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Management of Idiopathic Chronic hydrocephalus of the Adult in Guinea: A prospective Study in 16 patients

Open Journal of Modern Neurosurgery 2021年第4期11卷 272-280页

作者： Alpha Boubacar Bah Ibrahima Sory Souare Ibrahima Berete Seylan Diawara hugues Ghislain Atatla Aboubacar M’mah Camara Mamadou Khaira Bah Luc Kezely Beavogui service de Neurochirurgie H&#244 pital National Donka Conakry Guinea service de Neurochirurgie H&#244 pital de l’Amitié Sino-Guinéenne de Kipé Conakry Guinea

Object: Incidence of Idiopathic chronic hydrocephalus of the adult (IChA) is increasing in Guinea due to the aging of the population. The goal of this study was to describe its epidemiology, clinical presentation, and... 详细信息

Object: Incidence of Idiopathic chronic hydrocephalus of the adult (ICHA) is increasing in Guinea due to the aging of the population. The goal of this study was to describe its epidemiology, clinical presentation, and surgical outcome in a low-resource medical environment. Method: Sixteen patients operated for a probable ICHA were prospectively studied according to a uniform protocolpan> from June 2019 to December 2020. On computerized tomography, all operated patients had a clinical triad of gait disturbance, incontinence, dementia associated with ventriculomegaly, and transependymal edema. In addition, all patients underwent a single lumbar tap, improved clinically, and were subsequently offered a shunt consisting of a simple catheter in 37.5% and a non-adjustable high-pressure valve in 62.5%. Result: The mean age was 68.31 pan>± 10.4 (range 49 - 89). The sex ratio H/F was 1.67/1. Clinically, the most frequent comorbidity was a combination of hypertension and diabetes in 56.5% of cases. pan style="font-family:Verdana;">The mean time to diagnosis was 8.31 ± 2.75 months (range 3 - 14). The immediate postoperative mortality was 12.5% from a status epilepticus and pulmonary sepsis. In addition, we observed 2 cases of chronic subdural hematoma (12.5%) and 2 cas

关键词： Idiopathic Normal pressure hydrocephalus Comorbidities Ventriculoperitoneal Shunt Lumbar puncture

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Endoscopic Third Ventriculostomy with or without Choroid plexus Coagulation for Treatment of hydrocephalus in Guinea: Analysis of 76 Cases in the department of Neurosurgery of Kipe, Conakry

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Open Journal of Modern Neurosurgery 2021年第4期11卷 242-251页

作者： I. S. Souare A. B. Bah S. Diawara I. Berete I. J. S. Souare D. T. Boubane M. Cherif A. M. Camara L. K. Beavogui service de Neurochirurgie H&#244 pital de l’Amitié Sino-Guinéenne de Kipe Conakry Guinea service de Neurochirurgie H&#244 pital National Donka Conakry Guinea

In low-income countries, endoscopic third ventriculostomy (ETV) with or without choroid plexus coagulation (CpC) is an increasingly accepted alternative to shunt therapy in adult and pediatric hydrocephalus. The autho... 详细信息

In low-income countries, endoscopic third ventriculostomy (ETV) with or without choroid plexus coagulation (CPC) is an increasingly accepted alternative to shunt therapy in adult and pediatric hydrocephalus. The authors report the result of this treatment in Conakry in a mixed population of adult and pediatric patients regardless of the etiology of the hydrocephalus. A retrospective study was conducted on 76 patients undergoing 89 ETV from January 2013 to September 2020. The predominant group of patients was infants less than one year with a mean age of 4.3 months and extremes of 1 - 8 months. The H/F sex ratio was 1.7/1. All patients presented acutely with signs of high intracranial pressure. Post-infectious causes and malformations and tumors were the main etiologies, respectively 21%, 47.3%, and 15.7%. The mean duration of the endoscopic procedures was 49.93 ± 10.9 mm, associated with a choroid plexus coagulation in 42% of cases. The complication rate in the first month was 22%, with CSF leak (5%) and death (11%) accounting for the majority. At three months, the complications rates were 45%, with 14.4% closed stroma, 6% epilepsy, and 24% mortality. The mean follow-up was 28 months (range 2 - pan style="font-family:Verdana;">53), and the global success rate of 61%. Our study, with its limitations, shows that ETV with CpC is a safe primary approach for the treatment of hydrocephalus in low-income countries regardless of the etiology and the age of the patients.

