CRF2 protein was analyzed by fluorescent immunolabeling in normal rat colon and then by western blot in dissociated colonic epithelial cells and in the lysates of colon carcinoma cell lines or during the early differentiation of HT-29 cells (ten first days). To assess the impact of CRF2 signaling on colonic cell differentiation, HT-29 and Caco-2 cells were exposed to Urocortin 3 recombinant proteins (Ucn3, 100 nmol/L). In some experiments, cells were pre-exposed to the astressin 2b (A2b) a CRF2 antagonist in order to inhibit the action of Ucn3. Intestinal cell differentiation was first analyzed by functional assays: the trans-cellular permeability and the para-cellular permeability were determined by Dextran-FITC intake and measure of the transepithelial electrical resistance respectively. Morphological modifications associated to epithelial dysfunction were analyzed by confocal microscopy after fluorescent labeling of actin (phaloidin-TRITC) and intercellular adhesion proteins such as E-cadherin, p120ctn, occludin and ZO-1. The establishment of mature adherens junctions (AJ) was monitored by following the distribution of AJ proteins in lipid raft fractions, after separation of cell lysates on sucrose gradients. Finally, the mRNA and the protein expression levels of characteristic markers of intestinal epithelial cell (IEC) differentiation such as the transcriptional factor krüppel-like factor 4 (KLF4) or the dipeptidyl peptidase IV (DPPIV) were performed by RT-PCR and western blot respectively. The specific activities of DPPIV and alkaline phosphatase (AP) enzymes were determined by a colorimetric ***2 protein is preferentially expressed in undifferentiated epithelial cel

关键词： Urocortin3 Colon carcinoma cell lines Intercellular adhesion complexes Cell permeability Epithelial cell differentiation Corticotrophin releasing factor 2

Atrial embolism caused by portal vein embolization:Treatment by percutaneous withdrawal and stenting

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World Journal of Hepatology 2012年第12期4卷 412-414页

作者： Ahmed Fouad Bouras Stéphanie Truant Jean-Paul Beregi Geraldine Sergent Olivier Delemazure Guido Liddo Gilles Lebuffe Philippe Zerbib Franois-René Pruvot Emmanuel Boleslawski service de Chirurgie Digestive et Transplantation CHUUniv Nord de FranceF-59000 LilleFrance service d’imagerie cardiovasculaire diagnostique et interventionnelle Hopital cardiologiqueCHUUniv Nord de FranceF-59000 LilleFrance service d’imagerie digestive diagnostique et interventionnelle Hopital Claude HuriezCHUUniv Nord de FranceF-59000 LilleFrance service d’anesthésiologie Hopital Claude HuriezCHUUniv Nord de FranceF-59000 LilleFrance

Hepatectomy remains the only curative treatment for many primary and secondary liver *** vein embolization(PVE) has been used to increase the volume of the future liver remnant and thus lower the risk of small-for-size syndrome and postoperative liver *** technique has proven its safety,with a low post-procedure morbidity ***,we describe a very rare case in which a young patient suffered a glue embolism to the right atrial cavity following PVE in preparation for a major hepatectomy for colorectal *** foreign body was withdrawn from the heart with a femoral,percutaneous device and trapped against the wall of the femoral vein with a self-expanding metal *** report shows that this previously unknown complication of PVE can be resolved without recourse to sternotomy and open heart surgery.

关键词： Liver metastasis Percutaneous endovascular intervention Portal vein Embolization Glue Complications Stenting

Evaluation of Doppler-ultrasonography in the diagnosis of transjugular intrahepatic portosystemic shunt dysfunction: A prospective study

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World Journal of Hepatology 2017年第27期9卷 1125-1132页

作者： Charlotte Nicolas Amelie Le Gouge Louis d’Alteroche Jean Ayoub Monica Georgescu Vincent Vidal Denis Castaing Jean-Pierre Cercueil Patrick Chevallier Jerome Roumy Herve Trillaud Louis Boyer Vincent Le Pennec Christophe Perret Bruno Giraudeau Jean-Marc Perarnau STIC-TIPS group service d’Hepato-Gastroenterologie Hopital TrousseauCHRU Tours CIC CHRU de Tours INSERM United’echographie-doppler Hopital TrousseauCHRU Tours service de Radiologie Hopital de la Timone Centre Hepato-Biliaire Hopital Paul Brousse service de Radiologie CHRU Dijon service d’Imagerie Medicale diagnostique et interventionnelle Hopital de l’ArchetⅡNice service de Radiologie et Echographie CHRU Poitiers service d’Imagerie Medicale Hopital Saint Andre CHRU Bordeaux service d’Imagerie viscerale et vasculaire CHRU Clermont Ferrand service de Radiologie CHRU Caen service de Radiologie CHRU Nantes 不详

