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Pazopanib-induced posterior reversible encephalopathy syndrome with possible syndrome of inappropriate secretion of antidiuretic hormone: an incidental or pathophysiological association?

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Neural Regeneration Research 2020年第6期15卷 1166-1168页

作者： Jonathan Wong So Bérenger Largeau Frédérique Beau-Salinas Stephan Ehrmann Christophe Magni Jérome Meunier CHR d’Orléans Service d’Oncologie MédicaleOrléansFrance CHRU de Tours Centre d’Investigation Clinique-CIC INSERM 1415ToursFrance CHRU de Tours Service de PharmacosurveillanceCentre Régional de Pharmacovigilance Centre-Val de LoireToursFrance Universitéde Tours INSERMCentre d’étude des pathologies respiratoires(CEPR)-UMR 1100CHRU de ToursService de Médecine Intensive RéanimationCIC INSERM 1415réseau CRICS-TRIGGERSEPToursFrance CHR d’Orléans Service de NeuroradiologieOrléansFrance

Introduction:Pazopanib is an oral protein kinase inhibitor(PKI)that targets vascular endothelial growth factor(VEGF)receptors,fibroblastic growth factor receptors,platelet-derived growth factor receptors,and stem cell factor that inhibits VEGF-induced cellular *** is approved for use in advanced renal cell carcinoma and subtypes of advanced soft-tissue sarcoma(deguchi et al.,2018).Major adverse drug reactions of pazopanib include hypertension,high-grade hyponatremia and posterior reversible encephalopathy syndrome(PRES)(Berardi et al.,2016;deguchi et al.,2018).In clinical trials,few investigations have been conducted to determine the aetiology of PKI-associated hyponatremia,the mechanism remains therefore *** rare cases of PKI-induced syndrome of inappropriate secretion of antidiuretic hormone(SIADH)(Largeau et al.,2019),and none with pazopanib,have been *** is a clinical and radiological entity where a bilateral white matter oedema,occurring predominantly in the posterior occipital and parietal lobes,is associated with several neurologic ***,a recent review suggests that SIADH could be a symptom of PRES(Largeau et al.,2019).To our knowledge,this is the first case published where pazopanib-induced PRES occurs contemporaneously with possible SIADH.

关键词： al. SIADH antidiuretic

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脑积水病人手术治疗后脑脊液容积三维成像的初步研究

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国际医学放射学杂志 2014年第2期 186-187页

作者： J,Hodel P.Besson A.Rahmouni E.Petit A.Lebret B.Grandjacques 张倩 service de neuroradiologie Hpital Roger Salengro59037 LilleFrance

目的建立自动化变形模型以评估手术治疗前后脑积水病人脑脊液(CSF)容积的变化。方法采用Jacobian行列式对变形场术前、术后的图像进行非线性配准后,计算脑

关键词：脑脊液脑积水 MRI 变形模型 SPACE MR序列

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症状性脑内动脉粥样硬化性血栓形成性狭窄的前瞻性研究:GESICA研究

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世界核心医学期刊文摘（神经病学分册） 2006年第9期2卷 16-17页

作者： Mazighi M. Tanasescu R. Ducrocq X. 樊慧婷(译) service de neuroradiologie Hoepital Lariboisière 2 rue Ambroise Pare 75010 Paris France 不详

