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Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María portela-Lomba paloma Sobrado-Calvo Diana Simón Johnny Di pierdomenico Alejandro Gallego-Ortega Mar pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MhCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

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Role of immunosuppression and tumor differentiation in predicting recurrence after liver transplantation for hepatocellular carcinoma: A multicenter study of 412 patients

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World Journal of Gastroenterology 2006年第45期12卷 7319-7325页

作者： Thomas decaens Franoise Roudot-Thoraval Solange Bresson-hadni Carole Meyer Jean Gugenheim Francois Durand pierre-henri Bernard Olivier Boillot philippe Compagnon Yvon Calmus Jean hardwigsen Christian Ducerf Georges philippe pageaux Sébastien Dharancy Olivier Chazouillères Daniel Cherqui Christophe Duvoux service d'hépatologie et de Gastroentérologie AP-HP Hpital Henri Mondor Créteil Unité INSERM 581 France Département de Santé publique AP-HP Hpital Henri Mondor Créteil France service d’hépatologie Hpital Jean Minjoz Besanon France service de Transplantation Hpital HautefeuilleStrasbourg France service de Chirurgie Digestive Hpital L’Ar-chet 2 Nice France service d’hépatologie AP-HP Hpital Beau-jon Clichy France service d’hépatologie et de Gastroentéro-logie H?pital Pellegrin Bordeaux France service de Chirurgie Digestive Hpital Edouard Herriot Lyon France service de Chirurgie Digestive Hpital Ponchaillou Rennes France service de Chirurgie Digestive AP-HP HpitalCochin Paris France service de Chirurgie Digestive Hpital laConception Marseille France service de Chirurgie Digestive Hpital de laCroix Rousse Lyon France Fédération Médico-Chirurgicale deMaladies de l’Appareil Digestif Hpital Saint-Eloi MontpellierFrance service d’hépatologie et de Gastroentérologie H?pital Claude Huriez Lille France service d’hépatologie AP-HP Hpital SAntoine Paris France service de Chirurgie Générale et Digestive APHP Hopital Henri Mondor Créteil France

AIM： To assess pre-orthotopic liver transplantation （OLT） factors that could be evaluated pre-operatively or controlled post-operatively associated with hepatocellular carcinoma （hCC） recurrence and disease-free survival after liver transplantation （LT）.METhODS： Four hundred and twelve patients transplanted for hCC between 1988 and 1998 in 14 French centers, who survived the postoperative period were studied. Kaplan Meier estimates were calculated for 24 variables potentially associated with recurrence of hCC. Uni- and multivariate analyses were conducted to identify independent predictors of recurrence. RESULTS： Overall 5-year disease-free survival was 57.1%. By univariate analysis, variables associated with disease-free survival were： presence of cirrhosis （p = 0.001）, etiology of liver disease （p = 0.03）, α fetoprotein level （〈 200, 200 to 2000, or 〉 2000; p 〈 0.0001）, y-GT activity （N, N to 2N or 〉 2N; p = 0.02）, the number of nodules （1, 2-3 or ≥ 4; p = 0.02）, maximal diameter of the largest nodule （〈 3 cm, 3 to 5 cm or 〉 5 cm; p 〈 0.0001）, the sum of the diameter of the nodules （〈 3 cm, 3 to 5 cm, 5 to 10 cm or 〉10 cm; p 〈 0.0001）, bilobar location （p = 0.01）, preoperative portal thrombosis （p 〈 0.0001）, peri-operative treatment of the tumor （p = 0.002） and chemoembolization （p = 0.03）, tumor differentiation （p = 0.01）, initial type of calcineurin inhibitor （p = 0.003）, the use of antilymphocyte antibodies （p = 0.02）, rejection episodes （p = 0.003） and period of LT （p 〈 0.0001）. By multivariate analysis, 6 variables were independently associated with hCC recurrence： maximal diameter of the largest nodule （p 〈 0.0001）, time of LT （p 〈 0.0001）, tumor differentiation （p 〈 0.0001）, use of anti-lymphocyte antibody （ATG） or anti-CD3 antibody （OKT3）（p = 0.005）, preoperative portal thrombosis （p = 0.06） and the number of nodules （p = 0.06）. CONCLUSION： This study identifies immunosuppression, through the use of ATG or OKT3, as a predictive factor of tumor recur

关键词： Immunosuppression hepatocellular carcinoma Tumor differentiation Liver transplantation

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Management of Severe Acute Malnutrition in a Senegalese paediatric hospital

