检索结果-南通市图书馆

Eradication Treatment of Helicobacter pylori Infection: Evaluation of Therapeutic Strategies in N’Djamena

Open Journal of Gastroenterology 2024年第2期14卷 59-67页

作者： Mayanna Habkréo Ali Mahamat Moussa Tahir Mahamat Saleh Djerabet Franckly Fany Haby Mairé dehainssala Adama Ngaré Mahamat Ali Hachim service de medecine Interne et Gastroenterologie Centre Hospitalier Universitaire La Reference Nationale N’Djamena Tchad service de medecine Interne Centre Hospitalier Universitaire La Renaissance N’Djamena Tchad service de Médecine Hopital de l’Amitié Tchad-Chine N’Djamena Tchad

Background: Helicobacter pylori (Hp) infection is the most widespread bacterial infection in the world. The infection is generally acquired in childhood, but can persist into adulthood. Eradication therapy has undergone several modifications. The aim of this study was to evaluate the different therapeutic strategies used in the eradication of Helicobacter pylori infection in the Centre Hospitalier Universitaire La Reference Nationale of N’Djaména. Patients and Methods: This was a prospective, descriptive analytical study spread over one year, from September 2021 to September 2022. Patients at least 15 years of age presenting with dyspeptic symptoms, seen consecutively in a hepato-gastroenterology consultation and with a positive stool test for H. pylori infection, were included in the study. Equally, 1/3 of patients were treated with dual or triple therapy. The remaining third received quadritherapy. Results: A total of 268 patients were included in the study (mean age 38.40 ± 14.66 with extremes of 16 and 80 years). Males predominated in 58% of cases. Overall therapeutic efficacy was 88.9%. According to different therapeutic strategies, efficacy was 90.75% for dual therapy with PPI (Rabeprazole) and Amoxicillin. On the other hand, efficacy was 87% and 88.88% for PPI-based triple therapy and dual antibiotic therapy, and for PPI-based quadruple therapy and triple antibiotic therapy. Conclusion: H. pylori infection is a common disease in Chad. Dual therapy with rabeprazole combined with a high dose of amoxicillin over a period of at least two weeks showed similar if not better efficacy than triple or quadruple therapy.

关键词： Helicobacter pylori Therapeutic Strategies Eradication Dyspepsia Chad

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prevalence and Predictors of Viral Hepatitis D Co-Infection in Chronic HbsAg Carriers

引用

Open Journal of Gastroenterology 2022年第9期12卷 213-220页

作者： Ali Mahamat Moussa Tahir Mahamat Saleh Mayanna Habkreo Bessimbaye Nadlaou Adama Ahmed Ngare Doffou Adjeka Stanislas Assi Constant service de medecine Interne & Gastroentérologie CHU La Référence Nationale N’Djamena Tchad service de medecine Interne CHU La Renaissance N’Djamena Tchad service de Laboratoire CHU La Référence Nationale N’Djamena Tchad

The characteristics of viral hepatitis B and D co-infection are poorly documented in Chad. The aim of our study was to determine the prevalence of HBV/HDV co-infection and the characteristics of this co-infection. Materials and Methods: This was a retrospective study including all patients with chronic HBsAg carriers referred in our department from January 2014 to december 2018. Non-inclusion criteria were: absence of anti-HDV testing, presence of anti-viral hepatitis C or Human Immunodeficiency Virus antibodies or excessive alcohol consumption. The variables studied were age, sex, blood transaminase level, HBV DNA level, HDV RNA level, and liver fibrosis and activity score (Actitest Fibrotest). The prevalence of HDV and the characteristics of HDV/HBV co-infection were determined. Results: During the study period, 403 patients were seen in these two hospitals for chronic HBsAg carriage. Of these, 378 (75%) had performed the anti HDV assay. Anti-HDV antibodies were positive in 53 patients (14%). In multivariate analysis, HBV/HDV co-infected patients were less frequently HBeAg positive (5.4% vs. 28.1%;p = 0.0001), older (35 years vs. 32 years;p = 0.001), and more frequently had significant necrotic-inflammatory activity (3.9% vs. 3.2%;p = 0.031) compared with mono infected patients. Neither gender (76.9% male vs. 77.4% male;p = ns), nor viral load (median 530 IU/ml vs. 195 IU/ml;p = ns), nor significant liver fibrosis (35.1% vs. 47.1%;p = ns), nor transaminases (median 26 vs. 32 IU/ml) were different with mono infected patients. Conclusion: VHD is common in Chad. It is associated with increased hepatic necrotic-inflammatory activity.

