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Epidemiological, Clinical and Biological Aspects of Kidney Disease in People Living with HIV Naive Antiretroviral Therapy at chu sylvanus olympio of lome (TOGO)

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Open Journal of Nephrology 2019年第1期9卷 26-34页

作者： Kossi Akomola Sabi Badomta Dolaama Eyram Yoan Makafui Amekoudi Awereou Kotosso Befa Noto-Kadou-Kaza Claude Mawufemo Tsevi Komlan George Tona Eugene Ametepe Attisso Schyldia Bonou-Selegbe Hamat Ibrahim Guillaume Abderhamman Mahamat Jaques Vigan Majeste Ihou Wateba service de Néphrologie et Hémodialyse CHU Sylvanus Olympio Lomé Togo service des maladies infectieuses et tropicales du chu sylvanus olympio de lomé Lomé Togo service de Néphrologie et d’Hémodialyse H&ocirc pital Universitaire de N’djaména N’djamena Tchad Clinique de Néphrologie CNHU Cotonou Bénin

Introduction: Human immunodeficiency virus (HIV) infection is a common cause of kidney disease worldwide. HIV-related renal diseases are associated with high morbidity and mortality in Sub-Saharan African countries. The aim is to describe the epidemiological, clinical and biological aspects of kidney disease in people living with HIV naive antiretroviral therapy in lomé in Togo. Methods: This was a cross-sectional study done in the department of Infectious and Tropical Diseases in lomé from ESOPE database. Glomerular filtration rate (GFR) was calculated using the Modification of Diet in Renal Disease (MDRD) equation. Kidney disease was defined as GFR less than 90 mL/min/1.73 m2. Results: In total, 3118 HIV-infected ART-naive patients were included in this study. Among them, the prevalence of renal disease at the beginning of their care, was 41.8% or 1303 patients [95% CI: 40.0% - 43.5%]. The median estimated GFR was 94.7 ml/min/1.73 m2: 2.9% had eGFR 2. The median age was 40 years [IQR = 34 - 48 years] with a sex ratio at 0.45. BMI median was 20.6 Kg/m2. Most of patients (30.8%) were at clinic OMS stage 1. Median CD4 was 165/uL [IQR = 72 - 274/uL];median hemoglobin was 10.4 g/dl [IQR = 8.8 - 11.9 g/dl];median glycemia was 0.84 g/l [IQR = 0.75 - 0.95 g/l]. Most of patients (99.9%) had HIV-1. 8.5% had hyperleukocytosis, and all patients had thrombopenia. Conclusion: The incidence of kidney disease is high in Togolese HIV-infected ART naive patients.

关键词： HIV Kidney Disease Prevalence Togo

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Correlation between Asymptomatic Bacteriuria and HIV-1 Viral Load Level and CD4 Count in Pregnant Women on Antiretroviral Therapy in N’djamena (Chad)

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World Journal of AIDS 2015年第4期5卷 308-312页

作者： Adoum Fouda Abderrazzack Mounerou Salou Akouda Patassi degninou Yehadji Yaovi Ameyapoh service de Laboratoire et médicaments du Programme Sectoriel de lutte contre le sida et les Infections Sexuellement Transmissibles N’djamena Tchad Laboratoire de microbiologie et de controle de qualité de denrées alimentaires Ecole Supérieure des Techniques Biologiques et Alimentaires University of Lomé Lomé Togo Département des sciences fondamentales Faculty of Health Science University of Lomé Laboratory of Microbiology CHU Sylvanus OLIMPYO Lomé Togo Centre de biologie moléculaire et d’immunologie FSS/UL Lomé Togo service des maladies infectieuses CHU Sylvanus OLIMPYO Lomé Togo Ministry of Health Lomé Togo

A cross-sectional study was conducted at the “Centre de l’Appui Psycho-Médico-Social (APMS)” which is a centre for Psychological and Medical Support in N'Djamena (Chad) from January to March 2014. The aim of this study was to evaluate the correlation between asymptomatic bacteriuria (ASB) and viral load level and CD4 count in seventy-six (76) HIV-1 infected pregnant women on antiretroviral therapy (ART). Urine culture and bacteria identification were performed by using a chromogenic culture medium (UriselectR4). T CD4+ lymphocytes count and viral load measurement were done respectively on PIMATM test and Abbott m2000 RealTime HIV-1. In this study, 25 (32.9%) pregnant women were carrying ASB and major bacteria;Escherichia coli and Streptococcus agalactiae known to cause neonatal meningitis to newborns were identified. Bacteria were isolated mainly in women with CD4 lymphocytes 3log (70%) (19/25). Besides the prevention of mother to child transmission of HIV, which remains a goal, it is important to prevent also the transmission of other microorganisms causing neonatal infections. Our findings support the needs to do bacteriological analysis of urine in every HIV-infected pregnant woman at least in late pregnancy.

关键词： Pregnant Women Asymptomatic Bacteriuria Lymphocyte CD4 Viral Load

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