Background: Symptomatic intracranial atherothrombotic stenoses (ICAS) are associated with high rates of cerebrovascular ischemic events. Objective: To conduct a prospective multicenter study to evaluate the natural history of ICAS and, in those patients refractory to medical treatment, the outcomes associated with intracranial angioplasty. Methods: Patients aged 18 to 80 were enrolled with symptoms attributed to a single ICAS of ≥50%. Optimal medical therapy of vascular risk factors and preventive antithrombotic therapy were at the discretion of the local investigator. Patients were eligible for intracranial angioplasty after experiencing recurrent stroke despite medical therapy. Neurologic and ultrasonographic examinations were performed at study inclusion, 3 months after enrollment, and every 6 months of follow-up thereafter, for 36 months. Results:One hundred two patients were included, with a mean age of 63.3 ±10.4 years. Intracranial artery stenoses involved the vertebral artery in 22.5%, the basilar artery in 25.5%, the middle cerebral artery in 26.5%, and the internal carotid artery in 25.5%. In 27.4%of the patients, the stenoses had clinical hemodynamic characteristics. During a mean follow-up of 23.4 months, 38.2%of the patients had a cerebrovascular event: ischemic stroke in 13.7%and TIA in 24.5%. Among patients with a hemodynamically significant stenosis, 60.7%had a recurrent stroke or TIA in the territory of the stenotic artery; this association was significant in univariate ***-eight patients underwent an endovascular procedure with a neurologic periprocedural complication rate of 14.2%.The overall vascular death rate was 8.8%. Conclusions: despite medical treatment, the 2-year recurrence rate of ischemic events in the territory of the stenotic artery was 38.2%. Cardiovascular events occurred in 18.6%of patients. Clinically significant hemodynamic stenoses were associated with stroke recurrence and may help identify a high risk subset of pat

关键词：动脉粥样硬化性动脉狭窄血栓形成性症状性前瞻性研究脑内血流动力学特征脑血管事件

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Intracranial Atherosclerosis: The Natural History and Management Strategies

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World Journal of Cardiovascular Diseases 2014年第7期4卷 350-360页

作者： Ossama Mansour Martin Schumacher Mohammad A. Farrag Foad Abd-Allah Freiburg Uniklinik Neurozentrium Neuroradiologie Abt. Freiburg Germany Neurology and Interventional Neurology service department Alexandria University Hospital Alexandria Egypt Neurology department Cairo University Hospitals Cairo Egypt

Intracranial atherosclerotic disease (ICAD) represents a major cause of stroke and transient ischemic attacks. The prevalence and natural course of ICAD are closely related to race and ethnicity. The best treatment for ICAD is a crucial issue;data from recent trials indicate that aggressive medical management and life style modifications are better than endovascular treatments for prevention of recurrent stroke in high-risk patients with ICAD. Endovascular treatment is still an option for subgroup of patients who are not responded to optimal medical therapy.

关键词： Intracranial Atherosclerosis Medical Therapy Endovascular Treatment

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根据表观扩散系数预测梗死面积的增长:无需静脉注射对比剂评价半暗带

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国际医学放射学杂志 2009年第2期32卷 180-181页

作者： C.Rosso N.Hevia-Montiel S.deltour *** D.Dormont S. Crozier 高欣 AP-HP-Urgences Cérébro-Vasculaires Laboratoire de Neurosciences Cognitives et Imagerie Cérébraleand APHP-Service de NeuroradiologieUniversité Pierre et Marie Curie

目的通过对急性脑卒中病人的MR扩散加权成像（DWI）进行后处理得到表观扩散系数图（ADC图）来比较预测的和最终梗死的病变体积，证实预测的梗死面积的增长可反映因血管是否再通而处于危险状态的半暗带。方法法国立法规定基于病人医疗... 详细信息

目的通过对急性脑卒中病人的MR扩散加权成像（DWI）进行后处理得到表观扩散系数图（ADC图）来比较预测的和最终梗死的病变体积，证实预测的梗死面积的增长可反映因血管是否再通而处于危险状态的半暗带。方法法国立法规定基于病人医疗文件的此类研究无需通知病人并得到其同意，但病人和（或）其亲属也被告知可拒绝参加此研究。

关键词：表观扩散系数梗死面积半暗带静脉注射预测对比剂 MR扩散加权成像 ADC图

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Characteristics of a primate model of focal motor cortical seizures suitable for preclinical testing of therapies like DBS

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World Journal of Neuroscience 2014年第1期4卷 47-57页