AIM To prospectively evaluate the performance of Dopplerultrasonography(US) for the detection of transjugular intrahepatic portosystemic shunt(TIPS) dysfunction within a multicenter cohort of cirrhotic *** This study was conducted in 10 french teaching hospitals. After TIPS insertion, angiography and liver Doppler-US were carried out every six months to detect dysfunction(defined by a portosystemic gradient ≥ 12 mm Hg and/or a stent stenosis ≥ 50%). The association between ultrasonographic signs and dysfunction was studied by logistic random-effects models, and the diagnostic performance of each Doppler criterion was estimated by the bootstrap method. This study was approved by the ethics committee of *** Two hundred and eighteen pairs of examinations performed on 87 cirrhotic patients were analyzed. Variables significantly associated with dysfunction were: The speed of flow in the portal vein(P = 0.008), the reversal of flow in the right(P = 0.038) and left(P = 0.049) portal branch, the loss of modulation of portal flow by the right atrium(P = 0.0005), ascites(P = 0.001) and the overall impression of the operator(P = 0.0001). The diagnostic performances of these variables were low; sensitivity was etection of TIPS dysfunction is poor compared to angiography. New tools are needed to improve diagnosis of TIPS dysfunction.

关键词： Transjugular intrahepatic portosystemic shunt Dysfunction Doppler-ultrasonography

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放射学医师2013年痴呆神经成像须知

国际医学放射学杂志 2014年第1期 99-99页

作者： S.Haller V.Garibotto E.Kǒvari C.Bouras A.Xekardaki C.Rodriguez 袁涛 service neuro-diagnostique et neuro-interventionnel disim Univrsity hospitals of Geneva Reu Gabrielle Perret-Gentil 41211 Geneva 14 Switzerland

最近几年有关痴呆的结构与功能成像有了很大进展。本文第一部分首先回顾最常见的痴呆,如Alzheimer病(AD)、Lewy体痴呆(LBD)、额颞叶型退变(FTLD),随时间推

关键词：痴呆早老性痴呆 MCI 认知下降额叶型痴呆额颞叶型退变

应用磁敏感加权成像(SWI)的支持向量机分析鉴别帕金森病和其他种类的震颤麻痹征:初步结果

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国际医学放射学杂志 2013年第2期 180-180页

作者： S. Haller S. Badoud D. Nguyen I. Barnaure M.L. Montandon K.O. Lovblad 高飞 service neuro-diagnostique et neuro-interventionnel disim Hpitaux Universitaires de Genève Rue Gabrielle Perret-Gentil 4 1211 Genève 14 Switzerland

目的在个体水平上应用脑磁敏感加权成像(SWI)的模式识别诊断帕金森病(PD)。方法分析36例可疑PD的震颤麻痹病人的脑SWI数据。这些病人都有①3TMRSWI扫描数据;②大脑123I-SPECT数据;③神经学检查数据,包括随访记录[16例PD,(67.4±6.2)岁,... 详细信息

目的在个体水平上应用脑磁敏感加权成像(SWI)的模式识别诊断帕金森病(PD)。方法分析36例可疑PD的震颤麻痹病人的脑SWI数据。这些病人都有①3TMRSWI扫描数据;②大脑123I-SPECT数据;③神经学检查数据,包括随访记录[16例PD,(67.4±6.2)岁,女11例;20例非典型震颤麻痹综合征病人,(65.2±12.5)岁,女6例]。对比两组之间的SWI值,并在个体水平上进行支持向量机(SVM)分析。结果简单目视分析,两组之间的SWI值无差异。但是组间分析显示,比较其他震颤麻痹征病人,PD病人双侧丘脑和左侧黑质的SWI值升高。逆向比较亦未超出阈值。在个体水平,SVM正确归类PD病人的正确率达到86%以上。结论在个体水平,尽管目视无法发现SWI值的变化,但SWI数据的SVM模式识别可以在各种震颤麻痹征者中准确地识别出PD病人。本项初步实验的结果为将来使用不同MR设备和MR参数进行大样本PD病人研究提供了保证。要点①MRI数据为研究PD提供了新视角。②目视SWI分析无法区分特发性PD与非典型PD。③SVM分析提高了检出特发性PD的准确性。④SVM分析为临床上诊断个体PD提供信息。⑤常规MRI可较容易地获得这些数据。