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Open Journal of pediatrics 2021年第2期11卷 198-207页

作者： Ndiogou Seck Idrissa Basse Djibril Boiro Younoussa Keïta Lamine Thiam Aliou Abdoulaye Ndongo Ndéye Rama Diagne-Gueye service de pédiatrie Centre Hospitalier Régional de Saint-Louis Saint-Louis Sénégal hô pital pour Enfants de Diamniadio Bargny Sénégal service de pédiatrie Centre Hospitalier Abass Ndao Dakar Sénégal service de pédiatrie hô pital Aristide Ledantec Dakar Sénégal service de pédiatrie H&ocirc pital de la paix Boucoutte Ziguinchor Sénégal

Malnutrition is a global health problem. It is very common in developing countries where it contributes to an increase in morbidity and mortality, especially among children under five years of age. The main objective of this study was to describe the management of severe acute malnutrition (SAM) in children six months to five years of age hospitalized at Diamniadio Childrenpan>’s Hospital (DCH). This was an epidemiological, retrospective, descriptive and cross-sectional study of children aged six to 59 months hospitalized at DCH for SAM. The study took place over a 12-month period (from January 1, 2018 to December 31, 2018). During the study period, 67 children were admitted for SAM, representing a hospital prevalence of 8.4%. The majority (88%) children were less than 24 months old. Reasons for consultations were dominated by diarrhea (57.5%) vomiting (38.8%). Complications related to SAM were mainly: anaemia (74.6%), infections (85%) and severe acute dehydration (40.3%). Factors associated with SAM were young age (infants under 24 months of age), poverty, the first four children of a sibling, poor behaviour of food diversification. The average length of hospitalization was 12 days. The nutritional recovery rate was 73.1% and lethality was 3%.pan> Conclusion: The prevention of malnutrition must involve the fight against poverty, an optimal and well-diversified diet, monitoring the nutritional status of children up to five years of agepan style="font-family:Verdana;">.

关键词： Severe Acute Malnutrition Children Complications Risk Factors Lethality

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Gemcitabine in elderly patients with advanced pancreatic cancer

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World Journal of Gastroenterology 2011年第30期17卷 3497-3502页

作者： Olivia hentic Vinciane Rebours philippe Lévy philippe Ruszniewski pascal hammel Magaly Zappa Chantal Dreyer Eric Raymond ple des maladies de l'Appareil Digestif Service de PancréatologieHpital Beaujon100 boulevard du général Leclerc92110 ClichyFrance ple des maladies de l’Appareil Digestif Service de PancréatologieHpital Beaujon100 boulevard du général Leclerc92110 ClichyFrance service de Radiologie Hpital Beaujon100 boulevard du général Leclerc92110 ClichyFrance service de Cancérologie Hpital Beaujon100 boulevard du général Leclerc92110 ClichyFrance

AIM： TO assess feasibility, tolerability and efficacy of gemcitabine-based chemotherapy in patients ≥ 75 years old with advanced pancreatic cancer. METhODS： All consecutive patients ≥ 75 years old with advanced pancreatic adenocarcinoma were included in this retrospective study. Necessary criteria to receive chemotherapy were： performance status 0-2, adequate biological parameters and no serious comorbidities. Other patients received best supportive care （BSC）. RESULTS： Thirty-eight patients （53% women, median age 78 years, range 75-84） with pancreatic cancer （metastatic： n = 20, locally advanced： n = 18） were studied. Among them, 30 （79%） were able to receive chemotherapy [median number： 9 infusions （1-45）]. Six patients （23%） had at least one episode of grade 3 neutropenia and one patient developed a grade 3 hemolytic-uremic syndrome. No toxic death occurred. Three patients （11%） had a partial tumor response, 13 （46%） had a stable disease and 12 （43%） had a tumor progression. Median survival was 9.1 mo （metastatic： 6.9 too, locally advanced： 11.4 too）. CONCLUSION： Tolerance and efficacy of gemcitabinebased chemotherapy is acceptable in elderly patients in good condition, with similar results to younger patients.