作者： Shivadatta Prabhu Brigitte Piallat Annaelle devergnas Thomas Blauwblomme Ariana Sherdil Nathalie Chivoret Olivier David Stephan Chabardes Fonctions Cerebrales et Neuromodulation Universite Joseph FourierGrenobleFrance Inserm U836Grenoble Institut des NeurosciencesGrenobleFrance Yerkes National Primate Research Center Emory UniversityAtlantaUSA service de Neurochirurgie Pediatrique Hopital NeckerUniversite Paris DescartesSorbonne Paris CiteParisFrance Clinique Universitaire de neuroradiologie et IRM Centre Hospitalier UniversitaireGrenobleFrance Clinique Universitaire de Neurochirurgie Pole Tete et CouCentre Hospitalier UniversitaireGrenobleFrance

Background and objective: Generating and characterizing primate models of epileptic seizures are important for understanding pathophysiology of diseases and establishing preclinical efficacy of novel therapies like deep Brain Stimulation. A focal motor epilepsy model is described here. Method: Seizures were obtained after intracortical penicillin injection into the motor strip through a cannula in two awake monkeys and electrocorticograms were recorded by epidural screws. Seizures were analyzed and compared for number, average duration of each seizure and total duration of ictal activity. Pharmaco-resistance for antiepileptic drug was tested by administration of Diazepam during seizures. Results: A motor status with seizures mimicking those seen in Kojevnikov’s syndrome was easily generated several minutes after penicillin injection and lasted 24 h on an average. The model thus characterized appears stable and consistent. There is no significant variation between experiments in individual primate as well as between two specimens. Diazepam though reduced the total duration of seizures, failed to abolish behavioural seizures. Conclusion: This model represents a good alternative model for preclinical research aiming at testing novel therapies because seizures are obtained on demand, last up to 24 h after a single penicillin injection, are stable and resistant to Diazepam.

关键词： Focal Motor Epilepsy Primate Model Penicillin Preclinical Testing

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线粒体细胞病患者的脑部MRI表现

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世界核心医学期刊文摘（神经病学分册） 2005年第9期1卷 17-18页

作者： Barragn-Campos H.M. Vallée J.-N. L.D. 高中宝 service de neuroradiologie du Professeur Jacques Chiras Groupe Hospitalier Pi tié-Salpêtrière 47-83 Boulevard de l'hpital 75651 Paris Cedex 13 FranceDr.

Background: Mitochondrial cytopathies (MCs) are a heterogeneous group of clini cal entities, some of which have classic phenotypes. Magnetic resonance imaging (MRI) has been reported to be helpful in the diagnosis of MC. Objective: To corr elate the most common brain MRI findings reported in patients with MC with the c linical findings in patients in different MC subgroups. design: Case series. Set ting: Patients with MCs seen at the Instituto National de Ciencias Médicas y Nu tritin Salvador Zubirn, Mexico City, Mexico. Patients: Twenty-one patients with MC with the following phenotypes: chronic progressive external ophthalmople gia (n=7), Kearns-Sayre syndrome (n=7), mitochondrial neurogastrointestinal enc ephalopathy (n=6), and myoclonic epilepsy with ragged red fiber myopathy (n=1). Results: Brain MRI abnormalities were found in 20 (95%) of 21 patients. The mos t frequent abnormalities were widespread white matter hyperintensity in 19 patie nts (90%), supratentorial cortical atrophy in 18 patients (86%), and cerebella r atrophy in 13 patients (62%). Widespread white matter hyperin tensity (P despread white matter hyperintensity and/or supratentorial cortical atrophy in brain MRI may help to establish the diagnosis of MC. The radiologist has a role to play in the workup of MC by confirming the diagnosis and possibly distinguishing different subgroups of MC.