关键词： Viral Hepatitis D (Anti VHD Ac) Prevalence Favouring Factors Necrotic-Inflammatory Activity Chad

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insights in living-donor liver transplantation associated with two-stage total hepatectomy:First case in neuroendocrine tumor metastases and functional assessment techniques

引用

Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 392-395页

作者： Laurent Coubeau Samuele Iesari Paulina Henry Philippe D’Abadie Aude Vanbuggenhout Raymond Reding aTransplantation Abdominale Cliniques Universitaires Saint-LucUniversite catholique de LouvainBrusselsBelgium Pole de Chirurgie Experimentale et Transplantation Institut de Recherche Experimentale et CliniqueUniversite catholique de LouvainBrusselsBelgium department of Biotechnological and Applied Clinical Sciences University of L’AquilaL’AquilaItaly service d’anatomo-pathologie Cliniques Universitaires Saint-LucUniversite catholique de LouvainBrusselsBelgium service de medecine nucleaire Cliniques Universitaires Saint-LucUniversite catholique de LouvainBrusselsBelgium

To the Editor:While organ shortage commonly dooms patients on waiting list,alternative options as living-donor liver transplantation(LDLT)are assiduously *** principles of liver surgery rule LDLT:there must be suffici... 详细信息

关键词： donor liver surgery

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Terrorist attacks:cutaneous patterns of gunshot and secondary blast injuries

引用

Forensic Sciences Research 2020年第3期5卷 208-213页

作者： Yann delannoy Isabelle Plu Isabelle Sec Tania delabarde Marc Taccoen Antoine Tracqui Bertrand Ludes Institut Medico-Legal de Paris ParisFrance CHU de LILLE LilleFrance Sorbonne Universite ParisFrance Unite Medico Judiciaire Hotel DieuAPHPParisFrance service de medecine legale CHRU Besanc¸on—Hopital Saint-JacquesBesanconFrance Paris University CNRS FRE 2029ParisFrance

Terrorist attacks have been on the *** the recent terrorist attacks in France,terrorists perpetrated their acts using weapons of war,as well as explosive *** two modes of action,when combined,can create skin lesions with similar macroscopic appearances,which can sometimes go unnoticed because of body fragmentation.A total of 68 autopsies,83 external examinations,140 standard radiographic examinations,and 49 computed tomography(CT)scans were performed over 7 days during the 2015 terrorist attacks in *** were injured by firearms and shrapnel-like *** analysed the clinical findings for the secondary blast cutaneous lesions from the explosive devices and compared these lesions with ballistic-related lesions to highlight that patterns can be macroscopically similar on external *** blast injuries are characterised by penetrating trauma associated with materials added to explosive systems that are propelled by explosive air *** injuries are caused most often by small,shrapnel-like metallic objects,such as nails and *** causes ballistic-type injuries that must be recognised and distinguished from those caused by firearm *** between these lesions is very difficult when using conventional criteria(size,shape,number and distribution on the body)with only external examination of *** is why the particularities of these lesions must be further illustrated and then confirmed by complete autopsies and radiological and anatomopathological examinations.

关键词： Forensic sciences forensic medicine blast injuries explosive agents suicide gunshot wounds

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

公路事故的鉴定

公路事故的鉴定

引用

第十五届国际法庭科学大会

作者： Anne Becart Valery Hedouin Gilles Tournel Joel Blondiaux V.Dubreu Didier Cosset 杨玉璞任嘉诚刘华 Institut de medecine legale et Social Faculte de Medecine Place Theo Varlet59000 LilleFrance. Institut de medecine legale et Social Faculte de Medecine Place Theo Varlet59000 LilleFrance. Institut de medecine legale et Social Faculte de Medecine Place Theo Varlet59000 LilleFrance. Institut de medecine legale et Social Faculte de Medecine Place Theo Varlet59000 LilleFrance. Institut de medecine legale et Social Faculte de Medecine Place Theo Varlet59000 LilleFrance. Institut de medecine legale et Social Faculte de Medecine Place Theo Varlet59000 LilleFrance.