关键词： Elderly pancreas Cancer Gemcitabine

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descriptive and Analytical Study of Factors Associated with Mortality in Severe Malaria among Children in Dakar Emergency departments from July to december 2022

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Open Journal of pediatrics 2023年第6期13卷 866-878页

作者： Aliou Thiongane Abou Ba Fatou Ly Aliou A. Ndongo Djibril Boiro Younoussa Kéita Idrissa Basse Babacar Niang Indou Dême Ly Yaye Joor Dieng Djenaba Fafa Cissé Ndiogou Seck Lamine Thiam papa Moctar Faye Amadou Lamine Fall Assane Sylla Ousmane Ndiaye Centre hospitalier National d’Enfants Albert Royer Dakar Sénégal service de pédiatrie hô pital Dalal Jamm Dakar Sénégal service de pédiatrie hô pital Pikine Dakar Sénégal service de pédiatrie hô pital Abass Ndao Dakar Sénégal Centre hospitalier National d’Enfants de Diamniadio Dakar Sénégal service de pédiatrie hô pital régional Saint Louis Sénégal service de pédiatrie hô pital de la paix de Ziguinchor Ziguinchor Sénégal

Background: Malaria is the most widespread parasitic disease and remains a public health priority worldwide. The severe form is fatal if not treated early and appropriately. The aim was to carry out a descriptive and analytical study of the factors associated with mortality during severe malaria in children attending emergency departments in Dakar, Senegal. Methods: This is a prospective, observational and analytical study conducted over a 6-month period (July 1 to december 31, 2022), focusing on children hospitalized for severe malaria according to WhO severity criteria. Results: A total of 403 patients were hospitalized, including 78 cases of severe malaria (19.35%). Males predominated (60.26%) (sex ratio 1.51). The average age was 6.56 years [8 months - 14 years], with the [5 - 10 years] age group the most represented (40.26%). The average consultation time was 5.33 days (1 - 19 days). The main reasons for consultation were fever (70.51%), vomiting (24.35%) and convulsions (14.10%). Biological signs of severity were severe anemia (17.95%), renal failure (6.4%) and hypoglycemia (3.85%). Thrombocytopenia was noted in 52.56% of patients, including 32.05% of severe cases (sis in 61.41% of cases. hyponatremia was noted in 39.74% of cases and hyperkalemia in 2 patients. Artesunate was the main drug used (93.59% of cases). Mortality was estimated at 1.5%. Factors leading to death were coma (p piratory distress (p Conclusion: Malaria is still a public health problem, with a high mortality rate in emergency departments. Reducing this mortality rate requires effective management of the factors associated with death.

关键词： Children Malaria death Factors

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pediatric hIV Infection in Togo: Situation of Child Care in the Central Region from 2008 to 2015

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World Journal of AIDS 2017年第4期7卷 260-268页

作者： F. Agbeko T. Guedehoussou K. D. Azoumah O. E. Takassi M. Fiawoo K. A. R. Segbedji O. B. Tchagbele M. Kpegouni K. Tongon K. E. Djadou D. Y. Atakouma A. D. Agbere service de pédiatrie CHR-Lomé Commune Lomé Togo service de pédiatrie CHU Kara Kara Togo service de pediatrie CHU-Sylvanus Olympio Lomé Togo service de pédiatrie Centre Des Armées Lomé Togo

This piece of work covers thirteen (13) AIDS assistance programs sites over the period 1st January 2008 to 31st december 2015. The study is retrospective, descriptive, and cross-sectional based on 292 clinical cases of hIV infected children aged between 0 and 14 years old. A regional committee was charged to validate antiretroviral treatment (ART) prescriptions on a weekly basis. We have also used data from the regional committee register. hIV infected children represent 5.1% of casework on ART. The average starting age for ART was 4.5 years (1 - 180 months) with a sex ratio (Male/Female) of 0.9. The clinical classifications according to WhO guidelines were: Stage III (52.3%) and Stage IV (20.3%). The most frequent opportunistic infections were: wasting (40.12%), digestive candida infection (29.0%), acute respiratory infections (22.8%) and skin diseases (17.9%). The hIV type 1 was detected on all of the children (100%). The average rate of CD4 at the beginning of the ART was 552.98 cells/mm3, leading to a severe immuno-suppression in many cases (44.8%). The initial ART was essentially NEVIRApINE + LAMIVUDINE + STAVUDINE. hIV infections diagnosis are usually late in the Central Region of Togo and will therefore be improved by the UNAIDS 90-90-90 strategic plan by 2020, through various initiatives. These are: the prevention of Mother to Child hIV Transmission (pMTCT), the Early Infection Diagnosis (EID) based on polymerase Chain Reaction (pCR) and the provider Initiated Testing and Counseling (pITC).