关键词： hydrocephalus Endoscopic Third Ventriculostomy Choroid plexus Coagulation Low-Income Countries

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Ribavirin:past,present and future

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World Journal of hepatology 2016年第2期8卷 123-130页

作者： Véronique Loustaud-Ratti Marilyne debette-Gratien Jérémie Jacques Sophie Alain pierre Marquet denisSautereau Annick Rousseau paul Carrier Fédération hépatologie CHU Dupuytren87042 LimogesFrance service d’hépatogastroentérologie CHU Limoges87042 LimogesFrance U850 INSERM Universitéde LimogesCHU Limoges87042 LimogesFrance service de Bactériologie Virologie CHU Limoges87042 LimogesFrance U1092 INSERM Universitéde LimogesCHU Limoges87042 LimogesFrance service de pharmacologie CHU Limoges87042 LimogesFrance

Before the advent of direct acting antiviral agents(DAAs) ribavirin, associated to pegylated-interferon played a crucial role in the treatment of chronic hepatitis C, preventing relapses and breakthroughs. In the present era of new potent DAAs, a place is still devoted to the drug. Ribavirin associated with sofosbuvir alone is efficient in the treatment of most cases of G2 infected patients. All options currently available for the last difficult-to-treat cirrhotic G3 patients contain ribavirin. Reducing treatment duration to 12 wk in G1 or G4 cirrhotic compensated patients is feasible thanks to ribavirin. Retreating patients with acquired anti NS5 A resistance-associated variants using ribavirin-based strategies could be useful. The addition of ribavirin with DAAs combinations however, leads to more frequent but mild adverse events especially in cirrhotic patients. preliminary data with interferon-free second generation DAAs combinations without ribavirin suggest that future of the drug is jeopardized even in difficult-totreat patients: The optimization of ribavirin dosage according to an early monitoring of blood levels has been suggested to be relevant in double therapy with peginterferon or sofosbuvir but not with very potent combinations of more than two DAAs.

关键词： Ribavirin hepatitis C peginterferon Directacting antiviral agents

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L’hypnose en oncologie pédiatrique hypnosis in pediatric Oncology

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psycho-Oncologie 2023年第4期17卷 225-233页

作者： Jennifer Marini Audrey Vanhaudenhuyse Marie Lacasse Maud Jaspard Marie-Elisabeth Faymonville hadrien Tasset Christophe F.Chantrain Charlotte Grégoire service d’hémato-oncologie pédiatrique CHC MontLégiaLiège4000Belgique Sensation&perception Research Group(GIGA Consciousness Universitéde Liège)Liège4000Belgique Centre Interdisciplinaire d’Algologie CHU de LiègeLiège4000Belgique Institut de Cancérologie Arsène Burny CHU de LiègeLiège4000Belgique

hypnosis is a modified state of consciousness which showed its benefits to decrease different symptoms,mainly *** the last decade,this technique has also been proposed to adults with cancer to improve other symptoms,such as emotional distress,fatigue,or sleep *** pediatric oncology,hypnosis is also used to decrease disease-,treatment-,and procedure-related pain and *** learning of self-hypnosis and self-care techniques also improves the well-being of adults or children with cancer,their parents,and their *** several clinical cases,we will illustrate how hypnosis and self-care techniques have been implemented in the pediatric haemato-oncology department of the ChC MontLégia(Liège,Belgium)and will describe their benefits.

关键词： pediatric oncology hypnosis analgesia self-monitoring quality of life

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Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia

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Cellular & Molecular Immunology 2021年第11期18卷 1290-1304页

作者： Adeline Crinier pierre-Yves Dumas Bertrand Escalière Christelle piperoglou Laurine Gil Arnaud Villacreces Frédéric Vély Zoran Ivanovic pierre Milpied Émilie Narni-Mancinelli Éric Vivier Aix Marseille University CNRSINSERMCentre d’Immunologie de Marseille-LuminyMarseilleFrance ChU Bordeaux Service d’Hématologie Clinique et de Thérapie CellulaireBordeauxFrance Bordeaux University BordeauxFrance Institut National de la Santéet de la Recherche Médicale U1035BordeauxFrance AphM Hôpital de la TimoneMarseille-ImmunopôleMarseilleFrance Établissement Français du Sang Nouvelle Aquitaine BordeauxFrance Innate pharma Research Laboratories Innate PharmaMarseilleFrance