＜正＞这起惊人的案件强调了法医牙科专家在现场尸体毁灭,碎片分散情况下的作用。 1998年6月,一辆卡车司机对收费管理员报告说,他10分钟以前在公路与一头动物相撞,当时天已黑,下着小雨,能见度较差,30分钟后,警察在与公路交叉的一座桥下... 详细信息

＜正＞这起惊人的案件强调了法医牙科专家在现场尸体毁灭,碎片分散情况下的作用。 1998年6月,一辆卡车司机对收费管理员报告说,他10分钟以前在公路与一头动物相撞,当时天已黑,下着小雨,能见度较差,30分钟后,警察在与公路交叉的一座桥下发现一具死尸的遗骸。那天晚上,连接里尔和巴黎的公路交通非常繁忙,警察估计约有450辆车从尸体上开过。令人吃惊的是,现场没有请法医病理专家对尸体进行检查,而是将残骸迅速送到了法医研究所,同时,公路用清扫机和水管清洗了四次,警察在桥下发现了一辆遗弃的汽车。

关键词：法医鉴定齿科学自身

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Epileptiform seizures revealing neurocysticercosis:report of two clinical cases in Libreville,Gabon

引用

Asian Pacific Journal of Tropical Medicine 2010年第8期3卷 671-672页

作者： Okome-Nkoumou MML Ondounda M Dzeing-Ella A Mounguengui D Nziengui Madjinou MI Magne C Nzenze JR departement des maladies infectieuses faculte de medecine de LibrevilleBP 212LibrevilleGabon service de medecine interne Hopital d'Instruction des Armees Omar Bongo Ondimba(HIAOBO)LibrevilleGabon

Neurocysticercosis(NCC) is recognized as a cause of neurologic disease *** reported two cases(one co-infected with the HIV) of *** treatment led to *** should be considered in tropical countries as a cause of epilepsy... 详细信息

关键词： Neurocysticercosis Epilepsy Gabon HIV

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

1988年到1997年间瑞士日内瓦法医学尸检情况和统计

1988年到1997年间瑞士日内瓦法医学尸检情况和统计

引用

第十五届国际法庭科学大会

作者： Anne-Laure Rougemont R.La Harpe 李健杨玉璞任嘉诚 Institute Universitaire de medecine legale 9 av.de Champel1211 Geneve 4Switzerland Institute Universitaire de medecine legale 9 av.de Champel1211 Geneve 4Switzerland

＜正＞本篇的目的是回顾1988年到1997年间所有送往日内瓦法学院的尸体情况。在最近十年内,有3700具尸体是通过我们学院进行尸表检查,或是在我们学院进行解剖。虽然法医的观点和发现可影响尸检类型,但检查的类型主要由警方决定。

关键词：死因法医学日内瓦

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Preoperative biliary drainage for resectable or borderline resectable periampullary tumor: what is the best management?

引用

Hepatobiliary Surgery and Nutrition 2019年第4期8卷 398-400页

作者： Julie Perinel Mustapha Adham service de chirurgie Digestive Hopital Edouard HerriotHospices Civils de LyonLyonFrance Faculte de medecine de Lyon Universite Claude Bernard Lyon 1(UCBL1)LyonFrance

Management of preoperative biliary drainage (PBD) in patients undergoing pancreaticoduodenectomy (PD) is still debated. Obstructive jaundice is associated with a proinflammatory state, impaired immune function and disturbances in coagulation. Patients with jaundice are at high risk to develop renal dysfunction and bacteriobilia. In this context, PBD was traditionally performed before surgery to improve postoperative outcomes.