关键词： hIV AIDS ART Children Togo

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Epidemiology of Admissions in a pediatric Emergency department in Albert Royer hospital Dakar

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Open Journal of pediatrics 2022年第1期12卷 188-195页

作者： Aliou Thiongane Aliou Abdoulaye Ndongo Amadou Sow Younoussa Keita Djibril Boiro Yaye Joor Dieng Idrissa Basse Ndiogou Seck Lisimo Abwa hilaire papa Moctar Faye Amadou Lamine Fall Assane Sylla Saliou Diouf Ousmane Ndiaye Centre hospitalier National d’Enfants Albert Royer Dakar Sénégal service de pédiatrie hô pital Le Dantec Dakar Sénégal service de pédiatrie hô pital Abass ndao Dakar Sénégal Centre hospitalier National d’Enfants de Diamniadio Dakar Sénégal service de pédiatrie hô pital régional Saint Louis Sénégal service de pédiatrie hô pital Dalal Jamm Dakar Sénégal

Background: pediatric emergencies are a public health priority in Senegal. The objective was to describe the epidemiology of admissions to the emergency department of the Albert Royer National Children’s hospital in Dakar, Senegal. Methods: prospective, descriptive and analytical study over a period of 4 months (January-April 2020). The study population was children admitted for vital distress. Results: A total of 300 children met the inclusion criteria and represented the study population (2.83%). The majority (70.67%) were younger than 60 months, compared with 2.00% of newborns. Boys represented 53.8%, sex ratio 1.16. A proportion of 35.1% was referred. More than half of our patients (55.88%) were managed within 30 minutes of arrival. Medicalized transport concerned 21.5% against 78.5% of nonmedicalized. Emergencies were dominated by respiratory distress (56.33%), dehydration (29%) and shock (13.33%). We recorded 16 deaths (5.3%). This mortality was significantly related to the low socio-economic level (p = 0.000), as well as the young age of the children (p = 0.01). Conclusion: Life-threatening emergencies are frequent and responsible for significant lethality. health policy efforts are still needed to reduce this infant and child morbidity and mortality.

关键词： Children Emergencies Morbidity Mortality

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Clinical and Molecular Cytogenetic Study of 38 Williams-Beuren Syndrome Tunisian patients

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Open Journal of Genetics 2014年第5期4卷 385-391页

作者： Ines Ouertani Myriam Chaabouni Imen Chelly Lilia Kraoua Faouzi Maazoul Mediha Trabelsi Rym Meddeb Rafik Boussaada hatem Azzouz Fatma Charfi Emira Ben hamida Ahmed Meherzi Ridha Mrad habiba Bouhamed-Chaabouni service des Maladies Congénitales et héréditaires H&#244pital Charles Nicolle Tunis Tunisie service de pédiatrie H&#244pital Régional de Bizerte Bizerte Tunisie service de Cardiologie pédiatrique H&#244pital la Rabta Tunis Tunisie service de pédiatrie H&#244pital la Rabta Tunis Tunisie service de pédopsychiatrie H&#244pital Razi La Mannouba Tunisie service de Néonatologie H&#244pital Charles Nicolle Tunis Tunisie service de pédiatrie H&#244pital Mongi Slim La Marsa Tunisie

Background: Williams-Beuren syndrome (WBS) is a rare multi-system genomic disorder, caused by 7q11.23 microdeletion with a prevalence of 1/7500 - 1/20,000 live births. Clinical phenotype includes typical facial dysmorphism (elfin face), mental retardation associated with a peculiar neuropsychological profile and congenital heart defects. Other signs are occasional like ocular, skeletal, renal and dental anomalies. here in, we present 38 WBS Tunisian patients. Methods: All patients underwent a genetic consultation and in order to confirm the clinical diagnosis of WBS, fluorescent in situ hybridization (FISh) was applied on metaphase spreads using the dual color locus specific identifier WBS region probe (Vysis probe) that hybridized to the ELN and LIMK1 loci at 7q11.23 and to control loci D7S486 and D7S522 at 7q31. About 15 to 20 metaphases were analyzed for each case. Results: The mean age at diagnosis was 4 years and 4 months. All patients showed facial dysmorphism. 66% (23/35) have cardiovascular anomaly, peripheral pulmonary stenosis (10/35) is interestingly more frequent than the supravalvular aortic stenosis (7/35). Various degrees of mental retardation were present and a normal intelligence was found in three patients. The unique cognitive profile was found in all patients except one who had autistic disorders. Ocular anomalies (13/38) were less frequent than described, the skeletal anomalies too (12/38). dental malformations were frequent (22/32). Idiopathic hypercalcemia was present in 50% of children less than one year (2/4). Conclusions: WBS was a rare disorder, cardinal signs (facial dysmorphism, mental retardation and cardiovascular defects) were found in our patients in the same proportions than described. The occasional clinical signs have proportion different of precedent reported like hypercalcemia, ocular and dental anomalies. The identification of the different clinical signs in WBS patients permits to establish a strategy of follow up.