Natural killer(NK)cells are innate cytotoxic lymphoid cells(ILCs)involved in the killing of infected and tumor *** human and mouse NK cells from the spleen and blood,we previously identified by single-cell RNA sequencing(scRNAseq)two similar major subsets,NK1 and *** the same technology,we report here the identification,by single-cell RNA sequencing(scRNAseq),of three NK cell subpopulations in human bone *** analysis identified a subset of resident CD56^(bright) NK cells,NK0 cells,as the precursor of both circulating CD56dim NK1-like NK cells and CD56^(bright) NK2-like NK cells in human bone marrow and spleen under physiological *** profiles of bone marrow NK cells from patients with acute myeloid leukemia(AML)exhibited stress-induced repression of NK cell effector functions,highlighting the profound impact of this disease on NK cell *** marrow NK cells from AML patients exhibited reduced levels of CD160,but the CD160high group had a significantly higher survival rate.

关键词： NK cells scRNASeq AML

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The Outcome of Adolescent-Onset Anorexia Nervosa: A Study of 144 Cases

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health 2014年第14期6卷 1883-1893页

作者： Solenn Kermarrec Bernard Kabuth Anne-Christine Rat Michel Vidailhet Colette Vidailhet EA 3444 Faculté de Médecine Université Henri Poincaré Nancy I Nancy France p&ocirc le hospital Universitaire de psychiatrie de l’Enfant et l’adolescent Rennes France service de pédiatrie 3 et Génétique CHU Nancy Nancy France service de psychiatrie de l’Enfant et de l’Adolescent CHU Nancy Nancy France

Objectives: To evaluate the long-term outcome of adolescents with anorexia nervosa and attempt to define prognostic factors for outcome. Methods: Transversal, descriptive epidemiological study with a strict methodology: minimum interval of 4 years since first admission, evaluation using clearly defined diagnostic criteria (EAT-40 self-evaluation, hSCL, global patient-driven self-evaluation and hetero evaluation: clinical interview and LECE). The 198 subjects are former adolescent anorexics treated at the hôpital d’Enfants (Children’s hospital) in Nancy (France). Results: Clinical evaluation of the 144 subjects traced showed positive outcome for 68.1%, intermediate outcome for 23.2% and poor outcome for 8.7%. 5 factors for a good prognosis were found (middle socioeconomic class of parents, no prior treatment, hospitalization > 1 month,

关键词： Anorexia Nervosa Adolescent Epidemiology prognosis Outcome

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病例报道:儿童毛石5例

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世界核心医学期刊文摘（儿科学分册） 2006年第4期2卷 20-21页

作者： Roche C. Guye E. Coinde E. J.- L. Sté p-han 朱新菊 service de pédiatrie Hpital Nord CHU Saint-tienne 42055 de Saint-Etienne Cedex 02 France

Trichobezoars are made up of concretions of ingested hair and food. A history of occlusive syndrome in a context of trichotillomania and psychological problems must lead to this diagnosis. Bezoars can be fortuitously recognised by palpation of an epigastric abdominal mass while investigating anemia or esophageal reflux. This deviance is particularly dangerous. The first case of this series illustrates the Rapunzel syndrome with many perforations and necrosis of the small bowel. The 4 others are strict intragastric bezoars, quickly identified by echography. Treatment is exclusively surgical, digestion by papain or endoscopic extraction being impossible. psychological assistance is mandatory.

关键词：超声描记术拔毛癖内镜取石上腹部外科手术木瓜蛋白酶

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Transient and etiology-related transcription regulation in cirrhosis prior to hepatocellular carcinoma occurrence

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World Journal of Gastroenterology 2009年第3期15卷 300-309页

作者： Frédérique Caillot Céline derambure paulette Bioulac-Sage Arnaud Franois Michel Scotte Odile Goria Martine hiron Maryvonne Daveau Jean-philippe Salier Inserm Unité 905 and Institut Fédératif de Recherches Multidisciplinaires sur les peptides Faculté de Médecine-Pharmacie76183 RouenFrance service d'Anatomie pathologique Centre Hospitalier Universitaireand Inserm U88933000 BordeauxFrance Département pathologie Centre Hospitalier Universitaire76183 RouenFrance service de Chirurgie Générale et Digestive Centre Hospitalier Universitaire76183 RouenFrance service d'hépato-gastro-entérologie Centre Hospitalier Universitaire76183 RouenFrance