关键词： impaired biliary jaundice

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Risk Factors of Liver Cirrhosis in Chad: Large Proportion of Cases without Clear Etiology

引用

Open Journal of Gastroenterology 2023年第11期13卷 339-350页

作者： Ali Mahamat Moussa Pascal Pineau Mayanna Habkreo Moussa Hassan Elefi Tahir Mahamat Saleh Maire dehainsala Mahamat Ali Hachim Adama Ahmed N’Gare Adoum Abderrazak Fouda Bessimbaye Nadlaou Adawaye Chatté service de Médecine Interne et Gastroentérologie Centre Hospitalier Universitaire La Référence Nationale Ndjamena Tchad Unité “Organisation Nucléaire et Oncogenèse” Institut National de la Santé et de la Recherche Médicale U993 Paris France service de medecine Interne Centre Hospitalier Universitaire La Renaissance N’Djamena Tchad Programme de Lutte contre le VIH et SIDA Hépatites et Infectins Sexuellement Transmissibles Ministère de la Santé Publique N’Djamena Tchad service de Laboratoire Centre Hospitalier Universitaire La Reference Nationale N’Djamena Tchad

Background: In comparison to other forms of chronic liver diseases, cirrhosis is generally poorly studied in sub Saharan Africa. In Chad, more particularly, no data are available despite the burden of liver diseases considered as the first cause of hospitalizations in the country. Methods: We conducted a retrospective analysis of 268 patients with liver cirrhosis attending care at the University Reference Hospital between 2007 and 2016. Results: This series of liver cirrhoses was characterized by a weak mal predominance (M:F = 1.7). The age of onset occurs significantly earlier in women than in men (40.6 ± 12.0 vs. 44.4 ± 13.4, p = 0.0171). The principal risk factor was persistent infection with hepatitis B virus (49% of cases) followed distantly by infection with hepatitis C virus (13%) and excessive alcohol consumption (10%). Men were more frequently carrying HBV surface antigen than women (65.6% vs 35.9% p = 0.0019). HBV-associated liver cirrhosis was overall more severe than diseases from other causes. A large proportion of cirrhosis (30%), observed primarily in women (48.1% vs 24.1%, p = 0.0036), was considered are cryptogenic. Conclusions: The etiological spectrum of liver cirrhosis remains to be properly defined in Chad. This lack of knowledge prevents the implementation of an efficient policy of prevention. A significant effort should be secured to characterize hitherto neglected infectious, lifestyle or genetic risk factors responsible of this form of terminal disease and improve subsequently liver health of local populations.

关键词： Chad Liver Cirrhosis Hepatitis Viruses Alcohol Cryptogenic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Induction of antiproliferative effect by diosgenin through activation of p53, release of apoptosis-inducing factor (AIF) and modulation of caspase-3 activity in different human cancer cells

引用

Cell Research 2004年第3期14卷 188-196页

作者： Cecile CORBIERE,Bertrand LIAGRE,Faraj TERRO,Jean-Louis BENEYTOUT Laboratoire de Biochimie UPRES EA 1085 Faculté de Pharmacie rue du Docteur Marcland 87025 Limoges Cedex France Laboratoire de Biochimie UPRES EA 1085 Faculté de Pharmacie rue du Docteur Marcland 87025 Limoges Cedex France service d'Histologie et Biologic Cellulaire Faculte de medecine rue du Docteur Marcland 87025 Limoges Cedex France Laboratoire de Biochimie UPRES EA 1085 Faculté de Pharmacie rue du Docteur Marcland 87025 Limoges Cedex France

Previously, we demonstrated that a plant steroid, diosgenin, altered cell cycle distribution and induced apoptosis in the human osteosarcoma 1547 cell line. The objective of this study was to investigate if the antiproliferative effect of diosgenin was similar for different human cancer cell lines such as laryngocarcinoma HEp-2 and melanoma M4Beu cells. Moreover, this work essentially focused on the mitochondrial pathway. We found that diosgenin had an important and similar antiproliferative effect on different types of cancer cells. In addition, our new results show that diosgenin-induced apoptosis is caspase-3 dependent with a fall of mitochondrial membrane potential, nuclear localization of AIF and poly (ADP-ribose) polymerase cleavage. Diosgenin treatment also induces p53 activation and cell cycle arrest in the different cell lines studied.

关键词： diosgenin apoptosis p53 AIF caspase cancer cells.

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：