关键词： Williams-Beuren Syndrome FISh Dysmorphism Cardiovascular Malformation

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Respiratory Complications of Measles in the pediatric Ward of the Regional hospital of Kindia/Guinea

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Open Journal of pediatrics 2023年第5期13卷 727-733页

作者： Mohamed Lamine Diallo Mamadou Ciré Barry Fatoumata Binta Diallo Kaba Bangoura hessou Agossi Nouvidomé Chimène Telly Sy Urgences pédiatriques Donka National Hospital Conakry Guinea service de pédiatrie H&#244pital National Ignace Deen Conakry Guinea service de pédiatrie Donka National Hospital Conakry Guinea service de pédiatrie H&#244pital Régional de Kindia Kindia Guinea service de Gynécologie-Obstétrique hopital National Ignace deen Conakry Guinea

Introduction: Measles is a highly contagious infectious disease caused by the measles virus belonging to the morbillivirus genus, the measles morbillivirus species and the paramyxoviridae families. The aim was to study respiratory complications due to measles in children aged 1 to 15 in the pediatric ward of the Kindia regional hospital. Materials and Methods: A transversal descriptive study was carried out in the pediatrics department of the Kindia Regional hospital from October 1, 2019, to March 31, 2020, on children aged 1 to 15 years hospitalized for measles with respiratory complications. Results: 53 cases of measles were recorded, i.e. 11.71% of hospital pathologies including 32 cases of respiratory complications, i.e. 60.38% with an M/F sex ratio of 1.66, male predominance of 62.5%, and a mean age of 4.10 ± 2.8 years. The outcome was favorable in 90.62% of our patients. The mortality was 9.38% with an average hospital stay of 6.8 ± 3.04 days. Conclusion: The respiratory complication of measles is a serious pathology due to the risk of mortality that it can cause, a consultation followed by rapid treatment can contribute to a reduction in complications and a faster cure.

关键词： Measles Respiratory Complication Child Kindia

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Risk Factors for Neonatal Mortality at the Institute of Nutrition and Child health of the Donka/Guinea-Conakry National hospital

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Open Journal of pediatrics 2024年第2期14卷 327-337页

作者： Bangoura Mmah Aminata Kolié Ouo Ouo Camara Salématou hassimiou Baldé Mariama Bangoura Kaba Diop Mamadou Moustapha Camara Emmanuel Diallo Fatoumata Binta Doukouré Mamadou Aliou Mamadou Mouctar Sow Bémy pé Néabey Institut de Nutrition et de Santé de l’Enfant Conakry Guinea service de pédiatrie hô pital National Donka Conakry Guinea service de pédiatrie hô pital National d’Ignace Deen Conakry Guinea

Introduction: The birth of a baby is a moment of joy and celebration. however, the neonatal period is a very delicate phase of life. Neonatal mortality rates remain high in low-income countries. In Guinea, after 20 years, this rate has fallen from 34.2% in 1998 to 32% in 2018. Objective: To identify the main risk factors for neonatal mortality. Methods: This was an observational, analytical case-control study, lasting 6 months from January 1 to June 30, 2019, conducted at the Institut de Nutrition et de la Santé de l’Enfant (INSE) at Donka National hospital. Results: We collected 242 cases and 242 controls, i.e. a total of 484 records. 748 patients were registered, with 32.35% deaths. 82.86% of deaths occurred in the early neonatal period. Statistical analysis revealed the main risk factors: prematurity (RQ 7.39 95% CI 3.27 - 16.61 p = 0.0000003), hypothermia (RQ 2.29 95% CI 1.51 - 3.46 p = 0.0001), acute fetal distress (RQ 2.13 95% CI 1.33 - 3.43 p = 0.0016), low birth weight (QR 1.91 95% CI 1.12 - 3.24 p = 0.016), home birth (QR 3.26 95% CI 1.25 - 8.46 p = 0.015). Conclusion: Neonatal mortality is a health problem in the INSE neonatology department. To reduce the mortality rate in this referral facility, it is essential to equip it and provide ongoing training for staff.

关键词： Neonatal Mortality INSE Guinea-Conakry

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