AIM： To search for transcription dysregulation that could （1） differentiate hepatocellular carcinoma （hCC）-free from hCC-related cirrhosis （2） differentiate hCC-free cirrhosis related to hCV from that related to alcohol intake. METhODS： Using microarray analysis, we compared transcript levels in hCC-free cirrhosis （alcoholism： 7; hepatitis C： 7）, hCC-associated cirrhosis （alcoholism： 10; hepatitis C： 10） and eight control livers. The identified transcripts were validated by qRT-pCR in an independent cohort of 45 samples （20 hCC-free cirrhosis; 15 hCC-associated cirrhosis and 10 control livers）. We also confirmed our results by ***： In hCC-free livers, we identified 70transcripts which differentiated between alcoholicrelated-cirrhosis, hCV-related cirrhosis and control livers. They mainly corresponded to down-regulation. Dysregulation of Signal Transduction and Activator of Transcription-3 （STAT-3） was found along with related changes in STAT-3 targets which occurred in an etiology-dependent fashion in hCC-free cirrhosis. In contrast, in hCC, such transcription dysregulations were not observed. CONCLUSION： We report that transcriptional dysregulations exist in hCC-free cirrhosis, are transiently observed prior to detectable hCC onset and may be appear like markers from cirrhosis to hCC transition.

关键词： Liver pathology Alcoholism hepatitis Cvirus Gene expression Carcinogenesis

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have some landscapes in the eastern Canadian boreal forest moved beyond their natural range of variability?

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Forest Ecosystems 2018年第4期5卷 412-428页

作者： pierre Grondin Sylvie Gauthier Veronique poirier patrice Tardif Yan Boucher Yves Bergeron Direction de la Recherche Forestiere Ministere des Foretsde la Faune et des Pares (MFFP)2700rue EinsteinQuebecQC GIP 3W8Canada Ressources Naturelles Canada/Natural Resources Canada Service Canadien des forets/Canadian Forest ServiceCentre de foresterie des Laurentides/Laurentian Forestry Center1055 rue du P.E.P.SQuebecQC G1V 4C7 Canada Institut de Recherche sur les Forets Universite du Quebec en Abitibi-Temiscamingue445boul.de I'UniversiteRouyn-NorandaQC J9X 5E4Canada Centre d'etude de la Foret Universite du QuebecMontreal CP 8888succ AMontrealQC H3C 3P8Canada

Background: In the contxt of ecosystem management, the present study aims to compare the natural and the present-day forested landscapes of a large territory in Quebec(Canada). Using contemporary and long-term fire cycles, each natural forst landscape is defined according to the variability of its structure and composition, and compared to the present-day landscape. This analysis was conducted to address the question of whether human activities have moved these ecosystems outside the range of natural landscape ***: The study encompassed a forested area of 175 000 km2 divided into 14 landscapes. Using a framework that integrates fire cycles, age structure and forest dynamics, we characterized the forest composition and age structures that resulted from three historical fire cycles(110,140, and 180 years) representative of the boreal forest of eastern Canada. The modeled natural landscapes were compared with present-day landscapes in regard to the proportion of old-growth forests(landscape level) and the proportion of late-successional forest stands(landscape level and potential vegetation type).Results: Four landscapes(39%) remain within their natural range of variability. In contrast, nine landscapes(54%)show a large gap between natural and present-day landscapes. These nine are located in the southern portion of the study area, and are mainly associated with Abies-Betula vegetation where human activities have contributed to a strong increase in the proportion of populus tremuloides stands(early-successional stages) and a decrease of oldgrowth forest stands(more than 100 years old). A single landscape(7%), substantially changed from its potential natural state, is a candidate for adaptive-based ***: Comparison of corresponding natural(reference conditions) and present-day landscapes showed that ten landscapes reflecting an important shift in forest composition and age structure could be considered beyond the range of their natural v

关键词： Ecosystem management Reference conditions Natural variability Resilience Fire cycle Age structure Forest dynamics potential vegetation type Landscape ecology Theoretical natural landscape present-day landscape

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Introduction to Synchronized Kinematic and Electromagnetic Mechanics

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Journal of Modern physics 2023年第6期14卷 876-932页

作者： André Michaud service de Recherche pédagogique Québec Canada

Introduction to fundamental physics according to the parallel harmonization of kinematic and electromagnetic mechanics, in accordance with Wilhelm Wien’s project, which involved the integration in kinematic mechanics of the mass increase of the electron as a function of its velocity, as measured by Walter Kaufmann with his bubble-chamber experiments, and analyzed and confirmed by h. A. Lorentz and all the leading edge physicists who then re-analyzed this data.

关键词： Kinematic Mechanics Electromagnetic Mechanics Electrostatic Recall Constant Restoration Force Gravitation

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