关键词：帕金森病磁敏感加权成像脑内铁沉积支持向量机早期诊断

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乙胺丁醇导致视力损害的多焦视网膜电图检查

世界核心医学期刊文摘（眼科学分册） 2005年第11期1卷 25-26页

作者： Behbehani R.S. Affel E.L. Sergott R.C. Savino P.J. 曹绪胜 neuro -Ophthalmology service Wills Eye Hospital 840 Walnut Street Philadelphia PA 19107 United States Dr.

Aim: To determine the anatomical site and extent of electrophysiological dysfu nction in patients with ethambutol associated visual loss. Methods: A comparativ e case series. Four patients with ethambutol associated visual loss underwent mu ltifocal electroretinography (mERG). Two patients had advanced visual loss while two had early signs of toxicity. The N1-P1, N1, P1 amplitudes, N1, and P1 late ncies were compared to 10 age and sex matched controls. Results: mERG abnormalit ies were detected in the ethambutol treated patients. The N1 amplitude was signi ficantly lower in the ethambutol treated patients than in the control group. Con clusion: ethambutol is possibly toxic to the retina, and not only the optic nerv e. The multifocal ERG may be of value to diagnose and monitor patients taking et hambutol.

关键词：视网膜电图视力损害对视神经生理功能障碍性别匹配监测作用病例对照研究

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提高肝细胞腺瘤亚型分类的新MRI征象

国际医学放射学杂志 2019年第4期 496-496页

作者：吴越 S.Bise N.Frulio A.Hocquelet N.Alberti J.F.Blanc C.Laurent CHU de Bordeaux Service d'imagerie diagnostique et interventionnelle H?pital Haut-Lévêque

摘要目的 MRI对肝细胞腺瘤(HCA)亚型的分类至关重要。本研究的目的为回顾及提高HCA亚型分类的MRI标准,并定义其不足。方法回顾性分析116例HCA的病理及

关键词：肝细胞腺瘤 MRI

Assessment of diaphragmatic function by ultrasonography:Current approach and perspectives

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World Journal of Clinical Cases 2020年第12期8卷 2408-2424页

作者： Alain Boussuges Sarah Rives Julie Finance Fabienne Brégeon Institut de Recherche Biomédicale des Armées ERRSOToulon 83800France Center for Cardiovascular and Nutrition Research(C2VN) Aix Marseille UniversitéINSERM(1260)INRAE(1263)Toulon 83800France service d’Explorations Fonctionnelles Respiratoires CHU NordAssistance Publique des Hôpitaux de Marseille et Aix Marseille UniversitéIRDAPHMMEPHIIHU-Méditerranée InfectionMarseille 13015France

This article reports the various methods used to assess diaphragmatic function by *** excursions of the two hemidiaphragms can be measured using two-dimensional or M-mode ultrasonography,during respiratory maneuvers such as quiet breathing,voluntary sniffing and deep *** the zone of apposition to the rib cage for both hemidiaphragms,it is possible to measure the thickness on expiration and during deep breathing to assess the percentage of thickening during *** two approaches make it possible to assess the quality of the diaphragmatic function and the diagnosis of diaphragmatic paralysis or *** methods are particularly useful in circumstances where there is a high risk of phrenic nerve injury or in diseases affecting the contractility or the motion of the diaphragm such as neuro-muscular *** methods such as speckle tracking imaging and ultrasound shear wave elastography should provide more detailed information for better assessment of diaphragmatic function.

关键词： Ultrasound Hemidiaphragm Motion Thickness Paralysis Dysfunction Two-dimensional mode M-mode Speckle tracking imaging Ultrasound shear wave elastography