关键词：细胞病 MRI 肌阵挛型癫痫皮质萎缩脑白质放射科医师小脑萎缩鉴别诊断纤维肌脑病

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液体-衰减反转恢复(FLAIR)序列成像对急性卒中的评估:不同观察者和不同技术之间的重复性

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世界核心医学期刊文摘(神经病学分册) 2006年第10期 25-25页

作者： Gauvrit J.- Y. Leclerc X. Girot M. 牛亚利 service de neuroradiologie Hpital Roger Salengro Rue Emile Laine 59037 Lille Cedex France Dr.

Background and purpose: Diffusion- weighted magnetic resonance (MR) imaging (DWI), and three- dimensional (3D)- time- of- flight (TOF) MR angiography (MRA), are highly sensitive for the early detection of stroke and arterial occlusion. However, only a few studies have evaluated the sensitivity of conventional MR sequences that are usually included in the imaging protocol. The aim of this study was to evaluate interobserver and intertechnique reproducibility of Fluid- Attenuated Inversion Recovery (FLAIR) sequences for the diagnosis of early brain ischemia and arterial occlusion. Methods: Over a 30- month period, brain MR examinations were performed in 34 patients within 12 hours after stroke onset. Imaging protocol included FLAIR sequences, DWI and 3D TOF MRA. Ten observers including radiologists and neurologists, performed separately a visual interpretation of FLAIR images for the detection of brain ischemia and arterial occlusion seen as an arterial high signal. DWI and 3D TOF MRA were used as reference and interpreted independently by two senior radiologists. Interobserver agreement was assessed for image quality, detectability and conspicuity of lesions whereas intertechnique agreement was only judged for lesion detectability. Results: On FLAIR sequences, interobserver agreement for the detection of brain ischemia and arterial occlusion was excellent (κ =0.81 and 0.87 respectively). The concordance between FLAIR and DWI sequences for the detection of brain ischemia and between FLAIR and 3D TOFMRA for the detection of arterial occlusion were judged as excellent for all observers (κ = 0.91 and 0.89 respectively). Conclusion: Although DWI is the most sensitive technique with which to detect acute stroke, FLAIR imaging may alsobe useful todemonstrate both acute ischemia and arterial occlusion with an excellent interobserver reproducibility.

关键词： FLAIR 急性卒中反转恢复序列

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躯干前屈与帕金森病的MRI表现

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国际医学放射学杂志 2008年第5期31卷 422-422页

作者： F.Bonneville F.Bloch E.Kurys S.T.du Montcel M.L.Welter *** 唐光健 service de neuroradiologie Hopital de la Pitie-Salpetrière Assistance Publique-Hopitaux de Paris 47 Boulevard de l’ Hopital 75651 Paris Cedex 13 France. service de neuroradiologie Hopital de la Pitie-Salperière Assistance Publique-Hopitaux de Paris 47 Boulevard de l’ Hopital 75651 Paris Cedex 13 France.

躯干前屈的特点是仅在站立或行走时才有脊柱过度前屈。这种症状的起源不清，但近来的临床报告称躯干前屈与帕金森病（PD）有关，提示脑部受累在躯干前屈的发病机制中起一定作用。本研究的目的是探讨PD病人躯干前屈源于中枢神经系统的假... 详细信息

躯干前屈的特点是仅在站立或行走时才有脊柱过度前屈。这种症状的起源不清，但近来的临床报告称躯干前屈与帕金森病（PD）有关，提示脑部受累在躯干前屈的发病机制中起一定作用。本研究的目的是探讨PD病人躯干前屈源于中枢神经系统的假说。17例伴有躯干前屈的PD病人前瞻性纳入研究，与10例没有躯干前屈的PD病人及12名正常人行对照性研究。10例没有躯干前屈的PD病人与17例伴有躯干前屈的PD病人相匹配。在三维MRI上测量脑、纹状体核的标准化体积，以及中脑和桥脑的横截面积。

关键词：躯干前屈帕金森病 MRI 脑体积

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